AU2016309337B2 - Hydroxytriazine compound and medical use thereof - Google Patents

Hydroxytriazine compound and medical use thereof Download PDF

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Publication number
AU2016309337B2
AU2016309337B2 AU2016309337A AU2016309337A AU2016309337B2 AU 2016309337 B2 AU2016309337 B2 AU 2016309337B2 AU 2016309337 A AU2016309337 A AU 2016309337A AU 2016309337 A AU2016309337 A AU 2016309337A AU 2016309337 B2 AU2016309337 B2 AU 2016309337B2
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AU
Australia
Prior art keywords
compound
mixture
pharmaceutically acceptable
acceptable salt
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2016309337A
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English (en)
Other versions
AU2016309337A1 (en
Inventor
Yutaro HIRONO
Ikuo Mitani
Masaki Yamashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Tobacco Inc
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of AU2016309337A1 publication Critical patent/AU2016309337A1/en
Application granted granted Critical
Publication of AU2016309337B2 publication Critical patent/AU2016309337B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2016309337A 2015-08-17 2016-08-16 Hydroxytriazine compound and medical use thereof Ceased AU2016309337B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015160284 2015-08-17
JP2015-160284 2015-08-17
PCT/JP2016/073879 WO2017030115A1 (ja) 2015-08-17 2016-08-16 ヒドロキシトリアジン化合物及びその医薬用途

Publications (2)

Publication Number Publication Date
AU2016309337A1 AU2016309337A1 (en) 2018-02-01
AU2016309337B2 true AU2016309337B2 (en) 2021-03-04

Family

ID=58052084

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016309337A Ceased AU2016309337B2 (en) 2015-08-17 2016-08-16 Hydroxytriazine compound and medical use thereof

Country Status (19)

Country Link
US (3) US20170057943A1 (https=)
EP (2) EP4046991A1 (https=)
JP (4) JP2017039714A (https=)
KR (1) KR20180037270A (https=)
CN (1) CN108137515B (https=)
AR (1) AR105711A1 (https=)
AU (1) AU2016309337B2 (https=)
BR (1) BR112018001809A2 (https=)
CA (1) CA2992410A1 (https=)
CL (1) CL2018000430A1 (https=)
CO (1) CO2018002516A2 (https=)
IL (1) IL257559B (https=)
MX (1) MX375283B (https=)
PE (1) PE20180951A1 (https=)
PH (1) PH12018500181A1 (https=)
SG (1) SG11201800698VA (https=)
TW (1) TWI704139B (https=)
WO (1) WO2017030115A1 (https=)
ZA (1) ZA201801134B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI651310B (zh) 2014-02-20 2019-02-21 日商日本煙草產業股份有限公司 三化合物及其醫藥用途
PE20180951A1 (es) * 2015-08-17 2018-06-11 Japan Tobacco Inc Compuestos de hidroxitriazina y usos medicos de los mismos
US10710967B2 (en) * 2015-10-29 2020-07-14 Aska Pharmaceutical Co., Ltd. Pyrimidine derivative
RU2648181C1 (ru) * 2017-05-25 2018-03-22 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ лечения нейроретинопатии вследствие тяжелой преэклампсии
WO2019002183A1 (de) * 2017-06-26 2019-01-03 Merck Patent Gmbh Verfahren zur herstellung substituierter stickstoffhaltiger heterocyclen
TW202409037A (zh) * 2022-07-06 2024-03-01 日商Ａｓｋａ製藥股份有限公司 嘧啶衍生物

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WO2011037610A1 (en) * 2009-09-23 2011-03-31 Albert Einstein College Of Medicine Of Yeshiva University Prostaglandin transporter inhibitors and uses thereof
EP2383262A1 (en) * 2008-12-10 2011-11-02 Topharman Shanghai Co., Ltd. Phenyl pyrimidone compounds, pharmaceutical compositions, preparation methods and uses thereof
WO2015059618A1 (en) * 2013-10-22 2015-04-30 Glenmark Pharmaceuticals S.A. SUBSTITUTED PYRIMIDINE COMPOUNDS AS mPGES-1 INHIBITORS
WO2015125842A1 (ja) * 2014-02-20 2015-08-27 日本たばこ産業株式会社 トリアジン化合物及びその医薬用途

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CH473818A (de) 1964-03-18 1969-06-15 Ciba Geigy Verfahren zur Herstellung von neuen Hydroxyphenyl-1,3,5-triazinen und deren Verwendung
SU1313854A1 (ru) 1985-04-17 1987-05-30 Институт Органической Химии Ан Армсср Способ получени смеси 2-оксо-2,3-дигидро-4,6,-бис-(3 @ -диэтиламинометилен-4 @ -оксифенил)-1,3,5-триазина и 2,4,6-трис-(3 @ -диэтиламинометилен-4 @ -оксифенил)-1,3,5-триазина
DE19543730A1 (de) 1995-11-23 1997-05-28 Ciba Geigy Ag Bis-Resorcinyl-Triazine
AR038955A1 (es) 1996-12-05 2005-02-02 Amgen Inc Compuestos de pirimidinona y piridona sustituidos y metodos para su uso
US6410729B1 (en) 1996-12-05 2002-06-25 Amgen Inc. Substituted pyrimidine compounds and methods of use
ZA9710727B (en) 1996-12-05 1998-06-12 Amgen Inc Substituted pyrimidine compounds and methods of use.
US6096753A (en) 1996-12-05 2000-08-01 Amgen Inc. Substituted pyrimidinone and pyridone compounds and methods of use
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
AP2005003199A0 (en) 1999-04-01 2005-03-31 Pfizer Prod Inc Aminopyrimidines as sorbitol dehydrogenase inhibitors
WO2008124092A2 (en) 2007-04-03 2008-10-16 E. I. Du Pont De Nemours And Company Substituted benzene fungicides
JP5388270B2 (ja) 2008-06-04 2014-01-15 株式会社Ａｄｅｋａ ２，４，６−トリス（ヒドロキシフェニル）−１，３，５−トリアジン化合物の製造方法
EP2573076B1 (en) 2008-06-04 2014-08-20 Adeka Corporation Method for producing 2,4,6-tris(hydroxyphenyl)-1,3,5-triazine compound
GB2463788B (en) * 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
AR077999A1 (es) 2009-09-02 2011-10-05 Vifor Int Ag Antagonistas de pirimidin y triazin-hepcidina
WO2011048004A1 (en) 2009-10-23 2011-04-28 Boehringer Ingelheim International Gmbh Inhibitors of the microsomal prostaglandin e2 synthase-1
US8586604B2 (en) 2010-08-20 2013-11-19 Boehringer Ingelheim International Gmbh Inhibitors of the microsomal prostaglandin E2 synthase-1
AR086254A1 (es) * 2011-05-26 2013-11-27 Lilly Co Eli Derivados de imidazol utiles para el tratamiento de artritis
FR2983859B1 (fr) 2011-12-12 2014-01-17 Sanofi Sa Derives de 1,3,5-triazine-2-amine, leur preparation et leur application en diagnostique et en therapeutique
JP2015522546A (ja) 2012-05-23 2015-08-06 ステマージ バイオテクノロジー エスエー ミトコンドリア電子伝達鎖の複合体（ｉｉｉ）の活性の阻害剤およびその使用
TWI568722B (zh) * 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
CN105586773A (zh) 2014-11-13 2016-05-18 东丽纤维研究所（中国）有限公司 一种拒水抗紫外纺织品及其生产方法和用途
PE20180951A1 (es) * 2015-08-17 2018-06-11 Japan Tobacco Inc Compuestos de hidroxitriazina y usos medicos de los mismos

Patent Citations (8)

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Publication number Priority date Publication date Assignee Title
EP2138488A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
JP2011525905A (ja) * 2008-06-26 2011-09-29 田辺三菱製薬株式会社 神経変性疾患治療用のｇｓｋ３−ベータ阻害剤としての４−（ピリジン−４−イル）−１ｈ−（１，３，５）トリアジン−２−オン誘導体
EP2383262A1 (en) * 2008-12-10 2011-11-02 Topharman Shanghai Co., Ltd. Phenyl pyrimidone compounds, pharmaceutical compositions, preparation methods and uses thereof
JP2012511517A (ja) * 2008-12-10 2012-05-24 上海特化医薬科技有限公司 フェニルピリミドン骨格を有する化合物、その薬剤組成物、その製造方法及び用途
WO2011037610A1 (en) * 2009-09-23 2011-03-31 Albert Einstein College Of Medicine Of Yeshiva University Prostaglandin transporter inhibitors and uses thereof
WO2015059618A1 (en) * 2013-10-22 2015-04-30 Glenmark Pharmaceuticals S.A. SUBSTITUTED PYRIMIDINE COMPOUNDS AS mPGES-1 INHIBITORS
WO2015125842A1 (ja) * 2014-02-20 2015-08-27 日本たばこ産業株式会社 トリアジン化合物及びその医薬用途
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Also Published As

Publication number Publication date
JP2017039714A (ja) 2017-02-23
US12492182B2 (en) 2025-12-09
US20240076278A1 (en) 2024-03-07
TW201718524A (zh) 2017-06-01
JP2024019449A (ja) 2024-02-09
RU2018109220A (ru) 2019-09-19
MX375283B (es) 2025-03-06
IL257559B (en) 2021-07-29
EP3339296A1 (en) 2018-06-27
CN108137515B (zh) 2021-07-06
IL257559A (en) 2018-04-30
ZA201801134B (en) 2019-07-31
CL2018000430A1 (es) 2018-08-03
SG11201800698VA (en) 2018-03-28
PH12018500181A1 (en) 2018-07-30
JP2020193235A (ja) 2020-12-03
RU2018109220A3 (https=) 2019-11-15
WO2017030115A1 (ja) 2017-02-23
US20210024486A1 (en) 2021-01-28
JP7640658B2 (ja) 2025-03-05
CO2018002516A2 (es) 2018-05-31
AU2016309337A1 (en) 2018-02-01
CA2992410A1 (en) 2017-02-23
JP2022163169A (ja) 2022-10-25
BR112018001809A2 (pt) 2018-09-18
CN108137515A (zh) 2018-06-08
EP4046991A1 (en) 2022-08-24
EP3339296A4 (en) 2019-01-23
US20170057943A1 (en) 2017-03-02
MX2018002044A (es) 2018-04-13
KR20180037270A (ko) 2018-04-11
AR105711A1 (es) 2017-11-01
PE20180951A1 (es) 2018-06-11
TWI704139B (zh) 2020-09-11

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired