AU582789B2 - Vitamin d derivatives and methods for preparing same - Google Patents

Vitamin d derivatives and methods for preparing same

Info

Publication number
AU582789B2
AU582789B2 AU47761/85A AU4776185A AU582789B2 AU 582789 B2 AU582789 B2 AU 582789B2 AU 47761/85 A AU47761/85 A AU 47761/85A AU 4776185 A AU4776185 A AU 4776185A AU 582789 B2 AU582789 B2 AU 582789B2
Authority
AU
Australia
Prior art keywords
vitamin
gave
ethyl acetate
mmol
hexane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU47761/85A
Other languages
English (en)
Other versions
AU4776185A (en
Inventor
Hector F. Deluca
Nobuo Ikekawa
Yoko Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of AU4776185A publication Critical patent/AU4776185A/en
Application granted granted Critical
Publication of AU582789B2 publication Critical patent/AU582789B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU47761/85A 1984-10-04 1985-08-19 Vitamin d derivatives and methods for preparing same Ceased AU582789B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65754984A 1984-10-04 1984-10-04
US657549 1984-10-04

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU27614/88A Division AU605007B2 (en) 1984-10-04 1988-12-29 Steroidal compounds and process for lengthening the side-chain of certain steroids

Publications (2)

Publication Number Publication Date
AU4776185A AU4776185A (en) 1986-04-17
AU582789B2 true AU582789B2 (en) 1989-04-13

Family

ID=24637652

Family Applications (2)

Application Number Title Priority Date Filing Date
AU47761/85A Ceased AU582789B2 (en) 1984-10-04 1985-08-19 Vitamin d derivatives and methods for preparing same
AU27614/88A Ceased AU605007B2 (en) 1984-10-04 1988-12-29 Steroidal compounds and process for lengthening the side-chain of certain steroids

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU27614/88A Ceased AU605007B2 (en) 1984-10-04 1988-12-29 Steroidal compounds and process for lengthening the side-chain of certain steroids

Country Status (13)

Country Link
EP (1) EP0197949A1 (nl)
JP (3) JPS62500301A (nl)
AU (2) AU582789B2 (nl)
BE (1) BE903376A (nl)
CH (1) CH672920A5 (nl)
DE (2) DE3590488T (nl)
DK (5) DK154290C (nl)
FR (1) FR2571369B1 (nl)
GB (2) GB2167070B (nl)
IE (1) IE58104B1 (nl)
IT (1) IT1190401B (nl)
NL (1) NL8520265A (nl)
WO (1) WO1986002078A1 (nl)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU629831B2 (en) * 1988-04-29 1992-10-15 Wisconsin Alumni Research Foundation Side chain unsaturated 1 alpha-hydroxyvitamin d homologs for the treatment of leukemia

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0412110B1 (en) * 1988-04-21 1993-07-07 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
US5063221A (en) * 1989-04-05 1991-11-05 Chugai Seiyaku Kabushiki Kaisha Treatment for hyperparathyroidism with use of vitamin d derivatives
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5891865A (en) * 1996-10-04 1999-04-06 Wisconsin Alumni Research Foundation Treatment of arthritic disease induced by infectious agents
AU2005303773A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
AU2593784A (en) * 1983-03-21 1984-09-27 F. Hoffmann-La Roche Ag Pharmaceutical ergocalciferols and intermediates
AU3011584A (en) * 1983-05-09 1984-12-04 Wisconsin Alumni Research Foundation PROCESS FOR THE PREPARATION OF 1a, 25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833622A (en) * 1969-03-17 1974-09-03 Upjohn Co Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
AU527805B2 (en) * 1978-07-27 1983-03-24 Research Institute For Medicine And Chemistry Inc. 1alpha, 1beta dihydroxy steroid-5-enes
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
AU2593784A (en) * 1983-03-21 1984-09-27 F. Hoffmann-La Roche Ag Pharmaceutical ergocalciferols and intermediates
AU3011584A (en) * 1983-05-09 1984-12-04 Wisconsin Alumni Research Foundation PROCESS FOR THE PREPARATION OF 1a, 25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU629831B2 (en) * 1988-04-29 1992-10-15 Wisconsin Alumni Research Foundation Side chain unsaturated 1 alpha-hydroxyvitamin d homologs for the treatment of leukemia

Also Published As

Publication number Publication date
DK111188A (da) 1988-03-02
DK158989B (da) 1990-08-13
DK111188D0 (da) 1988-03-02
JPH0689022B2 (ja) 1994-11-09
NL8520265A (nl) 1986-09-01
DK15390A (da) 1990-01-19
JPH0569103B2 (nl) 1993-09-30
JPH05178887A (ja) 1993-07-20
DK260086A (da) 1986-06-03
IE852443L (en) 1986-04-04
WO1986002078A1 (en) 1986-04-10
GB2167070A (en) 1986-05-21
DK260086D0 (da) 1986-06-03
JPS62500301A (ja) 1987-02-05
DE3590488C2 (nl) 1992-10-01
DK158990C (da) 1991-01-21
CH672920A5 (nl) 1990-01-15
AU4776185A (en) 1986-04-17
JPH0635475B2 (ja) 1994-05-11
AU605007B2 (en) 1991-01-03
DK15290A (da) 1990-01-19
DK159389C (da) 1991-03-11
GB2167070B (en) 1988-09-01
IT8522359A0 (it) 1985-10-04
DE3590488T (de) 1986-10-09
GB2188932B (en) 1988-09-01
DK177489D0 (da) 1989-04-13
DK15390D0 (da) 1990-01-19
BE903376A (fr) 1986-02-03
DK158989C (da) 1991-01-21
DK154290C (da) 1989-03-28
GB2188932A (en) 1987-10-14
DK154290B (da) 1988-10-31
GB8524479D0 (en) 1985-11-06
FR2571369B1 (fr) 1987-12-04
DK15290D0 (da) 1990-01-19
DK177489A (da) 1989-04-13
IT1190401B (it) 1988-02-16
DK158991C (da) 1991-01-21
DK158990B (da) 1990-08-13
AU2761488A (en) 1989-06-08
GB8709579D0 (en) 1987-05-28
EP0197949A1 (en) 1986-10-22
IE58104B1 (en) 1993-06-30
DK158991B (da) 1990-08-13
DK159389B (da) 1990-10-08
FR2571369A1 (fr) 1986-04-11
JPH05222089A (ja) 1993-08-31

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