AU2019254237B2 - Method for preventing or treating side effects of cancer therapy - Google Patents

Method for preventing or treating side effects of cancer therapy Download PDF

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Publication number
AU2019254237B2
AU2019254237B2 AU2019254237A AU2019254237A AU2019254237B2 AU 2019254237 B2 AU2019254237 B2 AU 2019254237B2 AU 2019254237 A AU2019254237 A AU 2019254237A AU 2019254237 A AU2019254237 A AU 2019254237A AU 2019254237 B2 AU2019254237 B2 AU 2019254237B2
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Prior art keywords
inhibitor
vegfr
nitric oxide
administration
vegf
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AU2019254237A
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AU2019254237A1 (en
Inventor
Leying CHEN
Chao Liu
Jie Luo
Zhaoyu WU
Linan YANG
Shiyi ZHANG
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Onquality Pharmaceuticals China Ltd
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Onquality Pharmaceuticals China Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Ceramic Engineering (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2019254237A 2018-04-16 2019-04-15 Method for preventing or treating side effects of cancer therapy Active AU2019254237B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810339975 2018-04-16
CN201810339975.5 2018-04-16
PCT/CN2019/082623 WO2019201195A1 (zh) 2018-04-16 2019-04-15 预防或治疗肿瘤疗法副作用的方法

Publications (2)

Publication Number Publication Date
AU2019254237A1 AU2019254237A1 (en) 2020-12-03
AU2019254237B2 true AU2019254237B2 (en) 2025-01-30

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Application Number Title Priority Date Filing Date
AU2019254237A Active AU2019254237B2 (en) 2018-04-16 2019-04-15 Method for preventing or treating side effects of cancer therapy

Country Status (8)

Country Link
US (2) US10987336B2 (https=)
EP (1) EP3782618A4 (https=)
JP (1) JP7520366B2 (https=)
KR (1) KR102831159B1 (https=)
CN (3) CN114028568A (https=)
AU (1) AU2019254237B2 (https=)
TW (1) TW201943428A (https=)
WO (1) WO2019201195A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021073535A1 (zh) * 2019-10-16 2021-04-22 上海岸阔医药科技有限公司 预防或治疗与vegfr和/或vegf被抑制相关疾病的方法
CN111569078A (zh) * 2020-06-18 2020-08-25 上海馨颖生物技术有限公司 Sirt1抑制剂在vegfr抑制剂与免疫检查点抑制剂联用引起的副作用上的应用
WO2022052874A1 (zh) * 2020-09-09 2022-03-17 深圳微芯生物科技股份有限公司 西奥罗尼联合免疫检查点抑制剂在抗肿瘤治疗中的应用
US20240139316A1 (en) * 2021-03-10 2024-05-02 Canariabio Inc. Use of oregovomab and bevacizumab, paclitaxel, carboplatin for treatment of brca-wild type platinum sensitive recurrent
KR102511934B1 (ko) * 2021-04-27 2023-03-21 재단법인 아산사회복지재단 피부 색소침착의 예방, 개선, 또는 치료용 조성물
KR20240144944A (ko) * 2022-01-28 2024-10-04 온퀄리티 파마슈티컬스 차이나 리미티드 항종양제와 관련된 질병 또는 증상을 예방하거나 치료하는 방법
KR20230140407A (ko) * 2022-03-24 2023-10-06 서울대학교산학협력단 로-키나제 억제제를 포함하는 켈로이드 등 피부 섬유화 질환의 예방 또는 치료용 약학적 조성물 및 그의 용도
CN116211789A (zh) * 2023-01-28 2023-06-06 上海岸阔医药科技有限公司 组合物及其用途
CN117180246B (zh) * 2023-11-02 2024-01-26 西北农林科技大学深圳研究院 异甘草素在制备防治虾白斑综合征药物中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001080890A2 (en) * 2000-04-26 2001-11-01 Queen's University At Kingston Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
WO2010037095A2 (en) * 2008-09-29 2010-04-01 Nometics Agents and methods for the treatment of cancer
WO2014160628A2 (en) * 2013-03-25 2014-10-02 Sloan-Kettering Institute For Cancer Research Articles and methods for preventing and treating dermatologic adverse events
WO2019114705A1 (zh) * 2017-12-13 2019-06-20 上海小午医药科技有限公司 一种用于预防或治疗与egfr被抑制相关疾病的方法

Family Cites Families (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2833010A (en) 1954-02-01 1958-05-06 Rosenthal Harry Laundry clip
CA1163561A (en) 1979-11-06 1984-03-13 Cyril Boroda Preparation containing nitroglycerine and optionally other medicaments and preparation thereof
US4450175A (en) 1982-09-23 1984-05-22 Warshaw Thelma G Method and compositions for treating acne
US20030206899A1 (en) 1991-03-29 2003-11-06 Genentech, Inc. Vascular endothelial cell growth factor antagonists
US6582959B2 (en) 1991-03-29 2003-06-24 Genentech, Inc. Antibodies to vascular endothelial cell growth factor
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
AU687727B2 (en) 1992-10-28 1998-03-05 Genentech Inc. Vascular endothelial cell growth factor antagonists
US5698589A (en) 1993-06-01 1997-12-16 International Medical Innovations, Inc. Water-based topical cream containing nitroglycerin and method of preparation and use thereof
US5504117A (en) 1994-05-27 1996-04-02 Neptune Pharmaceutical Corporation Pharmacologic preparation for the treatment of anal disorders
JP3211892B2 (ja) 1994-05-27 2001-09-25 セイジィ ファーマスーティカルス インコーポレーテッド 肛門疾患を治療する窒素酸化物供与体及び方法
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
PT971959E (pt) 1997-04-07 2006-05-31 Genentech Inc Anticorpos humanizados e metodos para formar anticorpos humanizados
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
KR100816621B1 (ko) 1997-04-07 2008-03-24 제넨테크, 인크. 항-ｖｅｇｆ 항체
GB9802078D0 (en) 1998-01-30 1998-03-25 Futura Medical Limited Preparation for treatment of erectile dysfunction
US6103275A (en) 1998-06-10 2000-08-15 Nitric Oxide Solutions Systems and methods for topical treatment with nitric oxide
GB9818524D0 (en) 1998-08-25 1998-10-21 Futura Medical Limited Inorgasmia treatment
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
GB9904930D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Thiazoloindolinone compounds
US6703020B1 (en) 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
US20040191276A1 (en) 1999-11-30 2004-09-30 Cutispharma, Inc. Compositions and kits for compounding pharmaceuticals
US20020049188A1 (en) 1999-12-15 2002-04-25 Azarnoff Daniel L. Nitroglycerin ointment for treatment of pain associated with anal disease
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
WO2001070255A2 (en) 2000-03-20 2001-09-27 Pfizer Products, Inc. Combined treatment with keratinocyte growth factor and epidermal growth factor inhibitor
US20030157037A1 (en) 2000-05-24 2003-08-21 Joachim Bunger Use of aryl oximes for the prophylaxis and/or treatment of erythema formation and/or inflammatory reaction of the skin
KR20030065463A (ko) 2000-08-11 2003-08-06 데이비드 알. 휘트록 질소 산화물 및 질소 산화물 전구체의 생산을 증가시키기위한 암모니아 산화 박테리아를 포함하는 조성물 및 이를이용하는 방법
US6780849B2 (en) 2000-12-21 2004-08-24 Scimed Life Systems, Inc. Lipid-based nitric oxide donors
WO2002069906A2 (en) 2001-03-06 2002-09-12 Cellegy Pharmaceuticals, Inc. Compounds and methods for the treatment of urogenital disorders
CN1308438C (zh) 2002-01-11 2007-04-04 大卫·R·怀特洛克 含有氨氧化细菌的化合物以及使用的方法
US6979688B2 (en) 2002-02-12 2005-12-27 Ford John P Treatment method against side-effects of chemotherapy
US7816366B2 (en) 2002-02-12 2010-10-19 Asymmetric Therapeutics, Llc Compositions and methods for treating and preventing dermatoses
US6995165B2 (en) 2002-02-12 2006-02-07 Ford John P Methods, compositions, and kits for organ protection during systemic anticancer therapy
AU2003223491A1 (en) 2002-04-05 2003-10-27 Nitromed, Inc. Nitric oxide donors, compositions and methods of use
WO2004009253A1 (en) 2002-07-19 2004-01-29 University Of North Carolina At Chapel Hill Surface-localized release of an anti-biofouling agent via micropatterning
UA101945C2 (uk) 2003-05-30 2013-05-27 Дженентек, Инк. Лікування злоякісного новоутворення за допомогою бевацизумабу
NZ545001A (en) 2003-07-03 2009-09-25 Univ St Andrews Zeolites for delivery of nitric oxide
US20050106667A1 (en) 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
WO2005044853A2 (en) 2003-11-01 2005-05-19 Genentech, Inc. Anti-vegf antibodies
CN1997731A (zh) 2003-09-26 2007-07-11 大卫·R·怀特洛克 使用氨氧化细菌的方法
EP1667646A4 (en) 2003-09-26 2007-07-04 David R Whitlock METHOD FOR USE OF AMMONIA-OXIDATING BACTERIA
EP1732577B1 (en) 2004-02-23 2013-04-10 Strategic Science & Technologies, LLC Topical delivery of l-arginine to improve body and skin appearance
CN1568943A (zh) 2004-04-26 2005-01-26 江苏省药物研究所 硝酸甘油软膏及其制备方法和应用
US20060009360A1 (en) 2004-06-25 2006-01-12 Robert Pifer New adjuvant composition
EP1871433B1 (en) 2005-03-24 2009-04-22 NOLabs AB Cosmetic treatment with nitric oxide, device for performing said treatment and manufacturing method therefor
EP1704876A1 (en) 2005-03-24 2006-09-27 NOLabs AB Cosmetic treatment, device for performing said treatment and manufacturing method thereof
CA2603785C (en) 2005-04-15 2014-07-22 Roman Perez-Soler Vitamin k for prevention and treatment of skin rash secondary to anti-egfr therapy
DK2439273T3 (da) 2005-05-09 2019-06-03 Ono Pharmaceutical Co Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
WO2006127591A2 (en) 2005-05-23 2006-11-30 Nitromed, Inc. Organic nitric oxide enhancing salts of nonsteroidal antiinflammatory compounds, compositions and methods of use
EP1888510A4 (en) 2005-05-27 2013-01-16 Univ North Carolina NITROGEN OXIDE-RELATED PARTICLES FOR NITROGEN OXIDE THERAPEUTICS AND BIOMEDICAL APPLICATIONS
PT1907424E (pt) 2005-07-01 2015-10-09 Squibb & Sons Llc Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
CN101283275A (zh) 2005-10-11 2008-10-08 默克专利有限公司 趋化因子表达的依赖egfr的调控和对肿瘤的诊断和治疗的影响及其副作用
US20070172847A1 (en) 2005-11-15 2007-07-26 The Regents Of The University Of California Molecular signaling pathways triggered by rituximab: prognostic, diagnostic, and therapeutic uses
WO2007138103A1 (en) 2006-06-01 2007-12-06 Nobera Pharma, S.L. Use of allopurinol for the treatment of palmar plantar erythrodysesthesia
EP2043685B1 (en) 2006-07-03 2015-12-23 Genmab A/S Prevention of rash in patients undergoing anti-egfr therapy
GB0616350D0 (en) 2006-08-17 2006-09-27 Univ St Andrews Adsorption and release of nitric oxide in metal organic frameworks
US8399005B2 (en) 2007-10-12 2013-03-19 University Of North Carolina At Chapel Hill Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents
WO2009100367A2 (en) 2008-02-06 2009-08-13 Adherex Technologies Inc. Compositions comprising topical dpd inhibitors and methods of using same in the treatment of hand-foot syndrome
CN101970499B (zh) 2008-02-11 2014-12-31 治疗科技公司 用于肿瘤治疗的单克隆抗体
EP2262837A4 (en) 2008-03-12 2011-04-06 Merck Sharp & Dohme PD-1 BINDING PROTEINS
US8815953B2 (en) 2008-03-13 2014-08-26 Spectrum Pharmaceuticals, Inc. Formulations of vitamin K analogs for topical use
FR2929278A1 (fr) 2008-04-01 2009-10-02 Centre Nat Rech Scient Solide hybride cristallin poreux pour l'adsorption et la liberation de gaz a interet biologique.
US20100016446A1 (en) 2008-07-21 2010-01-21 Sylvia Gonda Stable water-based topical pharmaceutical creams and methods of making and using same
AU2009288730B2 (en) 2008-08-25 2013-06-20 Amplimmune, Inc. Compositions of PD-1 antagonists and methods of use
WO2010044875A2 (en) 2008-10-16 2010-04-22 Novan, Inc. Nitric oxide releasing particles for oral care applications
EP3255060A1 (en) 2008-12-09 2017-12-13 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
EP2201942A1 (de) 2008-12-23 2010-06-30 Intendis GmbH Zusammensetzung mit Hanföl für die Behandlung topischer Erkrankungen
EP2246057A1 (en) 2009-04-29 2010-11-03 Nobera Pharma, S.L. Use of allopurinol for the treatment of hand foot skin reaction
WO2010148572A1 (en) * 2009-06-26 2010-12-29 Asan Laboratories Co., Ltd. Method for treating or ameliorating mucocutaneous or ocular toxicities
JP6159084B2 (ja) 2009-06-30 2017-07-05 デルマン バイオメディシン カンパニー リミテッド 酒さまたは赤面に関連する皮膚疾患を治療するための、ベルベリンまたはその類似体を含有する組成物
BR112012003804B1 (pt) 2009-08-21 2019-02-19 Novan, Inc. Curativo para ferimentos, método para formar um curativo para ferimentos, e, kit de curativo para ferimento
WO2011022652A1 (en) 2009-08-21 2011-02-24 Novan, Inc. Topical gels
WO2011047013A1 (en) 2009-10-13 2011-04-21 Novan, Inc. Nitric oxide-releasing coatings
JP2013508295A (ja) 2009-10-16 2013-03-07 デューク・ユニヴァーシティ 薬物誘発性手足症候群を治療するための組成物および方法
US20110190244A1 (en) 2010-02-01 2011-08-04 Peter Maccallum Cancer Institute Method of treatment of egfr inhibitor toxicity
WO2011097360A1 (en) 2010-02-05 2011-08-11 Deland M Maitland Led treatment of dermatologic toxicities associated with epidermal growth factor receptor inhibitors
US8795263B2 (en) 2010-02-05 2014-08-05 M. Maitland DeLand LED treatment of dermatologic toxicities associated with multikinase inhibitors
WO2011097358A1 (en) 2010-02-05 2011-08-11 Deland M Maitland Led treatment of dermatologic toxicities associated with vascular endothelial growth factor inhibitors
EP2368549A1 (en) 2010-03-25 2011-09-28 BioAlliance Pharma Treating hand-foot syndrome and related pathologies using clonidine or its derivatives
US8729056B2 (en) 2010-03-31 2014-05-20 Ono Pharmaceutical Co., Ltd. Preventive and/or therapeutic agent of hand-foot syndrome
WO2012055057A1 (en) 2010-10-29 2012-05-03 Neurotune Ag Therapeutic use of dimiracetam to prevent the hand & foot syndrome caused by sorafenib
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
EP2665763B1 (en) 2011-01-20 2015-08-26 Novan, Inc. Temperature controlled sol-gel co-condensation
ES2695173T3 (es) 2011-02-28 2019-01-02 Novan Inc Partículas de sílice modificadas con S-nitrosotiol que liberan óxido nítrico y procedimientos de fabricación de las mismas
CN111789956B (zh) 2011-04-27 2023-02-17 耶鲁大学 用于抑制化疗引起副作用的药物治疗、筛选技术和试剂盒
WO2012153331A2 (en) 2011-05-09 2012-11-15 Topical Therapeutic Agent (Tta) Ltd. Nitric oxide-sequestering topical formulations
EP2729174A1 (en) 2011-07-08 2014-05-14 Merck Sharp & Dohme Corp. Il-23 antagonists for treatment or prevention of skin rash associated with treatment with p13k/akt pathway inhibitors
ES2658897T3 (es) 2011-08-24 2018-03-12 Novan, Inc. Macromoléculas de liberación de óxido nítrico ajustables que tienen múltiples estructuras donantes de óxido nítrico
WO2013063354A1 (en) 2011-10-27 2013-05-02 Novan, Inc. Nitric oxide releasing bath compositions and methods of using the same
CN103127504A (zh) 2011-12-05 2013-06-05 尼奥克斯(文莱)控股有限公司 局部产生一氧化氮的组合物和方法
EP2601965A1 (en) 2011-12-06 2013-06-12 Apeiron Biologics AG Compositions for preventing or treating adverse reactions of EGFR inhibition
EP2798365A1 (en) 2011-12-27 2014-11-05 Université Catholique de Louvain Method for measuring nitric oxide in blood
US20150111973A1 (en) 2012-03-13 2015-04-23 Novan, Inc. Methods of modulating steroid hormone activity
ES2861439T3 (es) 2012-03-14 2021-10-06 Novan Inc Composiciones farmacéuticas que liberan óxido nítrico
WO2013157891A1 (ko) 2012-04-19 2013-10-24 부산대학교 산학협력단 Ｅｇｆｒ 억제제 유발 피부 부작용의 예방 또는 치료용 국소용 약학 조성물
CN103446261B (zh) 2012-06-05 2015-04-15 中国医学科学院肿瘤医院 一种预防和/或治疗肿瘤治疗相关皮肤损害的中药组合物
EP2885323B1 (en) 2012-08-17 2023-08-30 The University of North Carolina At Chapel Hill Water soluble nitric oxide-releasing polyglucosamines and uses thereof
EP2700413B1 (en) 2012-08-20 2015-10-14 Bionoox Suisse SA Composition comprising dihydroquercetin, alpha-tocopherol and bisabolol
US9187501B2 (en) 2012-08-28 2015-11-17 The University Of North Carolina At Chapel Hill Nitric oxide-releasing nanorods and their methods of use
US8871256B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and systems for treatment of inflammatory diseases with nitric oxide
US8871254B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US9855211B2 (en) 2013-02-28 2018-01-02 Novan, Inc. Topical compositions and methods of using the same
GB201305947D0 (en) 2013-04-02 2013-05-15 Univ Sheffield New method 1
US20150313896A1 (en) 2013-07-26 2015-11-05 Galderma Research & Development Method for treating cell proliferation disorders
US11813284B2 (en) 2013-08-08 2023-11-14 Novan, Inc. Topical compositions and methods of using the same
TW201538156A (zh) 2013-12-19 2015-10-16 Twi Biotechnology Inc 小蘗鹼配方及其用途
US20160263092A1 (en) 2013-12-19 2016-09-15 Twi Biotechnology, Inc. Therapeutic uses of berberine formulations
KR20210100224A (ko) 2014-04-15 2021-08-13 에이오바이오미 엘엘씨 암모니아-산화 니트로소모나스 유트로파 균주 d23
US10078054B2 (en) 2014-05-08 2018-09-18 Aobiome Llc Systems and methods for detecting nitric oxide
CA2949833C (en) 2014-05-22 2024-06-11 Aobiome Llc Methods of preparing materials with ammonia oxidizing bacteria and testing materials for ammonia oxidizing bacteria
US10383900B2 (en) 2014-05-22 2019-08-20 Aobiome Llc Systems and methods for storage and delivery of ammonia oxidizing bacteria
US20170202917A1 (en) 2014-05-29 2017-07-20 Daewoong Pharmaceutical Co., Ltd. Pharmaceutical composition for preventing or treating skin rash
BR112016030275A2 (pt) 2014-06-24 2017-08-22 Galderma Sa Métodos para tratamento e redução dos sintomas da síndrome mão-pé (eritrodisestesia palmo-plantar)
WO2016160089A1 (en) 2015-03-27 2016-10-06 Novan, Inc. Topical antiviral compositions, delivery systems, and methods of using the same
EP3166593B1 (en) 2014-07-11 2020-05-20 Novan, Inc. Topical antiviral compositions and methods of using the same
US10925689B2 (en) 2014-07-14 2021-02-23 Novan, Inc. Nitric oxide releasing nail coating compositions, nitric oxide releasing nail coatings, and methods of using the same
EP3177262A4 (en) 2014-08-08 2018-04-18 Novan Inc. Topical emulsions
KR20170060042A (ko) * 2014-09-13 2017-05-31 노파르티스 아게 Alk 억제제의 조합 요법
EP3034092A1 (en) * 2014-12-17 2016-06-22 Université de Lausanne Adoptive immunotherapy for treating cancer
CN204411249U (zh) 2014-12-26 2015-06-24 朴瑛 一种肿瘤患者化疗后手足综合症的多功能康复装置
WO2016161285A1 (en) 2015-04-02 2016-10-06 Aobiome Llc Production of nitro-fatty acids and nitro-hydrocarbons by ammonia oxidizing bacteria
EP3313520A4 (en) 2015-06-24 2019-01-02 TWI Biotechnology, Inc. Therapeutic uses of berberine formulations
WO2017004557A1 (en) 2015-07-02 2017-01-05 Aobiome Llc Ammonia oxidizing bacteria for treatment of acne
CN109069878A (zh) 2015-07-02 2018-12-21 Ao生物医学有限责任公司 微生物群系相容性化妆品
WO2017009824A1 (en) 2015-07-16 2017-01-19 Neotech-Kordan Group Ltd. Formulation methods and ointment formulations therein containing uracil, thymine, and/or their derivatives for treatment and prevention of hand-and-foot syndrome
WO2017019614A1 (en) 2015-07-28 2017-02-02 Novan, Inc. Combinations and methods for the treatment and/or prevention of fungal infections
WO2017029647A1 (en) 2015-08-20 2017-02-23 Meir Eini Tetracycline management of egfr inhibitor associated dermatoses
US11420986B2 (en) 2015-11-02 2022-08-23 The University Of North Carolina At Chapel Hill Functionalized mesoporous silica via an aminosilane surfactant ion exchange reaction: controlled scaffold design and nitric oxide release
CN105381070A (zh) 2015-12-22 2016-03-09 浙江大学 犀角地黄药物组合物在制备预防及治疗表皮生长因子受体抑制剂所致相关皮疹药物中的用途
US10912743B2 (en) 2016-03-02 2021-02-09 Novan, Inc. Compositions for treating inflammation and methods of treating the same
JP2019507794A (ja) 2016-03-10 2019-03-22 ルトリス ファーマ エル ティー ディー． 皮膚反応を治療するためのｂｒａｆ阻害剤の使用
EP3432926A4 (en) 2016-03-21 2019-11-20 Mayo Foundation for Medical Education and Research METHOD FOR REDUCING THE TOXICITY OF CHEMOTHERAPEUTICS
WO2017223182A1 (en) 2016-06-22 2017-12-28 Medchem Partners, Llc. Nitric oxide donors
CN109689076A (zh) 2016-07-19 2019-04-26 Ao生物医学有限责任公司 用于胃肠系统使用和递送至胃肠系统的氨氧化微生物
BR112019005536A2 (pt) 2016-09-21 2019-06-25 Aobiome Llc microrganismos oxidantes de amônia para uso e entrega para o sistema intranasal
AU2017375944A1 (en) 2016-12-12 2019-07-04 Aobiome Llc Ammonia oxidizing microorganisms for the regulation of blood pressure
CN106539924A (zh) 2016-12-22 2017-03-29 张丽燕 一种预防和缓解化疗所致手足综合症的中药手套和袜子
CN107158287A (zh) 2017-03-25 2017-09-15 许进秀 缓解吉非替尼/厄洛替尼引起的皮肤毒性的中药
CN107412455A (zh) 2017-04-21 2017-12-01 曹师磊 一种治疗皮疹的天然外用药物组合物及其制备方法
CN107198718A (zh) 2017-05-04 2017-09-26 常州桐树生物科技有限公司 一种外用治疗皮疹的中药组合物及其制备方法和应用
JP7103363B2 (ja) 2017-09-21 2022-07-20 味の素株式会社 手足症候群の予防または改善用組成物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001080890A2 (en) * 2000-04-26 2001-11-01 Queen's University At Kingston Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
WO2010037095A2 (en) * 2008-09-29 2010-04-01 Nometics Agents and methods for the treatment of cancer
WO2014160628A2 (en) * 2013-03-25 2014-10-02 Sloan-Kettering Institute For Cancer Research Articles and methods for preventing and treating dermatologic adverse events
WO2019114705A1 (zh) * 2017-12-13 2019-06-20 上海小午医药科技有限公司 一种用于预防或治疗与egfr被抑制相关疾病的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KRUZLIAK P., et al., "Therapeutic potential of nitric oxide donors in the prevention and treatment of angiogenesis-inhibitor-induced hypertension", ANGIOGENESIS, (2013), vol. 16, pages 289 - 295. *

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