AU754379B2 - Therapies for treating pulmonary diseases - Google Patents

Therapies for treating pulmonary diseases Download PDF

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Publication number
AU754379B2
AU754379B2 AU54939/99A AU5493999A AU754379B2 AU 754379 B2 AU754379 B2 AU 754379B2 AU 54939/99 A AU54939/99 A AU 54939/99A AU 5493999 A AU5493999 A AU 5493999A AU 754379 B2 AU754379 B2 AU 754379B2
Authority
AU
Australia
Prior art keywords
treating
effective amount
pde4 inhibitor
pulmonary disease
long
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU54939/99A
Other languages
English (en)
Other versions
AU5493999A (en
Inventor
Richard Nieman
Anthony S. Rebuck
Theodore J. Torphy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of AU5493999A publication Critical patent/AU5493999A/en
Application granted granted Critical
Publication of AU754379B2 publication Critical patent/AU754379B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU54939/99A 1998-08-26 1999-08-24 Therapies for treating pulmonary diseases Ceased AU754379B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9797398P 1998-08-26 1998-08-26
US60/097973 1998-08-26
PCT/US1999/019332 WO2000012078A1 (en) 1998-08-26 1999-08-24 Therapies for treating pulmonary diseases

Publications (2)

Publication Number Publication Date
AU5493999A AU5493999A (en) 2000-03-21
AU754379B2 true AU754379B2 (en) 2002-11-14

Family

ID=22266001

Family Applications (1)

Application Number Title Priority Date Filing Date
AU54939/99A Ceased AU754379B2 (en) 1998-08-26 1999-08-24 Therapies for treating pulmonary diseases

Country Status (21)

Country Link
US (2) US6288118B1 (https=)
EP (1) EP1107747A4 (https=)
JP (1) JP2002523452A (https=)
KR (1) KR20010072931A (https=)
CN (1) CN1314811A (https=)
AR (1) AR022072A1 (https=)
AU (1) AU754379B2 (https=)
BR (1) BR9913152A (https=)
CA (1) CA2341488A1 (https=)
CZ (1) CZ293735B6 (https=)
DZ (1) DZ2876A1 (https=)
HU (1) HUP0103160A3 (https=)
IL (1) IL141335A0 (https=)
MA (1) MA26302A1 (https=)
MY (1) MY126544A (https=)
NO (1) NO20010882D0 (https=)
NZ (1) NZ527232A (https=)
PE (1) PE20001032A1 (https=)
PL (1) PL346271A1 (https=)
TR (1) TR200100500T2 (https=)
WO (1) WO2000012078A1 (https=)

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US20030186882A1 (en) * 2001-07-31 2003-10-02 Podolsky Daniel K. Methods and compositions for treating and preventing distal bowel lesions
JP2002523452A (ja) * 1998-08-26 2002-07-30 スミスクライン・ビーチャム・コーポレイション 肺疾患の治療方法
US8933032B2 (en) 1998-10-20 2015-01-13 Children's Hospital Medical Center Surfactant protein D for the treatment of disorders associated with lung injury
EP1212089B1 (en) * 1999-08-21 2006-03-22 ALTANA Pharma AG Synergistic combination of roflumilast and salmeterol
NZ522882A (en) 2000-06-05 2004-07-30 Altana Pharma Bv Pyridazinone compounds effective as beta-2-adrenoreceptor agonists as well as PDE4-inhibitors
US20060189526A1 (en) * 2002-04-24 2006-08-24 Podolsky Daniel K Compositions containing an intestinal trefoil peptide and a mucoadhesive
US20040171544A1 (en) * 2001-04-24 2004-09-02 Barker Nicholas P. Trefoil domain-containing polypeptides and uses thereof
US20030105016A1 (en) * 2001-09-06 2003-06-05 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
US20030181384A1 (en) * 2001-09-06 2003-09-25 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20030185839A1 (en) * 2001-10-05 2003-10-02 Podolsky Daniel K. Methods and compositions for treating dermal lesions
WO2003030824A2 (en) * 2001-10-05 2003-04-17 The General Hospital Corporation Methods and compositions for treating dermal lesions
US7931022B2 (en) * 2001-10-19 2011-04-26 Respirks, Inc. Method and apparatus for dispensing inhalator medicament
JP2005532988A (ja) * 2001-11-28 2005-11-04 ザ ジェネラル ホスピタル コーポレーション 呼吸上皮の病変を治療するための方法および組成物
GB0129395D0 (en) * 2001-12-07 2002-01-30 Pfizer Ltd Pharmaceutical combination
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
CN1655675A (zh) * 2002-03-26 2005-08-17 综合医院公司 利用三叶肽的联合治疗
DE10220458A1 (de) * 2002-05-07 2003-11-27 Altana Pharma Ag Kombination zur Behandlung von Atemwegserkrankungen
DE10220459A1 (de) * 2002-05-07 2003-11-27 Byk Gulden Lomberg Chem Fab Neue Kombination zur Behandlung von Atemwegserkrankungen
RS95204A (sr) * 2002-05-07 2006-12-15 Altana Pharma Ag. Kombinacija za tretman oboljenja disajnih puteva
EP1506016A2 (en) * 2002-05-07 2005-02-16 ALTANA Pharma AG New combination of reversible proton pump inhibitors and airway therapeutics for treating airway disorders
US20060188471A1 (en) * 2002-10-31 2006-08-24 Podolsky Daniel K Methods of treating epithelial lesions
PL216752B1 (pl) * 2002-11-27 2014-05-30 Nycomed Gmbh Środek leczniczy do zapobiegania objawom lub do leczenia chorób dróg oddechowych u ludzi i zastosowanie
MXPA05005438A (es) * 2002-11-27 2005-08-03 Altana Pharma Ag Combinacion sinergica que comprende roflumilast y (r, r) -formoterol.
PT1606261E (pt) 2003-03-10 2010-01-11 Nycomed Gmbh Novo processo para a preparação de roflumilast
JPWO2004087151A1 (ja) * 2003-03-31 2006-06-29 協和醗酵工業株式会社 医薬組成物
SE527200C2 (sv) * 2003-06-19 2006-01-17 Microdrug Ag Inhalatoranordning samt kombinerade doser av formaterol och fluticason
JP2008502699A (ja) * 2004-06-14 2008-01-31 セプラコール・インコーポレイテッド 肺疾患治療方法、及びそのための組成物
WO2005123071A1 (en) * 2004-06-14 2005-12-29 Sepracor Inc. Methods of using albuterol and calcium activated potassium channel openers
US8663694B2 (en) 2005-03-16 2014-03-04 Takeda Gmbh Taste masked dosage form containing roflumilast
DE102005030733A1 (de) * 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
TW200902025A (en) * 2007-04-11 2009-01-16 Alcon Res Ltd Use of an inhibitor of TNF α plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
CN107243076A (zh) * 2009-04-22 2017-10-13 印第安那大学科技研究公司 用于治疗慢性阻塞性肺病和哮喘的组合物和方法
US20110082145A1 (en) * 2009-10-01 2011-04-07 Alcon Research, Ltd. Olopatadine compositions and uses thereof
KR101035488B1 (ko) * 2009-10-05 2011-05-20 숭실대학교산학협력단 자동차 블랙박스 영상물 수집 방법
WO2011056561A1 (en) 2009-10-27 2011-05-12 Beth Israel Deaconess Medical Center Methods and compositions for the generation and use of conformation-specific antibodies
US8367829B2 (en) 2010-05-10 2013-02-05 Gilead Sciences, Inc. Bi-functional pyrazolopyridine compounds
EP2569285A1 (en) 2010-05-10 2013-03-20 Gilead Sciences, Inc. Bifunctional quinoline derivatives
WO2012149334A2 (en) 2011-04-27 2012-11-01 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
WO2015063669A1 (en) 2013-10-30 2015-05-07 Wockhardt Limited Pharmaceutical compositions comprising combination of roflumilast and acebrophylline or pharmaceutically acceptable salts thereof
US10433624B2 (en) * 2015-03-26 2019-10-08 Nike, Inc. Duffel bag
WO2019157144A1 (en) 2018-02-07 2019-08-15 Duke University System and method for homogenous gpcr phosphorylation and identification of beta-2 adrenergic receptor positive allosteric modulators

Citations (3)

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US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions
US5889003A (en) * 1996-09-27 1999-03-30 Adir Et Compagnie Flavone compounds
US5919801A (en) * 1996-09-20 1999-07-06 Adir Et Compagnie N-substituted piperidines as PDE4 inhibitors

Family Cites Families (6)

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BE791025A (fr) 1971-11-19 1973-05-07 Allen & Hanburys Ltd Composes heterocycliques
GB1457873A (en) 1973-01-04 1976-12-08 Allen & Hanburys Ltd Imidazotriazines
FR2390164A1 (fr) 1977-05-13 1978-12-08 Blanie Paul Association a action anti-asthmatique
US5602110A (en) 1994-08-31 1997-02-11 Case Western Reserve University Method and composition for treating cystic fibrosis
AU6823098A (en) * 1997-02-28 1998-09-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Synergistic combination of pde inhibitors and adenylate cyclase agonists or guanyl cyclyse agonists
JP2002523452A (ja) * 1998-08-26 2002-07-30 スミスクライン・ビーチャム・コーポレイション 肺疾患の治療方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919801A (en) * 1996-09-20 1999-07-06 Adir Et Compagnie N-substituted piperidines as PDE4 inhibitors
US5889003A (en) * 1996-09-27 1999-03-30 Adir Et Compagnie Flavone compounds
US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions

Also Published As

Publication number Publication date
MA26302A1 (fr) 2004-10-01
AU5493999A (en) 2000-03-21
NO20010882L (no) 2001-02-21
CZ2001692A3 (cs) 2002-02-13
NZ527232A (en) 2005-03-24
WO2000012078A1 (en) 2000-03-09
TR200100500T2 (tr) 2001-06-21
PL346271A1 (en) 2002-01-28
HUP0103160A2 (hu) 2002-01-28
CZ293735B6 (cs) 2004-07-14
NO20010882D0 (no) 2001-02-21
MY126544A (en) 2006-10-31
KR20010072931A (ko) 2001-07-31
HUP0103160A3 (en) 2002-11-28
US20010056122A1 (en) 2001-12-27
DZ2876A1 (fr) 2003-12-15
EP1107747A4 (en) 2003-04-23
BR9913152A (pt) 2001-05-15
PE20001032A1 (es) 2000-11-10
US6555583B2 (en) 2003-04-29
JP2002523452A (ja) 2002-07-30
CN1314811A (zh) 2001-09-26
EP1107747A1 (en) 2001-06-20
US6288118B1 (en) 2001-09-11
CA2341488A1 (en) 2000-03-09
IL141335A0 (en) 2002-03-10
AR022072A1 (es) 2002-09-04

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Legal Events

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FGA Letters patent sealed or granted (standard patent)