AU2016241568B2 - 7-(morpholin-4-yl)pyrazole[1,5-a]pyrimidine derivatives which are useful for the treatment of immune or inflammatory diseases or cancer - Google Patents
7-(morpholin-4-yl)pyrazole[1,5-a]pyrimidine derivatives which are useful for the treatment of immune or inflammatory diseases or cancer Download PDFInfo
- Publication number
- AU2016241568B2 AU2016241568B2 AU2016241568A AU2016241568A AU2016241568B2 AU 2016241568 B2 AU2016241568 B2 AU 2016241568B2 AU 2016241568 A AU2016241568 A AU 2016241568A AU 2016241568 A AU2016241568 A AU 2016241568A AU 2016241568 B2 AU2016241568 B2 AU 2016241568B2
- Authority
- AU
- Australia
- Prior art keywords
- morpholin
- methyl
- pyrazolo
- pyrimidine
- piperidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 CN1CCN(*)CC1 Chemical compound CN1CCN(*)CC1 0.000 description 2
- QITSGRSCSVBMLO-BQBZGAKWSA-N C1OCC1N1[C@@H](C2)CN[C@@H]2C1 Chemical compound C1OCC1N1[C@@H](C2)CN[C@@H]2C1 QITSGRSCSVBMLO-BQBZGAKWSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL411864 | 2015-04-02 | ||
| PL411864A PL236355B1 (pl) | 2015-04-02 | 2015-04-02 | Pochodne 7-(morfolin-4-ylo)pirazolo[1,5-α]pirymidyny jako inhibitory kinazy PI3 |
| PCT/IB2016/051792 WO2016157091A1 (en) | 2015-04-02 | 2016-03-30 | 7-(morpholin-4-yl)pyrazole[1,5-a]pyrimidine derivatives which are useful for the treatment of immune or inflammatory diseases or cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2016241568A1 AU2016241568A1 (en) | 2017-10-19 |
| AU2016241568B2 true AU2016241568B2 (en) | 2019-09-26 |
Family
ID=55650626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016241568A Ceased AU2016241568B2 (en) | 2015-04-02 | 2016-03-30 | 7-(morpholin-4-yl)pyrazole[1,5-a]pyrimidine derivatives which are useful for the treatment of immune or inflammatory diseases or cancer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10138247B2 (enExample) |
| EP (1) | EP3277687B1 (enExample) |
| JP (1) | JP6665201B2 (enExample) |
| KR (1) | KR102559190B1 (enExample) |
| CN (1) | CN107743489B (enExample) |
| AU (1) | AU2016241568B2 (enExample) |
| BR (1) | BR112017020131B1 (enExample) |
| CA (1) | CA2978828A1 (enExample) |
| DK (1) | DK3277687T3 (enExample) |
| EA (1) | EA032826B1 (enExample) |
| ES (1) | ES2765642T3 (enExample) |
| HR (1) | HRP20192195T1 (enExample) |
| HU (1) | HUE047822T2 (enExample) |
| MX (1) | MX2017011423A (enExample) |
| PL (2) | PL236355B1 (enExample) |
| PT (1) | PT3277687T (enExample) |
| SI (1) | SI3277687T1 (enExample) |
| WO (1) | WO2016157091A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12486274B2 (en) | 2020-01-13 | 2025-12-02 | Verge Analytics, Inc. | Substituted pyrazolo-pyrimidines and uses thereof |
| WO2022064458A1 (en) * | 2020-09-28 | 2022-03-31 | 1ST Biotherapeutics, Inc. | Indazoles as hematopoietic progenitor kinase 1 (hpk1) inhibitors and methods of using same |
| EP4229063A4 (en) * | 2020-10-19 | 2024-12-25 | TME Therapeutics LLC | NOVEL PIKFYVE INHIBITORS AND METHODS OF USE THEREOF |
| CN114957261B (zh) * | 2022-05-17 | 2023-06-23 | 重庆文理学院 | 一种具有抗头颈癌作用的化合物及其制备方法和应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010136491A1 (en) * | 2009-05-27 | 2010-12-02 | F. Hoffmann-La Roche Ag | Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2168237T3 (es) * | 1996-02-07 | 2007-04-01 | Neurocrine Biosciences, Inc. | Pirazolopirimidinas como antagonistas de receptores de crf. |
| CN1918172B (zh) | 2003-12-23 | 2011-09-14 | 活跃生物工艺学公司 | 利福霉素类似物及其用途 |
| ATE512966T1 (de) * | 2005-02-11 | 2011-07-15 | Hoffmann La Roche | Pyrazolo-pyrimidin-derivate als mglur2- antagonisten |
| KR101088239B1 (ko) * | 2006-09-20 | 2011-11-30 | 일라이 릴리 앤드 캄파니 | Ｃｒｆ１ 수용체 길항제로서의 티아졸 피라졸로피리미딘 |
| JP5638955B2 (ja) * | 2007-10-26 | 2014-12-10 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｐｉ３キナーゼ阻害剤として有用なプリン誘導体 |
| EA201001359A1 (ru) | 2008-02-26 | 2011-04-29 | Новартис Аг | Гетероциклические соединения в качестве ингибиторов cxcr2 |
| ES2533788T3 (es) * | 2008-05-30 | 2015-04-14 | Genentech, Inc. | Compuestos inhibidores de PI3K de tipo purina y métodos de uso |
| WO2010037765A2 (en) * | 2008-10-03 | 2010-04-08 | Merck Serono S.A. | 4-morpholino-pyrido[3,2-d]pyrimidines |
| WO2010074284A1 (ja) * | 2008-12-26 | 2010-07-01 | 味の素株式会社 | ピラゾロピリミジン化合物 |
| NZ596185A (en) * | 2009-04-16 | 2013-01-25 | Ct Nac Investigaciones Oncologicas Cnio | Imidazopyrazines for use as kinase inhibitors |
| MX2011012520A (es) * | 2009-05-27 | 2011-12-12 | Hoffmann La Roche | Compuestos inhibidores de pi3k de pirimidina biciclicos selectivos para p110 delta y metodos de uso de los mismos. |
| GB0912745D0 (en) | 2009-07-22 | 2009-08-26 | Wolfson Microelectronics Plc | Improvements relating to DC-DC converters |
| MX2012009059A (es) | 2010-02-22 | 2012-09-07 | Hoffmann La Roche | Compuestos inhibidores de fosfoinositida 3-cinasa delta (pi3k) pirido [3,2-d]pirimidina y metodos de uso. |
| CA2789475C (en) | 2010-03-04 | 2018-05-29 | Merck Sharp & Dohme Corp. | Inhibitors of catechol o-methyl transferase and their use in the treatment of psychotic disorders |
| WO2013028263A1 (en) * | 2011-08-24 | 2013-02-28 | Glaxosmithkline Llc | Pyrazolopyrimidine derivatives as pi3 kinase inhibitors |
-
2015
- 2015-04-02 PL PL411864A patent/PL236355B1/pl unknown
-
2016
- 2016-03-30 ES ES16714019T patent/ES2765642T3/es active Active
- 2016-03-30 BR BR112017020131-3A patent/BR112017020131B1/pt not_active IP Right Cessation
- 2016-03-30 HR HRP20192195TT patent/HRP20192195T1/hr unknown
- 2016-03-30 AU AU2016241568A patent/AU2016241568B2/en not_active Ceased
- 2016-03-30 EP EP16714019.3A patent/EP3277687B1/en active Active
- 2016-03-30 KR KR1020177031214A patent/KR102559190B1/ko active Active
- 2016-03-30 WO PCT/IB2016/051792 patent/WO2016157091A1/en not_active Ceased
- 2016-03-30 SI SI201630560T patent/SI3277687T1/sl unknown
- 2016-03-30 PT PT167140193T patent/PT3277687T/pt unknown
- 2016-03-30 DK DK16714019.3T patent/DK3277687T3/da active
- 2016-03-30 CN CN201680017259.4A patent/CN107743489B/zh not_active Expired - Fee Related
- 2016-03-30 US US15/562,537 patent/US10138247B2/en active Active
- 2016-03-30 HU HUE16714019A patent/HUE047822T2/hu unknown
- 2016-03-30 PL PL16714019T patent/PL3277687T3/pl unknown
- 2016-03-30 CA CA2978828A patent/CA2978828A1/en active Pending
- 2016-03-30 MX MX2017011423A patent/MX2017011423A/es active IP Right Grant
- 2016-03-30 JP JP2017551627A patent/JP6665201B2/ja not_active Expired - Fee Related
- 2016-03-30 EA EA201792087A patent/EA032826B1/ru not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010136491A1 (en) * | 2009-05-27 | 2010-12-02 | F. Hoffmann-La Roche Ag | Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2765642T3 (es) | 2020-06-10 |
| BR112017020131B1 (pt) | 2023-02-28 |
| PL411864A1 (pl) | 2016-10-10 |
| CN107743489A (zh) | 2018-02-27 |
| HUE047822T2 (hu) | 2020-05-28 |
| KR102559190B1 (ko) | 2023-07-25 |
| HRP20192195T1 (hr) | 2020-03-06 |
| SI3277687T1 (sl) | 2020-02-28 |
| US20180111939A1 (en) | 2018-04-26 |
| PL3277687T3 (pl) | 2020-09-21 |
| US10138247B2 (en) | 2018-11-27 |
| EA032826B1 (ru) | 2019-07-31 |
| JP6665201B2 (ja) | 2020-03-13 |
| BR112017020131A2 (pt) | 2018-05-29 |
| PL236355B1 (pl) | 2021-01-11 |
| EP3277687A1 (en) | 2018-02-07 |
| DK3277687T3 (da) | 2019-12-16 |
| PT3277687T (pt) | 2020-01-10 |
| CN107743489B (zh) | 2021-05-04 |
| KR20170132275A (ko) | 2017-12-01 |
| AU2016241568A1 (en) | 2017-10-19 |
| JP2018510192A (ja) | 2018-04-12 |
| CA2978828A1 (en) | 2016-10-06 |
| MX2017011423A (es) | 2018-05-17 |
| EP3277687B1 (en) | 2019-10-30 |
| EA201792087A1 (ru) | 2018-03-30 |
| WO2016157091A1 (en) | 2016-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |