AU2019277679B2 - Methods for the treatment of bladder cancer - Google Patents
Methods for the treatment of bladder cancer Download PDFInfo
- Publication number
- AU2019277679B2 AU2019277679B2 AU2019277679A AU2019277679A AU2019277679B2 AU 2019277679 B2 AU2019277679 B2 AU 2019277679B2 AU 2019277679 A AU2019277679 A AU 2019277679A AU 2019277679 A AU2019277679 A AU 2019277679A AU 2019277679 B2 AU2019277679 B2 AU 2019277679B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- leu
- pharmaceutically acceptable
- vol
- sting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862679495P | 2018-06-01 | 2018-06-01 | |
| US62/679,495 | 2018-06-01 | ||
| US201962826347P | 2019-03-29 | 2019-03-29 | |
| US62/826,347 | 2019-03-29 | ||
| PCT/US2019/034933 WO2019232392A1 (en) | 2018-06-01 | 2019-05-31 | Methods for the treatment of bladder cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2019277679A1 AU2019277679A1 (en) | 2020-12-24 |
| AU2019277679B2 true AU2019277679B2 (en) | 2024-11-28 |
Family
ID=67138025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019277679A Active AU2019277679B2 (en) | 2018-06-01 | 2019-05-31 | Methods for the treatment of bladder cancer |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12251394B2 (https=) |
| EP (1) | EP3801561B1 (https=) |
| JP (1) | JP7335277B2 (https=) |
| KR (1) | KR20210015937A (https=) |
| CN (1) | CN112512531B (https=) |
| AU (1) | AU2019277679B2 (https=) |
| BR (1) | BR112020024605A2 (https=) |
| CA (1) | CA3101623A1 (https=) |
| MX (1) | MX2020012964A (https=) |
| SG (1) | SG11202011434SA (https=) |
| WO (1) | WO2019232392A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202200136A (zh) | 2020-04-10 | 2022-01-01 | 日商小野藥品工業股份有限公司 | 癌治療方法 |
| JP2024533394A (ja) | 2021-09-09 | 2024-09-12 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Ｓｔｉｎｇアゴニストのバイオマーカー及びその使用方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2257704B (en) | 1991-07-18 | 1995-03-01 | Erba Carlo Spa | Cyclic oligonucleotides phosphorothioates |
| WO2005089777A1 (en) | 2004-03-15 | 2005-09-29 | Karaolis David K R | A method for inhibiting cancer cell proliferation or increasing cancer cell apoptosis |
| US7592326B2 (en) | 2004-03-15 | 2009-09-22 | Karaolis David K R | Method for stimulating the immune, inflammatory or neuroprotective response |
| US8076303B2 (en) | 2005-12-13 | 2011-12-13 | Spring Bank Pharmaceuticals, Inc. | Nucleotide and oligonucleotide prodrugs |
| WO2009133560A1 (en) | 2008-04-29 | 2009-11-05 | Smart Assays | Non-hydrolyzable and permeable cyclic bis-[nucleotide monophosphate] derivatives and uses thereof |
| CN102199183B (zh) | 2010-03-26 | 2013-12-18 | 北京大学 | 环二鸟苷酸及其类似物和制备方法 |
| US9695212B2 (en) | 2012-12-13 | 2017-07-04 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| WO2014179760A1 (en) | 2013-05-03 | 2014-11-06 | The Regents Of The University Of California | Cyclic di-nucleotide induction of type i interferon |
| PE20160080A1 (es) | 2013-05-18 | 2016-02-21 | Aduro Biotech Inc | Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon |
| US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
| JP2016538344A (ja) | 2013-11-19 | 2016-12-08 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | 癌処置としてのｓｔｉｎｇアゴニストの使用 |
| WO2015074145A1 (en) | 2013-11-22 | 2015-05-28 | Brock University | Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants |
| CR20160564A (es) | 2014-06-04 | 2017-01-20 | Glaxosmithkline Ip Dev Ltd | Dinucleótidos cíclicos como moduladores de sting |
| EP3546473B1 (en) | 2014-12-16 | 2025-12-10 | Kayla Therapeutics | Fluorinated cyclic [(2',5')p(3',5')p]-dinucleotides for cytokine induction |
| US20180344758A1 (en) | 2014-12-17 | 2018-12-06 | Lipogen Llc | Method of Treating Cancer with cGAMP or cGAsMP |
| GB201501462D0 (en) * | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| EA035817B1 (ru) | 2015-03-10 | 2020-08-14 | Адуро Байотек, Инк. | Композиции и способы для активации сигналинга, зависимого от "гена стимулятора интерферона" |
| KR102222186B1 (ko) | 2015-08-13 | 2021-03-03 | 머크 샤프 앤드 돔 코포레이션 | Sting 효능제로서 시클릭 디-뉴클레오티드 화합물 |
| JP2018534295A (ja) | 2015-10-28 | 2018-11-22 | アドゥロ バイオテック，インク． | 「インターフェロン遺伝子刺激因子」依存性シグナル伝達を活性化するための組成物および方法 |
| CN107849084B (zh) | 2015-12-03 | 2021-09-14 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为sting调节剂的环状嘌呤二核苷酸 |
| US10723756B2 (en) | 2016-01-11 | 2020-07-28 | Innate Tumor Immunity Inc. | Cyclic dinucleotides for treating conditions associated with STING activity such as cancer |
| JP2019510802A (ja) | 2016-04-07 | 2019-04-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | タンパク質調節物質として有用な複素環アミド |
| JOP20170188A1 (ar) | 2016-11-25 | 2019-01-30 | Janssen Biotech Inc | ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting) |
| US20190336615A1 (en) | 2017-01-27 | 2019-11-07 | Silverback Therapeutics, Inc. | Tumor targeting conjugates and methods of use thereof |
| US20200055883A1 (en) * | 2017-02-17 | 2020-02-20 | Eisai R&D Management Co., Ltd. | Cyclic di-nucleotides derivative for the treatment of cancer |
| WO2018198084A1 (en) | 2017-04-27 | 2018-11-01 | Lupin Limited | Cyclic di-nucleotide compounds with tricyclic nucleobases |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
| AR113224A1 (es) * | 2017-04-28 | 2020-02-19 | Novartis Ag | Conjugados de anticuerpo que comprenden un agonista de sting |
| MX2020002303A (es) | 2017-08-30 | 2020-09-10 | Beijing Xuanyi Pharmasciences Co Ltd | Dinucleotidos ciclicos como moduladores del estimulador de genes de interferon. |
| WO2019046511A1 (en) | 2017-08-31 | 2019-03-07 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE |
| US10947263B2 (en) | 2017-08-31 | 2021-03-16 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
| KR102812783B1 (ko) | 2017-08-31 | 2025-05-26 | 브리스톨-마이어스 스큅 컴퍼니 | 항암제로서의 시클릭 디뉴클레오티드 |
| JP7208225B2 (ja) | 2017-08-31 | 2023-01-18 | ブリストル－マイヤーズ スクイブ カンパニー | 抗癌剤としての環状ジヌクレオチド |
-
2019
- 2019-05-31 BR BR112020024605-0A patent/BR112020024605A2/pt unknown
- 2019-05-31 US US17/058,817 patent/US12251394B2/en active Active
- 2019-05-31 CN CN201980050644.2A patent/CN112512531B/zh active Active
- 2019-05-31 WO PCT/US2019/034933 patent/WO2019232392A1/en not_active Ceased
- 2019-05-31 SG SG11202011434SA patent/SG11202011434SA/en unknown
- 2019-05-31 CA CA3101623A patent/CA3101623A1/en active Pending
- 2019-05-31 MX MX2020012964A patent/MX2020012964A/es unknown
- 2019-05-31 JP JP2020566898A patent/JP7335277B2/ja active Active
- 2019-05-31 AU AU2019277679A patent/AU2019277679B2/en active Active
- 2019-05-31 KR KR1020207037794A patent/KR20210015937A/ko active Pending
- 2019-05-31 EP EP19734956.6A patent/EP3801561B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019232392A1 (en) | 2019-12-05 |
| JP7335277B2 (ja) | 2023-08-29 |
| CN112512531A (zh) | 2021-03-16 |
| US12251394B2 (en) | 2025-03-18 |
| CA3101623A1 (en) | 2019-12-05 |
| US20210205348A1 (en) | 2021-07-08 |
| MX2020012964A (es) | 2021-02-16 |
| CN112512531B (zh) | 2024-04-09 |
| SG11202011434SA (en) | 2020-12-30 |
| EP3801561A1 (en) | 2021-04-14 |
| JP2021525758A (ja) | 2021-09-27 |
| BR112020024605A2 (pt) | 2021-04-06 |
| KR20210015937A (ko) | 2021-02-10 |
| EP3801561B1 (en) | 2025-03-19 |
| AU2019277679A1 (en) | 2020-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |