AU602891B2 - 4H-1-benzopyran-4-one derivatives, a process for their preparation and their use as medicaments - Google Patents

4H-1-benzopyran-4-one derivatives, a process for their preparation and their use as medicaments

Info

Publication number
AU602891B2
AU602891B2 AU71397/87A AU7139787A AU602891B2 AU 602891 B2 AU602891 B2 AU 602891B2 AU 71397/87 A AU71397/87 A AU 71397/87A AU 7139787 A AU7139787 A AU 7139787A AU 602891 B2 AU602891 B2 AU 602891B2
Authority
AU
Australia
Prior art keywords
alkyl
aryl
cycloalkyl
represents hydrogen
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU71397/87A
Other languages
English (en)
Other versions
AU7139787A (en
Inventor
Alihussein Nomanbhai Dohadwalla
Samba Laxminarayan Kattige
Aftab Dawoodbhai Lakdawalla
Ramchandra Ganapati Naik
Richard Helmut Rupp
Noel John De Souza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU7139787A publication Critical patent/AU7139787A/en
Application granted granted Critical
Publication of AU602891B2 publication Critical patent/AU602891B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU71397/87A 1986-04-11 1987-04-10 4H-1-benzopyran-4-one derivatives, a process for their preparation and their use as medicaments Expired AU602891B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863612337 DE3612337A1 (de) 1986-04-11 1986-04-11 4h-1-benzopyran-4-on-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3612337 1986-04-11

Publications (2)

Publication Number Publication Date
AU7139787A AU7139787A (en) 1987-10-15
AU602891B2 true AU602891B2 (en) 1990-11-01

Family

ID=6298535

Family Applications (1)

Application Number Title Priority Date Filing Date
AU71397/87A Expired AU602891B2 (en) 1986-04-11 1987-04-10 4H-1-benzopyran-4-one derivatives, a process for their preparation and their use as medicaments

Country Status (15)

Country Link
US (1) US4900727A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0241003B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH0686446B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR950009861B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (2) ATE95519T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU602891B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1332238C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3612337A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK169760B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2060582T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE62244B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL82149A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN164232B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT84654B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA872555B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU628409B2 (en) * 1988-10-28 1992-09-17 Hoechst Aktiengesellschaft The use of 4h-1-benzopyran-4-one derivatives, novel 4h-1- benzopyran-4-one derivatives, and pharmaceuticals containing them
AU653800B2 (en) * 1991-04-10 1994-10-13 Hoechst Aktiengesellschaft 5,7-dihydroxy-2-methyl-8-{4-(3-hydroxy-1-(1-propyl) piperidinyl}-4H-1-benzophyran-4-one, its preparation and its use

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
US5278174A (en) * 1990-06-04 1994-01-11 Scios Nova, Inc. Sigma binding site agents
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
US6903084B2 (en) 1991-08-28 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
US6011024A (en) 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
GB9604709D0 (en) * 1996-03-05 1996-05-01 Imperial College A compound
CZ285937B6 (cs) * 1992-01-16 1999-12-15 Hoechst Aktiengesellschaft Arylcykloalkylové deriváty, způsob přípravy těchto derivátů a jejich použití
US5733920A (en) * 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
US20060241173A1 (en) * 1996-02-16 2006-10-26 Sterix Ltd. Compound
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
US6087366A (en) * 1996-03-07 2000-07-11 The Trustees Of Columbia University In The City Of New York Use of flavopiridol or a pharmaceutically acceptable salt thereof for inhibiting cell damage or cell death
US5849733A (en) * 1996-05-10 1998-12-15 Bristol-Myers Squibb Co. 2-thio or 2-oxo flavopiridol analogs
US5908934A (en) * 1996-09-26 1999-06-01 Bristol-Myers Squibb Company Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs
DE19802449A1 (de) 1998-01-23 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin
GB9807779D0 (en) * 1998-04-09 1998-06-10 Ciba Geigy Ag Organic compounds
US6399633B1 (en) * 1999-02-01 2002-06-04 Aventis Pharmaceuticals Inc. Use of 4-H-1-benzopryan-4-one derivatives as inhibitors of smooth muscle cell proliferation
DE19959546A1 (de) * 1999-12-09 2001-06-21 Rhone Poulenc Rorer Gmbh Pharmazeutische Zubereitung zur Behandlung von Tumorerkrankungen
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
ES2222332T3 (es) * 2000-01-18 2005-02-01 Aventis Pharmaceuticals Inc. Seudopolimorfo de hidrocloruro de (-)-cis-2-(2-clorofenil)-5,7-dihidroxi-8(4r-(3s-hidroxi-1-metil)piperidinil)-4h-1-benzopiran-4-ona.
US6576647B2 (en) 2000-01-18 2003-06-10 Aventis Pharmaceuticals Inc. Pseudopolymorph of (—)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy -1-methyl)piperidinyl]-4H-1-benzopyran-4-one
PL201690B1 (pl) * 2000-01-18 2009-04-30 Aventis Pharma Inc Forma II etanolowego solwatu chlorowodorku (-)-cis-2-(2-chlorofenylo)-5,7-dihydroksy-8[4R-(3S-hydroksy-1-metylo)-piperydynylo]-4H-1-benzopiran-4-onu, sposób jej wytwarzania, kompozycja farmaceutyczna i zastosowanie Formy II
US6821990B2 (en) 2000-01-18 2004-11-23 Aventis Pharma Deutschland Gmbh Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5, 7-dihydroxy-8 [4R-(3S-hydroxy-1-M ethyl) piperidinyl]-4H-1-benzopyran-4-one
FR2805538B1 (fr) * 2000-02-29 2006-08-04 Hoechst Marion Roussel Inc Nouveaux derives de flavones, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
KR100423899B1 (ko) 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
RU2308454C9 (ru) 2002-04-17 2008-05-10 Цитокинетикс, Инк. Соединения, композиции на их основе и способы их использования
US7271193B2 (en) * 2002-07-08 2007-09-18 Nicholas Piramal India, Ltd. Inhibitors of cyclin-dependent kinases and their use
US7915301B2 (en) * 2002-07-08 2011-03-29 Piramal Life Science Limited Inhibitors of cyclin dependent kinases and their use
US7884127B2 (en) * 2002-07-08 2011-02-08 Pirimal Life Sciences Ltd. Inhibitors of cyclin dependent kinases and their use
US6949538B2 (en) * 2002-07-17 2005-09-27 Cytokinetics, Inc. Compounds, compositions, and methods
WO2004024086A2 (en) * 2002-09-13 2004-03-25 Cytokinetics, Inc. Compounds, compositions and methods
EP1670456A2 (en) * 2003-10-06 2006-06-21 Cytokinetics, Inc. Compounds, compositions and methods
DE602004024115D1 (de) * 2003-12-09 2009-12-24 Us Gov Health & Human Serv Verfahren zur unterdrückung einer immunantwort oder zur behandlung von proliferativen erkrankungen
WO2005058341A2 (en) * 2003-12-11 2005-06-30 Theravance, Inc. Compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases
US20090036435A1 (en) 2005-01-21 2009-02-05 Astex Therapeutics Limited Pharmaceutical Compounds
ES2491140T3 (es) 2006-06-21 2014-09-05 Piramal Enterprises Limited Derivados de flavona enantioméricamente puros para el tratamiento de trastornos proliferativos y procesos para su preparación
EP2073803B1 (en) 2006-10-12 2018-09-19 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
TWI461194B (zh) 2009-05-05 2014-11-21 Piramal Entpr Ltd 吡咯啶取代黃酮作為輻射致敏劑
MX2012009830A (es) 2010-02-26 2013-02-11 Piramal Entpr Ltd Flavonas sustituidas de pirrolidina para el tratamiento de desordenes inflamatorios.
EP3399026B1 (en) 2010-06-14 2024-06-26 The Scripps Research Institute Reprogramming of cells to a new fate
TW201300105A (zh) 2011-05-31 2013-01-01 Piramal Life Sciences Ltd 治療頭頸鱗狀細胞癌之相乘藥物組合物
CA2909280C (en) 2013-04-10 2021-03-30 Council Of Scientific & Industrial Research Chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders
US9932327B2 (en) 2013-04-17 2018-04-03 The Council Of Scientific & Industrial Research Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof
AU2014288857B2 (en) 2013-07-12 2019-03-14 Piramal Enterprises Limited A pharmaceutical combination for the treatment of melanoma
JP6951973B2 (ja) 2014-11-12 2021-10-20 シージェン インコーポレイテッド グリカン相互作用化合物及び使用方法
MX2017013383A (es) 2015-04-20 2017-12-07 Tolero Pharmaceuticals Inc Prediccion de respuesta a alvocidib mediante perfilado mitocondrial.
JP6510075B2 (ja) 2015-05-18 2019-05-08 トレロ ファーマシューティカルズ， インコーポレイテッド バイオアベイラビリティが高いアルボシジブプロドラッグ
CA2993659A1 (en) 2015-08-03 2017-02-09 Tolero Pharmaceuticals, Inc. Combination therapies for treatment of cancer
MX2018005061A (es) 2015-11-12 2019-02-28 Siamab Therapeutics Inc Compuestos de interacción con glicanos y métodos de uso.
WO2018094143A1 (en) 2016-11-17 2018-05-24 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
US11279694B2 (en) 2016-11-18 2022-03-22 Sumitomo Dainippon Pharma Oncology, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
KR20190099260A (ko) 2016-12-19 2019-08-26 톨레로 파마수티컬스, 인크. 프로파일링 펩티드 및 감도 프로파일링을 위한 방법
AU2018226824A1 (en) 2017-03-03 2019-09-19 Seagen Inc. Glycan-interacting compounds and methods of use
US11497756B2 (en) 2017-09-12 2022-11-15 Sumitomo Pharma Oncology, Inc. Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib
CA3119807A1 (en) 2018-12-04 2020-06-11 Sumitomo Dainippon Pharma Oncology, Inc. Cdk9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
WO2020191326A1 (en) 2019-03-20 2020-09-24 Sumitomo Dainippon Pharma Oncology, Inc. Treatment of acute myeloid leukemia (aml) with venetoclax failure
WO2020213714A1 (ja) * 2019-04-18 2020-10-22 大日本住友製薬株式会社 シス－（－）－フロシノピペリドールの製造方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2591484A (en) * 1983-03-25 1984-09-27 Bayer Aktiengesellschaft Chromone- and thiochromone- substituted 1,4-dihydropyridine derivatives
EP0137193A2 (de) * 1983-08-12 1985-04-17 Hoechst Aktiengesellschaft Chromonalkaloid, Verfahren zu seiner Isolierung aus Dysoxylum Binectariferum, und seine Verwendung als Arzneimittel
AU5107085A (en) * 1984-12-15 1986-06-19 Bayer Aktiengesellschaft 1,4-dihydropyridine carboxamide derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1223690A (en) * 1967-10-17 1971-03-03 Fisons Pharmaceuticals Ltd Substituted chromon-2-carboxylic acids
DE2731566A1 (de) * 1977-07-13 1979-02-01 Bayer Ag Verfahren zur herstellung von neuen chromon-derivaten, sowie ihre verwendung als pflanzenschutzmittel
GB2101115A (en) * 1980-10-23 1983-01-12 Pfizer Ltd Thromboxane synthetase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2591484A (en) * 1983-03-25 1984-09-27 Bayer Aktiengesellschaft Chromone- and thiochromone- substituted 1,4-dihydropyridine derivatives
EP0137193A2 (de) * 1983-08-12 1985-04-17 Hoechst Aktiengesellschaft Chromonalkaloid, Verfahren zu seiner Isolierung aus Dysoxylum Binectariferum, und seine Verwendung als Arzneimittel
AU5107085A (en) * 1984-12-15 1986-06-19 Bayer Aktiengesellschaft 1,4-dihydropyridine carboxamide derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU628409B2 (en) * 1988-10-28 1992-09-17 Hoechst Aktiengesellschaft The use of 4h-1-benzopyran-4-one derivatives, novel 4h-1- benzopyran-4-one derivatives, and pharmaceuticals containing them
AU653800B2 (en) * 1991-04-10 1994-10-13 Hoechst Aktiengesellschaft 5,7-dihydroxy-2-methyl-8-{4-(3-hydroxy-1-(1-propyl) piperidinyl}-4H-1-benzophyran-4-one, its preparation and its use

Also Published As

Publication number Publication date
PT84654A (de) 1987-05-01
AU7139787A (en) 1987-10-15
ZA872555B (en) 1987-11-25
DE3787661D1 (de) 1993-11-11
IE870941L (en) 1987-10-11
DK185287D0 (da) 1987-04-10
ES2060582T3 (es) 1994-12-01
DK185287A (da) 1987-10-12
JPH0686446B2 (ja) 1994-11-02
AT389875B (de) 1990-02-12
ATE95519T1 (de) 1993-10-15
EP0241003A3 (en) 1988-10-12
EP0241003A2 (de) 1987-10-14
PT84654B (pt) 1989-12-29
CA1332238C (en) 1994-10-04
US4900727A (en) 1990-02-13
KR870010045A (ko) 1987-11-30
DE3612337A1 (de) 1987-10-15
HK1006021A1 (en) 1999-02-05
IL82149A (en) 1994-01-25
ATA260587A (de) 1989-07-15
IL82149A0 (en) 1987-10-30
IE62244B1 (en) 1995-01-11
JPS62242680A (ja) 1987-10-23
IN164232B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-02-04
DK169760B1 (da) 1995-02-20
EP0241003B1 (de) 1993-10-06
KR950009861B1 (en) 1995-08-29

Similar Documents

Publication Publication Date Title
AU602891B2 (en) 4H-1-benzopyran-4-one derivatives, a process for their preparation and their use as medicaments
AU8794291A (en) New oxazolopyridine derivatives, processes for preparing these and pharmaceutical compositions containing them
IL113011A (en) R-mandelic acid salt of (2s,3s)-3- (2-methoxybenzylamino)-2- phenylpiperidine
HU9400352D0 (en) New quinoline- and naphtiridine-carboxylic acid derivatives
ES8104215A1 (es) Un procedimiento para la preparacion de sulfamidas.
ES8104264A1 (es) Procedimiento para la preparacion de n- (trimetoxibencil)- n'-fenilpiperazinas
IE43847L (en) N-substituted phenylpiperidine derivatives.
PT93126A (pt) Processo para a preparacao de eteres carboxialquilicos da 2-amino-7- -hidroxitetralina
IE822330L (en) 2,2-disubstituted-ethylamines
ES8201140A1 (es) Procedimiento para la preparacion de 2-fenilamino-imidazoli nas-(2)sustituidas.
DE3787030D1 (de) 1-carboxy-1-vinyloxyiminoaminothiazol-cephalosporin-derivate und deren herstellung.
PT78918A (en) Process for preparing novel benzofuran derivatives
ZA888663B (en) Substituted derivatives of 20,21-dinoreburanamenine,their preparation process and the new intermediates thus obtained,their use as medicaments and the pharmaceutical compositions containing them
AU577159B2 (en) Morpholinoethylamino-1,3,4-thiadiazole compounds
ES8504754A1 (es) Procedimiento para preparar la n-(3-trifluorometil fenil)-n-propargil-piperazina.
IL72681A (en) 4-alkyl-5-haloimidazole-1-carboxylic acid esters and amides,their preparation and their use as nitrification inhibitors
ZA924888B (en) Process for the synthesis of enantiomers of 3-aminochroman compounds
DE3470741D1 (en) Azolylmethylcycloacetals, process for their preparation and their use as medicaments
DE3068245D1 (en) Substituted 2-phenylamino-2-imidazolines, acid addition salts thereof, medicaments containing them and process for preparing them
ZA807905B (en) 2-phenylamino-imidazolines-(2),compositions thereof and process for the preparation thereof
AT383811B (de) Verfahren zur herstellung von monoalkalisalzen von 7-amino-3-cephem-4-carbonsaeurederivaten
GR3015467T3 (en) p-Oxybenzoic acid derivatives, process for preparing them and their use as medicaments.
DE69109072D1 (de) Aminoalkylketonderivate, Verfahren zu ihrer Herstellung und ihre therapeutischen Anwendungen.
JPS5387389A (en) Novel cephalosporin derivative, pharmaceuticals containing the same, and its preparation