HK1006021A1 - 4h-1-benzopyran-4-one derivatives, process for their preparation and their use as medicaments - Google Patents

4h-1-benzopyran-4-one derivatives, process for their preparation and their use as medicaments Download PDF

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Publication number
HK1006021A1
HK1006021A1 HK98105203A HK98105203A HK1006021A1 HK 1006021 A1 HK1006021 A1 HK 1006021A1 HK 98105203 A HK98105203 A HK 98105203A HK 98105203 A HK98105203 A HK 98105203A HK 1006021 A1 HK1006021 A1 HK 1006021A1
Authority
HK
Hong Kong
Prior art keywords
methyl
alkyl
formula
compound
cis
Prior art date
Application number
HK98105203A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1006021B (en
Inventor
Laxminarayan Kattige Samba
Ganapati Naik Ramchandra
Dawoodbhai Lakdawalla Aftab
Nomanbhai Dohadwalla Alihussein
Helmut Rupp Richard
John De Souza Noel
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Publication of HK1006021B publication Critical patent/HK1006021B/xx
Publication of HK1006021A1 publication Critical patent/HK1006021A1/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK98105203A 1986-04-11 1998-06-11 4h-1-benzopyran-4-one derivatives, process for their preparation and their use as medicaments HK1006021A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863612337 DE3612337A1 (de) 1986-04-11 1986-04-11 4h-1-benzopyran-4-on-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3612337 1986-04-11

Publications (2)

Publication Number Publication Date
HK1006021B HK1006021B (en) 1999-02-05
HK1006021A1 true HK1006021A1 (en) 1999-02-05

Family

ID=6298535

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98105203A HK1006021A1 (en) 1986-04-11 1998-06-11 4h-1-benzopyran-4-one derivatives, process for their preparation and their use as medicaments

Country Status (16)

Country Link
US (1) US4900727A (enExample)
EP (1) EP0241003B1 (enExample)
JP (1) JPH0686446B2 (enExample)
KR (1) KR950009861B1 (enExample)
AT (2) ATE95519T1 (enExample)
AU (1) AU602891B2 (enExample)
CA (1) CA1332238C (enExample)
DE (2) DE3612337A1 (enExample)
DK (1) DK169760B1 (enExample)
ES (1) ES2060582T3 (enExample)
HK (1) HK1006021A1 (enExample)
IE (1) IE62244B1 (enExample)
IL (1) IL82149A (enExample)
IN (1) IN164232B (enExample)
PT (1) PT84654B (enExample)
ZA (1) ZA872555B (enExample)

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US5733920A (en) * 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
US20060241173A1 (en) * 1996-02-16 2006-10-26 Sterix Ltd. Compound
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
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FR2805538B1 (fr) * 2000-02-29 2006-08-04 Hoechst Marion Roussel Inc Nouveaux derives de flavones, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
KR100423899B1 (ko) 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
CN100381437C (zh) 2002-04-17 2008-04-16 赛特凯恩蒂克公司 化合物、组合物和方法
US7884127B2 (en) * 2002-07-08 2011-02-08 Pirimal Life Sciences Ltd. Inhibitors of cyclin dependent kinases and their use
US7915301B2 (en) 2002-07-08 2011-03-29 Piramal Life Science Limited Inhibitors of cyclin dependent kinases and their use
US7271193B2 (en) * 2002-07-08 2007-09-18 Nicholas Piramal India, Ltd. Inhibitors of cyclin-dependent kinases and their use
DE60326248D1 (de) * 2002-07-17 2009-04-02 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen
WO2004024086A2 (en) * 2002-09-13 2004-03-25 Cytokinetics, Inc. Compounds, compositions and methods
US20050165089A1 (en) * 2003-10-06 2005-07-28 Gustave Bergnes Compounds, compositions and methods
US8044057B2 (en) * 2003-12-09 2011-10-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for suppressing an immune response or treating a proliferative disorder
US20050171182A1 (en) * 2003-12-11 2005-08-04 Roger Briesewitz Methods and compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases
KR101346886B1 (ko) 2005-01-21 2014-01-02 아스텍스 테라퓨틱스 리미티드 제약 화합물
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TW201300105A (zh) 2011-05-31 2013-01-01 Piramal Life Sciences Ltd 治療頭頸鱗狀細胞癌之相乘藥物組合物
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US9932327B2 (en) 2013-04-17 2018-04-03 The Council Of Scientific & Industrial Research Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof
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JP6510075B2 (ja) 2015-05-18 2019-05-08 トレロ ファーマシューティカルズ， インコーポレイテッド バイオアベイラビリティが高いアルボシジブプロドラッグ
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Also Published As

Publication number Publication date
DK185287D0 (da) 1987-04-10
CA1332238C (en) 1994-10-04
KR870010045A (ko) 1987-11-30
DK169760B1 (da) 1995-02-20
IL82149A0 (en) 1987-10-30
ATE95519T1 (de) 1993-10-15
DE3787661D1 (de) 1993-11-11
IE62244B1 (en) 1995-01-11
AU602891B2 (en) 1990-11-01
EP0241003B1 (de) 1993-10-06
AT389875B (de) 1990-02-12
KR950009861B1 (en) 1995-08-29
EP0241003A2 (de) 1987-10-14
ATA260587A (de) 1989-07-15
IN164232B (enExample) 1989-02-04
JPH0686446B2 (ja) 1994-11-02
US4900727A (en) 1990-02-13
IL82149A (en) 1994-01-25
DK185287A (da) 1987-10-12
EP0241003A3 (en) 1988-10-12
DE3612337A1 (de) 1987-10-15
AU7139787A (en) 1987-10-15
JPS62242680A (ja) 1987-10-23
PT84654B (pt) 1989-12-29
PT84654A (de) 1987-05-01
ZA872555B (en) 1987-11-25
ES2060582T3 (es) 1994-12-01
IE870941L (en) 1987-10-11

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Effective date: 20070407