AU2016289965B2 - Oxysterols and methods of use thereof - Google Patents

Oxysterols and methods of use thereof Download PDF

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Publication number
AU2016289965B2
AU2016289965B2 AU2016289965A AU2016289965A AU2016289965B2 AU 2016289965 B2 AU2016289965 B2 AU 2016289965B2 AU 2016289965 A AU2016289965 A AU 2016289965A AU 2016289965 A AU2016289965 A AU 2016289965A AU 2016289965 B2 AU2016289965 B2 AU 2016289965B2
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Prior art keywords
compound
pharmaceutically acceptable
independently
substituted
acceptable salt
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AU2016289965A1 (en
Inventor
Gabriel Martinez Botella
Albert Jean Robichaud
Francesco G. Salituro
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Sage Therapeutics Inc
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Sage Therapeutics Inc
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Publication of AU2016289965A1 publication Critical patent/AU2016289965A1/en
Priority to AU2021218227A priority Critical patent/AU2021218227B2/en
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Publication of AU2016289965B2 publication Critical patent/AU2016289965B2/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2016289965A 2015-07-06 2016-07-06 Oxysterols and methods of use thereof Active AU2016289965B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021218227A AU2021218227B2 (en) 2015-07-06 2021-08-20 Oxysterols and methods of use thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562189065P 2015-07-06 2015-07-06
US62/189,065 2015-07-06
PCT/US2016/041160 WO2017007832A1 (en) 2015-07-06 2016-07-06 Oxysterols and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021218227A Division AU2021218227B2 (en) 2015-07-06 2021-08-20 Oxysterols and methods of use thereof

Publications (2)

Publication Number Publication Date
AU2016289965A1 AU2016289965A1 (en) 2018-01-18
AU2016289965B2 true AU2016289965B2 (en) 2021-09-09

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016289965A Active AU2016289965B2 (en) 2015-07-06 2016-07-06 Oxysterols and methods of use thereof
AU2021218227A Active AU2021218227B2 (en) 2015-07-06 2021-08-20 Oxysterols and methods of use thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2021218227A Active AU2021218227B2 (en) 2015-07-06 2021-08-20 Oxysterols and methods of use thereof

Country Status (8)

Country Link
US (4) US10696712B2 (OSRAM)
EP (2) EP3319610A4 (OSRAM)
JP (3) JP6882996B2 (OSRAM)
AU (2) AU2016289965B2 (OSRAM)
CA (1) CA2991311C (OSRAM)
HK (1) HK1255500A1 (OSRAM)
MA (1) MA42409A (OSRAM)
WO (1) WO2017007832A1 (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012304412A1 (en) 2011-09-08 2014-03-27 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
PT2968369T (pt) 2013-03-13 2018-12-05 Sage Therapeutics Inc Esteroides neuroativos e métodos para o seu uso
WO2015195967A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
CA2963938C (en) * 2014-10-07 2023-10-24 Sage Therapeutics, Inc. Neuroactive compounds and methods of use thereof
CN113292623A (zh) 2015-07-06 2021-08-24 萨奇治疗股份有限公司 孕甾醇及其使用方法
EP3319610A4 (en) 2015-07-06 2019-03-06 Sage Therapeutics, Inc. OXYSTEROLS AND METHOD OF USE THEREOF
PT3319612T (pt) * 2015-07-06 2021-08-24 Sage Therapeutics Inc Oxisteróis e métodos de utilização dos mesmos
ES2921010T3 (es) 2016-04-01 2022-08-16 Sage Therapeutics Inc Oxisteroles y procedimientos de uso de los mismos
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
ES2884071T3 (es) 2016-07-07 2021-12-10 Sage Therapeutics Inc 24-hidroxiesteroles sustituidos en 11 para el tratamiento de afecciones relacionadas con NMDA
ES2935057T3 (es) 2016-09-30 2023-03-01 Sage Therapeutics Inc C7 oxisteroles sustituidos y estos compuestos para su uso como moduladores de la NMDA
EP4105223B1 (en) 2016-10-18 2025-04-30 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
BR112019008032A2 (pt) 2016-10-18 2019-09-03 Sage Therapeutics, Inc. oxiesteróis e métodos de uso dos mesmos
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
CN110628737B (zh) * 2019-10-14 2022-06-07 南京农业大学 一个调控黄瓜矮化性状相关基因及其应用
CA3223179A1 (en) 2021-06-11 2022-12-15 Sage Therapeutics, Inc. Neuroactive steroid for the treatment of alzheimer's disease
EP4447953A1 (en) 2021-12-13 2024-10-23 Sage Therapeutics, Inc. Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators

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Also Published As

Publication number Publication date
EP3319610A4 (en) 2019-03-06
NZ738582A (en) 2024-10-25
AU2021218227A1 (en) 2021-09-09
HK1255500A1 (zh) 2019-08-16
US20230047157A1 (en) 2023-02-16
CA2991311C (en) 2025-05-06
US20180201643A1 (en) 2018-07-19
US20210101925A1 (en) 2021-04-08
US20250154192A1 (en) 2025-05-15
AU2016289965A1 (en) 2018-01-18
CA2991311A1 (en) 2017-01-12
JP7478190B2 (ja) 2024-05-02
EP4316591A2 (en) 2024-02-07
JP2018519329A (ja) 2018-07-19
JP2022130668A (ja) 2022-09-06
JP2021063118A (ja) 2021-04-22
EP4316591A3 (en) 2024-04-24
AU2021218227B2 (en) 2023-08-03
MA42409A (fr) 2018-05-16
JP6882996B2 (ja) 2021-06-02
JP7410062B2 (ja) 2024-01-09
WO2017007832A1 (en) 2017-01-12
EP3319610A1 (en) 2018-05-16
US10696712B2 (en) 2020-06-30

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