AU690768B2 - Process for preparing N-protected amino acid alpha-halomethyl ketones and alcohols from N-protected amino acid esters - Google Patents

Process for preparing N-protected amino acid alpha-halomethyl ketones and alcohols from N-protected amino acid esters Download PDF

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Publication number
AU690768B2
AU690768B2 AU40360/95A AU4036095A AU690768B2 AU 690768 B2 AU690768 B2 AU 690768B2 AU 40360/95 A AU40360/95 A AU 40360/95A AU 4036095 A AU4036095 A AU 4036095A AU 690768 B2 AU690768 B2 AU 690768B2
Authority
AU
Australia
Prior art keywords
compound
formula
process according
amino acid
xiii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU40360/95A
Other languages
English (en)
Other versions
AU4036095A (en
Inventor
Joel C. Barrish
Ping Chen
Peter Tai Wah Cheng
Richard P. Polniaszek
Steven H. Spergel
John K. Thottathil
Xuebao Wang
Robert Zahler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AU4036095A publication Critical patent/AU4036095A/en
Application granted granted Critical
Publication of AU690768B2 publication Critical patent/AU690768B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU40360/95A 1994-12-13 1995-12-12 Process for preparing N-protected amino acid alpha-halomethyl ketones and alcohols from N-protected amino acid esters Ceased AU690768B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/355,373 US5481011A (en) 1994-12-13 1994-12-13 Process for preparing N-protected amino acid α-halomethyl ketones and alcohols from N-protected amino acid esters
US355373 1994-12-13

Publications (2)

Publication Number Publication Date
AU4036095A AU4036095A (en) 1996-06-20
AU690768B2 true AU690768B2 (en) 1998-04-30

Family

ID=23397213

Family Applications (1)

Application Number Title Priority Date Filing Date
AU40360/95A Ceased AU690768B2 (en) 1994-12-13 1995-12-12 Process for preparing N-protected amino acid alpha-halomethyl ketones and alcohols from N-protected amino acid esters

Country Status (11)

Country Link
US (1) US5481011A (enExample)
EP (1) EP0719769A2 (enExample)
JP (1) JPH08225557A (enExample)
KR (1) KR960022492A (enExample)
CN (1) CN1132203A (enExample)
AU (1) AU690768B2 (enExample)
CA (1) CA2163062C (enExample)
FI (1) FI955955A7 (enExample)
HU (1) HU215249B (enExample)
IL (1) IL116319A0 (enExample)
TW (1) TW365605B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100411856B1 (ko) * 1995-02-03 2004-05-20 카네카 코포레이션 α-할로케톤,α-할로히드린및에폭사이드의제조법
USH1893H (en) * 1996-07-23 2000-10-03 Bristol-Myers Squibb Company Enzymatic reduction method for the preparation of halohydrins
CA2319088A1 (en) * 1998-01-28 1999-08-05 Nippon Kayaku Kabushiki Kaisha Process for producing optically active threo-3-amino-1,2-epoxy compounds
DE60005304T2 (de) * 1999-01-21 2004-06-24 Kaneka Corp. Methode zur reinigung und abtrennung von (2s,3s)- oder (2r,3s)-halohydrinderivaten
CA2361475A1 (en) * 1999-01-28 2000-08-03 Ajinomoto Co., Inc. Process for the preparation of .alpha.-aminoketones
EP1661893A3 (en) * 1999-01-29 2006-06-07 Kaneka Corporation Process for the preparation of threo-1,2-epoxy-3-amino-4-phenylbutane derivatives
US6605732B1 (en) * 1999-05-03 2003-08-12 Aerojet Fine Chemicals Llc Clean, high-yield preparation of S,S and R,S amino acid isosteres
KR100339831B1 (ko) * 1999-08-18 2002-06-07 김태성 신규의 에틸 아지리딘 유도체 및 그 제조방법
KR100708221B1 (ko) * 1999-08-31 2007-04-17 아지노모토 가부시키가이샤 에폭사이드 결정의 제조방법
US6992081B2 (en) 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
ATE343562T1 (de) 2000-03-23 2006-11-15 Elan Pharm Inc Verbindungen und verfahren zur behandlung der alzheimerschen krankheit
CN1217920C (zh) * 2000-06-30 2005-09-07 艾兰制药公司 治疗早老性痴呆的化合物
EP1666452A2 (en) 2000-06-30 2006-06-07 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
US20030096864A1 (en) * 2000-06-30 2003-05-22 Fang Lawrence Y. Compounds to treat alzheimer's disease
US6846813B2 (en) 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
US7253194B2 (en) * 2000-07-24 2007-08-07 The University Of Queensland Compounds and inhibitors of phospholipases
US7122696B2 (en) * 2000-11-30 2006-10-17 Ajinomoto Co., Inc. Processes for preparation of N-protected-β-amino alcohols and N-protected-β-amino epoxides
KR20020046948A (ko) 2000-12-12 2002-06-21 에가시라 구니오 에폭사이드 결정의 제조방법
AR035960A1 (es) * 2001-04-23 2004-07-28 Elan Pharm Inc Epoxidos sustituidos y procesos para prepararlos
MXPA04000140A (es) * 2001-06-27 2004-06-03 Elan Pharm Inc Derivados de beta-hidroxiamina utiles en el tratamiento de enfermedad de alzheimer.
DE10143742A1 (de) 2001-09-06 2003-03-27 Consortium Elektrochem Ind Verfahren zur Herstellung von alpha-Halogenketonen
GB0417824D0 (en) * 2004-08-11 2004-09-15 Phoenix Chemicals Ltd Process for asymmetric catalytic hydrogenation
KR101299972B1 (ko) * 2011-03-30 2013-08-26 순천향대학교 산학협력단 수소화붕소나트륨을 이용한 (3Ｓ)-3-(ｔｅｒｔ-부톡시카르보닐)아미노-1-클로로-4-페닐-(2Ｓ)-부탄올의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1290787A (enExample) * 1970-03-12 1972-09-27
GB1335317A (en) * 1971-06-23 1973-10-24 Leo Pharm Prod Ltd Cephalosporin esters salts thereof and methods for their pre paration
JPS53124226A (en) * 1977-04-07 1978-10-30 Mitsubishi Gas Chem Co Inc Preparation of polyglycidyl compounds
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
DD295369A5 (de) * 1988-10-06 1991-10-31 Tech Hochschule C Schorlemmer Verfahren zur herstellung von substituierten glycidylanilinen
ATE141265T1 (de) * 1992-05-20 1996-08-15 Searle & Co Verfahren zur herstellung von intermediaten in der synthese von retroviralen protease inhibitoren
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors

Also Published As

Publication number Publication date
AU4036095A (en) 1996-06-20
FI955955A0 (fi) 1995-12-12
HUT73644A (en) 1996-09-30
FI955955L (fi) 1996-06-14
EP0719769A3 (enExample) 1996-07-31
TW365605B (en) 1999-08-01
CA2163062C (en) 1999-02-09
FI955955A7 (fi) 1996-06-14
IL116319A0 (en) 1996-03-31
HU9503544D0 (en) 1996-02-28
KR960022492A (ko) 1996-07-18
US5481011A (en) 1996-01-02
HU215249B (hu) 1998-11-30
CA2163062A1 (en) 1996-06-14
EP0719769A2 (en) 1996-07-03
JPH08225557A (ja) 1996-09-03
CN1132203A (zh) 1996-10-02

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired