CN1314811A - 治疗肺病的方法 - Google Patents

治疗肺病的方法 Download PDF

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Publication number
CN1314811A
CN1314811A CN99810111A CN99810111A CN1314811A CN 1314811 A CN1314811 A CN 1314811A CN 99810111 A CN99810111 A CN 99810111A CN 99810111 A CN99810111 A CN 99810111A CN 1314811 A CN1314811 A CN 1314811A
Authority
CN
China
Prior art keywords
long
pde4 inhibitor
compounds
pde4
effective dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99810111A
Other languages
English (en)
Chinese (zh)
Inventor
R·尼曼
A·S·雷布克
T·J·托尔菲
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of CN1314811A publication Critical patent/CN1314811A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN99810111A 1998-08-26 1999-08-24 治疗肺病的方法 Pending CN1314811A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9797398P 1998-08-26 1998-08-26
US60/097,973 1998-08-26

Publications (1)

Publication Number Publication Date
CN1314811A true CN1314811A (zh) 2001-09-26

Family

ID=22266001

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99810111A Pending CN1314811A (zh) 1998-08-26 1999-08-24 治疗肺病的方法

Country Status (21)

Country Link
US (2) US6288118B1 (https=)
EP (1) EP1107747A4 (https=)
JP (1) JP2002523452A (https=)
KR (1) KR20010072931A (https=)
CN (1) CN1314811A (https=)
AR (1) AR022072A1 (https=)
AU (1) AU754379B2 (https=)
BR (1) BR9913152A (https=)
CA (1) CA2341488A1 (https=)
CZ (1) CZ293735B6 (https=)
DZ (1) DZ2876A1 (https=)
HU (1) HUP0103160A3 (https=)
IL (1) IL141335A0 (https=)
MA (1) MA26302A1 (https=)
MY (1) MY126544A (https=)
NO (1) NO20010882D0 (https=)
NZ (1) NZ527232A (https=)
PE (1) PE20001032A1 (https=)
PL (1) PL346271A1 (https=)
TR (1) TR200100500T2 (https=)
WO (1) WO2000012078A1 (https=)

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US20060189526A1 (en) * 2002-04-24 2006-08-24 Podolsky Daniel K Compositions containing an intestinal trefoil peptide and a mucoadhesive
US20040171544A1 (en) * 2001-04-24 2004-09-02 Barker Nicholas P. Trefoil domain-containing polypeptides and uses thereof
US20030105016A1 (en) * 2001-09-06 2003-06-05 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US7538082B2 (en) 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
US20030181384A1 (en) * 2001-09-06 2003-09-25 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20030185839A1 (en) * 2001-10-05 2003-10-02 Podolsky Daniel K. Methods and compositions for treating dermal lesions
WO2003030824A2 (en) * 2001-10-05 2003-04-17 The General Hospital Corporation Methods and compositions for treating dermal lesions
US7931022B2 (en) * 2001-10-19 2011-04-26 Respirks, Inc. Method and apparatus for dispensing inhalator medicament
JP2005532988A (ja) * 2001-11-28 2005-11-04 ザ ジェネラル ホスピタル コーポレーション 呼吸上皮の病変を治療するための方法および組成物
GB0129395D0 (en) * 2001-12-07 2002-01-30 Pfizer Ltd Pharmaceutical combination
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
CN1655675A (zh) * 2002-03-26 2005-08-17 综合医院公司 利用三叶肽的联合治疗
DE10220458A1 (de) * 2002-05-07 2003-11-27 Altana Pharma Ag Kombination zur Behandlung von Atemwegserkrankungen
DE10220459A1 (de) * 2002-05-07 2003-11-27 Byk Gulden Lomberg Chem Fab Neue Kombination zur Behandlung von Atemwegserkrankungen
RS95204A (sr) * 2002-05-07 2006-12-15 Altana Pharma Ag. Kombinacija za tretman oboljenja disajnih puteva
EP1506016A2 (en) * 2002-05-07 2005-02-16 ALTANA Pharma AG New combination of reversible proton pump inhibitors and airway therapeutics for treating airway disorders
US20060188471A1 (en) * 2002-10-31 2006-08-24 Podolsky Daniel K Methods of treating epithelial lesions
PL216752B1 (pl) * 2002-11-27 2014-05-30 Nycomed Gmbh Środek leczniczy do zapobiegania objawom lub do leczenia chorób dróg oddechowych u ludzi i zastosowanie
MXPA05005438A (es) * 2002-11-27 2005-08-03 Altana Pharma Ag Combinacion sinergica que comprende roflumilast y (r, r) -formoterol.
PT1606261E (pt) 2003-03-10 2010-01-11 Nycomed Gmbh Novo processo para a preparação de roflumilast
JPWO2004087151A1 (ja) * 2003-03-31 2006-06-29 協和醗酵工業株式会社 医薬組成物
SE527200C2 (sv) * 2003-06-19 2006-01-17 Microdrug Ag Inhalatoranordning samt kombinerade doser av formaterol och fluticason
JP2008502699A (ja) * 2004-06-14 2008-01-31 セプラコール・インコーポレイテッド 肺疾患治療方法、及びそのための組成物
WO2005123071A1 (en) * 2004-06-14 2005-12-29 Sepracor Inc. Methods of using albuterol and calcium activated potassium channel openers
US8663694B2 (en) 2005-03-16 2014-03-04 Takeda Gmbh Taste masked dosage form containing roflumilast
DE102005030733A1 (de) * 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
TW200902025A (en) * 2007-04-11 2009-01-16 Alcon Res Ltd Use of an inhibitor of TNF α plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
CN107243076A (zh) * 2009-04-22 2017-10-13 印第安那大学科技研究公司 用于治疗慢性阻塞性肺病和哮喘的组合物和方法
US20110082145A1 (en) * 2009-10-01 2011-04-07 Alcon Research, Ltd. Olopatadine compositions and uses thereof
KR101035488B1 (ko) * 2009-10-05 2011-05-20 숭실대학교산학협력단 자동차 블랙박스 영상물 수집 방법
WO2011056561A1 (en) 2009-10-27 2011-05-12 Beth Israel Deaconess Medical Center Methods and compositions for the generation and use of conformation-specific antibodies
US8367829B2 (en) 2010-05-10 2013-02-05 Gilead Sciences, Inc. Bi-functional pyrazolopyridine compounds
EP2569285A1 (en) 2010-05-10 2013-03-20 Gilead Sciences, Inc. Bifunctional quinoline derivatives
WO2012149334A2 (en) 2011-04-27 2012-11-01 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
WO2015063669A1 (en) 2013-10-30 2015-05-07 Wockhardt Limited Pharmaceutical compositions comprising combination of roflumilast and acebrophylline or pharmaceutically acceptable salts thereof
US10433624B2 (en) * 2015-03-26 2019-10-08 Nike, Inc. Duffel bag
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US5602110A (en) 1994-08-31 1997-02-11 Case Western Reserve University Method and composition for treating cystic fibrosis
FR2753706B1 (fr) * 1996-09-20 1998-10-30 Nouvelles amines cycliques n-substituees, leur procede de preparation et les compositions pharmaceutiques les renfermant
FR2753969B1 (fr) * 1996-09-27 1998-10-30 Adir Nouveaux derives de flavones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU6823098A (en) * 1997-02-28 1998-09-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Synergistic combination of pde inhibitors and adenylate cyclase agonists or guanyl cyclyse agonists
US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions
JP2002523452A (ja) * 1998-08-26 2002-07-30 スミスクライン・ビーチャム・コーポレイション 肺疾患の治療方法

Also Published As

Publication number Publication date
MA26302A1 (fr) 2004-10-01
AU5493999A (en) 2000-03-21
NO20010882L (no) 2001-02-21
CZ2001692A3 (cs) 2002-02-13
NZ527232A (en) 2005-03-24
WO2000012078A1 (en) 2000-03-09
TR200100500T2 (tr) 2001-06-21
PL346271A1 (en) 2002-01-28
HUP0103160A2 (hu) 2002-01-28
CZ293735B6 (cs) 2004-07-14
NO20010882D0 (no) 2001-02-21
MY126544A (en) 2006-10-31
KR20010072931A (ko) 2001-07-31
HUP0103160A3 (en) 2002-11-28
US20010056122A1 (en) 2001-12-27
DZ2876A1 (fr) 2003-12-15
EP1107747A4 (en) 2003-04-23
BR9913152A (pt) 2001-05-15
PE20001032A1 (es) 2000-11-10
US6555583B2 (en) 2003-04-29
AU754379B2 (en) 2002-11-14
JP2002523452A (ja) 2002-07-30
EP1107747A1 (en) 2001-06-20
US6288118B1 (en) 2001-09-11
CA2341488A1 (en) 2000-03-09
IL141335A0 (en) 2002-03-10
AR022072A1 (es) 2002-09-04

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C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication