AU2017363246B2 - Peptide-containing linkers for antibody-drug conjugates - Google Patents

Peptide-containing linkers for antibody-drug conjugates Download PDF

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Publication number
AU2017363246B2
AU2017363246B2 AU2017363246A AU2017363246A AU2017363246B2 AU 2017363246 B2 AU2017363246 B2 AU 2017363246B2 AU 2017363246 A AU2017363246 A AU 2017363246A AU 2017363246 A AU2017363246 A AU 2017363246A AU 2017363246 B2 AU2017363246 B2 AU 2017363246B2
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conjugate
ome
alkyl
independently
integer
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AU2017363246A1 (en
Inventor
Natalya D. Bodyak
Bingfan Du
Dmitry R. Gumerov
Mariya KOZYTSKA
Timothy B. Lowinger
Cheri A. Stevenson
Mao Yin
Aleksandr V. Yurkovetskiy
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Mersana Therapeutics Inc
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Mersana Therapeutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2017363246A 2016-11-23 2017-11-22 Peptide-containing linkers for antibody-drug conjugates Active AU2017363246B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662425895P 2016-11-23 2016-11-23
US62/425,895 2016-11-23
US201762572010P 2017-10-13 2017-10-13
US62/572,010 2017-10-13
US15/819,650 2017-11-21
US15/819,650 US11135307B2 (en) 2016-11-23 2017-11-21 Peptide-containing linkers for antibody-drug conjugates
PCT/US2017/063002 WO2018098269A2 (en) 2016-11-23 2017-11-22 Peptide-containing linkers for antibody-drug conjugates

Publications (2)

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AU2017363246A1 AU2017363246A1 (en) 2019-05-16
AU2017363246B2 true AU2017363246B2 (en) 2025-01-30

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US (3) US11135307B2 (https=)
EP (1) EP3544635A2 (https=)
JP (3) JP7291629B2 (https=)
KR (2) KR20190087535A (https=)
CN (1) CN110234357A (https=)
AU (1) AU2017363246B2 (https=)
CA (1) CA3041559A1 (https=)
IL (2) IL266310B2 (https=)
MX (2) MX2019005879A (https=)
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