AU641577B2 - Trifluoromethylketone derivatives, processes for preparation thereof and use thereof - Google Patents

Trifluoromethylketone derivatives, processes for preparation thereof and use thereof Download PDF

Info

Publication number
AU641577B2
AU641577B2 AU89853/91A AU8985391A AU641577B2 AU 641577 B2 AU641577 B2 AU 641577B2 AU 89853/91 A AU89853/91 A AU 89853/91A AU 8985391 A AU8985391 A AU 8985391A AU 641577 B2 AU641577 B2 AU 641577B2
Authority
AU
Australia
Prior art keywords
carboxy
alkyl
pharmaceutically acceptable
salt
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU89853/91A
Other languages
English (en)
Other versions
AU8985391A (en
Inventor
Keiji Hemmi
Keisuke Imai
Ichiro Shima
Hirokazu Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909028231A external-priority patent/GB9028231D0/en
Priority claimed from GB919119713A external-priority patent/GB9119713D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of AU8985391A publication Critical patent/AU8985391A/en
Application granted granted Critical
Publication of AU641577B2 publication Critical patent/AU641577B2/en
Assigned to ASTELLAS PHARMA INC. reassignment ASTELLAS PHARMA INC. Alteration of Name(s) in Register under S187 Assignors: FUJISAWA PHARMACEUTICAL CO., LTD.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Magnetically Actuated Valves (AREA)
  • Control Of Throttle Valves Provided In The Intake System Or In The Exhaust System (AREA)
  • Pyrrole Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Hydrogenated Pyridines (AREA)
AU89853/91A 1990-12-31 1991-12-19 Trifluoromethylketone derivatives, processes for preparation thereof and use thereof Expired AU641577B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9028231 1990-12-31
GB909028231A GB9028231D0 (en) 1990-12-31 1990-12-31 Trifluoromethylketone derivatives,processes for preparation thereof and use thereof
GB919119713A GB9119713D0 (en) 1991-09-16 1991-09-16 Trifluoremethylketone derivatives, processes for preparation thereof and use thereof
GB9119713 1991-09-16

Publications (2)

Publication Number Publication Date
AU8985391A AU8985391A (en) 1992-07-02
AU641577B2 true AU641577B2 (en) 1993-09-23

Family

ID=26298196

Family Applications (1)

Application Number Title Priority Date Filing Date
AU89853/91A Expired AU641577B2 (en) 1990-12-31 1991-12-19 Trifluoromethylketone derivatives, processes for preparation thereof and use thereof

Country Status (19)

Country Link
US (2) US5296591A (https=)
EP (1) EP0494071B1 (https=)
JP (1) JPH0699378B2 (https=)
KR (1) KR100192991B1 (https=)
CN (1) CN1040003C (https=)
AT (1) ATE151775T1 (https=)
AU (1) AU641577B2 (https=)
CA (1) CA2058560C (https=)
DE (1) DE69218977T2 (https=)
DK (1) DK0494071T3 (https=)
ES (1) ES2099755T3 (https=)
FI (1) FI106379B (https=)
GR (1) GR3023719T3 (https=)
HU (2) HU210263B (https=)
IE (1) IE914360A1 (https=)
MX (1) MX9102612A (https=)
NO (1) NO309274B1 (https=)
RU (1) RU2073684C1 (https=)
SG (1) SG50457A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU662232B2 (en) * 1992-07-28 1995-08-24 Adir Et Compagnie New peptides derived from trifluoromethyl ketones, process for their preparation and the pharmaceutical compositions which contain them

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
FR2719589B1 (fr) * 1994-05-05 1996-06-14 Adir Nouveaux peptides dérivés de trifluorométhylcétones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
EP0763055B1 (en) * 1994-06-02 1999-11-03 Merrell Pharmaceuticals Inc. Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
DE69522940T2 (de) * 1994-06-02 2002-04-04 Merrell Pharmaceuticals Inc., Cincinnati Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
JP2002161051A (ja) * 1996-12-24 2002-06-04 Fujisawa Pharmaceut Co Ltd 脳虚血性疾患等の治療剤
US6610748B1 (en) * 1998-02-24 2003-08-26 Fujisawa Pharmaceutical Co., Ltd. Preventives/remedies for skin aging
US20020045231A1 (en) * 1999-02-02 2002-04-18 Napper Andrew D. Catalytic antibodies which hydrolyze primary amides and methods for eliciting such antibodies
WO2001026685A1 (en) * 1999-10-12 2001-04-19 Fujisawa Pharmaceutical Co., Ltd. Remedies for intractable wound
IL148924A (en) * 2002-03-26 2015-06-30 Mor Research Applic Ltd Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases
DE10219464A1 (de) 2002-04-30 2003-11-13 Focke & Co Zigarettenpackung
SE0202462D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab Novel use
CN101443348A (zh) * 2006-05-23 2009-05-27 Irm责任有限公司 作为通道活化蛋白酶抑制剂的化合物和组合物
JP4101276B2 (ja) * 2006-08-25 2008-06-18 株式会社ステリック再生医科学研究所 慢性閉塞性肺疾患改善剤
CA2669917A1 (en) * 2006-11-17 2008-05-22 Dawn M. George Aminopyrrolidines as chemokine receptor antagonists
JP5819305B2 (ja) * 2009-10-13 2015-11-24 リガンド・ファーマシューティカルズ・インコーポレイテッド 造血成長因子模倣小分子化合物およびそれらの使用
WO2014181788A1 (ja) * 2013-05-08 2014-11-13 キッセイ薬品工業株式会社 α－置換グリシンアミド誘導体
CN104650016A (zh) * 2015-01-29 2015-05-27 武汉大学 拟三肽类化合物及其制备方法
MY189548A (en) * 2016-06-24 2022-02-16 Pola Chem Ind Inc External preparation for skin for wrinkle improvement
MX2020004892A (es) 2017-11-15 2020-08-06 Pola Chem Ind Inc Composicion a base de aceite.
CN119241385B (zh) * 2024-11-29 2025-03-25 江西师范大学 β-酰氧基烯酰胺衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
EP0276101A3 (en) * 1987-01-19 1989-11-23 Ici Americas Inc. Substituted peptide derivatives
EP0369391A3 (en) 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituted amides
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU662232B2 (en) * 1992-07-28 1995-08-24 Adir Et Compagnie New peptides derived from trifluoromethyl ketones, process for their preparation and the pharmaceutical compositions which contain them

Also Published As

Publication number Publication date
DE69218977T2 (de) 1997-08-07
EP0494071A3 (en) 1993-05-05
FI915996L (fi) 1992-07-01
AU8985391A (en) 1992-07-02
HU914153D0 (en) 1992-03-30
HU210263B (en) 1995-03-28
FI915996A0 (fi) 1991-12-19
JPH0699378B2 (ja) 1994-12-07
HU211943A9 (en) 1996-01-29
IE914360A1 (en) 1992-07-01
DE69218977D1 (de) 1997-05-22
KR920011988A (ko) 1992-07-25
FI106379B (fi) 2001-01-31
JPH04297446A (ja) 1992-10-21
US5296591A (en) 1994-03-22
KR100192991B1 (ko) 1999-06-15
NO309274B1 (no) 2001-01-08
DK0494071T3 (https=) 1997-05-12
MX9102612A (es) 1992-06-01
EP0494071B1 (en) 1997-04-16
CN1063108A (zh) 1992-07-29
NO920035D0 (no) 1992-01-02
ATE151775T1 (de) 1997-05-15
GR3023719T3 (en) 1997-09-30
CA2058560A1 (en) 1992-07-01
RU2073684C1 (ru) 1997-02-20
US5430025A (en) 1995-07-04
HUT60507A (en) 1992-09-28
ES2099755T3 (es) 1997-06-01
NO920035L (no) 1992-07-01
EP0494071A2 (en) 1992-07-08
CN1040003C (zh) 1998-09-30
CA2058560C (en) 2000-12-12
SG50457A1 (en) 1998-07-20

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