AU2017387695B2 - (Aza)indole-, benzothiophene-, and benzofuran-3-sulfonamides - Google Patents

(Aza)indole-, benzothiophene-, and benzofuran-3-sulfonamides Download PDF

Info

Publication number
AU2017387695B2
AU2017387695B2 AU2017387695A AU2017387695A AU2017387695B2 AU 2017387695 B2 AU2017387695 B2 AU 2017387695B2 AU 2017387695 A AU2017387695 A AU 2017387695A AU 2017387695 A AU2017387695 A AU 2017387695A AU 2017387695 B2 AU2017387695 B2 AU 2017387695B2
Authority
AU
Australia
Prior art keywords
chloro
sulfonamide
fluoro
indole
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2017387695A
Other languages
English (en)
Other versions
AU2017387695A1 (en
Inventor
Anaïs BARRÉ
Sanjay BHATTARAI
Nader M. BOSHTA
Michael Louis Robert Deligny
Ali El-Tayeb
Mario Funke
Sabrina GOLLOS
Joerg Hockemeyer
Marie LEDECQ
Joël MERCIER
Christa E. Mueller
Vigneshwaran NAMASIVAYAM
Cécile PEGURIER
Laurent Provins
Lukas SCHWACH
Daniel Von Laufenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Pharma GmbH
Original Assignee
UCB Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Pharma GmbH filed Critical UCB Pharma GmbH
Publication of AU2017387695A1 publication Critical patent/AU2017387695A1/en
Application granted granted Critical
Publication of AU2017387695B2 publication Critical patent/AU2017387695B2/en
Priority to AU2022235580A priority Critical patent/AU2022235580B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D421/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms
    • C07D421/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings
    • C07D421/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2017387695A 2016-12-28 2017-12-27 (Aza)indole-, benzothiophene-, and benzofuran-3-sulfonamides Active AU2017387695B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022235580A AU2022235580B2 (en) 2016-12-28 2022-09-21 (AZA)indole-, benzothiophene-, and benzofuran-3-sulfonamides

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16207137.7 2016-12-28
EP16207137 2016-12-28
PCT/EP2017/084602 WO2018122232A1 (en) 2016-12-28 2017-12-27 (aza)indole-, benzothiophene-, and benzofuran-3-sulfonamides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022235580A Division AU2022235580B2 (en) 2016-12-28 2022-09-21 (AZA)indole-, benzothiophene-, and benzofuran-3-sulfonamides

Publications (2)

Publication Number Publication Date
AU2017387695A1 AU2017387695A1 (en) 2019-06-06
AU2017387695B2 true AU2017387695B2 (en) 2022-06-23

Family

ID=57614285

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2017387695A Active AU2017387695B2 (en) 2016-12-28 2017-12-27 (Aza)indole-, benzothiophene-, and benzofuran-3-sulfonamides
AU2022235580A Active AU2022235580B2 (en) 2016-12-28 2022-09-21 (AZA)indole-, benzothiophene-, and benzofuran-3-sulfonamides

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2022235580A Active AU2022235580B2 (en) 2016-12-28 2022-09-21 (AZA)indole-, benzothiophene-, and benzofuran-3-sulfonamides

Country Status (25)

Country Link
US (4) US11345662B2 (https=)
EP (1) EP3562820A1 (https=)
JP (2) JP6946436B2 (https=)
KR (1) KR102537100B1 (https=)
CN (3) CN116283712B (https=)
AR (1) AR110592A1 (https=)
AU (2) AU2017387695B2 (https=)
CL (1) CL2019001660A1 (https=)
CO (1) CO2019007829A2 (https=)
CR (1) CR20190287A (https=)
EA (1) EA201991553A1 (https=)
EC (1) ECSP19044183A (https=)
IL (2) IL295047B2 (https=)
MX (1) MX2019006190A (https=)
MY (1) MY199872A (https=)
NZ (1) NZ753651A (https=)
PE (1) PE20191475A1 (https=)
PH (1) PH12019501095A1 (https=)
RU (1) RU2767904C2 (https=)
TN (1) TN2019000165A1 (https=)
TW (1) TWI754702B (https=)
UA (1) UA127890C2 (https=)
UY (1) UY37554A (https=)
WO (1) WO2018122232A1 (https=)
ZA (1) ZA201903466B (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations
TWI754702B (zh) 2016-12-28 2022-02-11 德商Ｕｃｂ製藥有限公司 （氮雜）吲哚－和苯並呋喃－３－磺醯胺類
CN112262141A (zh) * 2018-04-20 2021-01-22 弗吉尼亚理工大学知识产权有限公司 可用作线粒体解偶联剂的咪唑吡啶
TWI857957B (zh) 2018-06-19 2024-10-11 德商Ｕｃｂ製藥有限公司 吡啶基及吡基-（氮）吲哚磺醯胺
EP3584244A1 (en) * 2018-06-20 2019-12-25 UCB Pharma GmbH Substituted alkoxypyridinyl indolsulfonamides
WO2020051099A1 (en) * 2018-09-03 2020-03-12 Genentech, Inc. Carboxamide and sulfonamide derivatives useful as tead modulators
CN110128422B (zh) * 2019-01-04 2022-03-18 金凯(辽宁)生命科技股份有限公司 5-甲氧基-7-氮杂吲哚的合成方法
MA54753A (fr) * 2019-01-17 2021-11-24 Ifm Due Inc Composés et compositions pour traiter des états pathologiques associés à une activité de sting
GB201903671D0 (en) * 2019-03-18 2019-05-01 Univ Edinburgh Small molecule photosensitizers for photodynamic therapy
EP3983384B1 (en) * 2019-06-17 2023-10-11 UCB Pharma GmbH N-(phenyl)-indole-3-sulfonamide derivatives and related compounds as gpr17 modulators for treating cns disorders such as multiple sclerosis
US20230167406A1 (en) * 2020-05-01 2023-06-01 The Children's Medical Center Corporation Compositions and methods of promoting myelination
CN112375027B (zh) * 2020-12-07 2023-03-31 中国药科大学 吲哚磺酰胺类衍生物及其医药用途
CN112266328B (zh) * 2020-12-09 2023-11-03 郑州萃智医药科技有限公司 3-氟-4-硝基苯甲醛的合成路线及制备方法
PE20240125A1 (es) 2021-02-26 2024-01-22 Hoffmann La Roche Derivados novedosos de pirimidin-2-il sulfonamida
EP4347558A1 (en) * 2021-06-04 2024-04-10 ReWind Therapeutics NV 3-pyrrolylsulfonamide compounds as gpr17 antagonists
UY39892A (es) 2021-08-10 2023-03-31 Novartis Pharma Ag Compuestos y composiciones para tratar afecciones asociadas con la actividad de STING
CN114276319B (zh) * 2022-01-06 2023-11-03 滁州学院 一种劳拉替尼中间体的合成方法
CN114315741B (zh) * 2022-01-19 2023-09-12 贵州医科大学 一种硫代化合物及其制备方法与应用
WO2024017863A1 (en) 2022-07-20 2024-01-25 F. Hoffmann-La Roche Ag Novel pyrimidinyl and triazinyl sulfonamide derivatives
WO2024017856A1 (en) 2022-07-20 2024-01-25 F. Hoffmann-La Roche Ag Novel isoquinolinone, pyrrolopyridinone and thienopyridinone sulfonamide derivatives
CN119585264A (zh) 2022-07-20 2025-03-07 豪夫迈·罗氏有限公司 新颖异噻唑-3-基和异噁唑-3-基磺酰胺化合物
US20260027104A1 (en) 2022-07-20 2026-01-29 Hoffmann-La Roche Inc. Novel naphthyl and isoquinoline sulfonamide derivatives
EP4558498A1 (en) * 2022-07-20 2025-05-28 F. Hoffmann-La Roche AG Novel imidazopyridine and pyrazolopyridine sulfonamide derivatives
EP4619402A1 (en) * 2022-11-20 2025-09-24 Myrobalan Therapeutics, Inc. Gpr17 modulators and uses thereof
AU2023401169A1 (en) * 2022-12-02 2025-05-29 Rewind Therapeutics Nv Fused pyrrolyl-sulfonamide compounds
WO2024153233A1 (en) * 2023-01-19 2024-07-25 Nanjing Immunophage Biotech Co., Ltd Compounds and their uses as gpr17 antagonists
CN116947879B (zh) * 2023-07-25 2025-10-31 沈阳药科大学 一种bbi608类衍生物及其制备方法和在制备治疗stat3介导疾病的药物中的应用
TW202515863A (zh) * 2023-08-15 2025-04-16 美商百健Ｍａ公司 作為ｇｐｒ１７調節劑之吲哚及吡咯并吡啶衍生物
WO2025195241A1 (zh) * 2024-03-19 2025-09-25 迈巴制药(南京)有限公司 Gpr17受体抑制剂及其用途
GB202508013D0 (en) 2024-05-23 2025-07-09 Pheno Therapeutics Ltd Compunds
GB2700773A (en) 2024-05-23 2026-03-11 Pheno Therapeutics Ltd Compounds
GB2642355A (en) 2024-07-05 2026-01-07 Pheno Therapeutics Ltd Polymorphs

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010126002A1 (ja) * 2009-04-28 2010-11-04 塩野義製薬株式会社 ヘテロ環スルホンアミド化合物を含有する医薬
US10562898B2 (en) * 2016-02-05 2020-02-18 Ea Pharma Co., Ltd. Substituted benzenesulfonamides as inhibitors of alpha-4 beta-7 integrin activity

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814084B4 (de) 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
WO2000050391A1 (en) * 1999-02-26 2000-08-31 Merck & Co., Inc. Novel sulfonamide compounds and uses thereof
US6521658B1 (en) * 1999-05-28 2003-02-18 Abbott Laboratories Cell proliferation inhibitors
SE9904750D0 (sv) 1999-12-23 1999-12-23 Pharmacia & Upjohn Ab New formulation, use and method
WO2002092585A1 (en) * 2001-05-11 2002-11-21 Biovitrum Ab Novel, arylsusfonamide compounds for the treatment of obesity, type ii diabetes and cns-disorders
SE0102048D0 (sv) * 2001-06-11 2001-06-11 Pharmacia Ab New Compounds
US7833722B2 (en) 2004-04-27 2010-11-16 Takeda Pharmaceutical Company Limited Ligands for G protein-coupled receptor protein and use thereof
ITMI20042007A1 (it) 2004-10-21 2005-01-21 Consiglio Nazionale Ricerche "modulatori del ricettore gpr17 e loro impieghi terapeutici"
WO2009000262A1 (de) 2007-06-25 2008-12-31 Acino Ag Elektrophoretisches transdermales applikationssystem
BRPI0821915A2 (pt) * 2007-12-26 2015-06-16 Sanofi Aventis Piridil-n-(1,3,4)-tiadiazol-2-il-benzeno sulfonamidas cíclicas, processos para sua preparação e seu uso como produtos farmacêuticos
WO2010032257A1 (en) * 2008-09-17 2010-03-25 Suven Life Sciences Limited Aryl indolyl sulfonamide compounds and their use as 5-ht6 ligands
WO2011113032A2 (en) 2010-03-11 2011-09-15 Swinford Jerry L Method and apparatus for washing dowhole tubulars and equipment
EP2567698B1 (en) * 2011-09-07 2014-02-12 Rheinische Friedrich-Wilhelms-Universität Bonn GPR 17 agonists and screening assay
EP2850068B1 (en) * 2012-05-09 2019-05-29 Universita' degli Studi di Milano N-(phenyl)-2-[[3-(phenyl)-1H-1,2,4-triazol-5-yl]thio]-acetamide derivatives and related compounds as G protein coupled receptor 17 (GPCR17) modulators for use in the treatment of neuro-degenerative diseases
RU2519546C1 (ru) * 2013-01-16 2014-06-10 Общество С Ограниченной Ответственностью "Биоинтегратор" (Ооо "Биоинтегратор") КОНЪЮГАТЫ И МАЛЫЕ МОЛЕКУЛЫ, ВЗАИМОДЕЙСТВУЮЩИЕ С РЕЦЕПТОРОМ CD16а
EP2998294A1 (en) * 2014-09-16 2016-03-23 Sanofi Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders
EP2997966A1 (en) * 2014-09-16 2016-03-23 Sanofi Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders
WO2016089062A2 (en) * 2014-12-02 2016-06-09 C&C Research Laboratories Heterocyclic derivatives and use thereof
TWI754702B (zh) 2016-12-28 2022-02-11 德商Ｕｃｂ製藥有限公司 （氮雜）吲哚－和苯並呋喃－３－磺醯胺類

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010126002A1 (ja) * 2009-04-28 2010-11-04 塩野義製薬株式会社 ヘテロ環スルホンアミド化合物を含有する医薬
US10562898B2 (en) * 2016-02-05 2020-02-18 Ea Pharma Co., Ltd. Substituted benzenesulfonamides as inhibitors of alpha-4 beta-7 integrin activity

Non-Patent Citations (26)

* Cited by examiner, † Cited by third party
Title
CAS Registry Number 1197538-68-3; STN Entry Date 16 December 2009; N-(4-Chloro-2-methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1197852-65-5; STN Entry Date 16 December 2009; N-(4-Fluorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1241235-39-1; STN Entry Date 15 September 2010; N-[4-Methoxy-3-(2-methoxyethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1358213-68-9; STN Entry Date 29 February 2012; N-[2-(Trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1358235-83-2; STN Entry Date 29 February 2012; N-(4-Methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1358354-29-6; STN Entry Date 29 February 2012; N-(3-Ethylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1358448-98-2; STN Entry Date 29 February 2012; N-(4-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1358449-27-0; STN Entry Date 29 February 2012; N-(2,5-Difluorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1358719-46-6; STN Entry Date 29 February 2012; N-(2,5-Dimethylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1359422-68-6; STN Entry Date 02 March 2012; N-(3-Chloro-4-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1359448-60-4; STN Entry Date 02 March 2012; N-(2-Chloro-4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1359642-72-0; STN Entry Date 02 March 2012; N-(4-Fluoro-2-methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1359642-80-0; STN Entry Date 02 March 2012; N-(2,4-Difluorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1375957-18-8; STN Entry Date 07 June 2012; N-(5-Chloro-2-pyridinyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1387586-17-5; STN Entry Date 07 August 2012; N-(2,4-Dichlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1389071-66-2; STN Entry Date 12 August 2012; N-[4-(Ethylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1389155-28-5; STN Entry Date 10 August 2012; N-(2-Ethyl-6-methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide *
CAS Registry Number 1394701-89-3; STN Entry Date 18 September 2012; N-(3-Cyanophenyl)-6-nitro-1H-Indole-3-sulfonamide *
CAS Registry Number 1394728-80-3; STN Entry Date 18 September 2012; N-(4-Cyanophenyl)-6-nitro-1H-Indole-3-sulfonamide *
CAS Registry Number 1481651-22-2; STN Entry Date 26 November 2013; 1H-Indole-3-sulfonamide, 6-amino-N-(2-fluorophenyl)- *
CAS Registry Number 1482288-47-0; STN Entry Date 27 November 2013; 1H-Indole-3-sulfonamide, 6-amino-N-(3-bromophenyl)- *
CAS Registry Number 1489219-47-7; STN Entry Date 06 December 2013; 1H-Indole-3-sulfonamide, 6-amino-N-(3-bromo-2-pyridinyl)- *
CAS Registry Number 1648122-51-3; STN Entry Date 16 February 2015; 1H-Pyrrolo[2,3-b]pyridine-3-sulfonamide, N-(4-propylphenyl)- *
CAS Registry Number 1710850-08-0; STN Entry Date 24 May 2015; 1H-Pyrrolo[2,3-b]pyridine-3-sulfonamide, N-(6-bromo-2-pyridinyl)- *
RUKMANKESH M. et al, "Identification and optimization of Escherichia coli GlmU inhibitors: An in silico approach with validation thereof", European Journal of Medicinal Chemistry, 2015, vol. 92, pages 78 - 90 *
Substance Record for SID 74606340; N-(4-fluorophenyl)benzothiophene-3-sulfonamide, PubChem, published 2009-06-11, , retrieved from the internet on 2018-04-06 *

Also Published As

Publication number Publication date
IL295047A (en) 2022-09-01
JP2020504753A (ja) 2020-02-13
CA3045244A1 (en) 2018-07-05
CN116036078B (zh) 2025-09-02
US20230348384A1 (en) 2023-11-02
US20220127227A1 (en) 2022-04-28
JP6946436B2 (ja) 2021-10-06
IL267438B2 (en) 2023-07-01
RU2019123031A (ru) 2021-02-01
UY37554A (es) 2018-07-31
KR102537100B1 (ko) 2023-05-25
BR112019012550A2 (pt) 2019-11-12
UA127890C2 (uk) 2024-02-07
TW201831448A (zh) 2018-09-01
RU2019123031A3 (https=) 2021-03-22
KR20190098243A (ko) 2019-08-21
IL295047B2 (en) 2024-09-01
IL267438A (en) 2019-08-29
AU2022235580B2 (en) 2024-03-28
IL267438B1 (en) 2023-03-01
TWI754702B (zh) 2022-02-11
CR20190287A (es) 2019-08-06
US20220048858A1 (en) 2022-02-17
CO2019007829A2 (es) 2019-07-31
CN116036078A (zh) 2023-05-02
JP7270011B2 (ja) 2023-05-09
CN116283712A (zh) 2023-06-23
NZ753651A (en) 2022-10-28
CL2019001660A1 (es) 2019-10-25
JP2022003051A (ja) 2022-01-11
US12071404B2 (en) 2024-08-27
MX2019006190A (es) 2019-11-18
ECSP19044183A (es) 2020-01-31
CN110121499A (zh) 2019-08-13
PE20191475A1 (es) 2019-10-16
RU2767904C2 (ru) 2022-03-22
US11820746B2 (en) 2023-11-21
US11345662B2 (en) 2022-05-31
ZA201903466B (en) 2020-11-25
EA201991553A1 (ru) 2020-01-09
AU2022235580A1 (en) 2022-10-13
AR110592A1 (es) 2019-04-10
CN116283712B (zh) 2025-08-19
TN2019000165A1 (en) 2020-10-05
IL295047B1 (en) 2024-05-01
MY199872A (en) 2023-11-27
US20190345104A1 (en) 2019-11-14
CN110121499B (zh) 2022-12-20
WO2018122232A1 (en) 2018-07-05
AU2017387695A1 (en) 2019-06-06
PH12019501095A1 (en) 2019-12-02
EP3562820A1 (en) 2019-11-06

Similar Documents

Publication Publication Date Title
AU2022235580B2 (en) (AZA)indole-, benzothiophene-, and benzofuran-3-sulfonamides
AU2019289788B2 (en) Pyridinyl and pyrazinyl-(aza)indolsulfonamides
JP7017521B2 (ja) アクチビン受容体様キナーゼの阻害剤
CN106459042B (zh) 抗纤维化吡啶酮类
EP3172202B1 (en) Heterocyclic carboxylic acids as activators of soluble guanylate cyclase
TW201004940A (en) Heteroaryl compounds and uses thereof
WO2017040963A1 (en) [6,6] fused bicyclic hdac8 inhibitors
WO2017184658A1 (en) ACYL SULFONAMIDE NaV1.7 INHIBITORS
CA3045244C (en) (aza)indole-, benzothiophene-, and benzofuran-3-sulfonamides
CN115884970B (zh) 芳基甲酰胺类化合物及其制备方法和医药用途
WO2020151232A1 (zh) 1,2,3,4-四氢喹喔啉衍生物及其制备方法和应用
EA039985B1 (ru) (аза)индол-, бензотиофен- и бензофуран-3-сульфонамиды
CN119613397A (zh) N杂芳并环-3-磺酰胺类化合物及其用于制备gpr17受体抑制剂中的用途
BR112019012550B1 (pt) Compostos (aza)indol-, benzotiofeno- e benzofuran-3- sulfonamidas, uso de tais compostos e composição farmacêutica compreendendo tais compostos

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)