AU2017291826B2 - Phosphorus prodrugs of sGC stimulators - Google Patents

Phosphorus prodrugs of sGC stimulators Download PDF

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Publication number
AU2017291826B2
AU2017291826B2 AU2017291826A AU2017291826A AU2017291826B2 AU 2017291826 B2 AU2017291826 B2 AU 2017291826B2 AU 2017291826 A AU2017291826 A AU 2017291826A AU 2017291826 A AU2017291826 A AU 2017291826A AU 2017291826 B2 AU2017291826 B2 AU 2017291826B2
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disease
pulmonary
hypertension
diseases
syndrome
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AU2017291826A1 (en
Inventor
Timothy Claude Barden
Rajesh R. Iyengar
Ara Mermerian
Takashi Nakai
Paul Allan Renhowe
Glen Robert RENNIE
James Edward SHEPPECK
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Cyclerion Therapeutics Inc
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Cyclerion Therapeutics Inc
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Assigned to CYCLERION THERAPEUTICS, INC. reassignment CYCLERION THERAPEUTICS, INC. Request for Assignment Assignors: IRONWOOD PHARMACEUTICALS, INC.
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Priority to AU2022200331A priority Critical patent/AU2022200331B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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    • C—CHEMISTRY; METALLURGY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

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AU2017291826A 2016-07-07 2017-07-06 Phosphorus prodrugs of sGC stimulators Active AU2017291826B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022200331A AU2022200331B2 (en) 2016-07-07 2022-01-19 Phosphorus prodrugs of sGC stimulators

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662359419P 2016-07-07 2016-07-07
US62/359,419 2016-07-07
PCT/US2017/040809 WO2018009596A1 (en) 2016-07-07 2017-07-06 Phosphorus prodrugs of sgc stimulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022200331A Division AU2022200331B2 (en) 2016-07-07 2022-01-19 Phosphorus prodrugs of sGC stimulators

Publications (2)

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AU2017291826A1 AU2017291826A1 (en) 2019-01-24
AU2017291826B2 true AU2017291826B2 (en) 2021-10-21

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AU2017291826A Active AU2017291826B2 (en) 2016-07-07 2017-07-06 Phosphorus prodrugs of sGC stimulators
AU2022200331A Active AU2022200331B2 (en) 2016-07-07 2022-01-19 Phosphorus prodrugs of sGC stimulators

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US (4) US10927136B2 (cg-RX-API-DMAC7.html)
EP (1) EP3481837B1 (cg-RX-API-DMAC7.html)
JP (2) JP7016853B2 (cg-RX-API-DMAC7.html)
KR (1) KR102513343B1 (cg-RX-API-DMAC7.html)
CN (2) CN109476686B (cg-RX-API-DMAC7.html)
AU (2) AU2017291826B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019000290B1 (cg-RX-API-DMAC7.html)
CA (1) CA3029374A1 (cg-RX-API-DMAC7.html)
EA (1) EA039683B1 (cg-RX-API-DMAC7.html)
IL (1) IL263993B2 (cg-RX-API-DMAC7.html)
MA (1) MA45592A (cg-RX-API-DMAC7.html)
MX (2) MX391896B (cg-RX-API-DMAC7.html)
WO (1) WO2018009596A1 (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10927136B2 (en) * 2016-07-07 2021-02-23 Cyclerion Therapeutics, Inc. Phosphorus prodrugs of pyrazolo-substituted pyrimidine sGC stimulators
EP3820476A1 (en) 2018-07-11 2021-05-19 Cyclerion Therapeutics, Inc. Use of sgc stimulators for the treatment of mitochonrial disorders
CN114377149B (zh) * 2021-12-14 2023-11-10 西北工业大学 一种Mn基可降解MOF纳米反应器及其制备方法和应用
IL320636A (en) * 2022-11-07 2025-07-01 Univ Virginia Commonwealth Benzaldehyde compounds with destabilizing effects on polymers for the treatment of sickle cell disease
CN116478309B (zh) * 2023-05-19 2024-05-17 青海大学 锁阳精多糖、锁阳多糖化合物及制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014144100A2 (en) * 2013-03-15 2014-09-18 Takashi Nakai Sgc stimulators
WO2015106268A1 (en) * 2014-01-13 2015-07-16 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS

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