AU741037B2 - Methods for treatment of diabetes using peptide analogues of insulin - Google Patents

Methods for treatment of diabetes using peptide analogues of insulin Download PDF

Info

Publication number
AU741037B2
AU741037B2 AU27831/99A AU2783199A AU741037B2 AU 741037 B2 AU741037 B2 AU 741037B2 AU 27831/99 A AU27831/99 A AU 27831/99A AU 2783199 A AU2783199 A AU 2783199A AU 741037 B2 AU741037 B2 AU 741037B2
Authority
AU
Australia
Prior art keywords
peptide analogue
chain
peptide
residues
residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU27831/99A
Other languages
English (en)
Other versions
AU2783199A (en
Inventor
Paul J. Conlon
Amitabh Gaur
Nicholas Ling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurocrine Biosciences Inc
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of AU2783199A publication Critical patent/AU2783199A/en
Application granted granted Critical
Publication of AU741037B2 publication Critical patent/AU741037B2/en
Priority to AU18040/02A priority Critical patent/AU781405B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU27831/99A 1998-02-23 1999-02-23 Methods for treatment of diabetes using peptide analogues of insulin Ceased AU741037B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU18040/02A AU781405B2 (en) 1998-02-23 2002-02-22 Methods for treatment of diabetes using peptide analogues of insulin

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2815698A 1998-02-23 1998-02-23
US09/028156 1998-02-23
PCT/US1999/003915 WO1999042482A1 (en) 1998-02-23 1999-02-23 Methods for treatment of diabetes using peptide analogues of insulin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU18040/02A Division AU781405B2 (en) 1998-02-23 2002-02-22 Methods for treatment of diabetes using peptide analogues of insulin

Publications (2)

Publication Number Publication Date
AU2783199A AU2783199A (en) 1999-09-06
AU741037B2 true AU741037B2 (en) 2001-11-22

Family

ID=21841884

Family Applications (1)

Application Number Title Priority Date Filing Date
AU27831/99A Ceased AU741037B2 (en) 1998-02-23 1999-02-23 Methods for treatment of diabetes using peptide analogues of insulin

Country Status (20)

Country Link
US (1) US6197926B1 (enExample)
EP (1) EP1056776A1 (enExample)
JP (1) JP2002504491A (enExample)
KR (1) KR20010041238A (enExample)
CN (1) CN1241942C (enExample)
AP (1) AP2000001888A0 (enExample)
AU (1) AU741037B2 (enExample)
BR (1) BR9908178A (enExample)
CA (1) CA2321929A1 (enExample)
EA (1) EA003944B1 (enExample)
HU (1) HUP0100928A3 (enExample)
ID (1) ID26788A (enExample)
IL (1) IL137904A0 (enExample)
NO (1) NO20004198L (enExample)
NZ (1) NZ506447A (enExample)
OA (1) OA11453A (enExample)
PL (1) PL342517A1 (enExample)
SK (1) SK12412000A3 (enExample)
TR (1) TR200003048T2 (enExample)
WO (1) WO1999042482A1 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562942B1 (en) * 1999-02-23 2003-05-13 Neurocrine Biosciences, Inc. Methods for treatment of diabetes using peptide analogues of insulin
CN1125081C (zh) * 1999-09-08 2003-10-22 中国科学院上海生物化学研究所 重组天然和新型人胰岛素及其制备方法
US7462486B2 (en) * 2000-05-12 2008-12-09 Oregon Health & Science University Methods of selecting T cell receptor V peptides for therapeutic use
US7371385B2 (en) * 2000-05-12 2008-05-13 Oregon Health & Science University Method of treating immune pathologies with low dose estrogen
US20020103131A1 (en) * 2001-01-26 2002-08-01 Jacobson Jill D. Prevention of diabetes by administration of GnRH antagonists
US20040138116A1 (en) * 2002-08-30 2004-07-15 Vincent Geenen Tolerogenic approach for type 1 diabetes
US20070172453A1 (en) * 2002-08-30 2007-07-26 Vincent Geenen Tolerogenic approach for type 1 diabetes
CN100582085C (zh) 2002-10-10 2010-01-20 耶达研究及发展有限公司 脂肪醇的碱性酯及它们作为抗炎药或免疫调节剂的用途
CN1798569A (zh) * 2003-06-02 2006-07-05 莫西亚药物公司 用于治疗1型糖尿病的治疗性疫苗组合物
CA2575604A1 (en) * 2004-07-30 2006-02-02 Oregon Health And Science University Methods for detecting and treating autoimmune disorders
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
RU2524423C2 (ru) 2008-01-09 2014-07-27 Санофи-Авентис Дойчланд Гмбх Новые производные инсулина с чрезвычайно замедленным профилем время/действие
DE102008003566A1 (de) * 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
US20110065633A1 (en) 2008-01-30 2011-03-17 Indiana University Research And Technology Corporation Ester-based peptide prodrugs
PT3228320T (pt) 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
JP5789515B2 (ja) * 2008-12-19 2015-10-07 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン類似体
US8697632B2 (en) 2008-12-19 2014-04-15 Indiana University Research And Technology Corporation Amide based insulin prodrugs
WO2011056226A1 (en) 2009-11-05 2011-05-12 Mercia Pharma Llc Adjuvanted nanoparticulate influenza vaccine
SG10201500871TA (en) 2009-11-13 2015-04-29 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
JP5832439B2 (ja) 2009-11-13 2015-12-16 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｇｌｐ−１アゴニスト、インスリン及びメチオニンを含む薬学的組成物
US20110311536A1 (en) * 2010-06-11 2011-12-22 Dana-Farber Cancer Institute, Inc. Prevention of type 1 diabetes by treg vaccination with an insulin mimetope
JP5969469B2 (ja) 2010-06-16 2016-08-17 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン受容体に対して高い活性を示す単鎖インスリンアゴニスト
CA2803164C (en) 2010-06-24 2018-08-21 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
CN103179978A (zh) 2010-08-30 2013-06-26 赛诺菲-安万特德国有限公司 Ave0010用于制造供治疗2型糖尿病用的药物的用途
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
UA113626C2 (xx) * 2011-06-02 2017-02-27 Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CN104114183A (zh) 2011-12-20 2014-10-22 印第安纳大学研究及科技有限公司 用于治疗糖尿病的基于ctp的胰岛素类似物
CN108383902A (zh) 2012-09-26 2018-08-10 印第安纳大学研究及科技有限公司 胰岛素类似物二聚体
JP6538645B2 (ja) 2013-03-14 2019-07-03 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン‐インクレチン複合物
EP3197912B1 (en) 2014-09-24 2023-01-04 Indiana University Research & Technology Corporation Lipidated amide-based insulin prodrugs
CN108271356A (zh) 2014-09-24 2018-07-10 印第安纳大学研究及科技有限公司 肠降血糖素-胰岛素缀合物
CN107206058A (zh) 2014-12-12 2017-09-26 赛诺菲-安万特德国有限公司 甘精胰岛素/利西拉来固定比率配制剂
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN111925420B (zh) * 2019-12-11 2022-04-01 山东大学 一种多肽作为嗅觉受体Olfr109激动剂配体的应用
USD1043348S1 (en) * 2021-09-24 2024-09-24 H.J. Heinz Company Brands Llc Bottle

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004307A1 (en) * 1994-08-02 1996-02-15 Eli Lilly And Company Aspb1 insulin analogs
WO1997002043A1 (en) * 1995-06-30 1997-01-23 Novo Nordisk A/S Prevention of a disease having the characteristics of diabetes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
US5594100A (en) * 1995-02-22 1997-01-14 Regents Of The University Of Colorado Epitope for prevention of type I diabetes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004307A1 (en) * 1994-08-02 1996-02-15 Eli Lilly And Company Aspb1 insulin analogs
WO1997002043A1 (en) * 1995-06-30 1997-01-23 Novo Nordisk A/S Prevention of a disease having the characteristics of diabetes

Also Published As

Publication number Publication date
CN1294597A (zh) 2001-05-09
TR200003048T2 (tr) 2000-12-21
EP1056776A1 (en) 2000-12-06
HUP0100928A3 (en) 2001-11-28
IL137904A0 (en) 2001-10-31
JP2002504491A (ja) 2002-02-12
SK12412000A3 (sk) 2002-05-09
ID26788A (id) 2001-02-08
NO20004198D0 (no) 2000-08-22
CN1241942C (zh) 2006-02-15
KR20010041238A (ko) 2001-05-15
NO20004198L (no) 2000-10-20
US6197926B1 (en) 2001-03-06
PL342517A1 (en) 2001-06-18
CA2321929A1 (en) 1999-08-26
OA11453A (en) 2003-12-08
EA200000872A1 (ru) 2001-02-26
AU2783199A (en) 1999-09-06
EA003944B1 (ru) 2003-10-30
NZ506447A (en) 2002-11-26
BR9908178A (pt) 2002-01-15
WO1999042482A1 (en) 1999-08-26
AP2000001888A0 (en) 2000-09-30
HUP0100928A2 (hu) 2001-08-28

Similar Documents

Publication Publication Date Title
US6197926B1 (en) Methods for treatment of diabetes using peptide analogues of insulin
JP2761402B2 (ja) 普遍的なｔ―細胞エピトープ
IL101452A (en) Analogs of the factor that releases the growth hormone, their preparation and the pharmaceutical preparations that contain them
AU2018202802A1 (en) Combinations of modalities for the treatment of diabetes
IL98638A (en) Analogs of the factor that releases human growth hormone, their preparation and pharmaceutical preparations that contain them
JPH04503812A (ja) メラニン濃縮ホルモンおよびそれを用いた処置法
US6045796A (en) Vaccination with peptide of MHC class II molecules for treatment of autoimmune disease
US6562942B1 (en) Methods for treatment of diabetes using peptide analogues of insulin
AU2605097A (en) Cyclic peptide vaccines for treatment and prevention of diabetes
WO1996020950A2 (en) Compositions and methods for treating rheumatoid arthritis
AU781405B2 (en) Methods for treatment of diabetes using peptide analogues of insulin
JP2002507886A (ja) アンギオテンシン誘導体
MXPA00008268A (en) Methods for treatment of diabetes using peptide analogues of insulin
CZ20003065A3 (cs) Peptidové analogy insulinu a jejich využití pro léčení diabetes mellitus
US5945401A (en) Peptide analogues of the 65KD isoform of human glutamic acid decarboxylase and uses thereof
HUP0000836A2 (hu) Kollagén II-re specifikus T-sejt epitópot tartalmazó peptidek
WO1997000891A9 (en) Methods for treatment and prevention of diabetes
US20040180063A1 (en) Vaccination with peptide of MHC class ll molecules for treatment of autoimmune disease
EP0482598A2 (en) Peptide analog of human TSH receptor affective against autoimmune hyperthyroidism
AU4863900A (en) Vaccination with peptide of MHC class II molecules for treatment of autoimmune disease
AU1495700A (en) Methods for treatment and prevention of diabetes
HK1030625A1 (en) Methods and compositions for immunomodulation

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)