AU754379B2 - Therapies for treating pulmonary diseases - Google Patents

Therapies for treating pulmonary diseases Download PDF

Info

Publication number
AU754379B2
AU754379B2 AU54939/99A AU5493999A AU754379B2 AU 754379 B2 AU754379 B2 AU 754379B2 AU 54939/99 A AU54939/99 A AU 54939/99A AU 5493999 A AU5493999 A AU 5493999A AU 754379 B2 AU754379 B2 AU 754379B2
Authority
AU
Australia
Prior art keywords
treating
effective amount
pde4 inhibitor
pulmonary disease
long
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU54939/99A
Other languages
English (en)
Other versions
AU5493999A (en
Inventor
Richard Nieman
Anthony S. Rebuck
Theodore J. Torphy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of AU5493999A publication Critical patent/AU5493999A/en
Application granted granted Critical
Publication of AU754379B2 publication Critical patent/AU754379B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU54939/99A 1998-08-26 1999-08-24 Therapies for treating pulmonary diseases Ceased AU754379B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9797398P 1998-08-26 1998-08-26
US60/097973 1998-08-26
PCT/US1999/019332 WO2000012078A1 (en) 1998-08-26 1999-08-24 Therapies for treating pulmonary diseases

Publications (2)

Publication Number Publication Date
AU5493999A AU5493999A (en) 2000-03-21
AU754379B2 true AU754379B2 (en) 2002-11-14

Family

ID=22266001

Family Applications (1)

Application Number Title Priority Date Filing Date
AU54939/99A Ceased AU754379B2 (en) 1998-08-26 1999-08-24 Therapies for treating pulmonary diseases

Country Status (21)

Country Link
US (2) US6288118B1 (https=)
EP (1) EP1107747A4 (https=)
JP (1) JP2002523452A (https=)
KR (1) KR20010072931A (https=)
CN (1) CN1314811A (https=)
AR (1) AR022072A1 (https=)
AU (1) AU754379B2 (https=)
BR (1) BR9913152A (https=)
CA (1) CA2341488A1 (https=)
CZ (1) CZ293735B6 (https=)
DZ (1) DZ2876A1 (https=)
HU (1) HUP0103160A3 (https=)
IL (1) IL141335A0 (https=)
MA (1) MA26302A1 (https=)
MY (1) MY126544A (https=)
NO (1) NO20010882D0 (https=)
NZ (1) NZ527232A (https=)
PE (1) PE20001032A1 (https=)
PL (1) PL346271A1 (https=)
TR (1) TR200100500T2 (https=)
WO (1) WO2000012078A1 (https=)

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US20030114384A1 (en) * 2001-11-28 2003-06-19 Podolsky Daniel K. Methods and compositions for treating lesions of the respiratory epithelium
US20030185838A1 (en) * 2001-11-28 2003-10-02 Podolsky Daniel K. Methods and compositions for treating lesions of the respiratory epithelium
US20030186882A1 (en) * 2001-07-31 2003-10-02 Podolsky Daniel K. Methods and compositions for treating and preventing distal bowel lesions
BR9913152A (pt) * 1998-08-26 2001-05-15 Smithkline Beecham Corp Terapias para tratamento de doenças pulmonares
US8933032B2 (en) 1998-10-20 2015-01-13 Children's Hospital Medical Center Surfactant protein D for the treatment of disorders associated with lung injury
CA2715683A1 (en) * 1999-08-21 2001-03-01 Nycomed Gmbh Synergistic combination
NZ522882A (en) 2000-06-05 2004-07-30 Altana Pharma Bv Pyridazinone compounds effective as beta-2-adrenoreceptor agonists as well as PDE4-inhibitors
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
US20030105016A1 (en) * 2001-09-06 2003-06-05 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20060189526A1 (en) * 2002-04-24 2006-08-24 Podolsky Daniel K Compositions containing an intestinal trefoil peptide and a mucoadhesive
US20040171544A1 (en) * 2001-04-24 2004-09-02 Barker Nicholas P. Trefoil domain-containing polypeptides and uses thereof
US20030181384A1 (en) * 2001-09-06 2003-09-25 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20030185839A1 (en) * 2001-10-05 2003-10-02 Podolsky Daniel K. Methods and compositions for treating dermal lesions
WO2003030824A2 (en) * 2001-10-05 2003-04-17 The General Hospital Corporation Methods and compositions for treating dermal lesions
US7931022B2 (en) * 2001-10-19 2011-04-26 Respirks, Inc. Method and apparatus for dispensing inhalator medicament
GB0129395D0 (en) * 2001-12-07 2002-01-30 Pfizer Ltd Pharmaceutical combination
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
AU2003224773B2 (en) * 2002-03-26 2010-08-26 The General Hospital Corporation Combination therapy using trefoil peptides
RS95304A (sr) * 2002-05-07 2006-12-15 Altana Pharma Ag. Nova kombinacija za tretman oboljenja disajnih puteva
DE10220458A1 (de) * 2002-05-07 2003-11-27 Altana Pharma Ag Kombination zur Behandlung von Atemwegserkrankungen
DE10220459A1 (de) * 2002-05-07 2003-11-27 Byk Gulden Lomberg Chem Fab Neue Kombination zur Behandlung von Atemwegserkrankungen
US20050165041A1 (en) * 2002-05-07 2005-07-28 Altana Pharma Ag Combination for the treatment of airway disorders
US20060188471A1 (en) * 2002-10-31 2006-08-24 Podolsky Daniel K Methods of treating epithelial lesions
DK1567139T3 (da) * 2002-11-27 2008-11-03 Nycomed Gmbh Hidtil ukendt synergistisk kombination der omfatter roflumilast og formoterol
NZ540658A (en) * 2002-11-27 2007-03-30 Altana Pharma Ag Synergistic combination comprising roflumilas and (R,R)-formoterol
ES2335498T3 (es) 2003-03-10 2010-03-29 Nycomed Gmbh Nuevo proceso para la preparacion de reflumilast.
JPWO2004087151A1 (ja) * 2003-03-31 2006-06-29 協和醗酵工業株式会社 医薬組成物
SE527200C2 (sv) * 2003-06-19 2006-01-17 Microdrug Ag Inhalatoranordning samt kombinerade doser av formaterol och fluticason
WO2005123072A1 (en) * 2004-06-14 2005-12-29 Sepracor Inc. Methods and compositions for the treatment of pulmonary diseases
CA2570386A1 (en) * 2004-06-14 2005-12-29 Sepracor Inc. Methods of using albuterol and calcium activated potassium channel openers
US8663694B2 (en) 2005-03-16 2014-03-04 Takeda Gmbh Taste masked dosage form containing roflumilast
DE102005030733A1 (de) * 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
KR20100014565A (ko) * 2007-04-11 2010-02-10 알콘 리서치, 리미티드 알레르기성 비염 및 알레르기성 결막염을 치료하기 위한 ｔｎｆａ의 억제제 및 항히스타민의 용도
ES2618881T3 (es) * 2009-04-22 2017-06-22 Indiana University Research And Technology Corporation Colágeno V para su uso en el tratamiento del asma
CN102548536A (zh) * 2009-10-01 2012-07-04 爱尔康研究有限公司 奥洛他定组合物及其用途
KR101035488B1 (ko) * 2009-10-05 2011-05-20 숭실대학교산학협력단 자동차 블랙박스 영상물 수집 방법
WO2011056561A1 (en) 2009-10-27 2011-05-12 Beth Israel Deaconess Medical Center Methods and compositions for the generation and use of conformation-specific antibodies
CA2796826A1 (en) 2010-05-10 2011-11-17 Gilead Sciences, Inc. Bifunctional quinoline derivatives
UY33373A (es) 2010-05-10 2011-12-30 Gilead Sciences Inc ?Compuestos de pirazolopiridina bifuncionales, su uso en terapia y composiciones que los comprenden?.
US10487114B2 (en) 2011-04-27 2019-11-26 Beth Israel Deaconess Medical Center, Inc. Methods for administering peptides for the generation of effective c/s conformation-specific antibodies to a human subject in need thereof
WO2015063669A1 (en) 2013-10-30 2015-05-07 Wockhardt Limited Pharmaceutical compositions comprising combination of roflumilast and acebrophylline or pharmaceutically acceptable salts thereof
US10433624B2 (en) * 2015-03-26 2019-10-08 Nike, Inc. Duffel bag
US11866482B2 (en) 2018-02-07 2024-01-09 Duke University System and method for homogenous GPCR phosphorylation and identification of beta-2 adrenergic receptor positive allosteric modulators

Citations (3)

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Publication number Priority date Publication date Assignee Title
US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions
US5889003A (en) * 1996-09-27 1999-03-30 Adir Et Compagnie Flavone compounds
US5919801A (en) * 1996-09-20 1999-07-06 Adir Et Compagnie N-substituted piperidines as PDE4 inhibitors

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BE791025A (fr) 1971-11-19 1973-05-07 Allen & Hanburys Ltd Composes heterocycliques
GB1457873A (en) 1973-01-04 1976-12-08 Allen & Hanburys Ltd Imidazotriazines
FR2390164A1 (fr) 1977-05-13 1978-12-08 Blanie Paul Association a action anti-asthmatique
US5602110A (en) 1994-08-31 1997-02-11 Case Western Reserve University Method and composition for treating cystic fibrosis
ES2302350T3 (es) * 1997-02-28 2008-07-01 Nycomed Gmbh Combinacion sinergica de inhibidores de pde y agonistas de adenilatociclasa o agonistas de guanililciclasa.
BR9913152A (pt) * 1998-08-26 2001-05-15 Smithkline Beecham Corp Terapias para tratamento de doenças pulmonares

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919801A (en) * 1996-09-20 1999-07-06 Adir Et Compagnie N-substituted piperidines as PDE4 inhibitors
US5889003A (en) * 1996-09-27 1999-03-30 Adir Et Compagnie Flavone compounds
US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions

Also Published As

Publication number Publication date
CZ2001692A3 (cs) 2002-02-13
NZ527232A (en) 2005-03-24
AR022072A1 (es) 2002-09-04
KR20010072931A (ko) 2001-07-31
WO2000012078A1 (en) 2000-03-09
EP1107747A4 (en) 2003-04-23
DZ2876A1 (fr) 2003-12-15
AU5493999A (en) 2000-03-21
MY126544A (en) 2006-10-31
US20010056122A1 (en) 2001-12-27
JP2002523452A (ja) 2002-07-30
US6555583B2 (en) 2003-04-29
EP1107747A1 (en) 2001-06-20
IL141335A0 (en) 2002-03-10
MA26302A1 (fr) 2004-10-01
NO20010882L (no) 2001-02-21
HUP0103160A3 (en) 2002-11-28
HUP0103160A2 (hu) 2002-01-28
US6288118B1 (en) 2001-09-11
BR9913152A (pt) 2001-05-15
NO20010882D0 (no) 2001-02-21
CN1314811A (zh) 2001-09-26
CA2341488A1 (en) 2000-03-09
PL346271A1 (en) 2002-01-28
TR200100500T2 (tr) 2001-06-21
PE20001032A1 (es) 2000-11-10
CZ293735B6 (cs) 2004-07-14

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