AU602891B2 - 4H-1-benzopyran-4-one derivatives, a process for their preparation and their use as medicaments - Google Patents

4H-1-benzopyran-4-one derivatives, a process for their preparation and their use as medicaments

Info

Publication number
AU602891B2
AU602891B2 AU71397/87A AU7139787A AU602891B2 AU 602891 B2 AU602891 B2 AU 602891B2 AU 71397/87 A AU71397/87 A AU 71397/87A AU 7139787 A AU7139787 A AU 7139787A AU 602891 B2 AU602891 B2 AU 602891B2
Authority
AU
Australia
Prior art keywords
alkyl
aryl
cycloalkyl
represents hydrogen
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU71397/87A
Other languages
English (en)
Other versions
AU7139787A (en
Inventor
Alihussein Nomanbhai Dohadwalla
Samba Laxminarayan Kattige
Aftab Dawoodbhai Lakdawalla
Ramchandra Ganapati Naik
Richard Helmut Rupp
Noel John De Souza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU7139787A publication Critical patent/AU7139787A/en
Application granted granted Critical
Publication of AU602891B2 publication Critical patent/AU602891B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU71397/87A 1986-04-11 1987-04-10 4H-1-benzopyran-4-one derivatives, a process for their preparation and their use as medicaments Expired AU602891B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863612337 DE3612337A1 (de) 1986-04-11 1986-04-11 4h-1-benzopyran-4-on-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3612337 1986-04-11

Publications (2)

Publication Number Publication Date
AU7139787A AU7139787A (en) 1987-10-15
AU602891B2 true AU602891B2 (en) 1990-11-01

Family

ID=6298535

Family Applications (1)

Application Number Title Priority Date Filing Date
AU71397/87A Expired AU602891B2 (en) 1986-04-11 1987-04-10 4H-1-benzopyran-4-one derivatives, a process for their preparation and their use as medicaments

Country Status (15)

Country Link
US (1) US4900727A (enExample)
EP (1) EP0241003B1 (enExample)
JP (1) JPH0686446B2 (enExample)
KR (1) KR950009861B1 (enExample)
AT (2) ATE95519T1 (enExample)
AU (1) AU602891B2 (enExample)
CA (1) CA1332238C (enExample)
DE (2) DE3612337A1 (enExample)
DK (1) DK169760B1 (enExample)
ES (1) ES2060582T3 (enExample)
IE (1) IE62244B1 (enExample)
IL (1) IL82149A (enExample)
IN (1) IN164232B (enExample)
PT (1) PT84654B (enExample)
ZA (1) ZA872555B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU628409B2 (en) * 1988-10-28 1992-09-17 Hoechst Aktiengesellschaft The use of 4h-1-benzopyran-4-one derivatives, novel 4h-1- benzopyran-4-one derivatives, and pharmaceuticals containing them
AU653800B2 (en) * 1991-04-10 1994-10-13 Hoechst Aktiengesellschaft 5,7-dihydroxy-2-methyl-8-{4-(3-hydroxy-1-(1-propyl) piperidinyl}-4H-1-benzophyran-4-one, its preparation and its use

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US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
US5278174A (en) * 1990-06-04 1994-01-11 Scios Nova, Inc. Sigma binding site agents
US6903084B2 (en) 1991-08-28 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
US6011024A (en) 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
GB9604709D0 (en) * 1996-03-05 1996-05-01 Imperial College A compound
CZ285937B6 (cs) * 1992-01-16 1999-12-15 Hoechst Aktiengesellschaft Arylcykloalkylové deriváty, způsob přípravy těchto derivátů a jejich použití
US5733920A (en) * 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
US20060241173A1 (en) * 1996-02-16 2006-10-26 Sterix Ltd. Compound
US6087366A (en) * 1996-03-07 2000-07-11 The Trustees Of Columbia University In The City Of New York Use of flavopiridol or a pharmaceutically acceptable salt thereof for inhibiting cell damage or cell death
US5849733A (en) * 1996-05-10 1998-12-15 Bristol-Myers Squibb Co. 2-thio or 2-oxo flavopiridol analogs
US5908934A (en) * 1996-09-26 1999-06-01 Bristol-Myers Squibb Company Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs
DE19802449A1 (de) * 1998-01-23 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin
GB9807779D0 (en) * 1998-04-09 1998-06-10 Ciba Geigy Ag Organic compounds
US6399633B1 (en) * 1999-02-01 2002-06-04 Aventis Pharmaceuticals Inc. Use of 4-H-1-benzopryan-4-one derivatives as inhibitors of smooth muscle cell proliferation
DE19959546A1 (de) * 1999-12-09 2001-06-21 Rhone Poulenc Rorer Gmbh Pharmazeutische Zubereitung zur Behandlung von Tumorerkrankungen
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
JP2003520797A (ja) * 2000-01-18 2003-07-08 アベンテイス・フアーマシユーチカルズ・インコーポレーテツド （−）−シス−２−（２−クロロフェニル）−５，７−ジヒドロキシ−８［４Ｒ−（３Ｓ−ヒドロキシ−１−メチル）ピペリジニル］−４Ｈ−１−ベンゾピラン−４−オンの偽多形体（ｐｓｅｕｄｏｐｏｌｙｍｏｒｐｈ）
US6576647B2 (en) 2000-01-18 2003-06-10 Aventis Pharmaceuticals Inc. Pseudopolymorph of (—)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy -1-methyl)piperidinyl]-4H-1-benzopyran-4-one
US6821990B2 (en) * 2000-01-18 2004-11-23 Aventis Pharma Deutschland Gmbh Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5, 7-dihydroxy-8 [4R-(3S-hydroxy-1-M ethyl) piperidinyl]-4H-1-benzopyran-4-one
BR0107724A (pt) * 2000-01-18 2002-10-01 Aventis Pharma Inc Composto, processo para a preparação do mesmo, composição farmacêutica e, uso de um composto
FR2805538B1 (fr) * 2000-02-29 2006-08-04 Hoechst Marion Roussel Inc Nouveaux derives de flavones, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
KR100423899B1 (ko) 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
ATE471931T1 (de) 2002-04-17 2010-07-15 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren
US7271193B2 (en) * 2002-07-08 2007-09-18 Nicholas Piramal India, Ltd. Inhibitors of cyclin-dependent kinases and their use
US7915301B2 (en) 2002-07-08 2011-03-29 Piramal Life Science Limited Inhibitors of cyclin dependent kinases and their use
US7884127B2 (en) * 2002-07-08 2011-02-08 Pirimal Life Sciences Ltd. Inhibitors of cyclin dependent kinases and their use
WO2004006865A2 (en) * 2002-07-17 2004-01-22 Cytokinetics, Inc. Compounds, compositions, and methods
JP2005539062A (ja) * 2002-09-13 2005-12-22 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
WO2005042697A2 (en) * 2003-10-06 2005-05-12 Cytokinetics, Inc. Compounds, compositions and methods
ATE447957T1 (de) * 2003-12-09 2009-11-15 Us Gov Health & Human Serv Verfahren zur unterdrückung einer immunantwort oder zur behandlung von proliferativen erkrankungen
JP2007513967A (ja) * 2003-12-11 2007-05-31 セラヴァンス， インコーポレーテッド 変異レセプターチロシンキナーゼが駆動する細胞増殖性疾患の処置において使用するための組成物
EP1845973B1 (en) 2005-01-21 2015-08-12 Astex Therapeutics Limited Pharmaceutical compounds
MX2008016398A (es) 2006-06-21 2009-01-21 Piramal Life Sciences Ltd Compuestos enantiomericamente puros novedosos para el tratamiento de trastornos proliferativos.
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
TWI461194B (zh) 2009-05-05 2014-11-21 Piramal Entpr Ltd 吡咯啶取代黃酮作為輻射致敏劑
US8906953B2 (en) 2010-02-26 2014-12-09 Piramal Enterprises Limited Pyrrolidine substitute flavones for the treatment of inflammatory disorders
EP2580320B1 (en) 2010-06-14 2018-08-01 The Scripps Research Institute Reprogramming of cells to a new fate
TW201300105A (zh) 2011-05-31 2013-01-01 Piramal Life Sciences Ltd 治療頭頸鱗狀細胞癌之相乘藥物組合物
EP2984078B1 (en) 2013-04-10 2017-11-15 Council of Scientific & Industrial Research Novel chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders
WO2014170914A1 (en) 2013-04-17 2014-10-23 Council Of Scientific And Industrial Research Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof
TWI839690B (zh) 2013-07-12 2024-04-21 印度商皮拉馬爾企業有限公司 治療黑色素瘤的藥物組合的用途
EP4183806A3 (en) 2014-11-12 2023-08-02 Seagen Inc. Glycan-interacting compounds and methods of use
BR112017022666A8 (pt) 2015-04-20 2022-10-18 Tolero Pharmaceuticals Inc Preparando resposta à alvocidib por perfilamento mitocondrial
CN111349118B (zh) 2015-05-18 2023-08-22 住友制药肿瘤公司 具有增加的生物利用度的阿伏西地前药
RU2759963C2 (ru) 2015-08-03 2021-11-19 Сумитомо Даиниппон Фарма Онколоджи, Инк. Комбинированные терапии для лечения рака
CN108463248B (zh) 2015-11-12 2022-10-21 西雅图基因公司 聚糖相互作用化合物及使用方法
WO2018094143A1 (en) 2016-11-17 2018-05-24 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
US11279694B2 (en) 2016-11-18 2022-03-22 Sumitomo Dainippon Pharma Oncology, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
JP6619519B2 (ja) 2016-12-19 2019-12-11 トレロ ファーマシューティカルズ， インコーポレイテッド プロファイリングペプチドおよび感受性プロファイリングのための方法
WO2018160909A1 (en) 2017-03-03 2018-09-07 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
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Citations (3)

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Publication number Priority date Publication date Assignee Title
AU2591484A (en) * 1983-03-25 1984-09-27 Bayer Aktiengesellschaft Chromone- and thiochromone- substituted 1,4-dihydropyridine derivatives
EP0137193A2 (de) * 1983-08-12 1985-04-17 Hoechst Aktiengesellschaft Chromonalkaloid, Verfahren zu seiner Isolierung aus Dysoxylum Binectariferum, und seine Verwendung als Arzneimittel
AU5107085A (en) * 1984-12-15 1986-06-19 Bayer Aktiengesellschaft 1,4-dihydropyridine carboxamide derivatives

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GB1223690A (en) * 1967-10-17 1971-03-03 Fisons Pharmaceuticals Ltd Substituted chromon-2-carboxylic acids
DE2731566A1 (de) * 1977-07-13 1979-02-01 Bayer Ag Verfahren zur herstellung von neuen chromon-derivaten, sowie ihre verwendung als pflanzenschutzmittel
GB2101115A (en) * 1980-10-23 1983-01-12 Pfizer Ltd Thromboxane synthetase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2591484A (en) * 1983-03-25 1984-09-27 Bayer Aktiengesellschaft Chromone- and thiochromone- substituted 1,4-dihydropyridine derivatives
EP0137193A2 (de) * 1983-08-12 1985-04-17 Hoechst Aktiengesellschaft Chromonalkaloid, Verfahren zu seiner Isolierung aus Dysoxylum Binectariferum, und seine Verwendung als Arzneimittel
AU5107085A (en) * 1984-12-15 1986-06-19 Bayer Aktiengesellschaft 1,4-dihydropyridine carboxamide derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU628409B2 (en) * 1988-10-28 1992-09-17 Hoechst Aktiengesellschaft The use of 4h-1-benzopyran-4-one derivatives, novel 4h-1- benzopyran-4-one derivatives, and pharmaceuticals containing them
AU653800B2 (en) * 1991-04-10 1994-10-13 Hoechst Aktiengesellschaft 5,7-dihydroxy-2-methyl-8-{4-(3-hydroxy-1-(1-propyl) piperidinyl}-4H-1-benzophyran-4-one, its preparation and its use

Also Published As

Publication number Publication date
AU7139787A (en) 1987-10-15
DE3787661D1 (de) 1993-11-11
KR950009861B1 (en) 1995-08-29
JPH0686446B2 (ja) 1994-11-02
PT84654A (de) 1987-05-01
AT389875B (de) 1990-02-12
ATA260587A (de) 1989-07-15
DE3612337A1 (de) 1987-10-15
ATE95519T1 (de) 1993-10-15
PT84654B (pt) 1989-12-29
HK1006021A1 (en) 1999-02-05
DK185287A (da) 1987-10-12
IE870941L (en) 1987-10-11
KR870010045A (ko) 1987-11-30
EP0241003A2 (de) 1987-10-14
US4900727A (en) 1990-02-13
IE62244B1 (en) 1995-01-11
EP0241003B1 (de) 1993-10-06
IN164232B (enExample) 1989-02-04
CA1332238C (en) 1994-10-04
ZA872555B (en) 1987-11-25
DK169760B1 (da) 1995-02-20
DK185287D0 (da) 1987-04-10
JPS62242680A (ja) 1987-10-23
IL82149A0 (en) 1987-10-30
ES2060582T3 (es) 1994-12-01
EP0241003A3 (en) 1988-10-12
IL82149A (en) 1994-01-25

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