AU690257B2 - Tropane-2-alcoxime derivatives as neurotransmitter reuptake inhibitors - Google Patents

Tropane-2-alcoxime derivatives as neurotransmitter reuptake inhibitors Download PDF

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Publication number
AU690257B2
AU690257B2 AU22575/95A AU2257595A AU690257B2 AU 690257 B2 AU690257 B2 AU 690257B2 AU 22575/95 A AU22575/95 A AU 22575/95A AU 2257595 A AU2257595 A AU 2257595A AU 690257 B2 AU690257 B2 AU 690257B2
Authority
AU
Australia
Prior art keywords
tropane
aldoxime
dichlorophenyl
alkyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU22575/95A
Other languages
English (en)
Other versions
AU2257595A (en
Inventor
Peter Moldt
Jorgen Scheel-Kruger
Frank Watjen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Publication of AU2257595A publication Critical patent/AU2257595A/en
Application granted granted Critical
Publication of AU690257B2 publication Critical patent/AU690257B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AU22575/95A 1994-04-19 1995-04-12 Tropane-2-alcoxime derivatives as neurotransmitter reuptake inhibitors Ceased AU690257B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DK447/94 1994-04-19
DK44794 1994-04-19
DK133894 1994-11-24
DK1338/94 1994-11-24
PCT/EP1995/001358 WO1995028401A1 (fr) 1994-04-19 1995-04-12 Derives de tropane-2-aldoxime en tant qu'inhibiteurs de recaptage des neurotransmetteurs

Publications (2)

Publication Number Publication Date
AU2257595A AU2257595A (en) 1995-11-10
AU690257B2 true AU690257B2 (en) 1998-04-23

Family

ID=26064021

Family Applications (1)

Application Number Title Priority Date Filing Date
AU22575/95A Ceased AU690257B2 (en) 1994-04-19 1995-04-12 Tropane-2-alcoxime derivatives as neurotransmitter reuptake inhibitors

Country Status (25)

Country Link
US (1) US5736556A (fr)
EP (1) EP0756596B1 (fr)
JP (1) JP2899418B2 (fr)
KR (1) KR100210417B1 (fr)
CN (1) CN1043763C (fr)
AT (1) ATE222587T1 (fr)
AU (1) AU690257B2 (fr)
BG (1) BG63259B1 (fr)
BR (1) BR9507489A (fr)
CA (1) CA2187309C (fr)
CZ (1) CZ284379B6 (fr)
DE (1) DE69527839T2 (fr)
DK (1) DK0756596T3 (fr)
EE (1) EE03877B1 (fr)
FI (1) FI965074A (fr)
GE (1) GEP19991749B (fr)
HU (1) HU215830B (fr)
LV (1) LV11738B (fr)
NO (1) NO964180L (fr)
NZ (1) NZ284075A (fr)
PL (1) PL183025B1 (fr)
RU (1) RU2134264C1 (fr)
SK (1) SK280875B6 (fr)
UA (1) UA49801C2 (fr)
WO (1) WO1995028401A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0859777B1 (fr) * 1995-10-13 2007-05-23 Neurosearch A/S Derives de 8-azabicyclo(3.2.1)oct-2-ene, leur preparation et leur utilisation
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
IL123898A (en) * 1995-11-02 2001-08-08 Neurosearch As The history of compressed tropane, their preparation and the pharmaceutical preparations containing them
US5948933A (en) * 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
CA2244773C (fr) 1996-02-22 2006-01-03 Neurosearch A/S Derives du tropane, leur preparation et utilisation
US6232326B1 (en) 1998-07-14 2001-05-15 Jodi A. Nelson Treatment for schizophrenia and other dopamine system dysfunctions
US6417177B1 (en) 1999-07-13 2002-07-09 Alpha Research Group, Llc Chloroquine derivatives for the treatment of Parkinson's disease
US20040229908A1 (en) * 1999-07-13 2004-11-18 Jodi Nelson Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias
US6667314B2 (en) 2000-05-26 2003-12-23 Pfizer, Inc. Tropane derivatives useful in therapy
JP3693957B2 (ja) * 2000-05-26 2005-09-14 ファイザー・インク 療法において有用なトロパン誘導体
US20040106643A1 (en) * 2001-05-23 2004-06-03 Gouliaev Alex Haarh Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US6610849B2 (en) * 2001-06-28 2003-08-26 Boehringer Ingelheim Pharma Kg Process for the manufacture of tropenol
WO2003045388A1 (fr) * 2001-11-30 2003-06-05 Neurosearch A/S Derives de tropane possedant une activite inhibitrice de recaptage de dopamine destines au traitement de maladies ischemiques
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
CA2480742A1 (fr) * 2002-03-28 2003-12-04 President And Fellows Of Harvard College Composes de tropane
US7309790B2 (en) 2003-10-03 2007-12-18 Pfizer Inc Chemical compounds
JP2007508336A (ja) * 2003-10-16 2007-04-05 ニューロサーチ、アクティーゼルスカブ モノアミン神経伝達物質再取り込みインヒビター及びアセチルコリンエステラーゼインヒビターを含む医薬組成物
CA2554617A1 (fr) * 2004-01-22 2005-08-04 Boehringer Ingelheim International Gmbh Preparation pharmaceutique contenant un inhibiteur de recapture du neurotransmetteur monoamine et un antagoniste des recepteurs du n-methyl-d-aspartate (nmda)
NZ547919A (en) * 2004-01-22 2009-12-24 Neurosearch As Compounds for the sustained reduction of body weight
WO2006075976A1 (fr) * 2005-01-14 2006-07-20 Private Enterprise 'slavyanskaya Klinika' Utilisation d'un anesthesique local pour corriger un comportement alimentaire humain, et procede d'utilisation associe
EP1779851A1 (fr) 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Traitement du diabète

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds

Also Published As

Publication number Publication date
CZ284379B6 (cs) 1998-11-11
ATE222587T1 (de) 2002-09-15
EE9600132A (et) 1997-04-15
EP0756596A1 (fr) 1997-02-05
DE69527839T2 (de) 2003-01-02
NO964180D0 (no) 1996-10-02
EE03877B1 (et) 2002-10-15
SK128896A3 (en) 1997-04-09
PL183025B1 (pl) 2002-05-31
LV11738B (en) 1997-12-20
BR9507489A (pt) 1997-08-12
FI965074A0 (fi) 1996-12-17
US5736556A (en) 1998-04-07
RU2134264C1 (ru) 1999-08-10
EP0756596B1 (fr) 2002-08-21
HU215830B (hu) 2001-05-28
DE69527839D1 (en) 2002-09-26
KR100210417B1 (ko) 1999-07-15
MX9604966A (es) 1998-05-31
GEP19991749B (en) 1999-09-10
BG100883A (en) 1998-03-31
CA2187309A1 (fr) 1995-10-26
BG63259B1 (bg) 2001-07-31
UA49801C2 (uk) 2002-10-15
HUT75865A (en) 1997-05-28
DK0756596T3 (da) 2002-12-23
FI965074A (fi) 1996-12-17
WO1995028401A1 (fr) 1995-10-26
AU2257595A (en) 1995-11-10
CN1148854A (zh) 1997-04-30
NO964180L (no) 1996-12-16
NZ284075A (en) 1998-01-26
CZ298296A3 (en) 1997-06-11
CN1043763C (zh) 1999-06-23
SK280875B6 (sk) 2000-08-14
PL316876A1 (en) 1997-02-17
HU9602707D0 (en) 1996-11-28
JPH09505607A (ja) 1997-06-03
JP2899418B2 (ja) 1999-06-02
CA2187309C (fr) 2000-11-21
LV11738A (lv) 1997-04-20

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