AU775988B2 - Ligand activated transcriptional regulator proteins - Google Patents

Ligand activated transcriptional regulator proteins Download PDF

Info

Publication number
AU775988B2
AU775988B2 AU11438/01A AU1143801A AU775988B2 AU 775988 B2 AU775988 B2 AU 775988B2 AU 11438/01 A AU11438/01 A AU 11438/01A AU 1143801 A AU1143801 A AU 1143801A AU 775988 B2 AU775988 B2 AU 775988B2
Authority
AU
Australia
Prior art keywords
fusion protein
vector
sequence
dna
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU11438/01A
Other languages
English (en)
Other versions
AU1143801A (en
Inventor
Carlos F. Barbas
Roger Beerli
Michael Kadan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Novartis AG
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG, Scripps Research Institute filed Critical Novartis AG
Publication of AU1143801A publication Critical patent/AU1143801A/en
Application granted granted Critical
Publication of AU775988B2 publication Critical patent/AU775988B2/en
Assigned to SCRIPPS RESEARCH INSTITUTE, THE reassignment SCRIPPS RESEARCH INSTITUTE, THE Alteration of Name(s) in Register under S187 Assignors: NOVARTIS AG, SCRIPPS RESEARCH INSTITUTE, THE
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AU11438/01A 1999-10-25 2000-10-23 Ligand activated transcriptional regulator proteins Ceased AU775988B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43304299A 1999-10-25 1999-10-25
US09/433042 1999-10-25
US09/586625 2000-06-02
US09/586,625 US7329728B1 (en) 1999-10-25 2000-06-02 Ligand activated transcriptional regulator proteins
PCT/EP2000/010430 WO2001030843A1 (en) 1999-10-25 2000-10-23 Ligand activated transcriptional regulator proteins

Publications (2)

Publication Number Publication Date
AU1143801A AU1143801A (en) 2001-05-08
AU775988B2 true AU775988B2 (en) 2004-08-19

Family

ID=27029724

Family Applications (1)

Application Number Title Priority Date Filing Date
AU11438/01A Ceased AU775988B2 (en) 1999-10-25 2000-10-23 Ligand activated transcriptional regulator proteins

Country Status (8)

Country Link
US (3) US7329728B1 (ja)
EP (1) EP1226168A1 (ja)
JP (2) JP2003512827A (ja)
AU (1) AU775988B2 (ja)
CA (1) CA2388535A1 (ja)
IL (2) IL149142A0 (ja)
NZ (1) NZ518218A (ja)
WO (1) WO2001030843A1 (ja)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU778150B2 (en) * 1999-05-28 2004-11-18 Gendaq Limited Molecular switches
US7329728B1 (en) 1999-10-25 2008-02-12 The Scripps Research Institute Ligand activated transcriptional regulator proteins
DE60126913T2 (de) * 2000-01-24 2007-06-28 Gendaq Ltd. Nucleinsäure bindende polypeptide gekennzeichnet durch flexible linker verbundene nucleinsäuredomäne
DE60132208T2 (de) * 2000-07-18 2008-12-24 Novartis Ag Regulation der genexpression unter verwendung von einkettigen, monomeren, liganden-abhängigen polypeptidschaltern
US7011972B2 (en) 2000-07-18 2006-03-14 The Scripps Research Institute Fusion polypeptide comprising two ligand binding domains
WO2002026960A2 (en) * 2000-09-29 2002-04-04 Sangamo Biosciences, Inc. Modulation of gene expression using localization domains
US6919204B2 (en) 2000-09-29 2005-07-19 Sangamo Biosciences, Inc. Modulation of gene expression using localization domains
AU2002243645A1 (en) 2001-01-22 2002-07-30 Sangamo Biosciences, Inc. Zinc finger proteins for dna binding and gene regulation in plants
IL157335A0 (en) 2001-03-13 2004-02-19 Novartis Ag Lentiviral packaging constructs
US7381813B2 (en) 2001-05-31 2008-06-03 Novartis Ag Nucleic acids encoding estrogen receptor ligand binding domain variants
US8673589B2 (en) 2002-05-29 2014-03-18 Regeneron Pharmaceuticals, Inc. Inducible eukaryotic expression system
MXPA04011679A (es) * 2002-05-29 2005-03-07 Regeneron Pharma Sistema de expresion eucariotico inducible.
EP1627046A4 (en) * 2003-05-06 2008-02-13 Scripps Research Inst DOMAIN EXCHANGE BINDING MOLECULES, METHODS OF USE AND METHODS OF PRODUCTION
EP1680447A2 (en) * 2003-10-24 2006-07-19 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Orthogonal gene switches
WO2006031976A2 (en) * 2004-09-14 2006-03-23 Mcgill University Compositions and methods for treating stat-6 associated diseases or conditions
WO2009018576A1 (en) * 2007-08-02 2009-02-05 Biodesic Compositions and methods for analyte detection and quantitation
EP2441774B1 (en) 2010-10-15 2018-12-12 Fundació Centre de Regulació Genòmica Peptides having zinc finger domains and uses thereof
US8450107B1 (en) 2011-11-30 2013-05-28 The Broad Institute Inc. Nucleotide-specific recognition sequences for designer TAL effectors
US20130137173A1 (en) * 2011-11-30 2013-05-30 Feng Zhang Nucleotide-specific recognition sequences for designer tal effectors
US10801017B2 (en) 2011-11-30 2020-10-13 The Broad Institute, Inc. Nucleotide-specific recognition sequences for designer TAL effectors
KR102076728B1 (ko) * 2012-02-02 2020-02-12 다우 아그로사이언시즈 엘엘씨 식물 전사활성화 상호작용 모티프 및 그의 용도
WO2013119880A1 (en) 2012-02-07 2013-08-15 Global Bio Therapeutics Usa, Inc. Compartmentalized method of nucleic acid delivery and compositions and uses thereof
JP6297692B2 (ja) 2013-08-08 2018-03-20 グローバル・バイオ・セラピューティクス・インコーポレイテッドＧｌｏｂａｌ Ｂｉｏ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 低侵襲処置用クランプデバイスおよびその使用
WO2017134137A1 (en) * 2016-02-05 2017-08-10 Polygene Ag Glucocorticoid-based gene regulation system
CA3019199A1 (en) 2016-04-15 2017-10-19 Alpine Immune Sciences, Inc. Icos ligand variant immunomodulatory proteins and uses thereof
MA43552A (fr) 2016-04-15 2018-11-07 Alpine Immune Sciences Inc Protéines immunomodulatrices à variants de cd80 et leurs utilisations
WO2018022945A1 (en) 2016-07-28 2018-02-01 Alpine Immune Sciences, Inc. Cd112 variant immunomodulatory proteins and uses thereof
US11471488B2 (en) 2016-07-28 2022-10-18 Alpine Immune Sciences, Inc. CD155 variant immunomodulatory proteins and uses thereof
CN110088127A (zh) 2016-07-28 2019-08-02 高山免疫科学股份有限公司 Cd155变体免疫调节蛋白及其用途
CN110352245A (zh) 2016-10-20 2019-10-18 高山免疫科学股份有限公司 可分泌变体免疫调节蛋白和工程化细胞疗法
CN110831963A (zh) 2017-03-16 2020-02-21 高山免疫科学股份有限公司 Pd-l1变体免疫调节蛋白及其用途
JP2020511144A (ja) 2017-03-16 2020-04-16 アルパイン イミューン サイエンシズ インコーポレイテッド Ｐｄ−ｌ２バリアント免疫調節タンパク質及びその使用
EP3596114A2 (en) 2017-03-16 2020-01-22 Alpine Immune Sciences, Inc. Cd80 variant immunomodulatory proteins and uses thereof
CA3077509A1 (en) 2017-10-10 2019-04-18 Alpine Immune Sciences, Inc. Ctla-4 variant immunomodulatory proteins and uses thereof
AU2018351000B2 (en) 2017-10-18 2023-11-30 Alpine Immune Sciences, Inc. Variant ICOS Ligand immunomodulatory proteins and related compositions and methods
JP7401432B2 (ja) * 2017-12-01 2023-12-19 エンコーデッド セラピューティクス， インコーポレイテッド 操作されたｄｎａ結合タンパク質
CA3087149A1 (en) 2018-01-03 2019-07-11 Alpine Immune Sciences, Inc. Multi-domain immunomodulatory proteins and methods of use thereof
WO2019241758A1 (en) 2018-06-15 2019-12-19 Alpine Immune Sciences, Inc. Pd-1 variant immunomodulatory proteins and uses thereof
SG11202102644XA (en) 2018-09-19 2021-04-29 Alpine Immune Sciences Inc Methods and uses of variant cd80 fusion proteins and related constructs
SG11202104337PA (en) 2018-11-26 2021-05-28 Massachusetts Inst Technology Compositions and methods for immune tolerance
CA3120868A1 (en) 2018-11-30 2020-06-04 Alpine Immune Sciences, Inc. Cd86 variant immunomodulatory proteins and uses thereof
BR112021020447A2 (pt) 2019-04-17 2022-05-17 Alpine Immune Sciences Inc Métodos e usos de proteínas de fusão de ligante icos variante (icosl)
CN114585741A (zh) * 2019-05-28 2022-06-03 奥科坦特公司 转录中继系统
US20230174612A1 (en) * 2020-04-09 2023-06-08 The Regents Of The University Of California Notch receptors with zinc finger-containing transcriptional effector
EP4340855A1 (en) 2021-08-13 2024-03-27 Triovance Holding LLC A skin substitute composition and methods of producing and using the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018925A2 (en) * 1996-10-29 1998-05-07 Valentis, Inc. Modified glucocorticoid receptors, glucocorticoid receptors/progesterone receptors hybrids
WO1999045132A1 (en) * 1998-03-02 1999-09-10 Massachusetts Institute Of Technology Poly zinc finger proteins with improved linkers

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US540065A (en) * 1895-05-28 Andrew kriegee
US81614A (en) * 1868-09-01 Jacob erdle
US182698A (en) * 1876-09-26 Improvement in machines for canceling postage-stamps and postmarking letters
US147327A (en) * 1874-02-10 Improvement in weft-stop mechanisms for looms
US2996496A (en) 1956-06-22 1961-08-15 Central Pharmacal Company Calcium substitution products of dextran
US4394443A (en) 1980-12-18 1983-07-19 Yale University Method for cloning genes
US4446235A (en) 1982-03-22 1984-05-01 Genentech, Inc. Method for cloning human growth hormone varient genes
US4981784A (en) 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5317090A (en) 1987-12-16 1994-05-31 Institut Pasteur Steroid/thyroid hormone receptor-related gene, which is inappropriately expressed in human hepatocellular carcinoma, and which is a retinoic acid receptor
US5217867A (en) * 1988-11-30 1993-06-08 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
JPH04504654A (ja) 1988-12-23 1992-08-20 ザ　ソーク　インスティテュート　フォア　バイオロジカル　スタディーズ レセプターの転写抑制活性組成物および方法
US5198346A (en) 1989-01-06 1993-03-30 Protein Engineering Corp. Generation and selection of novel DNA-binding proteins and polypeptides
US4990607A (en) 1989-03-14 1991-02-05 The Rockefeller University Alteration of gene expression in plants
US5140466A (en) * 1990-12-20 1992-08-18 Hughes Aircraft Company Optical multiplexer
WO1993023431A1 (en) 1992-05-14 1993-11-25 Baylor College Of Medicine Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy
US6416998B1 (en) 1992-09-02 2002-07-09 Baylor College Of Medicine Plasmid encoding a modified steroid hormone
US5364791A (en) 1992-05-14 1994-11-15 Elisabetta Vegeto Progesterone receptor having C. terminal hormone binding domain truncations
GB9214857D0 (en) * 1992-07-13 1992-08-26 Medical Res Council Human nucleic acid fragments and their use
US20050084885A1 (en) 1994-01-18 2005-04-21 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US6242568B1 (en) 1994-01-18 2001-06-05 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
ATE310812T1 (de) 1994-01-18 2005-12-15 Scripps Research Inst Derivate von zinkfingerproteinen und methoden
US6140466A (en) 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US5789538A (en) 1995-02-03 1998-08-04 Massachusetts Institute Of Technology Zinc finger proteins with high affinity new DNA binding specificities
US6723531B2 (en) 1996-04-05 2004-04-20 The Salk Institute For Biological Studies Method for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6140081A (en) 1998-10-16 2000-10-31 The Scripps Research Institute Zinc finger binding domains for GNN
US6599692B1 (en) 1999-09-14 2003-07-29 Sangamo Bioscience, Inc. Functional genomics using zinc finger proteins
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US7329728B1 (en) * 1999-10-25 2008-02-12 The Scripps Research Institute Ligand activated transcriptional regulator proteins
US7151201B2 (en) * 2000-01-21 2006-12-19 The Scripps Research Institute Methods and compositions to modulate expression in plants
EP1276869A2 (en) 2000-01-21 2003-01-22 The Scripps Research Institute Methods and compositions to modulate expression in plants
JP2003531609A (ja) 2000-05-01 2003-10-28 ノバルティス アクチエンゲゼルシャフト 目に関する形質導入用ベクターおよび遺伝子治療を目的とするその用途
WO2002004522A2 (en) 2000-07-10 2002-01-17 Novartis Ag Bifunctional molecules and vectors complexed therewith for targeted gene delivery
DE60132208T2 (de) 2000-07-18 2008-12-24 Novartis Ag Regulation der genexpression unter verwendung von einkettigen, monomeren, liganden-abhängigen polypeptidschaltern
US7011972B2 (en) 2000-07-18 2006-03-14 The Scripps Research Institute Fusion polypeptide comprising two ligand binding domains
US7067617B2 (en) 2001-02-21 2006-06-27 The Scripps Research Institute Zinc finger binding domains for nucleotide sequence ANN
DE60233555D1 (de) 2001-02-21 2009-10-15 Novartis Ag Die nukleotidsequenz ann bindende zink-finger domänen
US7381813B2 (en) 2001-05-31 2008-06-03 Novartis Ag Nucleic acids encoding estrogen receptor ligand binding domain variants
JP2005500061A (ja) 2001-08-20 2005-01-06 ザ スクリップス リサーチ インスティテュート Ｃｎｎについての亜鉛フィンガー結合ドメイン
WO2003062400A2 (en) 2002-01-24 2003-07-31 The Scripps Research Institute Fiber shaft modifications for efficient targeting
AU2003215094B2 (en) 2002-02-07 2008-05-29 The Scripps Research Institute Zinc finger libraries
US20060211846A1 (en) * 2002-02-13 2006-09-21 Barbas Carlos F Iii Zinc finger binding domains for nucleotide sequence ANN
AU2003274404A1 (en) 2002-06-11 2003-12-22 The Scripps Research Institute Artificial transcription factors
CA2575359A1 (en) * 2004-07-28 2006-02-02 Glaxo Group Limited Piperazine derivatives useful for the treatment of gastrointestinal disorders
EP2130838A3 (en) * 2005-08-11 2010-04-07 The Scripps Research Institute Zinc finger binding domains for CNN
JP2009520463A (ja) * 2005-11-28 2009-05-28 ザ スクリプス リサーチ インスティテュート Ｔｎｎのための亜鉛フィンガー結合ドメイン
WO2007081647A2 (en) * 2006-01-03 2007-07-19 The Scripps Research Institute Zinc finger domains specifically binding agc
US8874746B1 (en) 2010-05-24 2014-10-28 Datacore Software Corporation Collaboration between discrete systems and a shared system to consolidate shared storage-related services

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018925A2 (en) * 1996-10-29 1998-05-07 Valentis, Inc. Modified glucocorticoid receptors, glucocorticoid receptors/progesterone receptors hybrids
WO1999045132A1 (en) * 1998-03-02 1999-09-10 Massachusetts Institute Of Technology Poly zinc finger proteins with improved linkers

Also Published As

Publication number Publication date
NZ518218A (en) 2004-04-30
US7442784B2 (en) 2008-10-28
JP2009273463A (ja) 2009-11-26
US20080318839A1 (en) 2008-12-25
JP2003512827A (ja) 2003-04-08
IL149142A (en) 2010-05-31
WO2001030843A1 (en) 2001-05-03
AU1143801A (en) 2001-05-08
US7329728B1 (en) 2008-02-12
IL149142A0 (en) 2002-11-10
WO2001030843A9 (en) 2002-09-19
CA2388535A1 (en) 2001-05-03
US20030186841A1 (en) 2003-10-02
EP1226168A1 (en) 2002-07-31

Similar Documents

Publication Publication Date Title
AU775988B2 (en) Ligand activated transcriptional regulator proteins
KR101666228B1 (ko) 생물치료학적 분자를 발현시키기 위한 치료학적 유전자-스위치 작제물 및 생물반응기, 및 이의 용도
US7527966B2 (en) Gene regulation in transgenic animals using a transposon-based vector
KR100880509B1 (ko) 재조합 단백질의 대량 생산을 위한 신규한 벡터, 발현세포주 및 이를 이용한 재조합 단백질의 생산 방법
AU2022200903B2 (en) Engineered Cascade components and Cascade complexes
US20030119104A1 (en) Chromosome-based platforms
JP2003534775A (ja) タンパク質を不安定化する方法とその使用
KR102584628B1 (ko) T-세포 수용체, t-세포 항원 및 이들의 기능성 상호작용의 식별 및 특징규명을 위한 조작된 다성분 시스템
KR20210108423A (ko) 아데노 관련 바이러스 (aav) 생산자 세포주 및 관련 방법
KR20160002880A (ko) 엔도솜 포집을 극복하기 위해 설계된 인공 전사 인자
CN111094569A (zh) 光控性病毒蛋白质、其基因及包含该基因的病毒载体
WO2005081716A2 (en) DNA VACCINES TARGETING ANTIGENS OF THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS (SARS-CoV)
CN110637090A (zh) 用于表达大型核酸转基因的质粒载体
KR20240037185A (ko) 키메라 공동자극 수용체, 케모카인 수용체, 및 세포 면역치료에서의 이의 용도
JP2023025182A (ja) Ｔ細胞レセプター及びｔ細胞抗原の同定及び特徴決定のための遺伝子操作された多成分システム
KR20230019063A (ko) C9orf72 연관 질환의 치료를 위한 삼중 기능 아데노-연관 바이러스 (aav) 벡터
CN112877292A (zh) 产生人抗体的细胞
KR20240021906A (ko) 발현 벡터, 박테리아 서열-무함유 벡터, 및 이를 제조하고 사용하는 방법
KR20230117327A (ko) 가용성 알칼리성 포스파타제 작제물 및 가용성 알칼리성 포스파타제 작제물을 인코딩하는 폴리뉴클레오티드를 포함하는 발현 벡터
KR102393402B1 (ko) 세포 내 존재 단백질과 세포 외부로 분비되는 단백질을 동시 발현하는 이중발현벡터를 포함하는 암의 예방 또는 치료용 조성물
KR20240022571A (ko) Rna-가이드된 이펙터 동원을 위한 시스템, 방법 및 성분
US20240207318A1 (en) Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
RU2774631C1 (ru) Сконструированные компоненты cascade и комплексы cascade
KR20240029020A (ko) Dna 변형을 위한 crispr-트랜스포손 시스템
CN117881788A (zh) 表达载体、无细菌序列载体及其制备和使用方法

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase
TH Corrigenda

Free format text: IN VOL 15, NO 33, PAGE(S) 6983-6987 UNDER THE HEADING APPLICATIONS LAPSED, REFUSED OR WITHDRAWN PLEASE DELETE ALL REFERENCE TO APPLICATION NO. 79207/00 AND 11438/01