AU637099B2 - 2,5-Diazabicyclo-(2.2.1) heptane derivatives - Google Patents

2,5-Diazabicyclo-(2.2.1) heptane derivatives Download PDF

Info

Publication number
AU637099B2
AU637099B2 AU54908/90A AU5490890A AU637099B2 AU 637099 B2 AU637099 B2 AU 637099B2 AU 54908/90 A AU54908/90 A AU 54908/90A AU 5490890 A AU5490890 A AU 5490890A AU 637099 B2 AU637099 B2 AU 637099B2
Authority
AU
Australia
Prior art keywords
formula
compound
alkyl
trifluoromethyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU54908/90A
Other languages
English (en)
Other versions
AU5490890A (en
Inventor
Tamim Fehme Braish
Darrell Eugene Fox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of AU5490890A publication Critical patent/AU5490890A/en
Application granted granted Critical
Publication of AU637099B2 publication Critical patent/AU637099B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU54908/90A 1989-05-11 1990-05-10 2,5-Diazabicyclo-(2.2.1) heptane derivatives Ceased AU637099B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35042389A 1989-05-11 1989-05-11
US350423 1989-05-11
US07/423,063 US5036153A (en) 1989-05-11 1989-10-18 Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates
US423063 1989-10-18

Publications (2)

Publication Number Publication Date
AU5490890A AU5490890A (en) 1990-11-15
AU637099B2 true AU637099B2 (en) 1993-05-20

Family

ID=26996610

Family Applications (1)

Application Number Title Priority Date Filing Date
AU54908/90A Ceased AU637099B2 (en) 1989-05-11 1990-05-10 2,5-Diazabicyclo-(2.2.1) heptane derivatives

Country Status (21)

Country Link
US (1) US5036153A (fr)
EP (1) EP0397351B1 (fr)
JP (1) JPH035482A (fr)
KR (1) KR920003560B1 (fr)
CN (1) CN1025852C (fr)
AT (1) ATE108795T1 (fr)
AU (1) AU637099B2 (fr)
CA (1) CA2016343C (fr)
CZ (1) CZ279947B6 (fr)
DE (1) DE69010761T2 (fr)
DK (1) DK0397351T3 (fr)
ES (1) ES2056381T3 (fr)
FI (1) FI96682C (fr)
HU (1) HU206718B (fr)
IE (1) IE64185B1 (fr)
IL (1) IL94303A (fr)
NO (1) NO902072L (fr)
NZ (1) NZ233624A (fr)
PT (1) PT93986B (fr)
RU (1) RU2024524C1 (fr)
YU (1) YU48131B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196548A (en) * 1989-05-11 1993-03-23 Pfizer Inc. Preparation of diazabicyclic Intermediates
US5128483A (en) * 1989-07-19 1992-07-07 American Cyanamid Company Dibromovinyl and acetylene-1-pyrrolidinecarboxylic acid intermediates
DE4029054A1 (de) * 1990-09-13 1992-03-19 Bayer Ag N-acylpyrrolidin-derivate
US5254696A (en) * 1990-09-13 1993-10-19 Bayer Aktiengesellschaft N-acylpyrrolidine derivatives
AT403803B (de) 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
US6589978B2 (en) * 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
JP4827154B2 (ja) * 2001-07-25 2011-11-30 株式会社オーイズミ 遊技装置
TW200303742A (en) * 2001-11-21 2003-09-16 Novartis Ag Organic compounds
JP4631262B2 (ja) * 2003-10-07 2011-02-16 東レ・ファインケミカル株式会社 （シス）−４−ヒドロキシプロリン誘導体の製造方法
JP2007244428A (ja) * 2006-03-13 2007-09-27 Olympia:Kk メダル貸出機
JP4771416B2 (ja) * 2006-03-22 2011-09-14 サミー株式会社 遊技機
CN102180824B (zh) * 2011-02-18 2012-11-14 华东理工大学 吡咯衍生物的制备方法
CN103755710B (zh) * 2014-01-14 2015-08-12 昆明理工大学 一类2,5-二氮杂双环庚烷类化合物及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470060A1 (de) * 1963-02-05 1969-07-17 Merck & Co Inc 2,5-Diazabicyclo-[2,2,1]-heptane und octane und Verfahren zu ihrer Herstellung
US3947445A (en) * 1974-05-09 1976-03-30 Stanford Research Institute Diazabicyclooctanes and diazabicycloheptanes
EP0324543A2 (fr) * 1988-01-13 1989-07-19 Pfizer Limited Agents antiarythmiques

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3083208A (en) * 1961-05-11 1963-03-26 Mead Johnson & Co 1-acyl and 1-carbalkoxy-3-pyrrolidinols
US3459768A (en) * 1966-05-24 1969-08-05 Richardson Merrell Inc Pyrrolidine-2,2-dimethanols and methods of preparing the same
US3905979A (en) * 1974-05-09 1975-09-16 Stanford Research Inst Diazabicyclooctanes and diazabicycloheptanes
HU184960B (en) * 1981-07-20 1984-11-28 Richter Gedeon Vegyeszet Process for preparing new derivatives of 3,7-diazabicyclo/3.3.1/ nonane
US4539411A (en) * 1982-02-05 1985-09-03 Hoffmann-La Roche Inc. Rhodium complexes of chiral phosphines
JPS60190760A (ja) * 1984-03-09 1985-09-28 Mitsubishi Chem Ind Ltd ピロリジン誘導体及びその製造法
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
IN166416B (fr) * 1985-09-18 1990-05-05 Pfizer
JPS63162672A (ja) * 1986-12-25 1988-07-06 Ono Pharmaceut Co Ltd 新規なプロリナ−ル誘導体、それらの製造方法およびそれらを含有する抗健忘症剤
US4923879A (en) * 1987-07-31 1990-05-08 Warner-Lambert Company 1,8-Naphthyridines and their use as antibacterial agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470060A1 (de) * 1963-02-05 1969-07-17 Merck & Co Inc 2,5-Diazabicyclo-[2,2,1]-heptane und octane und Verfahren zu ihrer Herstellung
US3947445A (en) * 1974-05-09 1976-03-30 Stanford Research Institute Diazabicyclooctanes and diazabicycloheptanes
EP0324543A2 (fr) * 1988-01-13 1989-07-19 Pfizer Limited Agents antiarythmiques

Also Published As

Publication number Publication date
HUT59926A (en) 1992-07-28
CN1047295A (zh) 1990-11-28
CZ227990A3 (en) 1995-04-12
US5036153A (en) 1991-07-30
CA2016343C (fr) 1998-01-27
EP0397351B1 (fr) 1994-07-20
JPH035482A (ja) 1991-01-11
RU2024524C1 (ru) 1994-12-15
CZ279947B6 (cs) 1995-09-13
HU902994D0 (en) 1990-09-28
NO902072L (no) 1990-11-12
PT93986B (pt) 1996-11-29
AU5490890A (en) 1990-11-15
IL94303A (en) 1995-08-31
KR900018104A (ko) 1990-12-20
IE64185B1 (en) 1995-07-12
IL94303A0 (en) 1991-03-10
ES2056381T3 (es) 1994-10-01
EP0397351A1 (fr) 1990-11-14
NO902072D0 (no) 1990-05-10
PT93986A (pt) 1991-01-08
FI902334A0 (fi) 1990-05-10
HU206718B (en) 1992-12-28
ATE108795T1 (de) 1994-08-15
DK0397351T3 (da) 1994-08-22
YU91390A (en) 1991-10-31
DE69010761D1 (de) 1994-08-25
CA2016343A1 (fr) 1990-11-11
YU48131B (sh) 1997-05-28
DE69010761T2 (de) 1994-10-27
FI96682C (fi) 1996-08-12
KR920003560B1 (ko) 1992-05-04
FI96682B (fi) 1996-04-30
NZ233624A (en) 1992-04-28
CN1025852C (zh) 1994-09-07
IE901689L (en) 1990-11-11

Similar Documents

Publication Publication Date Title
AU637099B2 (en) 2,5-Diazabicyclo-(2.2.1) heptane derivatives
IL159740A (en) A process for producing three-carbon amino-alcohol salts
PL200436B1 (pl) Sposób wytwarzania aminoalkoholi oraz ich pochodnych lub soli
US5144042A (en) Process for preparing optically active 3-hydroxypyrrolidine derivatives
JP3639449B2 (ja) ３−アミノ−ピロリジン誘導体の製造方法
US7511154B2 (en) Preparation of N-protected-3-pyrrolidine-lactam substituted phosphonium salts
US5196548A (en) Preparation of diazabicyclic Intermediates
KR100915551B1 (ko) 3-히드록시 피롤리딘 및 이의 유도체의 효율적 제조방법
FI94532C (fi) 2,5-diatsabisyklo/2,2,1/heptaanijohdannaisia
PL164450B1 (pl) Sposób wytwarzania pochodnych /2S,5S-diazablcyklo[2.2.1] heptanu PL
US20040236118A1 (en) Pyrrolidine derivatives and method of synthesizing these
EP0420487B1 (fr) Procédé de préparation de 2-alkyl-2,5-diazabicyclo[2.2.1]heptanes optiquement actif
US5013839A (en) Process for optically active 2-alkyl-2,5-diazabicyclo(2.2.1) heptanes
US5523413A (en) Process for optically active 2-alkyl-2,5-diazabicyclo[2.2.1] heptanes
US6706888B2 (en) Processes for preparing imidazole derivatives and salts thereof
US5095121A (en) Process for optically active 2-alkyl-2,5-diazabicyclo(2.2.1)heptanes
JPH03157382A (ja) ２―（２―チエニル）エチルアミンの製造法
KR980009266A (ko) 광학 활성을 갖는 2,8-디아자비시클로[4.3.0]논-5-엔 및 그 유도체의 제조방법