AU2020275845C1 - Dosing of KRAS inhibitor for treatment of cancers - Google Patents

Dosing of KRAS inhibitor for treatment of cancers

Info

Publication number
AU2020275845C1
AU2020275845C1 AU2020275845A AU2020275845A AU2020275845C1 AU 2020275845 C1 AU2020275845 C1 AU 2020275845C1 AU 2020275845 A AU2020275845 A AU 2020275845A AU 2020275845 A AU2020275845 A AU 2020275845A AU 2020275845 C1 AU2020275845 C1 AU 2020275845C1
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AU
Australia
Prior art keywords
compound
cancer
subject
administered
patients
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Active
Application number
AU2020275845A
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English (en)
Other versions
AU2020275845B2 (en
AU2020275845A1 (en
Inventor
Victor J. Cee
Haby HENARY
James Russell LIPFORD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
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Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AU2020275845A1 publication Critical patent/AU2020275845A1/en
Application granted granted Critical
Publication of AU2020275845B2 publication Critical patent/AU2020275845B2/en
Priority to AU2025217250A priority Critical patent/AU2025217250A1/en
Publication of AU2020275845C1 publication Critical patent/AU2020275845C1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2020275845A 2019-05-14 2020-05-13 Dosing of KRAS inhibitor for treatment of cancers Active AU2020275845C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025217250A AU2025217250A1 (en) 2019-05-14 2025-08-12 Dosing of KRAS inhibitor for treatment of cancers

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962847862P 2019-05-14 2019-05-14
US62/847,862 2019-05-14
US201962867747P 2019-06-27 2019-06-27
US62/867,747 2019-06-27
PCT/US2020/032686 WO2020232130A1 (en) 2019-05-14 2020-05-13 Dosing of kras inhibitor for treatment of cancers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025217250A Division AU2025217250A1 (en) 2019-05-14 2025-08-12 Dosing of KRAS inhibitor for treatment of cancers

Publications (3)

Publication Number Publication Date
AU2020275845A1 AU2020275845A1 (en) 2021-12-02
AU2020275845B2 AU2020275845B2 (en) 2025-05-15
AU2020275845C1 true AU2020275845C1 (en) 2026-01-29

Family

ID=68531369

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2020275845A Active AU2020275845C1 (en) 2019-05-14 2020-05-13 Dosing of KRAS inhibitor for treatment of cancers
AU2025217250A Abandoned AU2025217250A1 (en) 2019-05-14 2025-08-12 Dosing of KRAS inhibitor for treatment of cancers

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2025217250A Abandoned AU2025217250A1 (en) 2019-05-14 2025-08-12 Dosing of KRAS inhibitor for treatment of cancers

Country Status (14)

Country Link
US (4) US11426404B2 (https=)
EP (2) EP3738593A1 (https=)
JP (4) JP6963146B1 (https=)
CN (1) CN113840606B (https=)
AU (2) AU2020275845C1 (https=)
BR (1) BR112021022812A2 (https=)
CA (1) CA3139519C (https=)
IL (1) IL287838A (https=)
MA (1) MA55959A (https=)
MX (1) MX2021013788A (https=)
SG (1) SG11202112432PA (https=)
TW (3) TWI902129B (https=)
UA (1) UA129221C2 (https=)
WO (1) WO2020232130A1 (https=)

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CN110366550A (zh) 2016-12-22 2019-10-22 美国安进公司 作为用于治疗肺癌、胰腺癌或结直肠癌的KRAS G12C抑制剂的苯并异噻唑、异噻唑并[3,4-b]吡啶、喹唑啉、酞嗪、吡啶并[2,3-d]哒嗪和吡啶并[2,3-d]嘧啶衍生物
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AU2018329920B2 (en) 2017-09-08 2022-12-01 Amgen Inc. Inhibitors of KRAS G12C and methods of using the same
CA3098574A1 (en) 2018-05-04 2019-11-07 Amgen Inc. Kras g12c inhibitors and methods of using the same
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MA52564A (fr) 2018-05-10 2021-03-17 Amgen Inc Inhibiteurs de kras g12c pour le traitement du cancer
US11096939B2 (en) 2018-06-01 2021-08-24 Amgen Inc. KRAS G12C inhibitors and methods of using the same
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US11285156B2 (en) 2018-06-12 2022-03-29 Amgen Inc. Substituted piperazines as KRAS G12C inhibitors
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EP3849537B1 (en) 2018-09-10 2024-10-23 Mirati Therapeutics, Inc. Combination therapies
JP7516029B2 (ja) 2018-11-16 2024-07-16 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
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EP3738593A1 (en) 2019-05-14 2020-11-18 Amgen, Inc Dosing of kras inhibitor for treatment of cancers
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MX2022002465A (es) 2019-08-29 2022-05-19 Mirati Therapeutics Inc Inhibidores de kras g12d.
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WO2021061749A1 (en) 2019-09-24 2021-04-01 Mirati Therapeutics, Inc. Combination therapies
US20230028414A1 (en) * 2019-12-16 2023-01-26 Amgen Inc. Dosing regimen of kras g12c inhibitor
PH12022551513A1 (en) 2019-12-20 2023-04-24 Mirati Therapeutics Inc Sos1 inhibitors
EP4210833A4 (en) 2020-09-11 2024-09-11 Mirati Therapeutics, Inc. CRYSTALLINE FORMS OF A KRAS G12C INHIBITOR
JP2023553492A (ja) 2020-12-15 2023-12-21 ミラティ セラピューティクス， インコーポレイテッド アザキナゾリン汎ＫＲａｓ阻害剤
EP4262803A4 (en) 2020-12-16 2025-03-12 Mirati Therapeutics, Inc. Tetrahydropyridopyrimidine pan-kras inhibitors
MX2023007918A (es) * 2021-01-08 2023-07-13 Amgen Inc Uso de un inhibidor de kras g12c en el tratamiento de canceres.
US20220323446A1 (en) * 2021-03-17 2022-10-13 Amgen Inc. Sotorasib dosing regimen
MX2023012930A (es) * 2021-05-06 2023-11-13 Amgen Inc Formulacion de sotorasib.
MX2023013557A (es) * 2021-05-18 2023-11-29 Amgen Inc Pauta posologica de sotorasib.
TW202340202A (zh) 2021-12-22 2023-10-16 美國加利福尼亞大學董事會 Gtp酶抑制劑及其用途
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JP2022009090A (ja) 2022-01-14
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US20240408089A1 (en) 2024-12-12
TW202108142A (zh) 2021-03-01
US11426404B2 (en) 2022-08-30
JP7736742B2 (ja) 2025-09-09
EP3738593A1 (en) 2020-11-18
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JP2021534080A (ja) 2021-12-09
JP7300076B1 (ja) 2023-06-28
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