JP2022009090A - 癌を治療するためのkras阻害剤の投与 - Google Patents
癌を治療するためのkras阻害剤の投与 Download PDFInfo
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- JP2022009090A JP2022009090A JP2021168089A JP2021168089A JP2022009090A JP 2022009090 A JP2022009090 A JP 2022009090A JP 2021168089 A JP2021168089 A JP 2021168089A JP 2021168089 A JP2021168089 A JP 2021168089A JP 2022009090 A JP2022009090 A JP 2022009090A
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Abstract
Description
本出願は、2019年5月14日出願の米国仮特許出願第62/847,862号及び2019年6月27日に出願の米国仮特許出願第62/867,747号の利益を主張するものであり、前記特許はどちらも本明細書に完全に記載されているかのように全体として及びあらゆる目的のために参照により本明細書に組み込まれる。
第1実施形態では、本開示は、癌を治療する方法であって、それを必要とする対象に180mg、360mg、720mg若しくは960mgの1日量で化合物Aを投与するステップを含み、ここで化合物Aが、以下の構造:
本明細書に開示した方法の実施形態では、対象には化合物Aが本明細書に開示した用量で少なくとも1カ月間、少なくとも6週間、少なくとも2カ月間、少なくとも3カ月間、少なくとも4カ月間、少なくとも5カ月間又は少なくとも6カ月間投与される。
一部の実施形態では、本明細書に開示した方法における化合物Aによって治療される対象は、少なくとも1種以上の先行全身性癌療法を受けていた対象である(例えば、化合物Aは、第2選択又は第3選択療法である)。一部の実施形態では、本明細書に開示した方法における化合物Aによって治療される対象は、少なくとも1種の先行全身性癌の後に疾患の増悪を有する対象である(即ち、化合物Aは、第2選択療法である)。一部の実施形態では、本明細書に開示した方法における化合物Aによって治療される対象は、少なくとも2種の先行全身性癌療法の後に疾患の増悪を有する対象である(即ち、化合物Aは、第3選択療法である)。先行全身性癌療法は、規制当局(例えば、FDA又はEMA)によって所定のタイプ及び病期の癌の治療として承認された任意の療法であり得る。一部の場合に、先行全身性癌療法は、規制当局によっては未だ承認されていないが臨床試験を受けている癌療法である。対象が先行全身性癌療法を受けていた場合は、一部の場合に、対象は、化合物Aを用いる本明細書に開示した療法を開始する前に、少なくとも1カ月間、少なくとも2カ月間、少なくとも3カ月間、少なくとも4カ月間、少なくとも5カ月間又は少なくとも6カ月間に渡り何れかの全身性癌療法を受けていなかった。
血液学的毒性:発熱性好中球減少症;好中球減少性感染症;グレード4の好中球減少症;>7日間のグレード≧3の血小板減少症;≧2のグレードの出血を伴うグレード3の血小板減少症;グレード4の血小板減少症;グレード4の貧血
非血液学的毒性:グレード≧4の嘔吐若しくは下痢;グレード3の下痢若しくは最高の医療支援にもかかわらず4日間以上持続するグレード3の嘔吐;最高の医療支援にもかかわらず3日間以上に渡るグレード≧3の悪心;何れかの他のグレード≧3のAE
本開示は、他の経路若しくは同じ経路の他の成分を調節することが知られている薬剤又は更に標的酵素の重複するセットが化合物A又はその薬学的に許容される塩と組み合わせて使用される、併用療法の方法も又提供する。一態様では、そのような療法は、相乗的又は相加的な治療効果を提供するために、本明細書に開示した化合物Aと化学療法剤との併用を含むが、これには限定されない。
A.最初の結果
化合物Aの投与試験:本試験には、KRAS G12C突然変異を有する癌であると同定された患者が登録された。患者は、局所進行性若しくは転移性KRAS G12C突然変異固形腫瘍を有する成人患者であった。全患者は、以前に腫瘍のタイプ及び疾患病期に依存する先行標準療法を受けていた。進行性脳転移を示した患者はいなかった。投与試験を受ける患者は、次の診断を受けていた:14例は非小細胞肺癌(NSCLC)、10例は結腸直腸癌(CRC)及び2例は別のKRAS G12C突然変異固形腫瘍の診断を受けていた。化合物Aは、指定用量で1日1回経口投与された。患者には180mg、360mg、720mg又は960mgの用量の化合物Aが投与され、6週間毎に放射線による精査が実施された。
この試験の更新された結果は、これによりその内容が全体として本明細書に組み込まれる、スペインのバルセロナで2019年9月27日~10月1日まで開催された欧州臨床腫瘍学会議(European Society of Medical Onclology(ESMO))の会議でGovindan,R.,et.al.,“Phase 1 Study of AMG 510,a Novel KRASG12C Inhibitor,in Advanced Solid Tumors With KRAS p.G12C Mutation”によってポスターとして提示されている。本試験の詳細な結果は、それらの内容が全体として本明細書に組み込まれる、米国眼治療学会議(ASCO)の2020年5月29~31日の会議(バーチャル)でFakih,M.G.,et al.,‘‘CodeBreak 100:activity of AMG 510,a novel small molecule inhibitor of KRASG12C,in patients with advanced colorectal cancer’’及びHong,D.S.,et al.,“CodeBreak 100:Phase 1 study of AMG 510,a novel KRASG12C inhibitor,in patients with advanced solid tumors other than non-small-cell lung cancer(NSCLC)and colorectal cancer(CRC)’’によって提示されるであろう。
最初の患者は、2018年8月27日に登録された。2019年7月17日のカットオフ日現在までに患者76例が登録されたが、それらの内患者34例はNSCLCを有していた(SCLCの患者1例(この患者はカットオフ日現在にSCLC(「他の腫瘍タイプ」カテゴリー)であると記録されていたが、カットオフ後に治験参加機関によってNSCLCに変更された)。患者45例は用量漸増コホートに登録され(総1日量180mg(N=6)、総1日量360mg(N=13)、総1日量720mg(N=11)、総1日量960mg(N=15))、患者31例は用量拡大コホートに登録され(総1日量960mg(N=31))、初回の6週間毎の精査を受けた、又は早期進行(PD)を示した55例の患者が評価可能となった。登録患者76例中、52例は治療中のままとなったが、24例はPD(N=22)及び死亡(N=2)のために治療を中止した。ここで注目に値するのは、治療関連有害事象による治療中止が1例も誘発されなかったことである。
2020年1月8日のカットオフ日現在、CRC患者42例が登録された(総1日量180mgのコホート1:患者3例、総1日量360mgのコホート2:患者10例、総1日量720mgのコホート3:患者4例;総1日量960mgのコホート4:患者25例)。メジアンフォローアップ期間は、7.9カ月間(範囲:4.2~15.9カ月間)であった。患者8例は、治療を継続した。患者34例は、疾患の進行(32例)及び患者(2例)からの要請のために治療を中止した。全登録患者は、先行ラインの全身性抗癌療法を受けていた。患者の45%は、4ライン以上の治療を受けた。
2020年1月8日のカットオフ日までに、下記の腫瘍タイプ:膵臓癌(10例)、虫垂癌(4例)、子宮内膜癌(2例)、原発巣不明癌(2例)、胆管癌(1例)、副鼻腔癌(1例)、乳頭部癌(1例)、小腸癌(1例)、黒色腫(1例)、小細胞肺癌(1例)及び食道癌(1例)の患者25例が登録された。虫垂癌の患者2例は、化合物Aのそれぞれ360及び720mgの総1日量を摂取した。残りの患者23例は、総1日量960mgの化合物Aを摂取した。メジアンフォローアップ期間は、4.3カ月間(範囲:0.1~12.6カ月間)であった。患者22例は7週間以上のフォローアップ検査を受けており、応答について評価可能であった。カットオフ日までに、患者12例は、最も一般的な原因として進行を示し、治療を中止した。全登録患者は、先行ラインの全身性抗癌療法を受けており、登録患者の84%は、2つ以上の先行ラインを受けていた。
Claims (38)
- 前記癌は、固形腫瘍である、請求項1、2又は3の何れか一項に記載の方法。
- 前記癌は、非小細胞肺癌である、請求項1、2、3又は4の何れか一項に記載の方法。
- 前記癌は、結腸直腸癌である、請求項1~4の何れか一項に記載の方法。
- 前記癌は、膵臓癌である、請求項1~4の何れか一項に記載の方法。
- 前記癌は、KRAS G12C突然変異癌である、請求項1~7の何れか一項に記載の方法。
- 前記対象は、化合物A療法の開始前に、少なくとも1種の他の全身性癌療法を受けていた、請求項1~8の何れか一項に記載の方法。
- 前記対象は、少なくとも2種の他の全身性癌療法を受けていた、請求項9に記載の方法。
- 化合物Aは、経口投与される、請求項1~9の何れか一項に記載の方法。
- 前記化合物Aは、単回1日量として投与される、請求項1~11の何れか一項に記載の方法。
- 前記対象は、少なくとも1カ月間に渡り化合物Aの投与後に化合物A療法と関連する何れのグレード3又はグレード4の有害事象も示さない、請求項1~12の何れか一項に記載の方法。
- 前記対象は、少なくとも3カ月間に渡り化合物Aの投与後に化合物A療法と関連する何れのグレード3又はグレード4の有害事象も示さない、請求項13に記載の方法。
- 前記化合物Aの用量は、180mgである、請求項1~14の何れか一項に記載の方法。
- 前記化合物Aの用量は、360mgである、請求項1~14の何れか一項に記載の方法。
- 前記化合物Aの用量は、720mgである、請求項1~14の何れか一項に記載の方法。
- 前記化合物Aの用量は、960mgである、請求項1~14の何れか一項に記載の方法。
- 前記対象に化合物Aが、少なくとも1カ月間投与される、請求項1~18の何れか一項に記載の方法。
- 前記対象に、化合物Aが少なくとも3カ月間投与される、請求項1~18の何れか一項に記載の方法。
- 前記対象に、化合物Aが少なくとも6カ月間投与される、請求項1~18の何れか一項に記載の方法。
- 前記対象は、少なくとも安定(SD)を示す、請求項19~21の何れか一項に記載の方法。
- 前記対象は、少なくとも部分奏効(PR)を示す、請求項22に記載の方法。
- 前記対象は、用量制限毒性(DLT)を示さない、請求項1~23の何れか一項に記載の方法。
- 化合物Aは、Mアトロプ異性体としてである、請求項1~24の何れか一項に記載の方法。
- 前記対象に化学療法薬を投与するステップを更に含む、請求項1~25の何れか一項に記載の方法。
- 化学療法薬は、抗PD1抗体を含む、請求項24に記載の方法。
- 抗PD1抗体は、ペンブロリズマブ(Keytruda)、ニボルマブ、AUNP-12、AMG 404又はピジリズマブである、請求項25に記載の方法。
- 前記化学療法薬は、抗PDL1抗体を含む、請求項26に記載の方法。
- 前記抗PDL1抗体は、アテゾリズマブ、MPDL3280A、アベルマブ又はデュルバルマブである、請求項29に記載の方法。
- 前記化学療法薬は、MEK阻害剤を含む、請求項26に記載の方法。
- 前記MEK阻害剤は、トラメチニブ、ピマセルチブ、PD-325901、MEK162、TAK-733、GDC-0973又はAZD8330である、請求項31に記載の方法。
- 前記化学療法薬は、CDK4/6阻害剤を含む、請求項26に記載の方法。
- 前記CDK4/6阻害剤は、アベマシクリブ又はパルボシクリブを含む、請求項33に記載の方法。
- 前記化学療法薬は、PI3K阻害剤を含む、請求項26に記載の方法。
- 前記PI3K阻害剤は、AMG 511又はブパルリシブを含む、請求項35に記載の方法。
- 前記安定は、PRを適格とする有意な収縮でもPDを適格とする有意な増加でもない、請求項22に記載の方法。
- 前記部分奏効は、標的病変の径の合計における少なくとも30%の減少である、請求項23に記載の方法。
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WO2019217307A1 (en) | 2018-05-07 | 2019-11-14 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
EP3790886A1 (en) | 2018-05-10 | 2021-03-17 | Amgen Inc. | Kras g12c inhibitors for the treatment of cancer |
WO2019232419A1 (en) | 2018-06-01 | 2019-12-05 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
AU2019336588B2 (en) | 2018-06-12 | 2022-07-28 | Amgen Inc. | KRAS G12C inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer |
JP2020090482A (ja) | 2018-11-16 | 2020-06-11 | アムジエン・インコーポレーテツド | Kras g12c阻害剤化合物の重要な中間体の改良合成法 |
JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法 |
CA3117222A1 (en) | 2018-11-19 | 2020-05-28 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
EP3908283A4 (en) | 2019-01-10 | 2022-10-12 | Mirati Therapeutics, Inc. | KRAS G12C INHIBITORS |
EP3738593A1 (en) * | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
SG11202112855WA (en) | 2019-05-21 | 2021-12-30 | Amgen Inc | Solid state forms |
JP2022546043A (ja) | 2019-08-29 | 2022-11-02 | ミラティ セラピューティクス, インコーポレイテッド | Kras g12d阻害剤 |
MX2022003537A (es) | 2019-09-24 | 2022-07-11 | Mirati Therapeutics Inc | Terapias de combinacion. |
WO2021126816A1 (en) * | 2019-12-16 | 2021-06-24 | Amgen Inc. | Dosing regimen of a kras g12c inhibitor |
MX2022007515A (es) | 2019-12-20 | 2022-09-19 | Mirati Therapeutics Inc | Inhibidores de sos1. |
CA3212705A1 (en) * | 2021-03-17 | 2022-09-22 | Amgen Inc. | Sotorasib dosing regimen |
AU2022270124A1 (en) * | 2021-05-06 | 2023-11-02 | Amgen Inc. | Sotorasib formulation |
TW202340202A (zh) | 2021-12-22 | 2023-10-16 | 美國加利福尼亞大學董事會 | Gtp酶抑制劑及其用途 |
WO2024082724A1 (en) * | 2022-10-17 | 2024-04-25 | Ningbo Newbay Technology Development Co., Ltd. | Pim kinase inhibitor in combination with kras inhibitor |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019031476A (ja) * | 2017-05-22 | 2019-02-28 | アムジエン・インコーポレーテツド | Kras g12c阻害剤及びその使用方法 |
WO2019051291A1 (en) * | 2017-09-08 | 2019-03-14 | Amgen Inc. | KRAS G12C INHIBITORS AND METHODS OF USE |
Family Cites Families (222)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4232027A (en) | 1979-01-29 | 1980-11-04 | E. R. Squibb & Sons, Inc. | 1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives |
GB2116183B (en) | 1982-03-03 | 1985-06-05 | Genentech Inc | Human antithrombin iii dna sequences therefore expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby a process for expressing human antithrombin iii and pharmaceutical compositions comprising it |
GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
JP2762522B2 (ja) | 1989-03-06 | 1998-06-04 | 藤沢薬品工業株式会社 | 血管新生阻害剤 |
US5112946A (en) | 1989-07-06 | 1992-05-12 | Repligen Corporation | Modified pf4 compositions and methods of use |
PT98990A (pt) | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
US5892112A (en) | 1990-11-21 | 1999-04-06 | Glycomed Incorporated | Process for preparing synthetic matrix metalloprotease inhibitors |
US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
DE69222637T2 (de) | 1991-05-10 | 1998-02-26 | Rhone Poulenc Rorer Int | Bis mono- und bicyclische aryl- und heteroarylderivate mit inhibierender wirkung auf die egf und/oder pdgf-rezeptor tyrosinkinase |
US5118677A (en) | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
GB9125660D0 (en) | 1991-12-03 | 1992-01-29 | Smithkline Beecham Plc | Novel compound |
AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
ZA935111B (en) | 1992-07-17 | 1994-02-04 | Smithkline Beecham Corp | Rapamycin derivatives |
ZA935112B (en) | 1992-07-17 | 1994-02-08 | Smithkline Beecham Corp | Rapamycin derivatives |
US5256790A (en) | 1992-08-13 | 1993-10-26 | American Home Products Corporation | 27-hydroxyrapamycin and derivatives thereof |
GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
AU669960B2 (en) | 1992-11-13 | 1996-06-27 | Immunex Corporation | Novel cytokine designated elk ligand |
US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5629327A (en) | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
US5516658A (en) | 1993-08-20 | 1996-05-14 | Immunex Corporation | DNA encoding cytokines that bind the cell surface receptor hek |
JPH08503971A (ja) | 1993-10-01 | 1996-04-30 | チバ−ガイギー アクチェンゲゼルシャフト | ピリミジンアミン誘導体及びその調製のための方法 |
US5656643A (en) | 1993-11-08 | 1997-08-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
CA2175215C (en) | 1993-11-19 | 2008-06-03 | Yat Sun Or | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
CN1046944C (zh) | 1993-12-17 | 1999-12-01 | 山道士有限公司 | 雷怕霉素类衍生物 |
US5700823A (en) | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
WO1995024190A2 (en) | 1994-03-07 | 1995-09-14 | Sugen, Inc. | Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof |
WO1995028484A1 (en) | 1994-04-15 | 1995-10-26 | Amgen Inc. | Hek5, hek7, hek8, hek11, new eph-like receptor protein tyrosine kinases |
ATE159257T1 (de) | 1994-05-03 | 1997-11-15 | Ciba Geigy Ag | Pyrrolopyrimidinderivate mit antiproliferativer wirkung |
US6303769B1 (en) | 1994-07-08 | 2001-10-16 | Immunex Corporation | Lerk-5 dna |
US5919905A (en) | 1994-10-05 | 1999-07-06 | Immunex Corporation | Cytokine designated LERK-6 |
US6057124A (en) | 1995-01-27 | 2000-05-02 | Amgen Inc. | Nucleic acids encoding ligands for HEK4 receptors |
US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
DK0817775T3 (da) | 1995-03-30 | 2001-11-19 | Pfizer | Quinazolinderivater |
DE69609602T2 (de) | 1995-04-03 | 2001-04-12 | Novartis Ag | Pyrazolderivate und verfahren zu deren herstellung |
WO1996033172A1 (en) | 1995-04-20 | 1996-10-24 | Pfizer Inc. | Arylsulfonyl hydroxamic acid derivatives as mmp and tnf inhibitors |
GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
US5650415A (en) | 1995-06-07 | 1997-07-22 | Sugen, Inc. | Quinoline compounds |
RU2158267C2 (ru) | 1995-06-09 | 2000-10-27 | Новартис Аг | Производные рапамицина и фармацевтическая композиция на их основе |
JP4146514B2 (ja) | 1995-07-06 | 2008-09-10 | ノバルティス アクチエンゲゼルシャフト | ピロロピリミジン類およびその製造方法 |
DE19534177A1 (de) | 1995-09-15 | 1997-03-20 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
EP0780386B1 (en) | 1995-12-20 | 2002-10-02 | F. Hoffmann-La Roche Ag | Matrix metalloprotease inhibitors |
JP4275733B2 (ja) | 1996-01-23 | 2009-06-10 | ノバルティス アクチエンゲゼルシャフト | ピロロピリミジンおよびその製造法 |
JP3406763B2 (ja) | 1996-01-30 | 2003-05-12 | 東レ・ダウコーニング・シリコーン株式会社 | シリコーンゴム組成物 |
GB9603097D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline compounds |
GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
DE19608588A1 (de) | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE19629652A1 (de) | 1996-03-06 | 1998-01-29 | Thomae Gmbh Dr K | 4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
NZ331804A (en) | 1996-03-15 | 2000-04-28 | Novartis Ag | N-7-heterocyclyl pyrrolo[2,3-d]pyridines and their use |
SI0892789T2 (sl) | 1996-04-12 | 2010-03-31 | Warner Lambert Co | Ireverzibilni inhibitorji tirozin kinaz |
GB9607729D0 (en) | 1996-04-13 | 1996-06-19 | Zeneca Ltd | Quinazoline derivatives |
CA2258548C (en) | 1996-06-24 | 2005-07-26 | Pfizer Inc. | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases |
EP0818442A3 (en) | 1996-07-12 | 1998-12-30 | Pfizer Inc. | Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor |
US6258823B1 (en) | 1996-07-12 | 2001-07-10 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
ID19609A (id) | 1996-07-13 | 1998-07-23 | Glaxo Group Ltd | Senyawa-senyawa heterosiklik |
ES2191187T3 (es) | 1996-07-13 | 2003-09-01 | Glaxo Group Ltd | Compuestos heteroaromaticos biciclicos como inhibidores de la proteina tirosin-quinasa. |
EP0923585B1 (en) | 1996-07-18 | 2002-05-08 | Pfizer Inc. | Phosphinate based inhibitors of matrix metalloproteases |
US6111090A (en) | 1996-08-16 | 2000-08-29 | Schering Corporation | Mammalian cell surface antigens; related reagents |
DK0920505T3 (da) | 1996-08-16 | 2008-09-08 | Schering Corp | Pattedyrcelleoverfladeantigener og tilhörende reagenser |
WO1998007726A1 (en) | 1996-08-23 | 1998-02-26 | Novartis Ag | Substituted pyrrolopyrimidines and processes for their preparation |
SK21499A3 (en) | 1996-08-23 | 2000-05-16 | Pfizer | Arylsulfonylamino hydroxamic acid derivatives |
ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
DE69732780T2 (de) | 1996-10-02 | 2006-04-06 | Novartis Ag | Pyrimiderivate und verfahren zu ihrer herstellung |
WO1998014449A1 (en) | 1996-10-02 | 1998-04-09 | Novartis Ag | Fused pyrazole derivatives and processes for their preparation |
EP0837063A1 (en) | 1996-10-17 | 1998-04-22 | Pfizer Inc. | 4-Aminoquinazoline derivatives |
GB9621757D0 (en) | 1996-10-18 | 1996-12-11 | Ciba Geigy Ag | Phenyl-substituted bicyclic heterocyclyl derivatives and their use |
BR9714266A (pt) | 1997-01-06 | 2000-04-18 | Pfizer | Derivados de sulfona cìclicos. |
PL335027A1 (en) | 1997-02-03 | 2000-03-27 | Pfizer Prod Inc | Derivatives of arylsulphonylamino hydroxamic acid |
ES2301194T3 (es) | 1997-02-05 | 2008-06-16 | Warner-Lambert Company Llc | Pirido 2,3-d pirimidinas y 4-aminopirimidinas como inhibidores de la proliferacion celular. |
AU5493598A (en) | 1997-02-07 | 1998-08-26 | Pfizer Inc. | N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases |
AU722784B2 (en) | 1997-02-11 | 2000-08-10 | Pfizer Inc. | Arylsulfonyl hydroxamic acid derivatives |
CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
US6150395A (en) | 1997-05-30 | 2000-11-21 | The Regents Of The University Of California | Indole-3-carbinol (I3C) derivatives and methods |
AU8689298A (en) | 1997-08-05 | 1999-03-01 | Sugen, Inc. | Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors |
CA2299355C (en) | 1997-08-08 | 2005-09-27 | Pfizer Products Inc. | Aryloxyarylsulfonylamino hydroxamic acid derivatives |
EP1025228A4 (en) | 1997-10-21 | 2002-09-18 | Human Genome Sciences Inc | HUMAN PROTEIN TR11, TR11SV1 AND TR11SV2 SIMILAR TO THE TUMOR NECROSIS FACTOR RECEPTOR |
GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
GB9800575D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
RS49779B (sr) | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
GB9801690D0 (en) | 1998-01-27 | 1998-03-25 | Pfizer Ltd | Therapeutic agents |
IL137409A0 (en) | 1998-02-09 | 2001-07-24 | Genentech Inc | Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same |
DE69940808D1 (de) | 1998-03-04 | 2009-06-10 | Bristol Myers Squibb Co | Heterocyclen substituierte imidazopyrazine als protein- tyrosin-kinase-inhibitoren |
PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
SK287132B6 (sk) | 1998-05-29 | 2009-12-07 | Sugen, Inc. | Farmaceutická kompozícia obsahujúca pyrolom substituovaný 2-indolinón, súprava obsahujúca uvedenú kompozíciu a použitie pyrolom substituovaného 2-indolinónu |
UA60365C2 (uk) | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
EP1097147A4 (en) | 1998-07-10 | 2001-11-21 | Merck & Co Inc | NEW ANGIOGENESIS INHIBITORS |
CA2341409A1 (en) | 1998-08-31 | 2000-03-09 | Merck And Co., Inc. | Novel angiogenesis inhibitors |
DE69915004T2 (de) | 1998-11-05 | 2004-09-09 | Pfizer Products Inc., Groton | 5-Oxo-pyrrolidine-2-Carbonsäure-Hydroxamidderivate |
EP1158985B1 (en) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
ES2265929T3 (es) | 1999-03-30 | 2007-03-01 | Novartis Ag | Derivados de ftalazina para el tratamiento de enfermedades inflamatorias. |
GB9912961D0 (en) | 1999-06-03 | 1999-08-04 | Pfizer Ltd | Metalloprotease inhibitors |
EP1187918B9 (en) | 1999-06-07 | 2009-08-19 | Immunex Corporation | Tek antagonists |
US6521424B2 (en) | 1999-06-07 | 2003-02-18 | Immunex Corporation | Recombinant expression of Tek antagonists |
WO2001003720A2 (en) | 1999-07-12 | 2001-01-18 | Genentech, Inc. | Promotion or inhibition of angiogenesis and cardiovascularization by tumor necrosis factor ligand/receptor homologs |
WO2001014387A1 (en) | 1999-08-24 | 2001-03-01 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
EP1676845B1 (en) | 1999-11-05 | 2008-06-11 | AstraZeneca AB | New quinazoline derivatives |
JP5336686B2 (ja) | 1999-11-24 | 2013-11-06 | スージェン, インク. | 遊離酸または遊離塩基としてイオン化可能な医薬品のための処方 |
US6515004B1 (en) | 1999-12-15 | 2003-02-04 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
US6727225B2 (en) | 1999-12-20 | 2004-04-27 | Immunex Corporation | TWEAK receptor |
NZ521437A (en) | 2000-02-25 | 2004-04-30 | Immunex Corp | Integrin antagonists suitable as inhibitors of angiogenesis |
US6630500B2 (en) | 2000-08-25 | 2003-10-07 | Cephalon, Inc. | Selected fused pyrrolocarbazoles |
ES2324981T3 (es) | 2000-12-21 | 2009-08-21 | Smithkline Beecham Corporation | Pirimidinaminas como moduladores de la angiogenesis. |
US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US20020147198A1 (en) | 2001-01-12 | 2002-10-10 | Guoqing Chen | Substituted arylamine derivatives and methods of use |
US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
TWI329112B (en) | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
AU2004244626A1 (en) | 2003-05-23 | 2004-12-09 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | GITR ligand and GITR ligand-related molecules and antibodies and uses thereof |
PT1646634E (pt) | 2003-07-08 | 2009-02-16 | Novartis Ag | Utilização de rapamicina e derivados de rapamicina para o tratamento de perda óssea |
US20050048054A1 (en) | 2003-07-11 | 2005-03-03 | Shino Hanabuchi | Lymphocytes; methods |
WO2005016252A2 (en) | 2003-07-11 | 2005-02-24 | Ariad Gene Therapeutics, Inc. | Phosphorus-containing macrocycles |
TW200523262A (en) | 2003-07-29 | 2005-07-16 | Smithkline Beecham Corp | Inhibitors of AKT activity |
CA2531506A1 (en) | 2003-08-22 | 2005-03-10 | Avanir Pharmaceuticals | Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases |
WO2005055808A2 (en) | 2003-12-02 | 2005-06-23 | Genzyme Corporation | Compositions and methods to diagnose and treat lung cancer |
GB0409799D0 (en) | 2004-04-30 | 2004-06-09 | Isis Innovation | Method of generating improved immune response |
WO2006083289A2 (en) | 2004-06-04 | 2006-08-10 | Duke University | Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity |
EP1786785B9 (en) | 2004-08-26 | 2013-05-22 | Pfizer Inc. | Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors |
BRPI0516592A (pt) | 2004-10-13 | 2008-09-23 | Wyeth Corp | composto de fórmula |
JP4931823B2 (ja) | 2004-10-18 | 2012-05-16 | アムジエン・インコーポレーテツド | チアジアゾール化合物及び使用方法 |
EP2343320B1 (en) | 2005-03-25 | 2017-10-25 | GITR, Inc. | Anti-gitr antibodies and uses thereof |
CN109485727A (zh) | 2005-05-09 | 2019-03-19 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
CN101267824A (zh) | 2005-09-20 | 2008-09-17 | 辉瑞产品公司 | 使用酪氨酸激酶抑制剂的治疗剂型和方法 |
CA2636077C (en) | 2006-01-18 | 2012-01-03 | Amgen Inc. | Thiazole compounds as protein kinase b (pkb) inhibitors |
US20110212086A1 (en) | 2006-01-19 | 2011-09-01 | Genzyme Corporation | GITR Antibodies For The Treatment of Cancer |
PE20081679A1 (es) | 2006-12-07 | 2008-12-18 | Hoffmann La Roche | Compuestos del inhibidor de fosfoinositida 3-cinasa y metodos de uso |
JP5527761B2 (ja) | 2007-03-23 | 2014-06-25 | アムジエン・インコーポレーテツド | 複素環化合物およびそれの使用 |
CA2680783C (en) | 2007-03-23 | 2012-04-24 | Amgen Inc. | Heterocyclic compounds and their uses |
ES2446417T3 (es) | 2007-03-23 | 2014-03-07 | Amgen Inc. | Derivados de quinolina o quinoxalina sustituidos en 3 y su uso como inhibidores de fosfatidilinositol 3-cinasa (PI3K) |
ES2591281T3 (es) | 2007-07-12 | 2016-11-25 | Gitr, Inc. | Terapias de combinación que emplean moléculas de enlazamiento a GITR |
CA2693473A1 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of pkb |
CA2692713A1 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Heterocyclic modulators of pkb |
US7928140B2 (en) | 2007-08-02 | 2011-04-19 | Amgen Inc. | Benzothiazole PI3 kinase modulators for cancer treatment |
AR068402A1 (es) | 2007-09-12 | 2009-11-18 | Genentech Inc | Combinaciones de compuestos inhibidores de fosfoinositida 3-quinasa y agentes quimioterapeuticos y los metodos de uso |
ES2439705T3 (es) | 2007-10-25 | 2014-01-24 | Genentech, Inc. | Proceso para la preparación de compuestos de tienopirimidina |
CN101945867A (zh) | 2007-12-19 | 2011-01-12 | 安姆根有限公司 | 作为细胞周期抑制剂的稠合吡啶、嘧啶和三嗪化合物 |
CA2710194C (en) | 2007-12-19 | 2014-04-22 | Amgen Inc. | Inhibitors of p13 kinase |
WO2009126584A1 (en) | 2008-04-07 | 2009-10-15 | Amgen Inc. | Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors |
EP2307400B1 (en) | 2008-05-30 | 2014-04-23 | Amgen, Inc | Inhibitors of pi3 kinase |
JP2011526794A (ja) | 2008-07-02 | 2011-10-20 | エマージェント プロダクト デベロップメント シアトル, エルエルシー | TGF−βアンタゴニスト多重標的結合性分子 |
JPWO2010030002A1 (ja) | 2008-09-12 | 2012-02-02 | 国立大学法人三重大学 | 外来性gitrリガンド発現細胞 |
WO2010083246A1 (en) | 2009-01-15 | 2010-07-22 | Amgen Inc. | Fluoroisoquinoline substituted thiazole compounds and methods of use |
US20120165334A1 (en) | 2009-02-18 | 2012-06-28 | Amgen Inc. | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors |
CA2755285C (en) | 2009-03-20 | 2014-02-11 | Yunxin Y. Bo | Inhibitors of pi3 kinase |
UY32582A (es) | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
EP2430013B1 (en) | 2009-05-13 | 2014-10-15 | Amgen Inc. | Heteroaryl compounds as pikk inhibitors |
CA2765823A1 (en) | 2009-06-25 | 2010-12-29 | Amgen Inc. | Tricyclic heterocyclic compounds as mediators of p13k activity |
WO2010151740A2 (en) | 2009-06-25 | 2010-12-29 | Amgen Inc. | Heterocyclic compounds and their uses |
EP2445902A2 (en) | 2009-06-25 | 2012-05-02 | Amgen, Inc | Heterocyclic compounds and their uses as inhibitors of pi3k activity |
EP2445898A2 (en) | 2009-06-25 | 2012-05-02 | Amgen, Inc | 4h-pyrido[1,2-a]pyrimidin-4-one derivatives as pi3k inhibitors |
EP2266984A1 (en) | 2009-06-26 | 2010-12-29 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis |
KR101790802B1 (ko) | 2009-09-03 | 2017-10-27 | 머크 샤프 앤드 돔 코포레이션 | 항-gitr 항체 |
GB0919054D0 (en) | 2009-10-30 | 2009-12-16 | Isis Innovation | Treatment of obesity |
EP3112382A1 (en) | 2009-12-29 | 2017-01-04 | Emergent Product Development Seattle, LLC | Heterodimer binding proteins and uses thereof |
WO2012142498A2 (en) | 2011-04-13 | 2012-10-18 | Innovimmune Biotherapeutics, Inc. | Mif inhibitors and their uses |
US20130108641A1 (en) | 2011-09-14 | 2013-05-02 | Sanofi | Anti-gitr antibodies |
CN104379563B (zh) | 2012-04-10 | 2018-12-21 | 加利福尼亚大学董事会 | 用于治疗癌症的组合物和方法 |
US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
US9745319B2 (en) | 2013-03-15 | 2017-08-29 | Araxes Pharma Llc | Irreversible covalent inhibitors of the GTPase K-Ras G12C |
EP2970121B1 (en) | 2013-03-15 | 2017-12-13 | Araxes Pharma LLC | Covalent inhibitors of kras g12c |
GB201312059D0 (en) | 2013-07-05 | 2013-08-21 | Univ Leuven Kath | Novel GAK modulators |
JO3805B1 (ar) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | مثبطات كراس جي12سي |
CN106488910B (zh) | 2013-10-10 | 2020-07-31 | 亚瑞克西斯制药公司 | Kras g12c的抑制剂 |
GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
JO3556B1 (ar) | 2014-09-18 | 2020-07-05 | Araxes Pharma Llc | علاجات مدمجة لمعالجة السرطان |
WO2016049565A1 (en) | 2014-09-25 | 2016-03-31 | Araxes Pharma Llc | Compositions and methods for inhibition of ras |
AR102094A1 (es) | 2014-09-25 | 2017-02-01 | Araxes Pharma Llc | Inhibidores de proteínas kras con una mutación g12c |
US10011600B2 (en) | 2014-09-25 | 2018-07-03 | Araxes Pharma Llc | Methods and compositions for inhibition of Ras |
BR112017021869A2 (pt) | 2015-04-10 | 2018-12-11 | Araxes Pharma Llc | compostos quinazolina substituídos e métodos de uso dos mesmos |
WO2016168540A1 (en) | 2015-04-15 | 2016-10-20 | Araxes Pharma Llc | Fused-tricyclic inhibitors of kras and methods of use thereof |
CA2993013A1 (en) | 2015-07-22 | 2017-01-26 | Araxes Pharma Llc | Substituted quinazoline compounds and their use as inhibitors of g12c mutant kras, hras and/or nras proteins |
US10882847B2 (en) | 2015-09-28 | 2021-01-05 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
EP3356354A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
WO2017058768A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
WO2017058915A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
EP3356339A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
WO2017058728A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
EP3356347A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
CN108779097A (zh) | 2015-11-16 | 2018-11-09 | 亚瑞克西斯制药公司 | 包含取代的杂环基的2-取代的喹唑啉化合物及其使用方法 |
US9988357B2 (en) | 2015-12-09 | 2018-06-05 | Araxes Pharma Llc | Methods for preparation of quinazoline derivatives |
WO2017172979A1 (en) | 2016-03-30 | 2017-10-05 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use |
CA3024523A1 (en) | 2016-05-18 | 2017-11-23 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
US10280172B2 (en) | 2016-09-29 | 2019-05-07 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
EP3523289A1 (en) | 2016-10-07 | 2019-08-14 | Araxes Pharma LLC | Heterocyclic compounds as inhibitors of ras and methods of use thereof |
HUE056777T2 (hu) | 2016-12-22 | 2022-03-28 | Amgen Inc | Benzizotiazol-, izotiazolo[3,4-b]piridin-, kinazolin-, ftálazin-, pirido[2,3-d]piridazin- és pirido[2,3-d]pirimidin-származékok mint KRAS G12C inhibitorok tüdõ-, hasnyálmirigy- vagy vastagbélrák kezelésére |
US20200385364A1 (en) | 2017-01-26 | 2020-12-10 | Araxes Pharma Llc | Fused n-heterocyclic compounds and methods of use thereof |
WO2018218069A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant kras, hras or nras |
US11090304B2 (en) | 2018-05-04 | 2021-08-17 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
JP7361722B2 (ja) | 2018-05-04 | 2023-10-16 | アムジエン・インコーポレーテツド | Kras g12c阻害剤及び同一物の使用方法 |
EP3790886A1 (en) | 2018-05-10 | 2021-03-17 | Amgen Inc. | Kras g12c inhibitors for the treatment of cancer |
WO2019232419A1 (en) | 2018-06-01 | 2019-12-05 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
CA3099799A1 (en) | 2018-06-11 | 2019-12-19 | Amgen Inc. | Kras g12c inhibitors for treating cancer |
AU2019336588B2 (en) | 2018-06-12 | 2022-07-28 | Amgen Inc. | KRAS G12C inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer |
EP3810586A1 (en) | 2018-06-21 | 2021-04-28 | Janssen Pharmaceutica NV | Oga inhibitor compounds |
CN112313231B (zh) | 2018-06-21 | 2023-05-09 | 詹森药业有限公司 | Oga抑制剂化合物 |
JP2020090482A (ja) | 2018-11-16 | 2020-06-11 | アムジエン・インコーポレーテツド | Kras g12c阻害剤化合物の重要な中間体の改良合成法 |
CA3117222A1 (en) | 2018-11-19 | 2020-05-28 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法 |
EP3738593A1 (en) | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
JP2022532790A (ja) | 2019-05-21 | 2022-07-19 | アムジエン・インコーポレーテツド | 固体形態 |
SG11202112855WA (en) | 2019-05-21 | 2021-12-30 | Amgen Inc | Solid state forms |
CA3155857A1 (en) | 2019-10-24 | 2021-04-29 | Amgen Inc. | PYRIDOPYRIMIDINE DERIVATIVES USEFUL AS KRAS G12C AND KRAS G12D INHIBITORS IN THE TREATMENT OF CANCER |
AU2020381492A1 (en) | 2019-11-14 | 2022-05-26 | Amgen Inc. | Improved synthesis of KRAS G12C inhibitor compound |
US20230192682A1 (en) | 2019-11-14 | 2023-06-22 | Amgen Inc. | Improved synthesis of kras g12c inhibitor compound |
WO2021126816A1 (en) | 2019-12-16 | 2021-06-24 | Amgen Inc. | Dosing regimen of a kras g12c inhibitor |
EP4153588A1 (en) | 2020-05-20 | 2023-03-29 | Teva Pharmaceuticals International GmbH | Solid state forms of amg-510 and process for preparation thereof |
-
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019031476A (ja) * | 2017-05-22 | 2019-02-28 | アムジエン・インコーポレーテツド | Kras g12c阻害剤及びその使用方法 |
WO2019051291A1 (en) * | 2017-09-08 | 2019-03-14 | Amgen Inc. | KRAS G12C INHIBITORS AND METHODS OF USE |
Non-Patent Citations (3)
Title |
---|
BRIAN A. LANMAN; ET AL: "ABSTRACT 4455: DISCOVERY OF AMG 510, A FIRST-IN-HUMAN COVALENT INHIBITOR OF KRAS(G12C) FOR 以下備考", CANCER RESEARCH, vol. VOL:79, NR:13, SUPPL. S, JPN5022002916, July 2019 (2019-07-01), US, pages 4455 - 1, ISSN: 0005029178 * |
CLINICALTRIALS.GOV ARCHIVE, 3 APRIL 2019, NCT03600833:A PHASE 1, STUDY EVALUATING THE SAFETY, TOLERA, JPN6021040149, ISSN: 0005029179 * |
KAREN REX; ET AL: "ABSTRACT 3090: IN VIVO CHARACTERIZATION OF AMG 510-A POTENT AND SELECTIVE KRAS(G12C) 以下備考", CANCER RESEARCH, vol. VOL:79, NR:13, SUPPL. S, JPN5022002915, July 2019 (2019-07-01), US, pages 3090 - 1, ISSN: 0005029177 * |
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BR112021022812A2 (pt) | 2021-12-28 |
JP7265600B2 (ja) | 2023-04-26 |
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AU2020275845A1 (en) | 2021-12-02 |
IL287838A (en) | 2022-01-01 |
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EP3968998A1 (en) | 2022-03-23 |
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SG11202112432PA (en) | 2021-12-30 |
JP7300076B1 (ja) | 2023-06-28 |
MX2021013788A (es) | 2022-05-18 |
WO2020232130A1 (en) | 2020-11-19 |
TWI826344B (zh) | 2023-12-11 |
US20200360374A1 (en) | 2020-11-19 |
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