AU2017331930B2 - Crystalline forms - Google Patents
Crystalline forms Download PDFInfo
- Publication number
- AU2017331930B2 AU2017331930B2 AU2017331930A AU2017331930A AU2017331930B2 AU 2017331930 B2 AU2017331930 B2 AU 2017331930B2 AU 2017331930 A AU2017331930 A AU 2017331930A AU 2017331930 A AU2017331930 A AU 2017331930A AU 2017331930 B2 AU2017331930 B2 AU 2017331930B2
- Authority
- AU
- Australia
- Prior art keywords
- crystalline form
- vol
- piperazine
- amino
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2016072562 | 2016-09-22 | ||
| EPPCT/EP2016/072562 | 2016-09-22 | ||
| PCT/EP2017/073858 WO2018055016A1 (en) | 2016-09-22 | 2017-09-21 | Crystalline forms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2017331930A1 AU2017331930A1 (en) | 2019-03-07 |
| AU2017331930B2 true AU2017331930B2 (en) | 2021-07-15 |
Family
ID=59923448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017331930A Active AU2017331930B2 (en) | 2016-09-22 | 2017-09-21 | Crystalline forms |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US10730896B2 (OSRAM) |
| EP (2) | EP3515924B1 (OSRAM) |
| JP (1) | JP7097369B2 (OSRAM) |
| KR (1) | KR102552795B1 (OSRAM) |
| CN (1) | CN109715639B (OSRAM) |
| AU (1) | AU2017331930B2 (OSRAM) |
| CA (1) | CA3037794A1 (OSRAM) |
| CL (1) | CL2019000728A1 (OSRAM) |
| CY (1) | CY1125052T1 (OSRAM) |
| DK (1) | DK3515924T3 (OSRAM) |
| EA (1) | EA201990723A1 (OSRAM) |
| ES (1) | ES2908572T3 (OSRAM) |
| HR (1) | HRP20220234T1 (OSRAM) |
| HU (1) | HUE057772T2 (OSRAM) |
| IL (1) | IL265445B2 (OSRAM) |
| LT (1) | LT3515924T (OSRAM) |
| MA (1) | MA46266B1 (OSRAM) |
| MX (1) | MX381590B (OSRAM) |
| MY (1) | MY193080A (OSRAM) |
| PH (1) | PH12019500567B1 (OSRAM) |
| PL (1) | PL3515924T3 (OSRAM) |
| PT (1) | PT3515924T (OSRAM) |
| RS (1) | RS62946B1 (OSRAM) |
| SI (1) | SI3515924T1 (OSRAM) |
| TW (1) | TWI752086B (OSRAM) |
| UA (1) | UA124073C2 (OSRAM) |
| WO (1) | WO2018055016A1 (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3515924T (pt) | 2016-09-22 | 2022-03-11 | Idorsia Pharmaceuticals Ltd | Formas cristalinas |
| US11179390B2 (en) | 2017-03-15 | 2021-11-23 | Idorsia Pharmaceuticals Ltd | Subcutaneous administration of a P2Y12 receptor antagonist |
| EP4181872B1 (en) | 2020-07-15 | 2025-11-26 | Viatris Asia Pacific Pte. Ltd. | Aqueous pharmaceutical composition comprising a p2y12 receptor antagonist |
| MX2024000653A (es) | 2021-07-13 | 2024-01-31 | Idorsia Pharmaceuticals Ltd | Un proceso para la sintesis de ester de butilo de acido 4-((r)-2-{[6-((s)-3-metoxi-pirrolidin-1-il)-2-fenil-pirimidin-4-c arbonil]-amino}-3-fosfono-propionil)-piperazin-1-carboxilico. |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5373586A (en) | 1976-12-09 | 1978-06-30 | Mitsubishi Chem Ind Ltd | New penicillin derivatives |
| CA2020437A1 (en) | 1989-07-05 | 1991-01-06 | Yoshihide Fuse | Cinnamamide derivative |
| DE60022508T2 (de) | 1999-06-14 | 2006-06-08 | Eli Lilly And Co., Indianapolis | Inhibitoren von serin proteasen |
| US6861424B2 (en) | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| ES2348942T3 (es) | 2002-12-11 | 2010-12-17 | Bayer Schering Pharma Aktiengesellschaft | Compuestos de 2-aminocarbonil-quinolina como antagonistas del receptor plaquetario de adenosin difosfato. |
| CA2521313A1 (en) | 2003-04-09 | 2004-10-28 | Wyeth | Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.o)non-1(7)-3n-2-yl)-al kyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists |
| TW200640877A (en) | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
| WO2007046075A1 (en) | 2005-10-21 | 2007-04-26 | Actelion Pharmaceuticals Ltd | Piperazine derivatives as antimalarial agents |
| CL2007002920A1 (es) | 2006-10-13 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos. |
| AR063518A1 (es) | 2006-10-25 | 2009-01-28 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis |
| JP4785881B2 (ja) | 2007-02-27 | 2011-10-05 | 大塚製薬株式会社 | 医薬 |
| MX2009011089A (es) | 2007-04-23 | 2009-10-30 | Sanofi Aventis | Derivados de quinolina-carboxamida en calidad de antagonistas de p2y12. |
| CN101868469B (zh) | 2007-11-29 | 2014-04-02 | 埃科特莱茵药品有限公司 | 膦酸衍生物及其作为p2y12受体拮抗剂 |
| WO2009080227A2 (en) | 2007-12-26 | 2009-07-02 | Sanofi-Aventis | Pyrazole-carboxamide derivatives as p2y12 antagonists |
| WO2009080226A2 (en) | 2007-12-26 | 2009-07-02 | Sanofis-Aventis | Heterocyclic pyrazole-carboxamides as p2y12 antagonists |
| AR071653A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
| AR071652A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
| MA33260B1 (fr) | 2009-04-08 | 2012-05-02 | Actelion Pharmaceuticals Ltd | 6-(3-azabicyclo[3.1.0.]hex-3-yl)-2-phenylpyrimidines |
| SG175297A1 (en) | 2009-04-22 | 2011-12-29 | Actelion Pharmaceuticals Ltd | Thiazole derivatives and their use as p2y12 receptor antagonists |
| PT3515924T (pt) | 2016-09-22 | 2022-03-11 | Idorsia Pharmaceuticals Ltd | Formas cristalinas |
| US11179390B2 (en) | 2017-03-15 | 2021-11-23 | Idorsia Pharmaceuticals Ltd | Subcutaneous administration of a P2Y12 receptor antagonist |
| EP4181872B1 (en) | 2020-07-15 | 2025-11-26 | Viatris Asia Pacific Pte. Ltd. | Aqueous pharmaceutical composition comprising a p2y12 receptor antagonist |
-
2017
- 2017-09-21 PT PT177714367T patent/PT3515924T/pt unknown
- 2017-09-21 WO PCT/EP2017/073858 patent/WO2018055016A1/en not_active Ceased
- 2017-09-21 HU HUE17771436A patent/HUE057772T2/hu unknown
- 2017-09-21 PL PL17771436T patent/PL3515924T3/pl unknown
- 2017-09-21 RS RS20220163A patent/RS62946B1/sr unknown
- 2017-09-21 CN CN201780057793.2A patent/CN109715639B/zh active Active
- 2017-09-21 UA UAA201903751A patent/UA124073C2/uk unknown
- 2017-09-21 HR HRP20220234TT patent/HRP20220234T1/hr unknown
- 2017-09-21 EP EP17771436.7A patent/EP3515924B1/en active Active
- 2017-09-21 AU AU2017331930A patent/AU2017331930B2/en active Active
- 2017-09-21 TW TW106132387A patent/TWI752086B/zh active
- 2017-09-21 MA MA46266A patent/MA46266B1/fr unknown
- 2017-09-21 KR KR1020197011330A patent/KR102552795B1/ko active Active
- 2017-09-21 CA CA3037794A patent/CA3037794A1/en active Pending
- 2017-09-21 MX MX2019003093A patent/MX381590B/es unknown
- 2017-09-21 PH PH1/2019/500567A patent/PH12019500567B1/en unknown
- 2017-09-21 EP EP21206477.8A patent/EP3981774A1/en not_active Withdrawn
- 2017-09-21 MY MYPI2019001474A patent/MY193080A/en unknown
- 2017-09-21 ES ES17771436T patent/ES2908572T3/es active Active
- 2017-09-21 JP JP2019536696A patent/JP7097369B2/ja active Active
- 2017-09-21 LT LTEPPCT/EP2017/073858T patent/LT3515924T/lt unknown
- 2017-09-21 IL IL265445A patent/IL265445B2/en unknown
- 2017-09-21 US US16/335,973 patent/US10730896B2/en active Active
- 2017-09-21 DK DK17771436.7T patent/DK3515924T3/da active
- 2017-09-21 EA EA201990723A patent/EA201990723A1/ru unknown
- 2017-09-21 SI SI201731102T patent/SI3515924T1/sl unknown
-
2019
- 2019-03-21 CL CL2019000728A patent/CL2019000728A1/es unknown
-
2020
- 2020-07-24 US US16/938,730 patent/US11365209B2/en active Active
-
2022
- 2022-03-09 CY CY20221100195T patent/CY1125052T1/el unknown
- 2022-05-10 US US17/741,427 patent/US12227532B2/en active Active
-
2025
- 2025-01-17 US US19/028,423 patent/US20250163086A1/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| BALDONI, D. et al., CLINICAL DRUG INVESTIGATION,, 2014, 34, 807 - 818 * |
| Brittain, H.G. in "Polymorphism in Pharmaceutical Solids", 1999, Marcel Dekker, Inc., New York, Edited by Brittain, H. G. * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12227532B2 (en) | Crystalline forms | |
| AU705851B2 (en) | Aroyl-piperidine derivatives | |
| JP2016510033A (ja) | 強力なｒｏｃｋ１およびｒｏｃｋ２阻害剤としてのフェニルピラゾール誘導体 | |
| HUP0500736A2 (hu) | A nitrogén (II)-oxid szintáz inhibitor hatású (S)-2-amino-4-(2-etánimidoilamino-etiltio)-vajsav-foszfátsó, eljárás előállítására és az ezt tartalmazó gyógyszerkészítmény | |
| SK283211B6 (sk) | Piperidínové zlúčeniny s analgetickým účinkom, spôsob ich prípravy, medziprodukty na ich prípravu, ich použitie, diagnostické činidlo a farmaceutické kompozície s ich obsahom | |
| KR20130118220A (ko) | 광학 활성 디아민 유도체의 염의 제조 방법 | |
| JP2021535103A (ja) | グリコシダーゼ阻害剤として有用なピペラジン誘導体のコハク酸付加塩及びフマル酸付加塩 | |
| WO2011044327A1 (en) | Substituted phenylcarbamoyl alkylamino arene compounds and n,n'-bis-arylurea compounds | |
| RS59909B1 (sr) | Benzoimidazol-2-il pirimidinski modulatori histaminskog h4 receptora | |
| JP2015522037A (ja) | ベムラフェニブコリン塩の固体形態 | |
| KR20190015305A (ko) | 신장 외수질 칼륨 채널 억제제로서 약학적으로 허용 가능한 염 | |
| EP3481801B1 (en) | Indoline derivatives and method for using and producing the same | |
| HK40009744B (en) | Crystalline forms | |
| WO2019129755A1 (en) | Ketal hydrogenation | |
| NZ750772B2 (en) | Crystalline forms | |
| JP2011510997A (ja) | 新規ｓＥＨ阻害剤およびその使用 | |
| BR112019004845B1 (pt) | Forma cristalina de cloridrato de éster butílico de ácido 4-((r)-2-{[6-((s) -3-metoxi-pirrolidin-1-il)-2-fenilpirimidina-4 carbonil]-amino}-3-fosfono-propionil)- piperazina-1-carboxílico, usos da mesma e de éster butílico de ácido 4-((r)-2-{[6- ((s)-3-metoxi-pirrolidin-1-il)-2- fenil-pirimidina-4-carbonil]-amino}-3- fosfonopropionil)-piperazina-1-carboxílico, ou um sal farmaceuticamente aceitável do mesmo, processos para preparação da mesma, e, composição farmacêutica | |
| AU2018257332B2 (en) | Heterocyclic compound | |
| JP2025540298A (ja) | Ｈｄａｃ阻害剤およびその使用 | |
| Zhang et al. | A facile and efficient synthesis of d3‐labelled Reyataz™ | |
| WO2019129750A1 (en) | Processes for the racemization of dihydroimidazole ring systems | |
| HK1029042A (en) | Ligands for sigma receptors and their therapeutical applications |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| PC | Assignment registered |
Owner name: VIATRIS ASIA PACIFIC PTE. LTD. Free format text: FORMER OWNER(S): IDORSIA PHARMACEUTICALS LTD |