AU669345B2 - Amidino derivatives and their use as nitric oxide synthase inhibitors - Google Patents
Amidino derivatives and their use as nitric oxide synthase inhibitors Download PDFInfo
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- AU669345B2 AU669345B2 AU31692/93A AU3169293A AU669345B2 AU 669345 B2 AU669345 B2 AU 669345B2 AU 31692/93 A AU31692/93 A AU 31692/93A AU 3169293 A AU3169293 A AU 3169293A AU 669345 B2 AU669345 B2 AU 669345B2
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9127376 | 1991-12-24 | ||
| GB919127376A GB9127376D0 (en) | 1991-12-24 | 1991-12-24 | Amidino derivatives |
| PCT/GB1992/002387 WO1993013055A1 (en) | 1991-12-24 | 1992-12-23 | Amidino derivatives and their use as nitric oxide synthase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU3169293A AU3169293A (en) | 1993-07-28 |
| AU669345B2 true AU669345B2 (en) | 1996-06-06 |
Family
ID=10706815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU31692/93A Ceased AU669345B2 (en) | 1991-12-24 | 1992-12-23 | Amidino derivatives and their use as nitric oxide synthase inhibitors |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5863931A (https=) |
| EP (1) | EP0618898B1 (https=) |
| JP (1) | JP3171850B2 (https=) |
| AT (1) | ATE178588T1 (https=) |
| AU (1) | AU669345B2 (https=) |
| CA (1) | CA2126327C (https=) |
| CY (1) | CY2197B1 (https=) |
| DE (1) | DE69228879T2 (https=) |
| DK (1) | DK0618898T3 (https=) |
| ES (1) | ES2130247T3 (https=) |
| GB (1) | GB9127376D0 (https=) |
| GR (1) | GR3030492T3 (https=) |
| HU (1) | HU217618B (https=) |
| IL (1) | IL104212A (https=) |
| MY (1) | MY109421A (https=) |
| NZ (1) | NZ246202A (https=) |
| RU (1) | RU2130014C1 (https=) |
| TW (1) | TW255881B (https=) |
| WO (1) | WO1993013055A1 (https=) |
| ZA (1) | ZA9210018B (https=) |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9312761D0 (en) * | 1993-06-21 | 1993-08-04 | Wellcome Found | Amino acid derivatives |
| US5424447A (en) * | 1993-07-07 | 1995-06-13 | The Medical College Of Wisconsin Research Foundation, Inc. | Heme binding compounds and use thereof |
| CN1071746C (zh) * | 1993-08-12 | 2001-09-26 | 阿斯特拉公司 | 具有氧化氮合成酶活性的脒衍生物 |
| WO1995005363A1 (en) * | 1993-08-12 | 1995-02-23 | Astra Aktiebolag | Amidine derivatives with nitric oxide synthetase activities |
| US6297276B1 (en) | 1993-10-04 | 2001-10-02 | Glaxosmithkline | Substituted urea and isothiourea derivatives as no synthase inhibitors |
| US6225305B1 (en) | 1993-10-04 | 2001-05-01 | Glaxo Wellcome Inc. | Substituted urea and isothiorea derivatives as no synthase inhibitors |
| WO1995011014A1 (en) * | 1993-10-21 | 1995-04-27 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
| EP0724570B1 (en) | 1993-10-21 | 1999-03-03 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
| DE4337906A1 (de) * | 1993-11-08 | 1995-05-11 | Cassella Ag | Verwendung von Cumarinderivaten |
| JPH09508891A (ja) * | 1993-11-17 | 1997-09-09 | デューク ユニバーシティ メディカル センター | 自己免疫疾患の治療におけるナイトリックオキサイドシンターゼ阻害剤の使用 |
| GB9326136D0 (en) * | 1993-12-22 | 1994-02-23 | Erba Carlo Spa | Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents |
| GB9404400D0 (en) * | 1994-03-07 | 1994-04-20 | Wood Pauline J | Potentiation of bioreductive agents |
| ES2151055T3 (es) * | 1994-03-10 | 2000-12-16 | Searle & Co | Derivados de l-n6-(1-iminoetil)lisina utiles como inhibidores de oxido nitrico sintasa. |
| PT751930E (pt) * | 1994-03-24 | 2000-04-28 | Searle & Co | Derivados amidino uteis como inibidores da sintetase de oxido nitrico |
| EP0759027B1 (en) * | 1994-05-07 | 1999-08-04 | Astra Aktiebolag | Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase |
| EP0957087B1 (en) | 1994-06-15 | 2002-12-04 | The Wellcome Foundation Limited | Intermediates useful in the preparation of enzyme inhibitors |
| US6066333A (en) * | 1994-09-22 | 2000-05-23 | William Harvey Research Limited | Pharmaceutical control of inflammation |
| CA2132690A1 (en) * | 1994-09-22 | 1996-03-23 | Dean Willis | Control and modulation of inflammatory response in humans in need of such control and modulation |
| AU723677B2 (en) * | 1994-09-22 | 2000-08-31 | William Harvey Research Limited | Pharmaceutical control of inflammation |
| US5684008A (en) * | 1994-11-09 | 1997-11-04 | G. D. Searle & Co. | Aminotetrazole derivatives useful as nitric oxide synthase inhibitors |
| FR2727111B1 (fr) * | 1994-11-21 | 1997-01-17 | Hoechst Lab | Nouveaux analogues soufres d'aminoacides, leur procede de preparation et leurs applications comme medicaments |
| JPH08333258A (ja) | 1994-12-14 | 1996-12-17 | Japan Tobacco Inc | チアジン又はチアゼピン誘導体及びそれら化合物を含有してなる一酸化窒素合成酵素阻害剤 |
| GB9425701D0 (en) | 1994-12-20 | 1995-02-22 | Wellcome Found | Enzyme inhibitors |
| WO1996021445A1 (en) * | 1995-01-13 | 1996-07-18 | The General Hospital Corporation | Methods of inhibiting neurodegenerative diseases |
| WO1996033175A1 (en) * | 1995-04-20 | 1996-10-24 | G.D. Searle & Co. | Cyclic amidino agents useful as nitric oxide synthase inhibitors |
| US5830917A (en) * | 1995-09-11 | 1998-11-03 | G. D. Searle & Co. | L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors |
| US5908842A (en) * | 1995-12-08 | 1999-06-01 | Merck & Co., Inc. | Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase |
| US5981511A (en) * | 1996-03-06 | 1999-11-09 | G.D. Searle & Co. | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors |
| US5945408A (en) * | 1996-03-06 | 1999-08-31 | G.D. Searle & Co. | Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors |
| US6043218A (en) * | 1996-10-22 | 2000-03-28 | Medical University Of South Carolina | Positively charged non-natural amino acids, methods of making thereof, and use thereof in peptides |
| US6566330B1 (en) | 1996-10-22 | 2003-05-20 | Medical University Of South Carolina Foundation Research Development | Positively charged non-natural amino acids, methods of making and using thereof in peptides |
| US6160000A (en) * | 1996-12-23 | 2000-12-12 | Merck & Co., Inc. | Antidiabetic agents based on aryl and heteroarylacetic acids |
| US6090839A (en) * | 1996-12-23 | 2000-07-18 | Merck & Co., Inc. | Antidiabetic agents |
| MY117948A (en) * | 1997-01-13 | 2004-08-30 | Glaxo Group Ltd | Nitride oxide synthase inhibitors. |
| US6620848B2 (en) | 1997-01-13 | 2003-09-16 | Smithkline Beecham Corporation | Nitric oxide synthase inhibitors |
| US6369272B1 (en) | 1997-01-13 | 2002-04-09 | Glaxosmithkline | Nitric oxide synthase inhibitors |
| FR2764889B1 (fr) * | 1997-06-20 | 2000-09-01 | Sod Conseils Rech Applic | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
| JP4856295B2 (ja) * | 1997-07-03 | 2012-01-18 | アメリカ合衆国政府 | 新規な一酸化窒素放出アミジン誘導ジアゼニウムジオレート及びその組成物 |
| US5981556A (en) * | 1997-07-22 | 1999-11-09 | G.D. Searle & Co. | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors |
| WO1999046240A2 (en) | 1998-03-11 | 1999-09-16 | G.D. Searle & Co. | Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors |
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| PL346860A1 (en) | 1998-09-08 | 2002-03-11 | Monsanto Co | Methods of treating osteoarthritis with inducible nitric oxide synthase inhibitors |
| AU2847200A (en) * | 1999-01-27 | 2000-08-18 | G.D. Searle & Co. | Novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors |
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| AR034120A1 (es) | 2000-04-13 | 2004-02-04 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico |
| AR030416A1 (es) * | 2000-04-13 | 2003-08-20 | Pharmacia Corp | COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA |
| US6787668B2 (en) | 2000-04-13 | 2004-09-07 | Pharmacia Corporation | 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
| AR032318A1 (es) * | 2000-04-13 | 2003-11-05 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa |
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| RU2307121C1 (ru) * | 2006-04-17 | 2007-09-27 | Государственное образовательное учреждение высшего профессионального образования Волгоградский государственный технический университет (ВолгГТУ) | Способ получения адамантилсодержащих n-имидоилированных производных аминокарбоновых кислот |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2240041A (en) * | 1989-12-22 | 1991-07-24 | Scras | Agents for blocking endothelin derived relaxing factor |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI832053L (fi) * | 1982-06-10 | 1983-12-11 | Syntex Inc | Nonapeptid- och dekapeptidanaloger av lhrh anvaendbara som lhrh-antagonister samt deras framstaellningsfoerfarande |
| US5028627A (en) * | 1989-09-13 | 1991-07-02 | Cornell Research Foundation, Inc. | Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor |
| CA2036770C (en) * | 1990-02-26 | 2003-09-09 | Jeffrey P. Whitten | Inhibitors of nitric oxide biosynthesis |
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1991
- 1991-12-24 GB GB919127376A patent/GB9127376D0/en active Pending
-
1992
- 1992-12-23 RU RU94031155A patent/RU2130014C1/ru not_active IP Right Cessation
- 1992-12-23 HU HU9401848A patent/HU217618B/hu not_active IP Right Cessation
- 1992-12-23 ZA ZA9210018A patent/ZA9210018B/xx unknown
- 1992-12-23 AU AU31692/93A patent/AU669345B2/en not_active Ceased
- 1992-12-23 MY MYPI92002373A patent/MY109421A/en unknown
- 1992-12-23 EP EP93900357A patent/EP0618898B1/en not_active Expired - Lifetime
- 1992-12-23 CA CA002126327A patent/CA2126327C/en not_active Expired - Fee Related
- 1992-12-23 JP JP51127393A patent/JP3171850B2/ja not_active Expired - Fee Related
- 1992-12-23 IL IL104212A patent/IL104212A/en not_active IP Right Cessation
- 1992-12-23 TW TW081110312A patent/TW255881B/zh active
- 1992-12-23 AT AT93900357T patent/ATE178588T1/de active
- 1992-12-23 DK DK93900357T patent/DK0618898T3/da active
- 1992-12-23 DE DE69228879T patent/DE69228879T2/de not_active Expired - Lifetime
- 1992-12-23 ES ES93900357T patent/ES2130247T3/es not_active Expired - Lifetime
- 1992-12-23 WO PCT/GB1992/002387 patent/WO1993013055A1/en not_active Ceased
- 1992-12-23 US US08/256,032 patent/US5863931A/en not_active Expired - Lifetime
- 1992-12-23 NZ NZ246202A patent/NZ246202A/xx not_active IP Right Cessation
-
1999
- 1999-06-10 GR GR990401567T patent/GR3030492T3/el unknown
-
2000
- 2000-10-05 CY CY0000048A patent/CY2197B1/xx unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2240041A (en) * | 1989-12-22 | 1991-07-24 | Scras | Agents for blocking endothelin derived relaxing factor |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69228879D1 (de) | 1999-05-12 |
| TW255881B (https=) | 1995-09-01 |
| DK0618898T3 (da) | 1999-10-18 |
| HU217618B (hu) | 2000-03-28 |
| CA2126327A1 (en) | 1993-07-08 |
| CY2197B1 (en) | 2002-11-08 |
| EP0618898A1 (en) | 1994-10-12 |
| RU94031155A (ru) | 1996-04-20 |
| IL104212A0 (en) | 1993-05-13 |
| WO1993013055A1 (en) | 1993-07-08 |
| ES2130247T3 (es) | 1999-07-01 |
| GR3030492T3 (en) | 1999-10-29 |
| NZ246202A (en) | 1996-05-28 |
| US5863931A (en) | 1999-01-26 |
| JP3171850B2 (ja) | 2001-06-04 |
| MY109421A (en) | 1997-01-31 |
| RU2130014C1 (ru) | 1999-05-10 |
| CA2126327C (en) | 2005-05-17 |
| DE69228879T2 (de) | 1999-08-26 |
| IL104212A (en) | 1998-02-22 |
| HU9401848D0 (en) | 1994-09-28 |
| HUT70502A (en) | 1995-10-30 |
| EP0618898B1 (en) | 1999-04-07 |
| JPH07502512A (ja) | 1995-03-16 |
| ZA9210018B (en) | 1994-06-23 |
| AU3169293A (en) | 1993-07-28 |
| GB9127376D0 (en) | 1992-02-19 |
| ATE178588T1 (de) | 1999-04-15 |
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