CA2991311C - OXYSTEROLS AND THEIR METHODS OF USE - Google Patents

OXYSTEROLS AND THEIR METHODS OF USE

Info

Publication number
CA2991311C
CA2991311C CA2991311A CA2991311A CA2991311C CA 2991311 C CA2991311 C CA 2991311C CA 2991311 A CA2991311 A CA 2991311A CA 2991311 A CA2991311 A CA 2991311A CA 2991311 C CA2991311 C CA 2991311C
Authority
CA
Canada
Prior art keywords
compound
independently
substituted
unsubstituted
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2991311A
Other languages
English (en)
French (fr)
Other versions
CA2991311A1 (en
Inventor
Francesco G. Salituro
Albert Jean Robichaud
Gabriel MARTINEZ BOTELLA
Original Assignee
Sage Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sage Therapeutics Inc filed Critical Sage Therapeutics Inc
Publication of CA2991311A1 publication Critical patent/CA2991311A1/en
Application granted granted Critical
Publication of CA2991311C publication Critical patent/CA2991311C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2991311A 2015-07-06 2016-07-06 OXYSTEROLS AND THEIR METHODS OF USE Active CA2991311C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562189065P 2015-07-06 2015-07-06
US62/189,065 2015-07-06
PCT/US2016/041160 WO2017007832A1 (en) 2015-07-06 2016-07-06 Oxysterols and methods of use thereof

Publications (2)

Publication Number Publication Date
CA2991311A1 CA2991311A1 (en) 2017-01-12
CA2991311C true CA2991311C (en) 2025-05-06

Family

ID=57686058

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2991311A Active CA2991311C (en) 2015-07-06 2016-07-06 OXYSTEROLS AND THEIR METHODS OF USE

Country Status (8)

Country Link
US (4) US10696712B2 (OSRAM)
EP (2) EP3319610A4 (OSRAM)
JP (3) JP6882996B2 (OSRAM)
AU (2) AU2016289965B2 (OSRAM)
CA (1) CA2991311C (OSRAM)
HK (1) HK1255500A1 (OSRAM)
MA (1) MA42409A (OSRAM)
WO (1) WO2017007832A1 (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6205362B2 (ja) 2011-09-08 2017-09-27 セージ セラピューティクス， インコーポレイテッド 神経刺激性のステロイド、組成物、およびそれらの使用
SMT201800657T1 (it) 2013-03-13 2019-01-11 Sage Therapeutics Inc Steroidi neuroattivi e loro metodi di utilizzo
ES2970222T3 (es) 2014-06-18 2024-05-27 Sage Therapeutics Inc Oxiesteroles y procedimientos de uso de los mismos
CN107405352A (zh) * 2014-10-07 2017-11-28 萨奇治疗股份有限公司 神经活性化合物及其使用方法
EP3319610A4 (en) 2015-07-06 2019-03-06 Sage Therapeutics, Inc. OXYSTEROLS AND METHOD OF USE THEREOF
SMT202100226T1 (it) 2015-07-06 2021-05-07 Sage Therapeutics Inc Ossisteroli e metodi di uso degli stessi
SG10202002655VA (en) * 2015-07-06 2020-05-28 Sage Therapeutics Inc Oxysterols and methods of use thereof
PL3436022T3 (pl) 2016-04-01 2022-08-08 Sage Therapeutics, Inc. Oksysterole i sposoby ich stosowania
WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
HUE055263T2 (hu) 2016-07-07 2021-11-29 Sage Therapeutics Inc 11-Szubsztituált 24-hidroxiszterolok NMDA-hoz kapcsolódó állapotok kezelésére
ES2935057T3 (es) 2016-09-30 2023-03-01 Sage Therapeutics Inc C7 oxisteroles sustituidos y estos compuestos para su uso como moduladores de la NMDA
ES3038660T3 (en) 2016-10-18 2025-10-14 Sage Therapeutics Inc Oxysterols and methods of use thereof
CN119350419A (zh) 2016-10-18 2025-01-24 萨奇治疗股份有限公司 氧甾醇及其使用方法
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
CN110628737B (zh) * 2019-10-14 2022-06-07 南京农业大学 一个调控黄瓜矮化性状相关基因及其应用
JP2024520805A (ja) 2021-06-11 2024-05-24 セージ セラピューティクス， インコーポレイテッド アルツハイマー病の治療のための神経活性ステロイド
EP4447953A1 (en) 2021-12-13 2024-10-23 Sage Therapeutics, Inc. Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators

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Also Published As

Publication number Publication date
CA2991311A1 (en) 2017-01-12
MA42409A (fr) 2018-05-16
EP4316591A2 (en) 2024-02-07
US20210101925A1 (en) 2021-04-08
AU2021218227B2 (en) 2023-08-03
EP4316591A3 (en) 2024-04-24
AU2021218227A1 (en) 2021-09-09
JP2022130668A (ja) 2022-09-06
US20230047157A1 (en) 2023-02-16
JP2018519329A (ja) 2018-07-19
US10696712B2 (en) 2020-06-30
AU2016289965B2 (en) 2021-09-09
JP6882996B2 (ja) 2021-06-02
WO2017007832A1 (en) 2017-01-12
HK1255500A1 (zh) 2019-08-16
JP2021063118A (ja) 2021-04-22
NZ738582A (en) 2024-10-25
US20250154192A1 (en) 2025-05-15
EP3319610A1 (en) 2018-05-16
EP3319610A4 (en) 2019-03-06
US20180201643A1 (en) 2018-07-19
JP7410062B2 (ja) 2024-01-09
JP7478190B2 (ja) 2024-05-02
AU2016289965A1 (en) 2018-01-18

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