BRPI0516592A - composto de fórmula - Google Patents
composto de fórmulaInfo
- Publication number
- BRPI0516592A BRPI0516592A BRPI0516592-0A BRPI0516592A BRPI0516592A BR PI0516592 A BRPI0516592 A BR PI0516592A BR PI0516592 A BRPI0516592 A BR PI0516592A BR PI0516592 A BRPI0516592 A BR PI0516592A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- activity
- formula
- inhibiting
- pi3k
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- AIDS & HIV (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
COMPOSTO DE FóRMULA PROCESSO PARA FAZER O DITO COMPOSTO; MéTODO DE INIBIçãO DA ATIVIDADE DE PI3K EM UMA CéLULA; MéTODO DE INIBIçãO DA ATIVIDADE DE TOR EM UMA CéLULA; MéTODO DE INIBIR ATIVIDADE DE PI3K EM UM MAMìFERO; MéTODO DE INIBIR ATIVIDADE DE TOR EM UM MAMìFERO; MéTODO DE TRATAR UMA CONDIçãO DEPENDENTE DE PI3K; COMPOSIçãO FARMACêUTICA; MéTODO DE TRATAR PROLIFERAçãO DE CéLULA TUMORAL, CRESCIMENTO DE CéLULA TUMORAL OU TUMORIGêNESE; E COMPOSTO ACETATO DE DI-(1E,4S,4AR,5R,6AS, 7S)-1-{ ¢¢3- (DIMETILAMINO) PROPIL! (METIL)AMINO!METILENO}-7,1l- DIIDRóXI-4- (METOXIMETIL) -4A,6A-DIMETIL-2,1O-DIOXO-1,2,4,4A, 5,6,6A,7,8,9,9A,10-DODECAIDROINDENO ¢4,5-H! ISOCROMEN-5-ILA 17 - PEGUILADO. A presente invenção diz respeito a compostos de fórmula I: em que R˜ , R� , R� e R¬ 8¬ são aqui definidos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61765404P | 2004-10-13 | 2004-10-13 | |
PCT/US2005/036664 WO2006044453A1 (en) | 2004-10-13 | 2005-10-13 | Analogs of 17-hydroxywortmannin as pi3k inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0516592A true BRPI0516592A (pt) | 2008-09-23 |
Family
ID=35502459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0516592-0A BRPI0516592A (pt) | 2004-10-13 | 2005-10-13 | composto de fórmula |
Country Status (13)
Country | Link |
---|---|
US (1) | US7666901B2 (pt) |
EP (1) | EP1799699A1 (pt) |
JP (1) | JP2008515984A (pt) |
CN (1) | CN101039952A (pt) |
AR (1) | AR051388A1 (pt) |
AU (1) | AU2005295859A1 (pt) |
BR (1) | BRPI0516592A (pt) |
CA (1) | CA2582163A1 (pt) |
GT (1) | GT200500287A (pt) |
MX (1) | MX2007004489A (pt) |
PE (1) | PE20060608A1 (pt) |
TW (1) | TW200626610A (pt) |
WO (1) | WO2006044453A1 (pt) |
Families Citing this family (84)
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US7081475B2 (en) | 2001-09-14 | 2006-07-25 | Prolx Pharmaceuticals Corp. | Wortmannin analogs and methods of using same |
CA2578336C (en) * | 2004-07-09 | 2013-09-24 | Prolx Pharmaceuticals Corp. | Wortmannin analogs and methods of using same in combination with chemotherapeutic agents |
WO2006084058A2 (en) | 2005-02-03 | 2006-08-10 | The General Hospital Corporation | Method for treating gefitinib resistant cancer |
US8673347B2 (en) * | 2005-08-25 | 2014-03-18 | Creabilis Therapeutics S.P.A. | Polymer conjugates of K-252A and derivatives thereof |
WO2007056118A1 (en) * | 2005-11-04 | 2007-05-18 | Wyeth | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
PL1965790T3 (pl) * | 2005-12-30 | 2012-05-31 | Arizona Board Of Regents Acting On Behalf Of The Univ Of Arizona | Metabolity analogów wortmaniny i sposoby ich stosowania |
CA2654842A1 (en) * | 2006-06-12 | 2007-12-21 | Vertex Pharmaceuticals Incorporated | Thienopyrimidines useful as modulators of ion channels |
JP2010500994A (ja) | 2006-08-16 | 2010-01-14 | エグゼリクシス, インコーポレイテッド | Pi3kおよびmekモジュレーターを使用する方法 |
TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
EP2915532B1 (en) | 2008-06-17 | 2016-10-19 | Wyeth LLC | Antineoplastic combinations containing hki-272 and vinorelbine |
ES2614912T3 (es) | 2008-08-04 | 2017-06-02 | Wyeth Llc | Combinaciones antineoplásicas de 4-anilino-3-cianoquinolinas y capecitabina |
EP2356120B1 (en) * | 2008-09-30 | 2016-10-12 | Pfizer Inc. | Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions |
CA2736361C (en) * | 2008-10-31 | 2017-10-10 | Novartis Ag | Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor |
US20110135655A1 (en) * | 2009-01-13 | 2011-06-09 | PHILADELPHIA HEALTH AND EDUCATION CORPORATION d/b/a Drexel University College of Medicine; | Role of PI3K p110 delta Signaling in Retroviral Infection and Replication |
EP3000467B1 (en) | 2009-04-06 | 2023-03-01 | Wyeth LLC | Treatment regimen utilizing neratinib for breast cancer |
US20100316639A1 (en) | 2009-06-16 | 2010-12-16 | Genentech, Inc. | Biomarkers for igf-1r inhibitor therapy |
JP2013505962A (ja) * | 2009-09-28 | 2013-02-21 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 組合せ |
HUE046606T2 (hu) * | 2009-11-09 | 2020-03-30 | Wyeth Llc | Neratinib maleát tabletta formái |
WO2011067348A2 (en) | 2009-12-03 | 2011-06-09 | Novartis Ag | Mek inhibitor salts and solvates thereof |
WO2011067356A2 (en) | 2009-12-03 | 2011-06-09 | Novartis Ag | Polymorphs of a mek inhibitor |
RU2012146083A (ru) | 2010-03-30 | 2014-05-10 | Новартис Аг | Ингибиторы ркс для лечения в-клеточной лимфомы с хроническими активным сигнальным каскадом в-клеточного рецептора |
WO2011161216A1 (en) | 2010-06-25 | 2011-12-29 | Novartis Ag | Heteroaryl compounds and compositions as protein kinase inhibitors |
TWI431009B (zh) * | 2012-04-02 | 2014-03-21 | Food Industry Res & Dev Inst | 具細胞毒性之化合物、組合物以及其製備方法與用途 |
EP2914260A1 (en) | 2012-10-31 | 2015-09-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preventing antiphospholipid syndrome (aps) |
BR112015023203A8 (pt) | 2013-03-15 | 2018-01-23 | Constellation Pharmaceuticals Inc | métodos para tratamento de câncer, método para aumentar a eficiência de um tratamento de câncer, método para retardar e/ou prevenir o desenvolvimento de câncer, método para tratar um indivíduo com câncer, método para aumentar a sensibilidade para um agente de terapia para câncer, método para estender um período de sensibilidade e método para estender a duração da resposta para uma terapia para câncer. |
HUE056777T2 (hu) | 2016-12-22 | 2022-03-28 | Amgen Inc | Benzizotiazol-, izotiazolo[3,4-b]piridin-, kinazolin-, ftálazin-, pirido[2,3-d]piridazin- és pirido[2,3-d]pirimidin-származékok mint KRAS G12C inhibitorok tüdõ-, hasnyálmirigy- vagy vastagbélrák kezelésére |
JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
JP7150823B2 (ja) | 2017-09-08 | 2022-10-11 | アムジエン・インコーポレーテツド | KRas G12Cの阻害剤及びそれを使用する方法 |
US11090304B2 (en) | 2018-05-04 | 2021-08-17 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
JP7361722B2 (ja) | 2018-05-04 | 2023-10-16 | アムジエン・インコーポレーテツド | Kras g12c阻害剤及び同一物の使用方法 |
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JP2020090482A (ja) | 2018-11-16 | 2020-06-11 | アムジエン・インコーポレーテツド | Kras g12c阻害剤化合物の重要な中間体の改良合成法 |
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JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法 |
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EP3898616A1 (en) | 2018-12-20 | 2021-10-27 | Amgen Inc. | Heteroaryl amides useful as kif18a inhibitors |
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CA3130083A1 (en) | 2019-03-01 | 2020-09-10 | Revolution Medicines, Inc. | Bicyclic heterocyclyl compounds and uses thereof |
MX2021010319A (es) | 2019-03-01 | 2021-12-10 | Revolution Medicines Inc | Compuestos biciclicos de heteroarilo y usos de estos. |
EP3738593A1 (en) | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
SG11202112855WA (en) | 2019-05-21 | 2021-12-30 | Amgen Inc | Solid state forms |
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CN110563591B (zh) * | 2019-09-11 | 2022-06-24 | 西安瑞联新材料股份有限公司 | 一种n,n,n′-三甲基乙二胺的绿色环保合成方法 |
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AU2002330029B2 (en) | 2001-09-14 | 2006-07-06 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Wortmannin analogs and methods of using same |
WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
US20030194749A1 (en) * | 2002-02-15 | 2003-10-16 | Wandless Thomas J. | Wortmannin derivatives as probes of cellular proteins and processes |
US20040213757A1 (en) | 2003-04-23 | 2004-10-28 | Wyeth Holdings Corporation | Water soluble wortmannin derivatives |
CA2578336C (en) * | 2004-07-09 | 2013-09-24 | Prolx Pharmaceuticals Corp. | Wortmannin analogs and methods of using same in combination with chemotherapeutic agents |
-
2005
- 2005-10-13 BR BRPI0516592-0A patent/BRPI0516592A/pt not_active IP Right Cessation
- 2005-10-13 PE PE2005001208A patent/PE20060608A1/es not_active Application Discontinuation
- 2005-10-13 AR ARP050104294A patent/AR051388A1/es not_active Application Discontinuation
- 2005-10-13 JP JP2007536835A patent/JP2008515984A/ja not_active Withdrawn
- 2005-10-13 AU AU2005295859A patent/AU2005295859A1/en not_active Abandoned
- 2005-10-13 US US11/248,510 patent/US7666901B2/en not_active Expired - Fee Related
- 2005-10-13 CA CA002582163A patent/CA2582163A1/en not_active Abandoned
- 2005-10-13 TW TW094135618A patent/TW200626610A/zh unknown
- 2005-10-13 CN CNA2005800349346A patent/CN101039952A/zh active Pending
- 2005-10-13 EP EP05807576A patent/EP1799699A1/en not_active Withdrawn
- 2005-10-13 MX MX2007004489A patent/MX2007004489A/es unknown
- 2005-10-13 WO PCT/US2005/036664 patent/WO2006044453A1/en active Application Filing
- 2005-10-13 GT GT200500287A patent/GT200500287A/es unknown
Also Published As
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TW200626610A (en) | 2006-08-01 |
MX2007004489A (es) | 2007-09-21 |
GT200500287A (es) | 2006-04-17 |
AU2005295859A1 (en) | 2006-04-27 |
PE20060608A1 (es) | 2006-08-22 |
AR051388A1 (es) | 2007-01-10 |
US7666901B2 (en) | 2010-02-23 |
US20060128793A1 (en) | 2006-06-15 |
WO2006044453A1 (en) | 2006-04-27 |
EP1799699A1 (en) | 2007-06-27 |
JP2008515984A (ja) | 2008-05-15 |
CA2582163A1 (en) | 2006-04-27 |
CN101039952A (zh) | 2007-09-19 |
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