AU716923B2 - Human bikunin - Google Patents

Human bikunin Download PDF

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Publication number
AU716923B2
AU716923B2 AU22077/97A AU2207797A AU716923B2 AU 716923 B2 AU716923 B2 AU 716923B2 AU 22077/97 A AU22077/97 A AU 22077/97A AU 2207797 A AU2207797 A AU 2207797A AU 716923 B2 AU716923 B2 AU 716923B2
Authority
AU
Australia
Prior art keywords
seq
protein
bikunin
placental bikunin
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU22077/97A
Other languages
English (en)
Other versions
AU2207797A (en
Inventor
Gary Davis
Katherine A. Delaria
Christopher W. Marlor
Daniel K. Muller
Paul P Tamburini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aerovance Inc
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Publication of AU2207797A publication Critical patent/AU2207797A/en
Application granted granted Critical
Publication of AU716923B2 publication Critical patent/AU716923B2/en
Assigned to AEROVANCE, INC. reassignment AEROVANCE, INC. Alteration of Name(s) in Register under S187 Assignors: BAYER CORPORATION
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Wood Science & Technology (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
AU22077/97A 1996-03-11 1997-03-10 Human bikunin Ceased AU716923B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US1310696P 1996-03-11 1996-03-11
US60013106 1996-03-11
US1979396P 1996-06-14 1996-06-14
US60019793 1996-06-14
US72525196A 1996-10-04 1996-10-04
US08725251 1996-10-04
PCT/US1997/003894 WO1997033996A2 (en) 1996-03-11 1997-03-10 Human bikunin

Publications (2)

Publication Number Publication Date
AU2207797A AU2207797A (en) 1997-10-01
AU716923B2 true AU716923B2 (en) 2000-03-09

Family

ID=27359773

Family Applications (1)

Application Number Title Priority Date Filing Date
AU22077/97A Ceased AU716923B2 (en) 1996-03-11 1997-03-10 Human bikunin

Country Status (27)

Country Link
US (3) US6583108B1 (enExample)
EP (1) EP0891426B1 (enExample)
JP (2) JP3469584B2 (enExample)
KR (1) KR100356956B1 (enExample)
AR (3) AR006188A1 (enExample)
AT (1) ATE328083T1 (enExample)
AU (1) AU716923B2 (enExample)
BR (1) BR9708021A (enExample)
CA (1) CA2247888A1 (enExample)
CO (1) CO4600683A1 (enExample)
DE (1) DE69735996T2 (enExample)
DK (1) DK0891426T3 (enExample)
ES (1) ES2263174T3 (enExample)
HR (1) HRP970144B1 (enExample)
HU (1) HU226419B1 (enExample)
ID (1) ID16224A (enExample)
IL (1) IL126115A (enExample)
IN (1) IN192874B (enExample)
MY (1) MY120693A (enExample)
NZ (1) NZ331540A (enExample)
PA (1) PA8426301A1 (enExample)
PL (1) PL188387B1 (enExample)
PT (1) PT891426E (enExample)
SV (1) SV1997000018A (enExample)
TR (1) TR199801794T2 (enExample)
WO (1) WO1997033996A2 (enExample)
YU (1) YU8997A (enExample)

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Also Published As

Publication number Publication date
DE69735996T2 (de) 2007-02-15
HUP9902698A2 (hu) 1999-11-29
DK0891426T3 (da) 2006-10-02
AU2207797A (en) 1997-10-01
KR19990087697A (ko) 1999-12-27
ES2263174T3 (es) 2006-12-01
HRP970144B1 (en) 2004-10-31
PL188387B1 (pl) 2005-01-31
CA2247888A1 (en) 1997-09-18
JP3469584B2 (ja) 2003-11-25
NZ331540A (en) 1999-10-28
MY120693A (en) 2005-11-30
PT891426E (pt) 2006-10-31
CO4600683A1 (es) 1998-05-08
AR053063A2 (es) 2007-04-18
SV1997000018A (es) 1999-01-14
US20060172946A1 (en) 2006-08-03
WO1997033996A3 (en) 1997-11-13
DE69735996D1 (de) 2006-07-06
US7452859B2 (en) 2008-11-18
US7019123B2 (en) 2006-03-28
KR100356956B1 (ko) 2003-03-15
BR9708021A (pt) 1999-07-27
JP2004000208A (ja) 2004-01-08
YU8997A (sh) 1999-09-27
AR058982A1 (es) 2008-03-05
IL126115A (en) 2007-03-08
HU226419B1 (en) 2008-12-29
JP2001521367A (ja) 2001-11-06
PL328822A1 (en) 1999-02-15
ID16224A (id) 1997-09-11
EP0891426A2 (en) 1999-01-20
TR199801794T2 (xx) 2000-07-21
ATE328083T1 (de) 2006-06-15
EP0891426B1 (en) 2006-05-31
HRP970144A2 (en) 1998-04-30
IL126115A0 (en) 1999-05-09
HUP9902698A3 (en) 2001-06-28
IN192874B (enExample) 2004-05-29
US20030194398A1 (en) 2003-10-16
US6583108B1 (en) 2003-06-24
AR006188A1 (es) 1999-08-11
PA8426301A1 (es) 2000-05-24
WO1997033996A2 (en) 1997-09-18

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