AU2021276930A1 - Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha - Google Patents

Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha Download PDF

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Publication number
AU2021276930A1
AU2021276930A1 AU2021276930A AU2021276930A AU2021276930A1 AU 2021276930 A1 AU2021276930 A1 AU 2021276930A1 AU 2021276930 A AU2021276930 A AU 2021276930A AU 2021276930 A AU2021276930 A AU 2021276930A AU 2021276930 A1 AU2021276930 A1 AU 2021276930A1
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AU
Australia
Prior art keywords
antibody
seq
amino acid
antigen
acid sequence
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Pending
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AU2021276930A
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English (en)
Inventor
Matthew GERMINARO
Christopher O'brien
Jacqueline PERRIGOUE
Marion VETTER
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Janssen Biotech Inc
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Janssen Biotech Inc
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Publication of AU2021276930A1 publication Critical patent/AU2021276930A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
AU2021276930A 2020-05-21 2021-05-20 Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha Pending AU2021276930A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063028219P 2020-05-21 2020-05-21
US63/028,219 2020-05-21
US202063116383P 2020-11-20 2020-11-20
US63/116,383 2020-11-20
PCT/IB2021/054390 WO2021234634A1 (en) 2020-05-21 2021-05-20 Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha

Publications (1)

Publication Number Publication Date
AU2021276930A1 true AU2021276930A1 (en) 2023-02-02

Family

ID=78608637

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021276930A Pending AU2021276930A1 (en) 2020-05-21 2021-05-20 Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha

Country Status (11)

Country Link
US (2) US12258393B2 (https=)
EP (2) EP4153220A4 (https=)
JP (1) JP2023528265A (https=)
KR (1) KR20230023663A (https=)
CN (1) CN115768466A (https=)
AU (1) AU2021276930A1 (https=)
BR (1) BR112022023489A2 (https=)
CA (1) CA3183927A1 (https=)
IL (1) IL298389A (https=)
MX (1) MX2022014430A (https=)
WO (1) WO2021234634A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7805788B2 (ja) * 2019-05-23 2026-01-26 ヤンセン バイオテツク，インコーポレーテツド Ｉｌ－２３及びｔｎｆアルファに対する抗体の併用療法による炎症性腸疾患の治療方法
IL298389A (en) 2020-05-21 2023-01-01 Janssen Biotech Inc Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha
AU2021399266A1 (en) * 2020-12-17 2023-08-03 Janssen Biotech, Inc. Anti-tnf antibodies, compositions, and methods for the treatment of active ankylosing spondylitis
BR112023024064A2 (pt) * 2021-05-20 2024-01-30 Janssen Biotech Inc Método de tratamento de doença inflamatória intestinal com uma terapia de combinação de anticorpos para il-23 e tnf-alfa
KR20250075632A (ko) * 2022-09-21 2025-05-28 인매진 피티이. 엘티디. TNFα 및 IL-23을 표적으로 하는 항체 및 이의 용도
MX2025013098A (es) * 2023-05-03 2026-02-03 Janssen Biotech Inc Método para tratar la enfermedad de crohn con una combinación de anticuerpos contra il-23 y tnf alfa
KR20260007593A (ko) * 2023-05-03 2026-01-14 얀센 바이오테크 인코포레이티드 Il-23 및 tnf 알파에 대한 항체 조합에 의한 궤양성 대장염 치료 방법
WO2025071366A1 (ko) * 2023-09-27 2025-04-03 삼성바이오에피스 주식회사 항-il-23 항체의 자가-완충 액상 제형

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