AU648669B2 - 7-Isoindolinyl-quinolone- and -naphthyridonecarboxylic acid derivatives - Google Patents

7-Isoindolinyl-quinolone- and -naphthyridonecarboxylic acid derivatives Download PDF

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Publication number
AU648669B2
AU648669B2 AU17391/92A AU1739192A AU648669B2 AU 648669 B2 AU648669 B2 AU 648669B2 AU 17391/92 A AU17391/92 A AU 17391/92A AU 1739192 A AU1739192 A AU 1739192A AU 648669 B2 AU648669 B2 AU 648669B2
Authority
AU
Australia
Prior art keywords
acid
oxo
methyl
dihydro
cyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU17391/92A
Other languages
English (en)
Other versions
AU1739192A (en
Inventor
Klaus-Dieter Bremm
Rainer Endermann
Klaus Grohe
Ingo Haller
Andreas Krebs
Franz Kunisch
Karl-Georg Metzger
Uwe Petersen
Thomas Philipps
Thomas Schenke
Hans-Joachim Zeiler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU1739192A publication Critical patent/AU1739192A/en
Application granted granted Critical
Publication of AU648669B2 publication Critical patent/AU648669B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU17391/92A 1991-06-22 1992-06-03 7-Isoindolinyl-quinolone- and -naphthyridonecarboxylic acid derivatives Ceased AU648669B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4120646 1991-06-22
DE4120646A DE4120646A1 (de) 1991-06-22 1991-06-22 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate

Publications (2)

Publication Number Publication Date
AU1739192A AU1739192A (en) 1992-12-24
AU648669B2 true AU648669B2 (en) 1994-04-28

Family

ID=6434522

Family Applications (1)

Application Number Title Priority Date Filing Date
AU17391/92A Ceased AU648669B2 (en) 1991-06-22 1992-06-03 7-Isoindolinyl-quinolone- and -naphthyridonecarboxylic acid derivatives

Country Status (20)

Country Link
US (1) US5464796A (enExample)
EP (1) EP0520240A1 (enExample)
JP (1) JPH05239051A (enExample)
KR (1) KR930000503A (enExample)
CN (1) CN1068115A (enExample)
AU (1) AU648669B2 (enExample)
CA (1) CA2071677A1 (enExample)
CZ (1) CZ190192A3 (enExample)
DE (1) DE4120646A1 (enExample)
FI (1) FI922873A7 (enExample)
HU (1) HUT62288A (enExample)
IE (1) IE922003A1 (enExample)
IL (1) IL102261A (enExample)
MX (1) MX9202982A (enExample)
NO (1) NO922226L (enExample)
NZ (1) NZ243214A (enExample)
PH (1) PH30227A (enExample)
RU (1) RU2056411C1 (enExample)
SK (1) SK190192A3 (enExample)
TW (1) TW202442B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU667757B2 (en) * 1993-01-19 1996-04-04 Bayer Aktiengesellschaft Quinolone- and naphthyridonecarboxylic acid derivatives

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4230804A1 (de) * 1992-09-15 1994-03-17 Bayer Ag 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
DE4329600A1 (de) * 1993-09-02 1995-03-09 Bayer Ag Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
DE4418510A1 (de) * 1994-05-27 1995-11-30 Bayer Ag 1,9-überbrückte Thiazolol[3,4-a]chinolinderivate
DE4427530A1 (de) * 1994-08-04 1996-02-08 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
DE4435479A1 (de) * 1994-10-04 1996-04-11 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
DE19500792A1 (de) * 1995-01-13 1996-07-18 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
JPH08213881A (ja) * 1995-02-02 1996-08-20 Fujitsu Ltd 周波数制御回路
DE19506535A1 (de) * 1995-02-09 1996-08-14 Bayer Ag 1,6-Naphthyridoncarbonsäurederivate
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
CN1264837C (zh) * 1997-09-15 2006-07-19 普罗克特和甘保尔公司 喹诺酮抗微生物剂、其组合物和应用
PA8466701A1 (es) 1998-01-21 2000-09-29 Pfizer Prod Inc Comprimido de mesilato de trovafloxacino
SE9801474D0 (sv) * 1998-04-27 1998-04-27 Active Biotech Ab Quinoline Derivatives
SE9802549D0 (sv) * 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
SE9802550D0 (sv) * 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
ATE297912T1 (de) * 1998-11-24 2005-07-15 Daiichi Seiyaku Co Cycloalkylsubstituierte aminomethylpyrrolidin- derivate
DE19854357A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Semi-Hydrochlorid von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo/4.3.0/ -nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
AU3223801A (en) * 2000-02-09 2001-08-20 Daiichi Seiyaku Co Anti-acid-fast bacterial agents containing pyridonecarboxylic acids as the active ingredient
EP1277471B1 (en) * 2000-04-24 2008-05-28 Daiichi Sankyo Company, Limited Stable liquid preparation comprising sitafloxacin
US7220824B1 (en) 2000-08-28 2007-05-22 Bayer Aktiengesellschaft Integrin-mediated drug targeting
EP1219634A1 (en) * 2000-12-27 2002-07-03 Bayer Aktiengesellschaft Cytostatic-glycoconjugates having specifically cleavable peptidic linking units
JP2004528298A (ja) * 2001-02-21 2004-09-16 ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ゴナドトロピン放出ホルモンのアンタゴニストとしてのキノリン、イソキノリン及びフタラジン誘導体
EP1238678A1 (en) 2001-03-08 2002-09-11 Bayer Aktiengesellschaft Enzyme-activated cytostatic conjugates with integrin ligands
RU2275361C3 (ru) * 2002-11-20 2021-10-01 Джапан Тобакко Инк. Соединение 4-оксохинолина и его применение в качестве ингибитора вич интегразы
BRPI0617477A2 (pt) * 2005-10-19 2011-07-26 Teva Pharma mistura de partÍculas cristalinas de laquinimod sàdica, composiÇço, processo de cristalizaÇço de laquinimod sàdica, laquinimod sàdica, e, processo para produzir uma composiÇço farmacÊutica
US20070196398A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone fatty acid salt compositions
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
CA2647454A1 (en) * 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
ES2366150T3 (es) * 2006-03-28 2011-10-17 Warner Chilcott Company, Llc Malatos de polimorfos de ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinocarboxílico.
RU2399616C1 (ru) * 2006-06-23 2010-09-20 Джапан Тобакко Инк. Производное 6-(гетероциклзамещенный бензил)-4-оксохинолина и его применение в качестве ингибитора интегразы вич
KR100690084B1 (ko) * 2006-11-01 2007-03-09 주식회사 세홍이엔씨 출입문과 연동하는 주택 내 배전반
USD612227S1 (en) 2009-02-06 2010-03-23 Rockler Companies, Inc. Workpiece finishing support
WO2013111158A2 (en) * 2012-01-03 2013-08-01 Msn Laboratories Limited Process for the preparation of dpp-iv inhibitor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5404790A (en) * 1989-04-26 1990-11-16 Upjohn Company, The Antibacterial pyrido(1,2,3-de)-1,4-benzoxazinone agents
AU616277B2 (en) * 1988-07-15 1991-10-24 Bayer Schering Pharma Aktiengesellschaft 7-(1-pyrrolidinyl)-3-quinolone- and-naphthyridone-carboxylic acid derivatives, processes for their preparation and substituted mono- and bicyclic pyrrolidine derivatives as intermediate products for their preparation, and anti- bacterial agents and feed additives containing them

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
EP0154780B1 (en) * 1984-01-26 1990-04-11 Abbott Laboratories Quinoline antibacterial compounds
NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
GB8612137D0 (en) * 1986-05-19 1986-06-25 Fujisawa Pharmaceutical Co Quinolone compounds
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
JPH0262875A (ja) * 1988-05-23 1990-03-02 Wakunaga Pharmaceut Co Ltd 新規イソインドリン誘導体
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
CA2030217A1 (en) * 1989-11-21 1991-05-22 Jun Imose Pyridone-carboxylic acid derivatives useful as veterinary medicines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU616277B2 (en) * 1988-07-15 1991-10-24 Bayer Schering Pharma Aktiengesellschaft 7-(1-pyrrolidinyl)-3-quinolone- and-naphthyridone-carboxylic acid derivatives, processes for their preparation and substituted mono- and bicyclic pyrrolidine derivatives as intermediate products for their preparation, and anti- bacterial agents and feed additives containing them
AU5404790A (en) * 1989-04-26 1990-11-16 Upjohn Company, The Antibacterial pyrido(1,2,3-de)-1,4-benzoxazinone agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU667757B2 (en) * 1993-01-19 1996-04-04 Bayer Aktiengesellschaft Quinolone- and naphthyridonecarboxylic acid derivatives

Also Published As

Publication number Publication date
EP0520240A1 (de) 1992-12-30
PH30227A (en) 1997-02-05
CZ190192A3 (en) 1993-01-13
US5464796A (en) 1995-11-07
RU2056411C1 (ru) 1996-03-20
FI922873A0 (fi) 1992-06-18
CN1068115A (zh) 1993-01-20
HU9202085D0 (en) 1992-09-28
AU1739192A (en) 1992-12-24
DE4120646A1 (de) 1992-12-24
KR930000503A (ko) 1993-01-15
TW202442B (enExample) 1993-03-21
FI922873A7 (fi) 1992-12-23
NZ243214A (en) 1995-07-26
IL102261A (en) 1996-10-16
SK190192A3 (en) 1995-08-09
IL102261A0 (en) 1993-01-14
IE922003A1 (en) 1992-12-30
HUT62288A (en) 1993-04-28
NO922226D0 (no) 1992-06-05
CA2071677A1 (en) 1992-12-23
JPH05239051A (ja) 1993-09-17
NO922226L (no) 1992-12-23
MX9202982A (es) 1992-12-01

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