AU2018354090B2 - Fatty acid analogs and their use in the treatment of conditions related to metabolic syndrome - Google Patents

Fatty acid analogs and their use in the treatment of conditions related to metabolic syndrome Download PDF

Info

Publication number
AU2018354090B2
AU2018354090B2 AU2018354090A AU2018354090A AU2018354090B2 AU 2018354090 B2 AU2018354090 B2 AU 2018354090B2 AU 2018354090 A AU2018354090 A AU 2018354090A AU 2018354090 A AU2018354090 A AU 2018354090A AU 2018354090 B2 AU2018354090 B2 AU 2018354090B2
Authority
AU
Australia
Prior art keywords
disease
acid
compound
pharmaceutically acceptable
tetrazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2018354090A
Other languages
English (en)
Other versions
AU2018354090A1 (en
Inventor
Richard Lumpkin
John Reiner
Stephanie Venn-Watson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epitracker Inc
Original Assignee
Epitracker Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epitracker Inc filed Critical Epitracker Inc
Publication of AU2018354090A1 publication Critical patent/AU2018354090A1/en
Application granted granted Critical
Publication of AU2018354090B2 publication Critical patent/AU2018354090B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2018354090A 2017-10-23 2018-10-18 Fatty acid analogs and their use in the treatment of conditions related to metabolic syndrome Active AU2018354090B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762575973P 2017-10-23 2017-10-23
US62/575,973 2017-10-23
PCT/US2018/056545 WO2019083816A1 (en) 2017-10-23 2018-10-18 FATTY ACID ANALOGUES AND THEIR USE IN THE TREATMENT OF STATES RELATED TO METABOLIC SYNDROME

Publications (2)

Publication Number Publication Date
AU2018354090A1 AU2018354090A1 (en) 2020-03-12
AU2018354090B2 true AU2018354090B2 (en) 2024-10-24

Family

ID=66170875

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018354090A Active AU2018354090B2 (en) 2017-10-23 2018-10-18 Fatty acid analogs and their use in the treatment of conditions related to metabolic syndrome

Country Status (6)

Country Link
US (3) US10792266B2 (enExample)
EP (1) EP3661600A4 (enExample)
JP (2) JP7312184B2 (enExample)
KR (1) KR102701244B1 (enExample)
AU (1) AU2018354090B2 (enExample)
WO (1) WO2019083816A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3088131A1 (en) * 2017-01-13 2018-07-19 Pietro P. Sanna Methods and compositions for treating hpa hyperactivity
EP3661600A4 (en) 2017-10-23 2021-08-11 Epitracker, Inc. FATTY ACID ANALOGS AND ITS USE IN THE TREATMENT OF DISEASES RELATED TO METABOLISM SYNDROME
JP2021525249A (ja) 2018-05-23 2021-09-24 エピトラッカー インコーポレイテッドＥｐｉｔｒａｃｋｅｒ， Ｉｎｃ． 加齢及び長期性の質に関連する状態の診断及び治療のための組成物及び方法
WO2020146263A1 (en) 2019-01-09 2020-07-16 Epitracker, Inc. Compositions and methods for diagnosis and treatment of neurodegenerative diseases
EP3914242A4 (en) * 2019-01-23 2023-02-01 Epitracker, Inc. COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF QUALITY OF AGING AND LONGEVITY DISORDERS
JP7404382B2 (ja) 2019-03-04 2023-12-25 エピトラッカー インコーポレイテッド 脂肪酸アナログ、ならびに認知機能障害、行動症状および慢性疼痛の処置におけるそれらの使用
EP4199750A4 (en) * 2020-08-20 2024-09-18 Epitracker, Inc. COMPOSITIONS AND METHODS FOR TREATING OBESITY
WO2023080939A1 (en) 2021-11-03 2023-05-11 Epitracker, Inc. Pentadecanoylcarnitine for treatment of conditions related to the quality of aging and longevity
EP4543842A1 (en) * 2022-06-24 2025-04-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fatty acid compounds
WO2024151503A1 (en) * 2023-01-11 2024-07-18 Temple University- Of The Commonwealth System Of Higher Education Treatment of skin disorders with short chain fatty acids
WO2025035125A1 (en) * 2023-08-10 2025-02-13 The Curators Of The University Of Missouri Suppression of type 1 diabetes by intrathymic il-4

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006117668A1 (en) * 2005-05-04 2006-11-09 Pronova Biopharma Norge As Fatty acid analogues, i.e. dha derivatives for uses as a medicament
WO2010128401A1 (en) * 2009-05-08 2010-11-11 Pronova Biopharma Norge As Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas
WO2016111843A1 (en) * 2015-01-07 2016-07-14 Government Of The United States Of America, As Represented By The Secretary Of The Navy Compositions and methods for diagnosis and treatment of metabolic syndrome

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2615061A1 (de) 1976-04-05 1977-10-06 Wolfgang Dr Med Wagner Injektionsverfahren und -vorrichtungen
US4252159A (en) 1979-04-02 1981-02-24 Maki Eugene B Dosage device
JPS60172925A (ja) 1984-02-17 1985-09-06 Kao Corp 胆石溶解剤
JPS6115809A (ja) 1984-06-29 1986-01-23 Lion Corp 細胞賦活剤
DE3501534A1 (de) 1984-09-22 1986-05-15 Walter Ing.(grad.) 7758 Meersburg Holzer Verfahren und vorrichtung zum dosieren von insulin oder aehnlichen langzeitmedikamenten
JPS6212716A (ja) 1985-07-11 1987-01-21 Nippon Oil & Fats Co Ltd 制がん剤
JPH0672142B2 (ja) 1986-10-15 1994-09-14 コニカ株式会社 ４−アミノ−１，２，４−トリアゾリン−５−チオン系化合物の製造方法
EP0317705B1 (de) 1987-11-25 1992-09-30 Siemens Aktiengesellschaft Dosiergerät zum gesteuerten Injizieren von Flüssigkeiten aus einem Vorratsbehälter in einen Organismus
EP0569618B1 (de) 1992-05-12 1997-01-02 Siemens-Elema AB Dosiergerät zur gesteuerten Abgabe einer Flüssigkeit
JP3558351B2 (ja) 1992-12-07 2004-08-25 邦郎 辻 免疫抑制剤
US5449688A (en) 1993-03-30 1995-09-12 The United States Of America As Represented By The Department Of Health And Human Services Method of treating chronic inflammatory diseases
US5465728A (en) 1994-01-11 1995-11-14 Phillips; Michael Breath collection
US5741816A (en) 1994-06-20 1998-04-21 Tanabe Seiyaku Co., Ltd. Hair-growth agent
AUPN137895A0 (en) 1995-02-27 1995-03-16 Clover Corporation Pty Ltd Composition and method
AUPN250795A0 (en) 1995-04-20 1995-05-18 Cultor Ltd. Stress regulator
WO1998058939A1 (en) 1997-06-23 1998-12-30 Polychip Pharmaceuticals Pty. Ltd. Neurologically-active compounds
RU2141483C1 (ru) 1997-07-04 1999-11-20 Небольсин Владимир Евгеньевич Производные пептидов или их фармацевтически приемлемые соли, способ их получения, применение и фармацевтическая композиция
IL121268A0 (en) 1997-07-09 1998-01-04 Dpharm Ltd Branched chain fatty acids their derivatives and use in the treatment of central nervous system disorders
CA2306908C (en) 1997-10-23 2004-06-08 The Procter & Gamble Company Fatty acids, soaps, surfactant systems, and consumer products based thereon
DK0948963T3 (da) 1998-01-21 2003-08-11 Fideline Pacificerende pheromoner til grise med henblik på nedsættelse af stress, angst og aggressivitet
US6214875B1 (en) 1998-04-14 2001-04-10 Zhenhua Yang Anticancer effects of specific branched-chain fatty acids and related production process
WO1999058120A1 (en) 1998-05-08 1999-11-18 Rolf Berge USE OF NON-β-OXIDIZABLE FATTY ACID ANALOGUES FOR TREATMENT OF SYNDROME-X CONDITIONS
US6159485A (en) 1999-01-08 2000-12-12 Yugenic Limited Partnership N-acetyl aldosamines, n-acetylamino acids and related n-acetyl compounds and their topical use
US6544541B1 (en) 1999-06-02 2003-04-08 Cardiovascular Solutions, Inc. Devices and compounds for treating arterial restenosis
US7012053B1 (en) 1999-10-22 2006-03-14 The Procter & Gamble Company Fabric care composition and method comprising a fabric care polysaccharide and wrinkle control agent
US6835750B1 (en) 2000-05-01 2004-12-28 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
NO20006008L (no) 2000-11-28 2002-05-29 Thia Medica As Fettsyreanaloger for behandling av inflammatoriske og autoimmune sykdommer
US6635015B2 (en) 2001-04-20 2003-10-21 The Procter & Gamble Company Body weight management system
EP1404861A4 (en) 2001-06-05 2006-02-01 Philadelphia Children Hospital METHODS AND KITS FOR DIAGNOSING FAT MALABSORPTION DISORDER ASSOCIATED WITH PANCREAS
EP1417211B1 (en) 2001-07-27 2007-05-30 Neptune Technologies & Bioressources Inc. Natural phospholipids of marine origin containing flavonoids and polyunsaturated phospholipids and their uses
FR2828487B1 (fr) 2001-08-09 2005-05-27 Genfit S A Nouveaux composes derives d'acides gras, preparation et utilisations
JP2003160486A (ja) 2001-09-17 2003-06-03 Lion Corp 経口養育毛剤及び該養育毛剤を含有する飲食品
US20030203042A1 (en) 2002-04-24 2003-10-30 Cook Lisa Ann Compositions comprising milk protein concentrate and fatty acid and processes of their preparation
US20030203004A1 (en) 2002-04-24 2003-10-30 Kelm Gary Robert Compositions comprising short and long chain fatty acids and methods of their use for the management of body weight
US20060275294A1 (en) 2002-08-22 2006-12-07 Omoigui Osemwota S Method of prevention and treatment of aging, age-related disorders and/or age-related manifestations including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, arthritis, type 2 diabetes, dementia, alzheimers disease and cancer
JP4286513B2 (ja) 2002-09-26 2009-07-01 株式会社ファンケル 抗老化用組成物
SE0203886D0 (sv) 2002-12-27 2002-12-27 Ltp Lipid Technologies Provide Glycerolesterprodukt och dess användning
ITMI20030210A1 (it) 2003-02-07 2004-08-08 Res & Innovation Soc Coop A R L Composti endocannabinoido-simili e loro impiego
SE0303513D0 (sv) 2003-12-19 2003-12-19 Pronova Biocare As Use of a fatty acid composition comprising at least one of epa and dha or any combinations thereof
WO2005099483A1 (en) 2004-04-16 2005-10-27 Indevex Ab Ingestible composition
US7651845B2 (en) 2004-05-13 2010-01-26 The Regents Of The University Of California Method and apparatus for glucose control and insulin dosing for diabetics
WO2005120484A1 (ja) 2004-06-09 2005-12-22 Kurume University グレリンの生理学的機能のレギュレーター
CA2784585A1 (en) 2004-07-02 2006-02-09 Baylor Research Institute Glycogen or polysaccharide storage disease treatment method
CA2483675A1 (en) 2004-10-01 2006-04-01 Jens Peschardt Food bar
WO2006051314A2 (en) 2004-11-12 2006-05-18 Ucl Business Plc Guanidine derivatives as inhibitors of ddah
JP2006169386A (ja) 2004-12-16 2006-06-29 Showa Shell Sekiyu Kk 潤滑グリース組成物及びそれを用いた軸受
US20060269495A1 (en) 2005-05-25 2006-11-30 Popp Karl F Alpha hydroxy acid compositions
US8251904B2 (en) 2005-06-09 2012-08-28 Roche Diagnostics Operations, Inc. Device and method for insulin dosing
US20100104548A1 (en) 2005-06-24 2010-04-29 Albert Einstein College Of Medicine Of Yeshiva University Modulation of amino acid metabolism in the hypothalamus
CN100579534C (zh) 2005-09-30 2010-01-13 中国科学院上海药物研究所 S-腺苷同型半胱氨酸在制药中的应用
US20070203235A1 (en) 2006-02-28 2007-08-30 Rosales Francisco J Method for preventing or treating anemia
EP2123253B1 (en) 2007-03-16 2017-06-28 Shiseido Company, Ltd. Wrinkling-preventing and -alleviating agent
JP2008255022A (ja) 2007-04-02 2008-10-23 Kureha Corp 抗癌性物質
NZ555163A (en) 2007-05-14 2010-05-28 Fonterra Co Operative Group Methods of immune or hematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer, cancer symptoms, or the symptoms of cancer treatments
WO2009026153A1 (en) 2007-08-17 2009-02-26 Metabolon, Inc. Biomarkers for alzheimer's disease and methods using the same
DE102007055636A1 (de) 2007-11-21 2009-05-28 Robert Bosch Gmbh Medikamenten-Dosiervorrichtung zum Verabreichen eines flüssigen Medikaments
FR2931676B1 (fr) 2008-05-30 2011-01-14 Ceva Sante Animale Nouveaux modes d'administration d'un melange d'acides gras pour le traitement de mammiferes non humains
EP2316445A4 (en) 2008-06-11 2011-12-21 Ricom Corp HUMAN BETA3 ADRENERGER RECEPTOR LIGAND AND THEREOF FOOD OR PHARMACEUTICAL PREPARATION
EP2147910A1 (en) 2008-07-15 2010-01-27 Pronova BioPharma Norge AS Novel lipid compounds
CA2758976C (en) 2009-04-20 2015-02-03 Alain Baron Chemosensory receptor ligand-based therapies
JP2010260833A (ja) 2009-05-11 2010-11-18 Daicho Kikaku:Kk 抗自己免疫疾患剤
EP2493296B1 (en) 2009-10-30 2019-01-09 Retrotope, Inc. Alleviating oxidative stress disorders with pufa derivatives
MX348036B (es) 2009-12-30 2017-05-24 Baylor Res Institute Terapia anaplerótica para la enfermedad de alzheimer y el cerebro envejecido.
WO2011146922A2 (en) 2010-05-21 2011-11-24 Cytogel Pharma, Llc Materials and methods for treatment of inflammation
CA2803668A1 (en) 2010-07-01 2012-01-05 Isis Innovation Limited Treatment of cognitive disorders
US20120072236A1 (en) 2010-08-06 2012-03-22 Benjamin Atkin Insulin pen data recording and transmission device
CN102327368B (zh) 2010-09-06 2013-07-24 成都地奥制药集团有限公司 三白草根茎总有效部位及其制备方法和用途
RU2765155C2 (ru) 2010-09-10 2022-01-26 Эпизайм, Инк. Ингибиторы ezh2 человека и способы их применения
GB201020133D0 (en) 2010-11-26 2011-01-12 Royal Holloway & Bedford New College Therapeutic use of compounds
US9410116B2 (en) 2010-11-27 2016-08-09 Mycoworks, Inc. Method for producing fungus structures
CA2826816C (en) 2011-02-09 2019-09-24 Gary Searle Nighttime basal dosing device
ITMI20111284A1 (it) 2011-07-11 2013-01-12 Giovanni Nusca Composizione farmaceutica.
WO2013059234A1 (en) 2011-10-18 2013-04-25 Metabolon, Inc. Biomarkers for amyotrophic lateral sclerosis and methods using the same
EP2910547B1 (en) * 2012-10-17 2017-06-14 Okayama University Compound; tautomer and geometric isomer thereof; salt of said compound, tautomer, or geometric isomer; method for manufacturing said compound, tautomer, isomer, or salt; antimicrobial agent; and anti-infective drug
SG11201505247TA (en) 2013-01-14 2015-08-28 Infirst Healthcare Ltd Solid solution compositions and use in cardiovascular disease
US9295637B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Compositions and methods for affecting mood states
WO2014179341A1 (en) 2013-04-29 2014-11-06 Matinas Biopharma, Inc. Treatment with omega-3 fatty acid compositions
JP2015010067A (ja) 2013-06-28 2015-01-19 奥野製薬工業株式会社 肝機能改善用製剤
WO2015110977A1 (en) 2014-01-22 2015-07-30 Rolexi Marketing (Pty) Ltd Fatty acid composition and medicinal use thereof
AU2014386236B2 (en) 2014-03-14 2019-07-11 Alltech, Inc. Compositions of selenoorganic compounds and methods of use thereof
GB201405033D0 (en) 2014-03-20 2014-05-07 Isis Innovation Combination therapy
WO2015157514A1 (en) 2014-04-09 2015-10-15 The Johns Hopkins University Ribosomal protein s15 phosphorylation mediates lrrk2 neurodegeneration in parkinson's disease
EP3217879B1 (en) 2014-11-11 2020-01-08 Koninklijke Philips N.V. Source-detector arrangement
US10022347B2 (en) 2015-01-07 2018-07-17 The United States Of America, As Represented By The Secretary Of The Navy Compositions and methods for diagnosis and treatment of metabolic syndrome
US9662306B2 (en) 2015-01-07 2017-05-30 The United States Of America, As Represented By The Secretary Of The Navy Compositions and methods for diagnosis and treatment of metabolic syndrome
GB201521085D0 (en) 2015-11-30 2016-01-13 Biozep As Use
KR101830244B1 (ko) 2016-01-20 2018-02-21 서울대학교 산학협력단 신규한 헤테로방향족 고리 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 s1p 수용체 관련 질환의 예방 또는 치료용 약학적 조성물
JP2017200910A (ja) 2016-04-28 2017-11-09 ライオン株式会社 血糖値上昇抑制剤
US11596699B2 (en) 2016-04-29 2023-03-07 CureVac SE RNA encoding an antibody
KR20180036318A (ko) 2016-09-30 2018-04-09 경북대학교 산학협력단 2-아미노-2-(1-도데실-1h-1,2,3-트리아졸-4-일)프로판-1,3-디올 유도체를 유효성분으로 포함하는 퇴행성 신경질환 및 우울증 예방 또는 치료용 약학적 조성물
US10307388B2 (en) 2016-12-29 2019-06-04 The United States Of America As Represented By The Secretary Of The Navy Compositions and methods for diagnosis and treatment of inflammation
US10238618B2 (en) 2016-12-29 2019-03-26 The United States Of America As Represented By The Secretary Of The Navy Compositions and methods for diagnosis and treatment of anemia
US20200241011A1 (en) 2017-02-24 2020-07-30 Mattias ARNOLD Compositions and methods related to sex- specific metabolic drivers in alzheimers disease
EP3661600A4 (en) 2017-10-23 2021-08-11 Epitracker, Inc. FATTY ACID ANALOGS AND ITS USE IN THE TREATMENT OF DISEASES RELATED TO METABOLISM SYNDROME
KR102017324B1 (ko) 2018-04-30 2019-09-02 경북대학교 산학협력단 신규한 asm 활성 직접 억제 화합물 2-아미노-2-(1,2,3-트리아졸-4-일)프로판-1,3-디올 유도체 및 이의 용도
CA3099561A1 (en) 2018-05-16 2019-11-21 Epitracker, Inc. Compositions and methods for diagnosis and treatment of conditions related to aging
JP2021525249A (ja) 2018-05-23 2021-09-24 エピトラッカー インコーポレイテッドＥｐｉｔｒａｃｋｅｒ， Ｉｎｃ． 加齢及び長期性の質に関連する状態の診断及び治療のための組成物及び方法
KR102087634B1 (ko) 2018-10-11 2020-03-11 (주)바이텍 항비만용 조성물
MY196370A (en) 2018-12-05 2023-03-27 Celagenex Res India Pvt Ltd Synergistic Compositions Of Bioactive Agents For Optimizing Cellular Health
WO2020146263A1 (en) 2019-01-09 2020-07-16 Epitracker, Inc. Compositions and methods for diagnosis and treatment of neurodegenerative diseases
EP3914242A4 (en) 2019-01-23 2023-02-01 Epitracker, Inc. COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF QUALITY OF AGING AND LONGEVITY DISORDERS
JP7404382B2 (ja) 2019-03-04 2023-12-25 エピトラッカー インコーポレイテッド 脂肪酸アナログ、ならびに認知機能障害、行動症状および慢性疼痛の処置におけるそれらの使用
EP4199750A4 (en) 2020-08-20 2024-09-18 Epitracker, Inc. COMPOSITIONS AND METHODS FOR TREATING OBESITY
WO2022098572A1 (en) 2020-11-03 2022-05-12 Epitracker, Inc. Compositions and methods for diagnosis and treatment of conditions related to the quality of aging and longevity
WO2023080939A1 (en) 2021-11-03 2023-05-11 Epitracker, Inc. Pentadecanoylcarnitine for treatment of conditions related to the quality of aging and longevity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006117668A1 (en) * 2005-05-04 2006-11-09 Pronova Biopharma Norge As Fatty acid analogues, i.e. dha derivatives for uses as a medicament
WO2010128401A1 (en) * 2009-05-08 2010-11-11 Pronova Biopharma Norge As Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas
WO2016111843A1 (en) * 2015-01-07 2016-07-14 Government Of The United States Of America, As Represented By The Secretary Of The Navy Compositions and methods for diagnosis and treatment of metabolic syndrome

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BALLATORE C ET AL: "Carboxylic Acid (Bio)Isosteres in Drug Design", CHEMMEDCHEM, WILEY-VCH, DE, vol. 8, no. 3, 1 March 2013 (2013-03-01), pages 385 - 395, XP002755375, ISSN: 1860-7179, [retrieved on 20130129], DOI: 10.1002/CMDC.201200585 *

Also Published As

Publication number Publication date
KR20200075815A (ko) 2020-06-26
JP2021500403A (ja) 2021-01-07
US20190117607A1 (en) 2019-04-25
US20240277649A1 (en) 2024-08-22
KR102701244B1 (ko) 2024-09-02
EP3661600A4 (en) 2021-08-11
AU2018354090A1 (en) 2020-03-12
JP7312184B2 (ja) 2023-07-20
JP2023126953A (ja) 2023-09-12
US11951088B2 (en) 2024-04-09
EP3661600A1 (en) 2020-06-10
US20200345676A1 (en) 2020-11-05
WO2019083816A1 (en) 2019-05-02
US10792266B2 (en) 2020-10-06

Similar Documents

Publication Publication Date Title
AU2018354090B2 (en) Fatty acid analogs and their use in the treatment of conditions related to metabolic syndrome
AU2019274431B2 (en) Compositions and methods for diagnosis and treatment of conditions related to the quality of aging and longevity
JP6391572B2 (ja) 非アルコール性脂肪性肝疾患治療剤
EP3562480B1 (en) Compositions comprising heptadecanoic acid for the treatment of inflammation and related conditions
US20230293491A1 (en) Compositions and methods for diagnosis and treatment of conditions related to the quality of aging and longevity
US20230321051A1 (en) Agent for reducing visceral fat weight
US10238618B2 (en) Compositions and methods for diagnosis and treatment of anemia
AU2016290963B2 (en) Pyrrolidine carboxamido derivatives and methods for preparing and using the same
WO2018131626A1 (ja) 非アルコール性脂肪性肝疾患の予防及び治療薬
CA3112907A1 (en) Compositions comprising a crac inhibitor and a corticosteroid and methods of use thereof
US10603296B1 (en) Compositions and methods for diagnosis and treatment of neuromuscular disorders

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)