CN108137515B - 羟基三嗪化合物和其医药用途 - Google Patents

羟基三嗪化合物和其医药用途 Download PDF

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Publication number
CN108137515B
CN108137515B CN201680060597.6A CN201680060597A CN108137515B CN 108137515 B CN108137515 B CN 108137515B CN 201680060597 A CN201680060597 A CN 201680060597A CN 108137515 B CN108137515 B CN 108137515B
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compound
acid
mixture
added
stirred
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Chinese (zh)
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CN108137515A (zh
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三谷育生
广野佑太郎
山下正树
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Japan Tobacco Inc
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Japan Tobacco Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680060597.6A 2015-08-17 2016-08-16 羟基三嗪化合物和其医药用途 Active CN108137515B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015160284 2015-08-17
JP2015-160284 2015-08-17
PCT/JP2016/073879 WO2017030115A1 (ja) 2015-08-17 2016-08-16 ヒドロキシトリアジン化合物及びその医薬用途

Publications (2)

Publication Number Publication Date
CN108137515A CN108137515A (zh) 2018-06-08
CN108137515B true CN108137515B (zh) 2021-07-06

Family

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CN201680060597.6A Active CN108137515B (zh) 2015-08-17 2016-08-16 羟基三嗪化合物和其医药用途

Country Status (19)

Country Link
US (3) US20170057943A1 (https=)
EP (2) EP4046991A1 (https=)
JP (4) JP2017039714A (https=)
KR (1) KR20180037270A (https=)
CN (1) CN108137515B (https=)
AR (1) AR105711A1 (https=)
AU (1) AU2016309337B2 (https=)
BR (1) BR112018001809A2 (https=)
CA (1) CA2992410A1 (https=)
CL (1) CL2018000430A1 (https=)
CO (1) CO2018002516A2 (https=)
IL (1) IL257559B (https=)
MX (1) MX375283B (https=)
PE (1) PE20180951A1 (https=)
PH (1) PH12018500181A1 (https=)
SG (1) SG11201800698VA (https=)
TW (1) TWI704139B (https=)
WO (1) WO2017030115A1 (https=)
ZA (1) ZA201801134B (https=)

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TWI651310B (zh) 2014-02-20 2019-02-21 日商日本煙草產業股份有限公司 三化合物及其醫藥用途
PE20180951A1 (es) * 2015-08-17 2018-06-11 Japan Tobacco Inc Compuestos de hidroxitriazina y usos medicos de los mismos
US10710967B2 (en) * 2015-10-29 2020-07-14 Aska Pharmaceutical Co., Ltd. Pyrimidine derivative
RU2648181C1 (ru) * 2017-05-25 2018-03-22 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ лечения нейроретинопатии вследствие тяжелой преэклампсии
WO2019002183A1 (de) * 2017-06-26 2019-01-03 Merck Patent Gmbh Verfahren zur herstellung substituierter stickstoffhaltiger heterocyclen
TW202409037A (zh) * 2022-07-06 2024-03-01 日商Ａｓｋａ製藥股份有限公司 嘧啶衍生物

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JP2012511517A (ja) * 2008-12-10 2012-05-24 上海特化医薬科技有限公司 フェニルピリミドン骨格を有する化合物、その薬剤組成物、その製造方法及び用途
WO2015059618A1 (en) * 2013-10-22 2015-04-30 Glenmark Pharmaceuticals S.A. SUBSTITUTED PYRIMIDINE COMPOUNDS AS mPGES-1 INHIBITORS
WO2015125842A1 (ja) * 2014-02-20 2015-08-27 日本たばこ産業株式会社 トリアジン化合物及びその医薬用途

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WO2011037610A1 (en) * 2009-09-23 2011-03-31 Albert Einstein College Of Medicine Of Yeshiva University Prostaglandin transporter inhibitors and uses thereof
WO2015059618A1 (en) * 2013-10-22 2015-04-30 Glenmark Pharmaceuticals S.A. SUBSTITUTED PYRIMIDINE COMPOUNDS AS mPGES-1 INHIBITORS
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AU2016309337B2 (en) 2021-03-04
JP2017039714A (ja) 2017-02-23
US12492182B2 (en) 2025-12-09
US20240076278A1 (en) 2024-03-07
TW201718524A (zh) 2017-06-01
JP2024019449A (ja) 2024-02-09
RU2018109220A (ru) 2019-09-19
MX375283B (es) 2025-03-06
IL257559B (en) 2021-07-29
EP3339296A1 (en) 2018-06-27
IL257559A (en) 2018-04-30
ZA201801134B (en) 2019-07-31
CL2018000430A1 (es) 2018-08-03
SG11201800698VA (en) 2018-03-28
PH12018500181A1 (en) 2018-07-30
JP2020193235A (ja) 2020-12-03
RU2018109220A3 (https=) 2019-11-15
WO2017030115A1 (ja) 2017-02-23
US20210024486A1 (en) 2021-01-28
JP7640658B2 (ja) 2025-03-05
CO2018002516A2 (es) 2018-05-31
AU2016309337A1 (en) 2018-02-01
CA2992410A1 (en) 2017-02-23
JP2022163169A (ja) 2022-10-25
BR112018001809A2 (pt) 2018-09-18
CN108137515A (zh) 2018-06-08
EP4046991A1 (en) 2022-08-24
EP3339296A4 (en) 2019-01-23
US20170057943A1 (en) 2017-03-02
MX2018002044A (es) 2018-04-13
KR20180037270A (ko) 2018-04-11
AR105711A1 (es) 2017-11-01
PE20180951A1 (es) 2018-06-11
TWI704139B (zh) 2020-09-11

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