AU2019371209B2 - Novel dipeptide compounds and uses thereof - Google Patents

Novel dipeptide compounds and uses thereof Download PDF

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Publication number
AU2019371209B2
AU2019371209B2 AU2019371209A AU2019371209A AU2019371209B2 AU 2019371209 B2 AU2019371209 B2 AU 2019371209B2 AU 2019371209 A AU2019371209 A AU 2019371209A AU 2019371209 A AU2019371209 A AU 2019371209A AU 2019371209 B2 AU2019371209 B2 AU 2019371209B2
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AU
Australia
Prior art keywords
optionally substituted
compound
ethyl
pharmaceutically acceptable
subject
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AU2019371209A
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AU2019371209A1 (en
Inventor
Yu Huang
Min Li
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Shanghai Synergy Pharmaceutical Sciences Ltd
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Shanghai Synergy Pharmaceutical Sciences Ltd
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Publication of AU2019371209A1 publication Critical patent/AU2019371209A1/en
Assigned to SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES, LTD. reassignment SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES, LTD. Request for Assignment Assignors: HUAHAI US INC
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2019371209A 2018-10-29 2019-10-25 Novel dipeptide compounds and uses thereof Active AU2019371209B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862751984P 2018-10-29 2018-10-29
US62/751,984 2018-10-29
PCT/US2019/057985 WO2020092139A1 (en) 2018-10-29 2019-10-25 Novel dipeptide compounds and uses thereof

Publications (2)

Publication Number Publication Date
AU2019371209A1 AU2019371209A1 (en) 2021-05-27
AU2019371209B2 true AU2019371209B2 (en) 2025-05-01

Family

ID=70464360

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019371209A Active AU2019371209B2 (en) 2018-10-29 2019-10-25 Novel dipeptide compounds and uses thereof

Country Status (10)

Country Link
US (1) US12209141B2 (OSRAM)
EP (1) EP3873916B8 (OSRAM)
JP (1) JP7503561B2 (OSRAM)
KR (1) KR102882178B1 (OSRAM)
CN (2) CN116813691B (OSRAM)
AU (1) AU2019371209B2 (OSRAM)
CA (1) CA3117599A1 (OSRAM)
IL (1) IL282676B1 (OSRAM)
TW (1) TWI870362B (OSRAM)
WO (1) WO2020092139A1 (OSRAM)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116813691B (zh) * 2018-10-29 2024-04-12 丽珠医药集团股份有限公司 新的二肽类化合物及其用途
JP2026504578A (ja) * 2023-02-16 2026-02-05 浙江華海薬業股▲フン▼有限公司 ジペプチド類化合物の塩、ならびにその調製方法および使用
CN118496301A (zh) * 2023-02-16 2024-08-16 丽珠医药集团股份有限公司 一种二肽类化合物的盐、其制备方法和用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2639230A1 (en) * 2010-11-08 2013-09-18 Shanghai Institute of Pharmaceutical Industry Prolinamide derivative as thrombin inhibitor, preparation method and application thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087380A (en) 1949-11-24 2000-07-11 Boehringer Ingelheim Pharma Kg Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions
MX9201416A (es) * 1991-03-28 1992-10-01 Rhone Poulenc Rorer Int Peptidos y pseudopeptidos antitromboticos.
JP4561696B2 (ja) 1994-01-27 2010-10-13 三菱化学株式会社 プロリンアミド誘導体
FR2793248B1 (fr) * 1999-05-03 2001-06-29 Adir Nouveaux derives de 2,3-methano-aminoacides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6774110B2 (en) 2001-03-19 2004-08-10 Lg Life Sciences Ltd. Orally available peptidic thrombin inhibitors
FR2836143B1 (fr) 2002-02-21 2004-04-16 Servier Lab Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20030181488A1 (en) 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
DE10339862A1 (de) 2003-08-29 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel
EP1778616A1 (en) * 2004-08-09 2007-05-02 Cancer Research Technology Limited Alpha-ketoglutarates and their use as therapeutic agents
DE102004062864A1 (de) 2004-12-21 2006-06-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Folienbehälter
CN100502914C (zh) * 2005-10-24 2009-06-24 丽珠医药集团股份有限公司 一种治疗脑中风的中药组合物及其制备方法
KR20080104352A (ko) * 2006-03-29 2008-12-02 쉐링 코포레이션 트롬빈 수용체 길항제로서 유용한 모노사이클릭 및 비사이클릭 힘바신 유도체
EP2152664B1 (en) * 2007-06-13 2014-09-03 Bristol-Myers Squibb Company Dipeptide analogs as coagulation factor inhibitors
TWI513466B (zh) 2010-01-20 2015-12-21 Boehringer Ingelheim Int 抗凝血劑解毒劑
CN102796168B (zh) * 2011-05-27 2014-02-26 首都医科大学 一种具有溶血栓活性的化合物，及其制备方法和应用
CN103833827B (zh) * 2012-11-27 2016-08-03 上海医药工业研究院 一种酰胺类化合物、其药物组合物、制备方法及应用
JP6386035B2 (ja) * 2013-06-12 2018-09-05 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 金属酵素阻害剤化合物
CN106316975A (zh) * 2015-06-15 2017-01-11 山东轩竹医药科技有限公司 酰胺类化合物及其作为tgr5激动剂的应用
CN116813691B (zh) * 2018-10-29 2024-04-12 丽珠医药集团股份有限公司 新的二肽类化合物及其用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2639230A1 (en) * 2010-11-08 2013-09-18 Shanghai Institute of Pharmaceutical Industry Prolinamide derivative as thrombin inhibitor, preparation method and application thereof

Also Published As

Publication number Publication date
CN113195515B (zh) 2024-11-15
AU2019371209A1 (en) 2021-05-27
CA3117599A1 (en) 2020-05-07
JP7503561B2 (ja) 2024-06-20
TW202031674A (zh) 2020-09-01
EP3873916B8 (en) 2025-03-26
US20210395299A1 (en) 2021-12-23
CN116813691B (zh) 2024-04-12
WO2020092139A1 (en) 2020-05-07
EP3873916A1 (en) 2021-09-08
EP3873916B1 (en) 2025-02-19
TWI870362B (zh) 2025-01-21
KR102882178B1 (ko) 2025-11-05
EP3873916C0 (en) 2025-02-19
US12209141B2 (en) 2025-01-28
JP2022509366A (ja) 2022-01-20
EP3873916A4 (en) 2022-08-10
IL282676A (en) 2021-06-30
IL282676B1 (en) 2026-03-01
CN116813691A (zh) 2023-09-29
KR20210086682A (ko) 2021-07-08
CN113195515A (zh) 2021-07-30

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