AU769571B2 - Polyionic coatings in analytic and sensor devices - Google Patents
Polyionic coatings in analytic and sensor devices Download PDFInfo
- Publication number
- AU769571B2 AU769571B2 AU46846/00A AU4684600A AU769571B2 AU 769571 B2 AU769571 B2 AU 769571B2 AU 46846/00 A AU46846/00 A AU 46846/00A AU 4684600 A AU4684600 A AU 4684600A AU 769571 B2 AU769571 B2 AU 769571B2
- Authority
- AU
- Australia
- Prior art keywords
- peg
- pll
- substrate
- functionalized
- adsorption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920000831 ionic polymer Polymers 0.000 title claims abstract description 56
- 238000000576 coating method Methods 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 160
- 238000001179 sorption measurement Methods 0.000 claims abstract description 152
- 239000000758 substrate Substances 0.000 claims abstract description 123
- -1 poly(ethylene glycol) Polymers 0.000 claims abstract description 83
- 229920001577 copolymer Polymers 0.000 claims abstract description 82
- 239000000463 material Substances 0.000 claims abstract description 80
- 239000012491 analyte Substances 0.000 claims abstract description 52
- 230000003993 interaction Effects 0.000 claims abstract description 43
- 239000000126 substance Substances 0.000 claims abstract description 13
- 229920000642 polymer Polymers 0.000 claims description 192
- 102000004169 proteins and genes Human genes 0.000 claims description 78
- 108090000623 proteins and genes Proteins 0.000 claims description 78
- 235000018102 proteins Nutrition 0.000 claims description 77
- 229960002685 biotin Drugs 0.000 claims description 58
- 239000011616 biotin Substances 0.000 claims description 58
- 238000003556 assay Methods 0.000 claims description 51
- 239000003446 ligand Substances 0.000 claims description 47
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 46
- 238000001514 detection method Methods 0.000 claims description 43
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 39
- 230000003287 optical effect Effects 0.000 claims description 37
- 229910044991 metal oxide Inorganic materials 0.000 claims description 36
- 150000004706 metal oxides Chemical class 0.000 claims description 36
- 229910052751 metal Inorganic materials 0.000 claims description 32
- 239000002184 metal Substances 0.000 claims description 32
- 230000002452 interceptive effect Effects 0.000 claims description 29
- 235000020958 biotin Nutrition 0.000 claims description 23
- 230000027455 binding Effects 0.000 claims description 22
- 125000002091 cationic group Chemical group 0.000 claims description 22
- 230000007935 neutral effect Effects 0.000 claims description 21
- 238000005859 coupling reaction Methods 0.000 claims description 18
- 230000008878 coupling Effects 0.000 claims description 17
- 238000010168 coupling process Methods 0.000 claims description 17
- 230000005284 excitation Effects 0.000 claims description 17
- 125000000524 functional group Chemical group 0.000 claims description 15
- 239000011248 coating agent Substances 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 14
- 239000010936 titanium Substances 0.000 claims description 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 13
- 150000004676 glycans Chemical class 0.000 claims description 12
- 150000002739 metals Chemical class 0.000 claims description 12
- 229920001282 polysaccharide Polymers 0.000 claims description 12
- 239000005017 polysaccharide Substances 0.000 claims description 12
- 238000000059 patterning Methods 0.000 claims description 11
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 10
- 125000000129 anionic group Chemical group 0.000 claims description 10
- 238000004113 cell culture Methods 0.000 claims description 10
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 9
- 150000001413 amino acids Chemical class 0.000 claims description 8
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical group C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims description 8
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 8
- 229910052737 gold Inorganic materials 0.000 claims description 8
- 239000010931 gold Substances 0.000 claims description 8
- 150000003573 thiols Chemical class 0.000 claims description 8
- 239000010955 niobium Substances 0.000 claims description 7
- 229910052719 titanium Inorganic materials 0.000 claims description 7
- 150000001720 carbohydrates Chemical class 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- 229910052710 silicon Inorganic materials 0.000 claims description 6
- 239000010703 silicon Substances 0.000 claims description 6
- 238000007306 functionalization reaction Methods 0.000 claims description 5
- 229920002643 polyglutamic acid Polymers 0.000 claims description 5
- 229920001059 synthetic polymer Polymers 0.000 claims description 5
- 229910052715 tantalum Inorganic materials 0.000 claims description 5
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 5
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- 229920000805 Polyaspartic acid Polymers 0.000 claims description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 4
- 229910052758 niobium Inorganic materials 0.000 claims description 4
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 claims description 4
- 229910052709 silver Inorganic materials 0.000 claims description 4
- 239000004332 silver Substances 0.000 claims description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 3
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims description 3
- 108010020346 Polyglutamic Acid Proteins 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 229940072056 alginate Drugs 0.000 claims description 3
- 235000010443 alginic acid Nutrition 0.000 claims description 3
- 229920000615 alginic acid Polymers 0.000 claims description 3
- 235000014633 carbohydrates Nutrition 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 229910052735 hafnium Inorganic materials 0.000 claims description 3
- VBJZVLUMGGDVMO-UHFFFAOYSA-N hafnium atom Chemical compound [Hf] VBJZVLUMGGDVMO-UHFFFAOYSA-N 0.000 claims description 3
- 229920000669 heparin Polymers 0.000 claims description 3
- 229960002897 heparin Drugs 0.000 claims description 3
- 229920002674 hyaluronan Polymers 0.000 claims description 3
- 229960003160 hyaluronic acid Drugs 0.000 claims description 3
- 238000000813 microcontact printing Methods 0.000 claims description 3
- 229920001277 pectin Polymers 0.000 claims description 3
- 239000001814 pectin Substances 0.000 claims description 3
- 235000010987 pectin Nutrition 0.000 claims description 3
- 108010064470 polyaspartate Proteins 0.000 claims description 3
- 108091033319 polynucleotide Proteins 0.000 claims description 3
- 102000040430 polynucleotide Human genes 0.000 claims description 3
- 239000002157 polynucleotide Substances 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 235000000346 sugar Nutrition 0.000 claims description 3
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 229920001287 Chondroitin sulfate Polymers 0.000 claims description 2
- 229920000045 Dermatan sulfate Polymers 0.000 claims description 2
- 108090000288 Glycoproteins Proteins 0.000 claims description 2
- 102000003886 Glycoproteins Human genes 0.000 claims description 2
- 229920002971 Heparan sulfate Polymers 0.000 claims description 2
- 229920002201 Oxidized cellulose Polymers 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 239000000679 carrageenan Substances 0.000 claims description 2
- 229920001525 carrageenan Polymers 0.000 claims description 2
- 235000010418 carrageenan Nutrition 0.000 claims description 2
- 229940113118 carrageenan Drugs 0.000 claims description 2
- 229940059329 chondroitin sulfate Drugs 0.000 claims description 2
- 229940051593 dermatan sulfate Drugs 0.000 claims description 2
- 229960000633 dextran sulfate Drugs 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 238000002513 implantation Methods 0.000 claims description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
- 239000011976 maleic acid Substances 0.000 claims description 2
- 229940107304 oxidized cellulose Drugs 0.000 claims description 2
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims description 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 2
- 229920000193 polymethacrylate Polymers 0.000 claims description 2
- 150000008163 sugars Chemical class 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 4
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 claims 1
- 229910000831 Steel Inorganic materials 0.000 claims 1
- 229910052804 chromium Inorganic materials 0.000 claims 1
- 239000011651 chromium Substances 0.000 claims 1
- UOUJSJZBMCDAEU-UHFFFAOYSA-N chromium(3+);oxygen(2-) Chemical class [O-2].[O-2].[O-2].[Cr+3].[Cr+3] UOUJSJZBMCDAEU-UHFFFAOYSA-N 0.000 claims 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 1
- 230000005670 electromagnetic radiation Effects 0.000 claims 1
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 1
- 238000004375 physisorption Methods 0.000 claims 1
- 229920001515 polyalkylene glycol Polymers 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
- 239000010959 steel Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract description 211
- 230000001629 suppression Effects 0.000 abstract description 11
- 239000000853 adhesive Substances 0.000 abstract description 9
- 230000001070 adhesive effect Effects 0.000 abstract description 9
- 230000001413 cellular effect Effects 0.000 abstract description 9
- 230000007423 decrease Effects 0.000 abstract description 9
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract description 3
- 238000002508 contact lithography Methods 0.000 abstract description 2
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 108
- 210000004027 cell Anatomy 0.000 description 63
- 239000000243 solution Substances 0.000 description 58
- 239000010410 layer Substances 0.000 description 52
- 108700043375 polylysine-graft-(poly(ethylene glycol)) Proteins 0.000 description 43
- 210000002966 serum Anatomy 0.000 description 40
- 239000007995 HEPES buffer Substances 0.000 description 38
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 37
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 33
- 238000006243 chemical reaction Methods 0.000 description 27
- 108010090804 Streptavidin Proteins 0.000 description 26
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 23
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 22
- 239000000427 antigen Substances 0.000 description 22
- 239000007864 aqueous solution Substances 0.000 description 22
- 239000007943 implant Substances 0.000 description 22
- 108091007433 antigens Proteins 0.000 description 21
- 102000036639 antigens Human genes 0.000 description 21
- 230000000694 effects Effects 0.000 description 19
- 210000002381 plasma Anatomy 0.000 description 19
- 238000004140 cleaning Methods 0.000 description 18
- 238000002474 experimental method Methods 0.000 description 18
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 17
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 17
- 210000001519 tissue Anatomy 0.000 description 17
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 16
- 239000004472 Lysine Substances 0.000 description 16
- 239000000412 dendrimer Substances 0.000 description 16
- 239000004793 Polystyrene Substances 0.000 description 15
- 229920000736 dendritic polymer Polymers 0.000 description 15
- 239000000203 mixture Substances 0.000 description 15
- 229920002223 polystyrene Polymers 0.000 description 15
- 230000015572 biosynthetic process Effects 0.000 description 14
- 239000000872 buffer Substances 0.000 description 14
- 230000035945 sensitivity Effects 0.000 description 14
- 108020004414 DNA Proteins 0.000 description 13
- 238000004458 analytical method Methods 0.000 description 13
- 239000011521 glass Substances 0.000 description 13
- 238000012986 modification Methods 0.000 description 13
- 230000004048 modification Effects 0.000 description 13
- 229910052757 nitrogen Inorganic materials 0.000 description 12
- 239000002356 single layer Substances 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 11
- 125000003277 amino group Chemical group 0.000 description 11
- 229920000578 graft copolymer Polymers 0.000 description 11
- 238000011065 in-situ storage Methods 0.000 description 11
- 235000018977 lysine Nutrition 0.000 description 11
- 229910052760 oxygen Inorganic materials 0.000 description 11
- 230000002269 spontaneous effect Effects 0.000 description 11
- 230000001225 therapeutic effect Effects 0.000 description 11
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 11
- 108091006905 Human Serum Albumin Proteins 0.000 description 10
- 102000008100 Human Serum Albumin Human genes 0.000 description 10
- 238000013459 approach Methods 0.000 description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- 239000001301 oxygen Substances 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- 230000004044 response Effects 0.000 description 10
- 239000004408 titanium dioxide Substances 0.000 description 10
- 238000002965 ELISA Methods 0.000 description 9
- 102000004190 Enzymes Human genes 0.000 description 9
- 108090000790 Enzymes Proteins 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 229940012952 fibrinogen Drugs 0.000 description 9
- 239000012634 fragment Substances 0.000 description 9
- 150000002500 ions Chemical class 0.000 description 9
- 102000013415 peroxidase activity proteins Human genes 0.000 description 9
- 108040007629 peroxidase activity proteins Proteins 0.000 description 9
- 238000003786 synthesis reaction Methods 0.000 description 9
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 8
- 102000008946 Fibrinogen Human genes 0.000 description 8
- 108010049003 Fibrinogen Proteins 0.000 description 8
- 235000001014 amino acid Nutrition 0.000 description 8
- 150000001768 cations Chemical class 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 8
- 239000010408 film Substances 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- 229920001308 poly(aminoacid) Polymers 0.000 description 8
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 8
- 108091034117 Oligonucleotide Proteins 0.000 description 7
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 7
- 150000001412 amines Chemical class 0.000 description 7
- 239000000178 monomer Substances 0.000 description 7
- URLJKFSTXLNXLG-UHFFFAOYSA-N niobium(5+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Nb+5].[Nb+5] URLJKFSTXLNXLG-UHFFFAOYSA-N 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 102000005962 receptors Human genes 0.000 description 7
- 108020003175 receptors Proteins 0.000 description 7
- 239000010935 stainless steel Substances 0.000 description 7
- 229910001220 stainless steel Inorganic materials 0.000 description 7
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 6
- 102000004506 Blood Proteins Human genes 0.000 description 6
- 108010017384 Blood Proteins Proteins 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 6
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 6
- 150000007942 carboxylates Chemical group 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 210000004351 coronary vessel Anatomy 0.000 description 6
- 210000002889 endothelial cell Anatomy 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 210000003494 hepatocyte Anatomy 0.000 description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 229910000484 niobium oxide Inorganic materials 0.000 description 6
- 239000003960 organic solvent Substances 0.000 description 6
- 239000011541 reaction mixture Substances 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 238000011895 specific detection Methods 0.000 description 6
- 238000004611 spectroscopical analysis Methods 0.000 description 6
- 239000004971 Cross linker Substances 0.000 description 5
- 241001415846 Procellariidae Species 0.000 description 5
- 230000000903 blocking effect Effects 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000001772 blood platelet Anatomy 0.000 description 5
- 230000036755 cellular response Effects 0.000 description 5
- 235000018417 cysteine Nutrition 0.000 description 5
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- 238000013508 migration Methods 0.000 description 5
- 210000002569 neuron Anatomy 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
- 239000010452 phosphate Substances 0.000 description 5
- 238000009832 plasma treatment Methods 0.000 description 5
- 238000001338 self-assembly Methods 0.000 description 5
- 230000009870 specific binding Effects 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- DQUHYEDEGRNAFO-QMMMGPOBSA-N (2s)-6-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid Chemical compound CC(C)(C)OC(=O)N[C@H](C(O)=O)CCCCN DQUHYEDEGRNAFO-QMMMGPOBSA-N 0.000 description 4
- 108091028026 C-DNA Proteins 0.000 description 4
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 4
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 4
- 229910010413 TiO 2 Inorganic materials 0.000 description 4
- 238000007792 addition Methods 0.000 description 4
- 229910052786 argon Inorganic materials 0.000 description 4
- 239000012298 atmosphere Substances 0.000 description 4
- 229910021538 borax Inorganic materials 0.000 description 4
- 239000007853 buffer solution Substances 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 230000021164 cell adhesion Effects 0.000 description 4
- 239000003599 detergent Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 4
- 230000010354 integration Effects 0.000 description 4
- 229920001427 mPEG Polymers 0.000 description 4
- 238000002493 microarray Methods 0.000 description 4
- 230000005012 migration Effects 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 229920001983 poloxamer Polymers 0.000 description 4
- 229920000656 polylysine Polymers 0.000 description 4
- 229920000307 polymer substrate Polymers 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 239000000700 radioactive tracer Substances 0.000 description 4
- 239000000376 reactant Substances 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 239000013545 self-assembled monolayer Substances 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- 235000010339 sodium tetraborate Nutrition 0.000 description 4
- 238000004381 surface treatment Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000004506 ultrasonic cleaning Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 4
- BDNKZNFMNDZQMI-UHFFFAOYSA-N 1,3-diisopropylcarbodiimide Chemical compound CC(C)N=C=NC(C)C BDNKZNFMNDZQMI-UHFFFAOYSA-N 0.000 description 3
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 108010067306 Fibronectins Proteins 0.000 description 3
- 102000016359 Fibronectins Human genes 0.000 description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 229920002873 Polyethylenimine Polymers 0.000 description 3
- 238000001069 Raman spectroscopy Methods 0.000 description 3
- 102000007562 Serum Albumin Human genes 0.000 description 3
- 108010071390 Serum Albumin Proteins 0.000 description 3
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 3
- 230000001588 bifunctional effect Effects 0.000 description 3
- 239000013060 biological fluid Substances 0.000 description 3
- 230000009141 biological interaction Effects 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 229940098773 bovine serum albumin Drugs 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 210000001612 chondrocyte Anatomy 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 238000001917 fluorescence detection Methods 0.000 description 3
- 238000001506 fluorescence spectroscopy Methods 0.000 description 3
- 239000003102 growth factor Substances 0.000 description 3
- 229940106780 human fibrinogen Drugs 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 3
- 238000003018 immunoassay Methods 0.000 description 3
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 229920001778 nylon Polymers 0.000 description 3
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 3
- 229920000744 poly(arginines) Polymers 0.000 description 3
- 229920002851 polycationic polymer Polymers 0.000 description 3
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 208000037803 restenosis Diseases 0.000 description 3
- 239000002094 self assembled monolayer Substances 0.000 description 3
- 239000001632 sodium acetate Substances 0.000 description 3
- 235000017281 sodium acetate Nutrition 0.000 description 3
- 230000007480 spreading Effects 0.000 description 3
- 238000003892 spreading Methods 0.000 description 3
- 125000003396 thiol group Chemical group [H]S* 0.000 description 3
- 229910021642 ultra pure water Inorganic materials 0.000 description 3
- 239000012498 ultrapure water Substances 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 235000012431 wafers Nutrition 0.000 description 3
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 description 2
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 2
- PVVTWNMXEHROIA-UHFFFAOYSA-N 2-(3-hydroxypropyl)-1h-quinazolin-4-one Chemical compound C1=CC=C2NC(CCCO)=NC(=O)C2=C1 PVVTWNMXEHROIA-UHFFFAOYSA-N 0.000 description 2
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- 102000005427 Asialoglycoprotein Receptor Human genes 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241001264766 Callistemon Species 0.000 description 2
- 102000019034 Chemokines Human genes 0.000 description 2
- 108010012236 Chemokines Proteins 0.000 description 2
- 229920001661 Chitosan Polymers 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 238000004566 IR spectroscopy Methods 0.000 description 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
- 108090001090 Lectins Proteins 0.000 description 2
- 102000004856 Lectins Human genes 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 2
- 208000012868 Overgrowth Diseases 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- 108010039918 Polylysine Proteins 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 108020004682 Single-Stranded DNA Proteins 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000001252 acrylic acid derivatives Chemical group 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 238000012801 analytical assay Methods 0.000 description 2
- 238000004873 anchoring Methods 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 108010006523 asialoglycoprotein receptor Proteins 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 238000010923 batch production Methods 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 238000011953 bioanalysis Methods 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
- 239000002981 blocking agent Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000008366 buffered solution Substances 0.000 description 2
- 230000004956 cell adhesive effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- BFGKITSFLPAWGI-UHFFFAOYSA-N chromium(3+) Chemical compound [Cr+3] BFGKITSFLPAWGI-UHFFFAOYSA-N 0.000 description 2
- JOPOVCBBYLSVDA-UHFFFAOYSA-N chromium(6+) Chemical compound [Cr+6] JOPOVCBBYLSVDA-UHFFFAOYSA-N 0.000 description 2
- 230000001143 conditioned effect Effects 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 238000010924 continuous production Methods 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 230000009849 deactivation Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000003795 desorption Methods 0.000 description 2
- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical group [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 238000000799 fluorescence microscopy Methods 0.000 description 2
- 229930182830 galactose Natural products 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 230000008611 intercellular interaction Effects 0.000 description 2
- 239000002523 lectin Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 2
- 229910000510 noble metal Inorganic materials 0.000 description 2
- 230000009871 nonspecific binding Effects 0.000 description 2
- 229960003104 ornithine Drugs 0.000 description 2
- 230000000399 orthopedic effect Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 2
- BPUBBGLMJRNUCC-UHFFFAOYSA-N oxygen(2-);tantalum(5+) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ta+5].[Ta+5] BPUBBGLMJRNUCC-UHFFFAOYSA-N 0.000 description 2
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical class [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 2
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 2
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 238000005240 physical vapour deposition Methods 0.000 description 2
- 229920000768 polyamine Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 150000003141 primary amines Chemical class 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 150000003839 salts Chemical group 0.000 description 2
- 238000007423 screening assay Methods 0.000 description 2
- 150000004756 silanes Chemical class 0.000 description 2
- 238000001542 size-exclusion chromatography Methods 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 238000006557 surface reaction Methods 0.000 description 2
- 229910001936 tantalum oxide Inorganic materials 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 2
- 238000003828 vacuum filtration Methods 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- 229910052726 zirconium Inorganic materials 0.000 description 2
- OERNJTNJEZOPIA-UHFFFAOYSA-N zirconium nitrate Chemical compound [Zr+4].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O OERNJTNJEZOPIA-UHFFFAOYSA-N 0.000 description 2
- MWOGMBZGFFZBMK-LJZWMIMPSA-N (2s)-2-[[(2s)-2-[[2-[[(2s,3s)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 MWOGMBZGFFZBMK-LJZWMIMPSA-N 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- CXCHEKCRJQRVNG-UHFFFAOYSA-N 2,2,2-trifluoroethanesulfonyl chloride Chemical group FC(F)(F)CS(Cl)(=O)=O CXCHEKCRJQRVNG-UHFFFAOYSA-N 0.000 description 1
- 150000003923 2,5-pyrrolediones Chemical class 0.000 description 1
- YEDUAINPPJYDJZ-UHFFFAOYSA-N 2-hydroxybenzothiazole Chemical compound C1=CC=C2SC(O)=NC2=C1 YEDUAINPPJYDJZ-UHFFFAOYSA-N 0.000 description 1
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 description 1
- 125000004042 4-aminobutyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 208000007788 Acute Liver Failure Diseases 0.000 description 1
- 206010000804 Acute hepatic failure Diseases 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
- 102000000844 Cell Surface Receptors Human genes 0.000 description 1
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 206010061762 Chondropathy Diseases 0.000 description 1
- 241000157855 Cinchona Species 0.000 description 1
- 235000001258 Cinchona calisaya Nutrition 0.000 description 1
- 241000284156 Clerodendrum quadriloculare Species 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- 238000000018 DNA microarray Methods 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 108010016626 Dipeptides Proteins 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 229910001200 Ferrotitanium Inorganic materials 0.000 description 1
- 229920001917 Ficoll Polymers 0.000 description 1
- 102000020897 Formins Human genes 0.000 description 1
- 108091022623 Formins Proteins 0.000 description 1
- BBBXWRGITSUJPB-YUMQZZPRSA-N Glu-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(O)=O BBBXWRGITSUJPB-YUMQZZPRSA-N 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 108060003393 Granulin Proteins 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 101001027128 Homo sapiens Fibronectin Proteins 0.000 description 1
- 235000019766 L-Lysine Nutrition 0.000 description 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 229920002302 Nylon 6,6 Polymers 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 239000002033 PVDF binder Substances 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 241000206607 Porphyra umbilicalis Species 0.000 description 1
- 102000029797 Prion Human genes 0.000 description 1
- 108091000054 Prion Proteins 0.000 description 1
- 238000012356 Product development Methods 0.000 description 1
- 108091006629 SLC13A2 Proteins 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 108010031318 Vitronectin Proteins 0.000 description 1
- 102100035140 Vitronectin Human genes 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- SDYPRBYZIXRWDU-UWVGGRQHSA-N [(2s)-6-amino-1-[(2s)-6-amino-2-(carboxyamino)hexanoyl]oxy-1-oxohexan-2-yl]carbamic acid Chemical compound NCCCC[C@H](NC(O)=O)C(=O)OC(=O)[C@@H](NC(O)=O)CCCCN SDYPRBYZIXRWDU-UWVGGRQHSA-N 0.000 description 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000002156 adsorbate Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-N alpha-L-IdopA-(1->3)-beta-D-GalpNAc4S Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS(O)(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C(O)=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 229920006318 anionic polymer Polymers 0.000 description 1
- 230000009830 antibody antigen interaction Effects 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 238000002820 assay format Methods 0.000 description 1
- 238000005102 attenuated total reflection Methods 0.000 description 1
- 238000010533 azeotropic distillation Methods 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 230000006287 biotinylation Effects 0.000 description 1
- 238000007413 biotinylation Methods 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 235000010633 broth Nutrition 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 238000000423 cell based assay Methods 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 230000008614 cellular interaction Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 238000005229 chemical vapour deposition Methods 0.000 description 1
- 238000005253 cladding Methods 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 239000012568 clinical material Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 229960002086 dextran Drugs 0.000 description 1
- 229920000359 diblock copolymer Polymers 0.000 description 1
- BGRWYRAHAFMIBJ-UHFFFAOYSA-N diisopropylcarbodiimide Natural products CC(C)NC(=O)NC(C)C BGRWYRAHAFMIBJ-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 230000010595 endothelial cell migration Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 238000010528 free radical solution polymerization reaction Methods 0.000 description 1
- 229920001002 functional polymer Polymers 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920006158 high molecular weight polymer Polymers 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 1
- 230000008073 immune recognition Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 239000003547 immunosorbent Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- 239000010954 inorganic particle Substances 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000002032 lab-on-a-chip Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 150000002669 lysines Chemical class 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 150000001247 metal acetylides Chemical class 0.000 description 1
- 150000002736 metal compounds Chemical class 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000004001 molecular interaction Effects 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- ZKATWMILCYLAPD-UHFFFAOYSA-N niobium pentoxide Inorganic materials O=[Nb](=O)O[Nb](=O)=O ZKATWMILCYLAPD-UHFFFAOYSA-N 0.000 description 1
- 150000004767 nitrides Chemical class 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 238000005935 nucleophilic addition reaction Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920000740 poly(D-lysine) polymer Polymers 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 231100000683 possible toxicity Toxicity 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012910 preclinical development Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 230000006916 protein interaction Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 125000003410 quininyl group Chemical group 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008844 regulatory mechanism Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 238000002444 silanisation Methods 0.000 description 1
- 150000003376 silicon Chemical class 0.000 description 1
- 239000002210 silicon-based material Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical group O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 1
- 238000004416 surface enhanced Raman spectroscopy Methods 0.000 description 1
- 239000002352 surface water Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000002042 time-of-flight secondary ion mass spectrometry Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 108010052768 tyrosyl-isoleucyl-glycyl-seryl-arginine Proteins 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- GBNDTYKAOXLLID-UHFFFAOYSA-N zirconium(4+) ion Chemical compound [Zr+4] GBNDTYKAOXLLID-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
- Y10S435/815—Enzyme separation or purification by sorption
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/969—Multiple layering of reactants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/819—Multifunctional antigen or antibody
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/823—Immunogenic carrier or carrier per se
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Food Science & Technology (AREA)
- Surgery (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Nanotechnology (AREA)
- Medical Informatics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Materials Engineering (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Composite Materials (AREA)
- Inorganic Chemistry (AREA)
- Vascular Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13140299P | 1999-04-28 | 1999-04-28 | |
| US13139199P | 1999-04-28 | 1999-04-28 | |
| US60/131402 | 1999-04-28 | ||
| US60/131391 | 1999-04-28 | ||
| US18461600P | 2000-02-24 | 2000-02-24 | |
| US60/184616 | 2000-02-24 | ||
| PCT/US2000/011708 WO2000065352A1 (en) | 1999-04-28 | 2000-04-28 | Polyionic coatings in analytic and sensor devices |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU4684600A AU4684600A (en) | 2000-11-10 |
| AU769571B2 true AU769571B2 (en) | 2004-01-29 |
Family
ID=27384152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU46846/00A Expired AU769571B2 (en) | 1999-04-28 | 2000-04-28 | Polyionic coatings in analytic and sensor devices |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6884628B2 (enExample) |
| EP (1) | EP1190252B1 (enExample) |
| JP (1) | JP4647792B2 (enExample) |
| AT (1) | ATE419528T1 (enExample) |
| AU (1) | AU769571B2 (enExample) |
| CA (1) | CA2371011C (enExample) |
| DE (1) | DE60041255D1 (enExample) |
| WO (1) | WO2000065352A1 (enExample) |
Families Citing this family (243)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
| WO2001002452A1 (en) | 1999-07-02 | 2001-01-11 | Symyx Technologies, Inc. | Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto |
| US20030059809A1 (en) * | 1999-12-17 | 2003-03-27 | Todor Vujasinovic | Biochips,preparation and uses |
| US7163712B2 (en) * | 2000-03-03 | 2007-01-16 | Duke University | Microstamping activated polymer surfaces |
| US6406777B1 (en) * | 2000-06-14 | 2002-06-18 | The United States Of America As Represented By The Secretary Of The Navy | Metal and glass structure for use in surface enhanced Raman spectroscopy and method for fabricating same |
| DE10036907B4 (de) * | 2000-07-28 | 2012-03-22 | Xantec Bioanalytics Gmbh | Verfahren zur Herstellung einer Beschichtung auf einem mit Gold bedampften Glassubstrat, Beschichtung hergestellt nach diesem Verfahren und deren Verwendung |
| US7678539B2 (en) * | 2000-08-10 | 2010-03-16 | Corning Incorporated | Arrays of biological membranes and methods and use thereof |
| WO2002016528A1 (en) * | 2000-08-21 | 2002-02-28 | National Institute Of Advanced Industrial Science And Technology | Magnetic particles and process for producing the same |
| WO2002056021A2 (en) * | 2001-01-10 | 2002-07-18 | Symyx Technologies Inc | Polymer brushes for immobilizing molecules to a surface |
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| EP2295971B1 (en) * | 2001-03-09 | 2016-09-07 | TrovaGene, Inc. | Conjugate probes and optical detection of analytes |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
| US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
| US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
| US6844028B2 (en) | 2001-06-26 | 2005-01-18 | Accelr8 Technology Corporation | Functional surface coating |
| US7501157B2 (en) * | 2001-06-26 | 2009-03-10 | Accelr8 Technology Corporation | Hydroxyl functional surface coating |
| US6989267B2 (en) | 2001-07-02 | 2006-01-24 | Agilent Technologies, Inc. | Methods of making microarrays with substrate surfaces having covalently bound polyelectrolyte films |
| US20040186359A1 (en) * | 2001-07-09 | 2004-09-23 | Beaudoin Stephen P. | Afinity biosensor for monitoring biological process |
| US20050009026A1 (en) * | 2001-08-27 | 2005-01-13 | Abel Andreas Peter | Surface for the immobilisation of nucleic acids |
| WO2003021253A2 (de) * | 2001-08-27 | 2003-03-13 | Zeptosens Ag | Bionalytische erkennungsoberfläche mit optimierter dichte der erkennungselemente |
| US9671396B2 (en) * | 2001-09-05 | 2017-06-06 | Joon Won Park | Solid substrate comprising array of dendrons and methods for using the same |
| EP1425583A1 (en) * | 2001-09-12 | 2004-06-09 | Eidgenössische Technische Hochschule Zürich | Device with chemical surface patterns |
| WO2003027674A1 (fr) * | 2001-09-21 | 2003-04-03 | Takara Bio Inc. | Support pour l'immobilisation des ligands |
| FI118061B (fi) | 2001-09-24 | 2007-06-15 | Beanor Oy | Menetelmä ja bioanturi analyysiä varten |
| AU2002366875B2 (en) * | 2001-12-21 | 2008-08-21 | Sense Proteomic Limited | Probe for mass spectrometry |
| DE60214118T2 (de) * | 2001-12-21 | 2007-03-01 | Interuniversitair Micro-Elektronica Centrum | Verfahren zum Nachweis eines Analyten |
| US8043868B2 (en) * | 2001-12-21 | 2011-10-25 | Imec | Method and apparatus for detecting an analyte |
| FI115166B (fi) * | 2001-12-31 | 2005-03-15 | Biofons Oy | Diagnostisia menetelmiä |
| ATE494010T1 (de) * | 2002-02-27 | 2011-01-15 | Pharmain Corp | Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendung |
| US7635463B2 (en) * | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
| WO2003072156A1 (en) * | 2002-02-28 | 2003-09-04 | Eidgenössische Technische Hochschule Zürich Oberflächentechnik | Biomedical implant surfaces with osteogenic properties |
| AU2003229645A1 (en) * | 2002-04-12 | 2003-10-27 | Holger Klapproth | Method for immobilizing molecules on surfaces |
| US7514150B2 (en) | 2002-04-16 | 2009-04-07 | Eidgenossische Technische Hochschule Zurich | Environmentally compatible additives for aqueous lubricants |
| US20030198967A1 (en) * | 2002-04-23 | 2003-10-23 | Matson Robert S. | Multi-functional microarrays and methods |
| US7010182B2 (en) * | 2002-07-31 | 2006-03-07 | Luna Innovations Incorporated | Biosensors having enhanced environmental sensitivity |
| US7998699B2 (en) | 2002-08-15 | 2011-08-16 | University Of South Florida | Early detection of pathogens in blood |
| US7384742B2 (en) * | 2002-08-16 | 2008-06-10 | Decision Biomarkers, Inc. | Substrates for isolating reacting and microscopically analyzing materials |
| US20090118605A1 (en) * | 2002-08-30 | 2009-05-07 | Northwestern University | Surface-enhanced raman nanobiosensor |
| US20040043508A1 (en) * | 2002-09-03 | 2004-03-04 | Frutos Anthony G. | Polymer-coated substrates for binding biological molecules |
| US20040062882A1 (en) * | 2002-09-30 | 2004-04-01 | Andrea Liebmann-Vinson | Cell adhesion resisting surfaces |
| ES2208121B1 (es) * | 2002-11-29 | 2005-08-16 | Consejo Sup. Investig. Cientificas | Anticuerpos y antigenos inmovilizados sobre particulas magneticas de silice como biosensores. |
| US7070922B2 (en) * | 2002-12-04 | 2006-07-04 | International Business Machines Corporation | Surface treatment |
| US20040121339A1 (en) * | 2002-12-19 | 2004-06-24 | Jizhong Zhou | Special film-coated substrate for bio-microarray fabrication and use thereof |
| CN100347545C (zh) * | 2003-04-08 | 2007-11-07 | 成都夸常科技有限公司 | 一种对样品中的目标物进行定性和/或定量分析的方法及其检测装置 |
| JP4006523B2 (ja) * | 2003-04-10 | 2007-11-14 | 独立行政法人産業技術総合研究所 | タンパク質アレイ及びその作製方法 |
| ATE412902T1 (de) * | 2003-04-14 | 2008-11-15 | Caliper Life Sciences Inc | Reduktion der migrations-shift-assay-interferenz |
| DE10320312A1 (de) * | 2003-05-06 | 2004-12-02 | Friz Biochem Gmbh | Substrat als Träger von Ligaten |
| US20040228766A1 (en) * | 2003-05-14 | 2004-11-18 | Witty Thomas R. | Point of care diagnostic platform |
| US7160867B2 (en) * | 2003-05-16 | 2007-01-09 | Isotechnika, Inc. | Rapamycin carbohydrate derivatives |
| EP3718635A1 (en) | 2003-07-31 | 2020-10-07 | Handylab, Inc. | Processing particle-containing samples |
| US9206414B2 (en) * | 2003-08-13 | 2015-12-08 | Axcelon Biopolymers Corporation | Anisotropic nanocomposite hydrogel |
| DE602004020999D1 (de) | 2003-08-15 | 2009-06-18 | Univ South Florida | Materialien und verfahren zum einfangen von krankheitserregern und zur abtrennung von aurintricarbonsäure aus einer probe |
| US20050070027A1 (en) * | 2003-09-30 | 2005-03-31 | Jacques Gollier | Double resonance interrogation of grating-coupled waveguides |
| JP2006514299A (ja) * | 2003-10-27 | 2006-04-27 | センス プロテオミック リミテッド | 酵素アレイ及びアッセイ |
| US20050244898A1 (en) * | 2003-11-19 | 2005-11-03 | Cohen Robert E | Large-area two-dimensional non-adhesive cell arrays for sensing and cell-sorting applications |
| US7510942B2 (en) * | 2003-11-25 | 2009-03-31 | Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University | Molecular modifications of metal/dielectric interfaces |
| US20050131513A1 (en) * | 2003-12-16 | 2005-06-16 | Cook Incorporated | Stent catheter with a permanently affixed conductor |
| WO2005072764A2 (en) * | 2004-01-16 | 2005-08-11 | Novocell, Inc. | Fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells |
| US7723126B2 (en) * | 2004-03-24 | 2010-05-25 | Wisconsin Alumni Research Foundation | Plasma-enhanced functionalization of inorganic oxide surfaces |
| JP4535490B2 (ja) * | 2004-04-09 | 2010-09-01 | 株式会社資生堂 | 蛋白質吸着防止方法 |
| WO2005112977A2 (en) * | 2004-04-23 | 2005-12-01 | Pharmain, Ltd. | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
| AU2005241080B2 (en) | 2004-05-03 | 2011-08-11 | Handylab, Inc. | Processing polynucleotide-containing samples |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| CA2566897A1 (en) * | 2004-05-21 | 2005-12-01 | Mds Inc. Doing Business Through Its Mds Pharma Services Division | Method of quantifying the cell-binding properties of a medical device |
| US7572766B2 (en) * | 2004-06-16 | 2009-08-11 | Affinergy, Inc. | IFBMs to promote the specific attachment of target analytes to the surface of orthopedic implants |
| US10150945B2 (en) * | 2004-07-23 | 2018-12-11 | Jnc Corporation | Cell culture device and manufacturing method therof |
| JP2008508531A (ja) * | 2004-08-04 | 2008-03-21 | アクセラ バイオセンサーズ インク． | 回折に基づく検出のための化学架橋剤でパターン化された表面 |
| US7595157B2 (en) * | 2004-08-19 | 2009-09-29 | Biocept, Inc. | Microarrays utilizing hydrogels |
| US20110177955A1 (en) * | 2004-10-12 | 2011-07-21 | Luis Alberto Burzio | Multiplexed protein adsorption assay |
| US20060110594A1 (en) * | 2004-11-24 | 2006-05-25 | Frutos Anthony G | Polymer-coated substrates for binding biomolecules and methods of making and using thereof |
| WO2006070841A1 (ja) | 2004-12-28 | 2006-07-06 | Japan Science And Technology Agency | 自己組織化材料または微粒子を基板上に固定化する方法、および当該方法を用いて作製した基板 |
| US20060141527A1 (en) * | 2004-12-29 | 2006-06-29 | Caracci Stephen J | Method for creating a reference region and a sample region on a biosensor and the resulting biosensor |
| US7604984B2 (en) * | 2004-12-29 | 2009-10-20 | Corning Incorporated | Spatially scanned optical reader system and method for using same |
| US7629173B2 (en) | 2004-12-29 | 2009-12-08 | Corning Incorporated | Optical reader system and method for monitoring and correcting lateral and angular misalignments of label independent biosensors |
| DE602006009980D1 (de) * | 2005-02-23 | 2009-12-10 | Fujifilm Corp | Biosensor |
| JP2006335912A (ja) * | 2005-06-03 | 2006-12-14 | Fujifilm Holdings Corp | 生理活性物質固定化剤 |
| JP2006271860A (ja) * | 2005-03-30 | 2006-10-12 | Japan Lifeline Co Ltd | 医療用具及びその製造方法 |
| WO2006102756A1 (en) | 2005-03-30 | 2006-10-05 | University Western Ontario | Anisotropic hydrogels |
| US20060234269A1 (en) * | 2005-04-18 | 2006-10-19 | Matthew Asplund | Laser Modification and Functionalization of Substrates |
| DK1877773T3 (en) | 2005-04-26 | 2015-01-19 | Bayer Ip Gmbh | NEW APPARATUS AND PROCEDURE FOR THE COATING OF CARRIER SUBSTRATES FOR ANALYTICAL DETECTION BY THE AFFINITY DETECTION PROCEDURE |
| US7723438B2 (en) * | 2005-04-28 | 2010-05-25 | International Business Machines Corporation | Surface-decorated polymeric amphiphile porogens for the templation of nanoporous materials |
| WO2006133027A2 (en) * | 2005-06-03 | 2006-12-14 | Bhatnagar Rajendra S | Methods for immobilizing molecules on surfaces |
| US8475886B2 (en) | 2005-08-05 | 2013-07-02 | Corning Incorporated | Methods for producing surfaces that resist non-specific protein binding and cell attachment |
| US7713689B2 (en) * | 2005-09-15 | 2010-05-11 | Duke University | Non-fouling polymeric surface modification and signal amplification method for biomolecular detection |
| US7763423B2 (en) * | 2005-09-30 | 2010-07-27 | Pacific Biosciences Of California, Inc. | Substrates having low density reactive groups for monitoring enzyme activity |
| JP4818056B2 (ja) * | 2005-10-07 | 2011-11-16 | キヤノン株式会社 | 標的物質を捕捉する捕捉分子を結合させるための結合用官能基を基体上に備えた構造体 |
| US20090148346A1 (en) * | 2005-10-07 | 2009-06-11 | Canon Kabushiki Kaisha | Substrate with binding functional group |
| WO2007053561A2 (en) * | 2005-11-01 | 2007-05-10 | Rensselaer Polytechnic Institute | Three-dimensional cellular array chip and platform for toxicology assays |
| US20070117152A1 (en) * | 2005-11-08 | 2007-05-24 | Fujifilm Corporation | Biosensor |
| CA2628915A1 (en) * | 2005-11-08 | 2007-05-18 | Smart Holograms Limited | Novel boronate complex and its use in a glucose sensor |
| US20070224164A1 (en) * | 2005-11-14 | 2007-09-27 | Maciej Radosz | Degradable nanogel for drug delivery |
| WO2007059514A2 (en) * | 2005-11-15 | 2007-05-24 | Oxonica, Inc. | Sers-based methods for detection of bioagents |
| US20070110786A1 (en) * | 2005-11-15 | 2007-05-17 | Boston Scientific Scimed, Inc. | Medical articles having enhanced therapeutic agent binding |
| KR100738083B1 (ko) * | 2005-12-20 | 2007-07-12 | 삼성전자주식회사 | 마이크로어레이용 기판 및 그의 제조방법 |
| US7723422B2 (en) * | 2005-12-23 | 2010-05-25 | Boston Scientific Scimed, Inc. | Functionalized block copolymers |
| US7674864B2 (en) * | 2005-12-23 | 2010-03-09 | Boston Scientific Scimed, Inc. | Polymeric hybrid precursors, polymeric hybrid precursor composite matrices, medical devices, and methods |
| US8455088B2 (en) * | 2005-12-23 | 2013-06-04 | Boston Scientific Scimed, Inc. | Spun nanofiber, medical devices, and methods |
| US7781203B2 (en) * | 2005-12-29 | 2010-08-24 | Corning Incorporated | Supports for assaying analytes and methods of making and using thereof |
| US8834912B2 (en) * | 2005-12-30 | 2014-09-16 | Boston Scientific Scimed, Inc. | Medical devices having multiple charged layers |
| EP1808187A1 (en) * | 2006-01-11 | 2007-07-18 | Straumann Holding AG | Cell selective implant surface with controlled release of bioactive agents |
| ES2601391T3 (es) * | 2006-01-27 | 2017-02-15 | Becton Dickinson And Company | Inmunoensayo de flujo lateral con modalidad de detección encapsulada |
| EP1993588B1 (en) * | 2006-02-28 | 2016-04-13 | Covidien LP | Tissue adhesives and sealants and methods for their use |
| US8349349B2 (en) * | 2006-02-28 | 2013-01-08 | Covidien Lp | Tissue adhesives and sealants and method for their use |
| US8835513B2 (en) | 2006-02-28 | 2014-09-16 | Covidien Lp | Drug delivery devices |
| WO2007108205A1 (ja) * | 2006-03-17 | 2007-09-27 | Sanyo Chemical Industries, Ltd. | 細胞培養用担体 |
| US20100111917A1 (en) * | 2006-03-21 | 2010-05-06 | Ying Jackie Y | Cell-adhesive polyelectrolyte material for use as membrane and coating |
| US9040288B2 (en) | 2006-03-24 | 2015-05-26 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using the same |
| US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US8545865B2 (en) * | 2006-03-24 | 2013-10-01 | Boston Scientific Scimed, Inc. | Medical devices having polymer brushes |
| US8088616B2 (en) | 2006-03-24 | 2012-01-03 | Handylab, Inc. | Heater unit for microfluidic diagnostic system |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US20080050747A1 (en) * | 2006-03-30 | 2008-02-28 | Pacific Biosciences Of California, Inc. | Articles having localized molecules disposed thereon and methods of producing and using same |
| US20080076189A1 (en) * | 2006-03-30 | 2008-03-27 | Visigen Biotechnologies, Inc. | Modified surfaces for the detection of biomolecules at the single molecule level |
| US8975216B2 (en) | 2006-03-30 | 2015-03-10 | Pacific Biosciences Of California | Articles having localized molecules disposed thereon and methods of producing same |
| EP2016391A1 (en) * | 2006-04-19 | 2009-01-21 | Universiteit Gent | Integrated surface mode biosensor |
| US8330951B2 (en) * | 2006-04-28 | 2012-12-11 | Hewlett-Packard Development Company, L.P. | Nano-enhanced Raman spectroscopy substrate packaging structure |
| US10741034B2 (en) | 2006-05-19 | 2020-08-11 | Apdn (B.V.I.) Inc. | Security system and method of marking an inventory item and/or person in the vicinity |
| US9790538B2 (en) | 2013-03-07 | 2017-10-17 | Apdn (B.V.I.) Inc. | Alkaline activation for immobilization of DNA taggants |
| EP2044402B2 (en) * | 2006-07-24 | 2016-11-30 | Becton Dickinson and Company | Apparatus and method for performing an assay using magnetic particles |
| CA2665493A1 (en) * | 2006-08-07 | 2008-02-14 | University Of Washington | Mixed charge copolymers and hydrogels |
| US20100137155A1 (en) * | 2006-08-08 | 2010-06-03 | Sharp Kabuchiki Kaisha | Biosensor, method for fabricating the same, detecting method utilizing the same |
| JP5001015B2 (ja) | 2006-09-28 | 2012-08-15 | 富士フイルム株式会社 | 非特異吸着を抑制した表面を有する生化学用器具 |
| US8709787B2 (en) | 2006-11-14 | 2014-04-29 | Handylab, Inc. | Microfluidic cartridge and method of using same |
| US7928038B2 (en) * | 2006-11-21 | 2011-04-19 | Applied Biosystems, Llc | Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby |
| US8029902B2 (en) * | 2006-12-11 | 2011-10-04 | Wisconsin Alumni Research Foundation | Plasma-enhanced functionalization of substrate surfaces with quaternary ammonium and quaternary phosphonium groups |
| WO2008083390A2 (en) * | 2006-12-29 | 2008-07-10 | University Of Washington | Dual-functional nonfouling surfaces and materials |
| JP2008185494A (ja) * | 2007-01-31 | 2008-08-14 | Fujifilm Corp | 生理活性物質固定化基板 |
| WO2008106048A1 (en) * | 2007-02-28 | 2008-09-04 | Corning Incorporated | Surfaces and methods for biosensor cellular assays |
| JP2008249502A (ja) * | 2007-03-30 | 2008-10-16 | Fujifilm Corp | 生理活性物質を固定化した固体基板 |
| US8093039B2 (en) * | 2007-04-10 | 2012-01-10 | The Trustees Of The Stevens Institute Of Technology | Surfaces differentially adhesive to eukaryotic cells and non-eukaryotic cells |
| US8084077B2 (en) | 2007-05-25 | 2011-12-27 | Abbott Laboratories | One-step phosphorylcholine-linked polymer coating and drug loading of stent |
| JP2010532485A (ja) | 2007-06-29 | 2010-10-07 | アプライド バイオシステムズ | ナノｆｅｔを含む電子検出のためのシステムおよび方法 |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| EP3222733B1 (en) | 2007-07-13 | 2021-04-07 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
| USD621060S1 (en) | 2008-07-14 | 2010-08-03 | Handylab, Inc. | Microfluidic cartridge |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| US20090136385A1 (en) | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube |
| US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| US7960336B2 (en) * | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
| EP2176066A4 (en) * | 2007-08-06 | 2011-08-24 | Canon Kk | STRUCTURAL ELEMENT AND METHOD FOR MANUFACTURING THE STRUCTURAL ELEMENT |
| US8563527B2 (en) * | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
| KR101050690B1 (ko) | 2007-09-07 | 2011-07-20 | 광주과학기술원 | 다기능성 고분자막 및 그의 용도 |
| WO2009031804A2 (en) * | 2007-09-07 | 2009-03-12 | Gwangju Institute Of Science And Technology | Multi-functional polymeric layers and its uses |
| US8445217B2 (en) | 2007-09-20 | 2013-05-21 | Vanderbilt University | Free solution measurement of molecular interactions by backscattering interferometry |
| DE102007049013A1 (de) * | 2007-10-11 | 2009-04-16 | Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG | Sensor mit Langzeitstabilität für Bio-Prozesse |
| US20090130746A1 (en) * | 2007-10-25 | 2009-05-21 | Canon U.S. Life Sciences, Inc. | Microchannel surface coating |
| WO2009057120A2 (en) * | 2007-10-31 | 2009-05-07 | Given Imaging Ltd. | Device, system and method for in-vivo analysis |
| JP5345335B2 (ja) * | 2007-12-03 | 2013-11-20 | 国立大学法人九州大学 | 新規双性イオン型多分岐樹脂、並びに、蛋白質チップ表面調節剤 |
| US7998696B2 (en) | 2007-12-05 | 2011-08-16 | Zyomyx, Inc. | Cell assay kit and method |
| US8796184B2 (en) | 2008-03-28 | 2014-08-05 | Sentilus, Inc. | Detection assay devices and methods of making and using the same |
| US8815611B2 (en) * | 2008-04-10 | 2014-08-26 | Corning Incorporated | Surface for label independent detection and method thereof |
| US8877298B2 (en) * | 2008-05-27 | 2014-11-04 | The Hong Kong University Of Science And Technology | Printing using a structure coated with ultraviolet radiation responsive material |
| JP2009286968A (ja) * | 2008-05-30 | 2009-12-10 | Canon Inc | グラフトポリマー含有基体、その製造方法および磁気バイオセンサ |
| US20090311540A1 (en) * | 2008-06-11 | 2009-12-17 | Yoram Cohen | Highly Sensitive and Selective Nano-Structured Grafted Polymer Layers |
| US20110184293A1 (en) * | 2008-07-10 | 2011-07-28 | Elisha Rabinovitz | Device, method and kit for in vivo detection of a biomarker |
| WO2010005444A1 (en) * | 2008-07-11 | 2010-01-14 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
| USD618820S1 (en) | 2008-07-11 | 2010-06-29 | Handylab, Inc. | Reagent holder |
| USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
| US8173198B2 (en) * | 2008-07-23 | 2012-05-08 | Life Technologies Corporation | Deposition of metal oxides onto surfaces as an immobilization vehicle for carboxylated or phophated particles or polymers |
| US20100034704A1 (en) * | 2008-08-06 | 2010-02-11 | Honeywell International Inc. | Microfluidic cartridge channel with reduced bubble formation |
| US8076529B2 (en) | 2008-09-26 | 2011-12-13 | Abbott Cardiovascular Systems, Inc. | Expandable member formed of a fibrous matrix for intraluminal drug delivery |
| US8049061B2 (en) | 2008-09-25 | 2011-11-01 | Abbott Cardiovascular Systems, Inc. | Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery |
| US8226603B2 (en) | 2008-09-25 | 2012-07-24 | Abbott Cardiovascular Systems Inc. | Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery |
| WO2010039247A2 (en) * | 2008-10-03 | 2010-04-08 | Molecular Sensing, Inc. | Substrates with surfaces modified with peg |
| DE102008053270A1 (de) | 2008-10-27 | 2010-05-12 | Medizinische Hochschule Hannover | Vorrichtung und Verfahren zur Analyse von Zellen |
| US8580240B1 (en) | 2008-11-19 | 2013-11-12 | University Of Kentucky Research Foundation | Compounds and methods for reducing the occurrence of post-surgical adhesions |
| EP2373355A4 (en) * | 2008-11-25 | 2013-10-02 | Univ California | FUNCTIONALIZED TITANIUM IMPLANTS AND RELATED REGENERATIVE MATERIALS |
| EP2192410B1 (en) * | 2008-11-26 | 2012-07-11 | Corning Incorporated | Nanoparticulate affininty capture for label independent detections system |
| EP2204650B1 (en) * | 2008-12-31 | 2012-06-27 | DWI an der RWTH Aachen e.V. | Novel biosensor system based on recognition induced birefringence (RIB) |
| EP2386060A2 (en) * | 2009-01-12 | 2011-11-16 | Molecular Sensing, Inc. | Sample collection and measurement in a single container by back scattering interferometry |
| JP5706393B2 (ja) * | 2009-03-20 | 2015-04-22 | アッタナ アクチボラゲット | その表面上に固定化細胞を含む質量応答センサーおよびそのセンサーを利用したリガンド結合の検出方法 |
| WO2010117460A1 (en) * | 2009-04-08 | 2010-10-14 | Michigan Molecular Institute | Surface modification of reverse osmosis membranes by hydrophilic dendritic polymers |
| WO2010123448A1 (en) * | 2009-04-21 | 2010-10-28 | Gyros Patent Ab | Method for reducing adsorption losses on metal oxide surfaces |
| WO2010127247A1 (en) * | 2009-05-01 | 2010-11-04 | University Of Utah Research Foundation | Methods and compositions for measuring high affinity interactions with kinetic imaging of single molecule interaction (kismi) |
| US8501406B1 (en) | 2009-07-14 | 2013-08-06 | Pacific Biosciences Of California, Inc. | Selectively functionalized arrays |
| WO2011028358A2 (en) * | 2009-09-02 | 2011-03-10 | Mayo Foundation For Medical Education And Research | System and method for detecting healing adjacent to implanted medical device |
| US20110225809A1 (en) * | 2010-03-17 | 2011-09-22 | Alan Francis Daher | Apparatus for removably attaching an item to a surface |
| WO2011119536A1 (en) | 2010-03-22 | 2011-09-29 | Abbott Cardiovascular Systems Inc. | Stent delivery system having a fibrous matrix covering with improved stent retention |
| EP3305192B1 (en) * | 2010-05-17 | 2019-10-09 | Sentilus Holdco, LLC | Detection devices and related methods of use |
| US9638632B2 (en) | 2010-06-11 | 2017-05-02 | Vanderbilt University | Multiplexed interferometric detection system and method |
| EP2409766A1 (de) * | 2010-07-23 | 2012-01-25 | F. Hoffmann-La Roche AG | Verfahren zur Hydrophilisierung von Oberflächen fluidischer Komponenten und derartige Komponenten enthaltende Bauteile |
| US9562853B2 (en) | 2011-02-22 | 2017-02-07 | Vanderbilt University | Nonaqueous backscattering interferometric methods |
| ES2617599T3 (es) | 2011-04-15 | 2017-06-19 | Becton, Dickinson And Company | Termociclador microfluídico de exploración en tiempo real y métodos para termociclado sincronizado y detección óptica de exploración |
| EP2541250A1 (en) * | 2011-06-30 | 2013-01-02 | Koninklijke Philips Electronics N.V. | Molecular architecture on magnetic particles for affinity assays with low non-specific binding |
| WO2013009308A1 (en) * | 2011-07-13 | 2013-01-17 | Empire Technology Development Llc | Method and system for analyte monitoring using surface plasmons with a refreshable surface |
| CA2841005C (en) * | 2011-07-15 | 2019-03-12 | University Of Georgia Research Foundation, Inc. | Compounds, methods of making, and methods of use |
| CA2872378C (en) | 2011-07-20 | 2016-01-12 | University Of Washington Through Its Center For Commercialization | Photonic blood typing |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| BR112014007440B1 (pt) | 2011-09-30 | 2020-11-03 | Becton, Dickinson And Company | lâmina de reagentes unificada e métodos para detectar a presença ou ausência de ponta de pipeta dentro de bainha de pipeta e para determinar o comprimento de ponta de pipeta dentro de bainha de pipeta na mesma |
| WO2013065016A1 (en) | 2011-11-02 | 2013-05-10 | University Of Cape Town | A method of detecting and/or quantifying an analyte in a biological sample |
| CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
| US10031138B2 (en) * | 2012-01-20 | 2018-07-24 | University Of Washington Through Its Center For Commercialization | Hierarchical films having ultra low fouling and high recognition element loading properties |
| DK2810080T3 (da) | 2012-02-03 | 2024-06-17 | Becton Dickinson Co | Eksterne filer til fordeling af molekylære diagnostiske tests og bestemmelse af kompatabilitet imellem tests |
| US9572580B2 (en) | 2012-03-16 | 2017-02-21 | Covidien Lp | Closure tape dispenser |
| US9161756B2 (en) | 2012-03-16 | 2015-10-20 | Covidien Lp | Closure tape dispenser |
| JP5844195B2 (ja) * | 2012-03-29 | 2016-01-13 | 三洋化成工業株式会社 | 磁性シリカ粒子並びにこれを用いた免疫測定法及び免疫測定用試薬 |
| US20140102899A1 (en) * | 2012-04-09 | 2014-04-17 | Applied Dna Sciences, Inc. | Plasma treatment for dna binding |
| US9273949B2 (en) | 2012-05-11 | 2016-03-01 | Vanderbilt University | Backscattering interferometric methods |
| EP3327090A1 (en) * | 2012-07-18 | 2018-05-30 | President and Fellows of Harvard College | Modification of surfaces for simulataneous repellency and targeted binding of desired moieties |
| US9758606B2 (en) | 2012-07-31 | 2017-09-12 | The Trustees Of Columbia University In The City Of New York | Cyclopropenium polymers and methods for making the same |
| WO2014022365A1 (en) * | 2012-07-31 | 2014-02-06 | The Trustees Of Columbia University In The City Of New York | Cyclopropenium polymers and methods for making the same |
| US9297032B2 (en) | 2012-10-10 | 2016-03-29 | Apdn (B.V.I.) Inc. | Use of perturbants to facilitate incorporation and recovery of taggants from polymerized coatings |
| US9266370B2 (en) | 2012-10-10 | 2016-02-23 | Apdn (B.V.I) Inc. | DNA marking of previously undistinguished items for traceability |
| US8994077B2 (en) * | 2012-12-21 | 2015-03-31 | International Business Machines Corporation | Field effect transistor-based bio sensor |
| TWI535750B (zh) | 2013-01-14 | 2016-06-01 | 國立臺灣大學 | 基材上的聚合物組成物以及表面改質方法 |
| US10060851B2 (en) * | 2013-03-05 | 2018-08-28 | Plexense, Inc. | Surface plasmon detection apparatuses and methods |
| US9963740B2 (en) | 2013-03-07 | 2018-05-08 | APDN (B.V.I.), Inc. | Method and device for marking articles |
| KR101592241B1 (ko) | 2013-04-15 | 2016-02-05 | (주)플렉센스 | 나노 입자 어레이의 제조 방법, 표면 플라즈몬 공명 기반의 센서, 및 이를 이용한 분석 방법 |
| US10544449B2 (en) | 2013-06-14 | 2020-01-28 | Pacific Biosciences Of California, Inc. | Bis-biotinylation tags |
| DE102013211850A1 (de) * | 2013-06-21 | 2014-12-24 | Gilupi Gmbh | Schnelltest zum Nachweisen von Erregermaterial, insbesondere zur Unterstützung der Diagnose einer Sepsis, sowie Kit und Vorrichtung zur Durchführung eines Sepsistests |
| DE102013211837A1 (de) * | 2013-06-21 | 2014-12-24 | Gilupi Gmbh | Katheter mit Detektionsvorrichtung zum Echtzeitnachweis eines Probenmaterials |
| US9366651B2 (en) | 2013-07-03 | 2016-06-14 | Matrix Sensors, Inc. | Array of sensors with surface modifications |
| US9904734B2 (en) | 2013-10-07 | 2018-02-27 | Apdn (B.V.I.) Inc. | Multimode image and spectral reader |
| CN106103121B (zh) | 2014-03-18 | 2019-12-06 | 亚普蒂恩(B.V.I.)公司 | 用于安全应用的加密光学标记物 |
| US10745825B2 (en) | 2014-03-18 | 2020-08-18 | Apdn (B.V.I.) Inc. | Encrypted optical markers for security applications |
| KR102592368B1 (ko) | 2014-07-02 | 2023-10-25 | 라이프 테크놀로지스 코포레이션 | 반도체 센서의 표면 처리 |
| US11754563B2 (en) | 2014-11-20 | 2023-09-12 | Global Life Sciences Solutions Operations UK Ltd | Porous membranes with a polymer grafting, methods and uses thereof |
| US10760182B2 (en) | 2014-12-16 | 2020-09-01 | Apdn (B.V.I.) Inc. | Method and device for marking fibrous materials |
| EP3247988A4 (en) | 2015-01-23 | 2018-12-19 | Vanderbilt University | A robust interferometer and methods of using same |
| TWI585401B (zh) * | 2015-12-17 | 2017-06-01 | 長庚大學 | 光定址電位感測元件 |
| EP3408649B1 (en) | 2016-01-29 | 2023-06-14 | Vanderbilt University | Free-solution response function interferometry |
| WO2017180302A1 (en) | 2016-04-11 | 2017-10-19 | Apdn (B.V.I.) Inc. | Method of marking cellulosic products |
| US10995371B2 (en) | 2016-10-13 | 2021-05-04 | Apdn (B.V.I.) Inc. | Composition and method of DNA marking elastomeric material |
| US9999899B2 (en) | 2016-11-01 | 2018-06-19 | International Business Machines Corporation | Controlled exposure of in-vivo sensors |
| US10920274B2 (en) | 2017-02-21 | 2021-02-16 | Apdn (B.V.I.) Inc. | Nucleic acid coated submicron particles for authentication |
| WO2018222034A1 (en) * | 2017-05-30 | 2018-12-06 | Jurriaan Huskens | Surface with poly-cationic polymers and functionalized using coupling chemistry, biosensor comprising the same and use thereof in bio-sensing |
| WO2018234564A1 (en) * | 2017-06-22 | 2018-12-27 | Paris Sciences Et Lettres - Quartier Latin | Redox cleavable comb-like copolymer for controlled adhesion between cells and substrates |
| US11472892B2 (en) | 2018-03-28 | 2022-10-18 | Mochida Pharmaceutical Co., Ltd. | Reactive alginic acid derivatives |
| WO2020027097A1 (ja) * | 2018-07-31 | 2020-02-06 | 富士フイルム株式会社 | 固相担体およびキット |
| CA3130195A1 (en) * | 2019-03-11 | 2020-09-17 | Jay Kenneth Fisher | Methods of surface modification of silicones for specific target and high efficiency binding |
| US11357542B2 (en) | 2019-06-21 | 2022-06-14 | Covidien Lp | Valve assembly and retainer for surgical access assembly |
| US12479933B2 (en) | 2019-09-25 | 2025-11-25 | Mochida Pharmaceutical Co., Ltd. | Crosslinked alginic acid structure |
| JP2022551523A (ja) | 2019-10-11 | 2022-12-09 | クアンタム－エスアイ インコーポレイテッド | 気相における表面修飾 |
| WO2021090787A1 (ja) * | 2019-11-05 | 2021-05-14 | 国立大学法人東海国立大学機構 | ポリペプチド |
| WO2023205353A1 (en) * | 2022-04-21 | 2023-10-26 | Ultima Genomics, Inc. | Self assembly of beads on substrates |
| EP4299596A1 (en) * | 2022-06-30 | 2024-01-03 | betaSENSE GmbH | Molecular probe functionalized element |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5250613A (en) * | 1990-10-22 | 1993-10-05 | Berol Nobel Ab | Solid surface coated with a hydrophilic outer layer with covalently bonded biopolymers, a method of making such a surface, and a conjugate therefor |
| WO1998047948A1 (en) * | 1997-04-18 | 1998-10-29 | California Institute Of Technology | Multifunctional polymeric tissue coatings |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4822867A (en) * | 1987-02-02 | 1989-04-18 | Semih Erhan | Protein polymer grafts |
| US4886836A (en) * | 1987-06-03 | 1989-12-12 | Pall Corporation | Activated medium with low non-specific protein adsorption |
| US5866322A (en) * | 1988-01-29 | 1999-02-02 | Abbott Laboratories | Method for performing Rubella assay |
| EP0335308B1 (en) * | 1988-03-31 | 1993-12-08 | W.R. Grace & Co.-Conn. | Protein non-adsorptive polyurea-urethane polymer coated devices |
| JP2570408B2 (ja) * | 1988-11-29 | 1997-01-08 | 東ソー株式会社 | 抗原，抗体又は生理活性物質固定化用の担体 |
| US5330911A (en) * | 1989-09-28 | 1994-07-19 | Board Of Regents, The University Of Texas System | Surfaces having desirable cell adhesive effects |
| US5459054A (en) * | 1989-12-05 | 1995-10-17 | Neocrin Company | Cells encapsulated in alginate containing a high content of a- l- guluronic acid |
| US5380536A (en) * | 1990-10-15 | 1995-01-10 | The Board Of Regents, The University Of Texas System | Biocompatible microcapsules |
| US5462990A (en) | 1990-10-15 | 1995-10-31 | Board Of Regents, The University Of Texas System | Multifunctional organic polymers |
| US5626863A (en) | 1992-02-28 | 1997-05-06 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| US5529914A (en) * | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| US6093558A (en) * | 1991-07-25 | 2000-07-25 | Edge Biosystems, Inc. | Binding protein of biologically active compositions to an adhesive formulation on a substrate |
| US5573934A (en) | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| DE4208645A1 (de) * | 1992-03-18 | 1993-09-23 | Bayer Ag | Optischer festphasenbiosensor auf basis fluoreszenzfarbstoffmarkierter polyionischer schichten |
| US5578442A (en) * | 1992-03-23 | 1996-11-26 | Vivorx, Inc. | Graft copolymers of polycationic species and water-soluble polymers, and use therefor |
| US6113946A (en) * | 1992-04-03 | 2000-09-05 | The Regents Of The University Of California | Self-assembling polynucleotide delivery system comprising dendrimer polycations |
| EP0565978B1 (de) * | 1992-04-16 | 1997-06-18 | MERCK PATENT GmbH | Aktivierte Trägermaterialien, ihre Herstellung und Verwendung |
| CA2135769A1 (en) | 1992-05-29 | 1993-12-09 | Kent C. Cochrum | Coated transplant and method for making same |
| US5344455A (en) * | 1992-10-30 | 1994-09-06 | Medtronic, Inc. | Graft polymer articles having bioactive surfaces |
| US5414075A (en) * | 1992-11-06 | 1995-05-09 | Bsi Corporation | Restrained multifunctional reagent for surface modification |
| SE509662C2 (sv) * | 1993-04-29 | 1999-02-22 | Tetra Laval Holdings & Finance | Förpackningslaminat belagt med en vattenolöslig chitosanförening samt sätt att tillverka förpackningslaminatet |
| EP0700514B1 (en) | 1993-05-18 | 2001-11-28 | University of Utah Research Foundation | Apparatus and methods for multianalyte homogeneous fluoroimmunoassays |
| US5512492A (en) * | 1993-05-18 | 1996-04-30 | University Of Utah Research Foundation | Waveguide immunosensor with coating chemistry providing enhanced sensitivity |
| US6284503B1 (en) * | 1993-08-20 | 2001-09-04 | University Of Utah Research Foundation | Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces |
| US5543326A (en) * | 1994-03-04 | 1996-08-06 | Heller; Adam | Biosensor including chemically modified enzymes |
| CA2193968A1 (en) * | 1994-06-28 | 1996-01-11 | Jeffrey G. Clark | Ph-modified biocompatible monomer and polymer compositions |
| US5853717A (en) * | 1994-07-20 | 1998-12-29 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
| US5507804A (en) * | 1994-11-16 | 1996-04-16 | Alcon Laboratories, Inc. | Cross-linked polyethylene oxide coatings to improve the biocompatibility of implantable medical devices |
| US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US6017577A (en) * | 1995-02-01 | 2000-01-25 | Schneider (Usa) Inc. | Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices |
| US5629213A (en) * | 1995-03-03 | 1997-05-13 | Kornguth; Steven E. | Analytical biosensor |
| DE19530078A1 (de) * | 1995-08-16 | 1997-02-20 | Bayer Ag | Optischer Festphasenbiosensor auf Basis von Streptavidin und Biotin |
| US5916585A (en) * | 1996-06-03 | 1999-06-29 | Gore Enterprise Holdings, Inc. | Materials and method for the immobilization of bioactive species onto biodegradable polymers |
| CA2258489C (en) * | 1996-06-28 | 2004-01-27 | Caliper Technologies Corporation | High-throughput screening assay systems in microscale fluidic devices |
| CA2202424A1 (en) * | 1997-04-11 | 1998-10-11 | Donald E. Brooks | A tethered polymer macromolecule-excluding surface, its mode of synthesis and use |
| US6287558B1 (en) * | 1997-08-01 | 2001-09-11 | Biohybrio Technologies Llc | Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule |
| US6121027A (en) * | 1997-08-15 | 2000-09-19 | Surmodics, Inc. | Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups |
| US6348322B1 (en) * | 1997-10-17 | 2002-02-19 | Duke University | Method of screening for specific binding interactions |
| WO1999052574A1 (en) * | 1998-04-10 | 1999-10-21 | Massachusetts Institute Of Technology | Biopolymers resistant coatings |
| DE69920198T2 (de) * | 1998-04-13 | 2005-09-22 | Massachusetts Institute Of Technology, Cambridge | Kamm-polymere zur regelung der zelloberflächenwechselwirkung |
| US6303136B1 (en) * | 1998-04-13 | 2001-10-16 | Neurotech S.A. | Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane |
| US6248127B1 (en) * | 1998-08-21 | 2001-06-19 | Medtronic Ave, Inc. | Thromboresistant coated medical device |
| US6303179B1 (en) * | 1999-02-08 | 2001-10-16 | Medtronic, Inc | Method for attachment of biomolecules to surfaces through amine-functional groups |
-
2000
- 2000-04-28 WO PCT/US2000/011708 patent/WO2000065352A1/en not_active Ceased
- 2000-04-28 US US09/560,472 patent/US6884628B2/en not_active Expired - Lifetime
- 2000-04-28 AU AU46846/00A patent/AU769571B2/en not_active Expired
- 2000-04-28 AT AT00928641T patent/ATE419528T1/de not_active IP Right Cessation
- 2000-04-28 CA CA002371011A patent/CA2371011C/en not_active Expired - Lifetime
- 2000-04-28 JP JP2000614041A patent/JP4647792B2/ja not_active Expired - Lifetime
- 2000-04-28 EP EP00928641A patent/EP1190252B1/en not_active Expired - Lifetime
- 2000-04-28 DE DE60041255T patent/DE60041255D1/de not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5250613A (en) * | 1990-10-22 | 1993-10-05 | Berol Nobel Ab | Solid surface coated with a hydrophilic outer layer with covalently bonded biopolymers, a method of making such a surface, and a conjugate therefor |
| WO1998047948A1 (en) * | 1997-04-18 | 1998-10-29 | California Institute Of Technology | Multifunctional polymeric tissue coatings |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003516519A (ja) | 2003-05-13 |
| DE60041255D1 (de) | 2009-02-12 |
| EP1190252A1 (en) | 2002-03-27 |
| EP1190252B1 (en) | 2008-12-31 |
| ATE419528T1 (de) | 2009-01-15 |
| US6884628B2 (en) | 2005-04-26 |
| CA2371011C (en) | 2009-12-22 |
| JP4647792B2 (ja) | 2011-03-09 |
| CA2371011A1 (en) | 2000-11-02 |
| WO2000065352A1 (en) | 2000-11-02 |
| AU4684600A (en) | 2000-11-10 |
| US20020128234A1 (en) | 2002-09-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU769571B2 (en) | Polyionic coatings in analytic and sensor devices | |
| Wu et al. | DNA and protein microarray printing on silicon nitride waveguide surfaces | |
| Hucknall et al. | In pursuit of zero: polymer brushes that resist the adsorption of proteins | |
| US20100151491A1 (en) | Chemical surface nanopatterns to increase activity of surface-immobilized biomolecules | |
| US20050014151A1 (en) | Device with chemical surface patterns | |
| JP4270511B2 (ja) | バイオセンサー | |
| Myles et al. | Modification of the adhesive properties of collagen by covalent grafting with RGD peptides | |
| US20020068157A1 (en) | Products with biofunctional coating | |
| Vuoriluoto et al. | Control of protein affinity of bioactive nanocellulose and passivation using engineered block and random copolymers | |
| US20040253596A1 (en) | Bioanalytical recognition surface with optimized recognition element density | |
| US20100129830A1 (en) | Label Independent Detection Biosensor Composition and Methods Thereof | |
| Huang et al. | Competitive protein adsorption on biomaterial surface studied with reflectometric interference spectroscopy | |
| JP4580291B2 (ja) | バイオセンサーを用いた測定方法 | |
| Davila et al. | Bioaffinity sensor based on nanoarchitectonic films: Control of the specific adsorption of proteins through the dual role of an ethylene oxide spacer | |
| Pan et al. | Three-dimensional biosensor surface based on novel thorns-like polyelectrolytes | |
| EP1826565A1 (en) | Biosensor and method for immobilizing a physiologically active substance | |
| JP2006266742A (ja) | バイオセンサー | |
| EP1783493A1 (en) | Biosensor for detecting or measuring a substance that interacts with a physiologically active substance comprising a polysaccharide capable of chemically immobilizing physiologically active subtances | |
| JP4037428B2 (ja) | センサー用基板 | |
| JP2006327984A (ja) | ヘテロ二官能性オリゴエチレングリコールの合成方法及びこれを用いたバイオセンサーの製造方法 | |
| Veiseh | Protein and cell patterning for cell-based biosensor applications | |
| Moore et al. | Bioactive Self‐Assembled Monolayer Gradients | |
| JP4369295B2 (ja) | バイオセンサーを用いた測定方法 | |
| Ma | Engineering oligo (ethylene glycol) based nonfouling surfaces and microstructures for biomedical applications | |
| Brynda et al. | Coatings and Monoclonal Antibodies for Optical Immunosensors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |