CN107743489B - 治疗免疫疾病、炎性疾病或癌症的7-(吗啉-4-基)吡唑并[1，5-a]嘧啶衍生物 - Google Patents

治疗免疫疾病、炎性疾病或癌症的7-(吗啉-4-基)吡唑并[1，5-a]嘧啶衍生物 Download PDF

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Publication number
CN107743489B
CN107743489B CN201680017259.4A CN201680017259A CN107743489B CN 107743489 B CN107743489 B CN 107743489B CN 201680017259 A CN201680017259 A CN 201680017259A CN 107743489 B CN107743489 B CN 107743489B
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methyl
pyrazolo
morpholin
pyrimidine
tert
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CN107743489A (zh
Inventor
芭芭拉·迪梅克
马克新·扎戈兹达
马切伊·维克佐雷克
克日什托夫·杜比尔
阿莱克桑德拉·施坦查克
达莉亚·兹扎里克
巴威尔·古内尔卡
马里奥拉·塞库拉尔
马切伊·达滋阿克汗
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Celon Pharma SA
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Celon Pharma SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201680017259.4A 2015-04-02 2016-03-30 治疗免疫疾病、炎性疾病或癌症的7-(吗啉-4-基)吡唑并[1，5-a]嘧啶衍生物 Expired - Fee Related CN107743489B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PL411864 2015-04-02
PL411864A PL236355B1 (pl) 2015-04-02 2015-04-02 Pochodne 7-(morfolin-4-ylo)pirazolo[1,5-α]pirymidyny jako inhibitory kinazy PI3
PCT/IB2016/051792 WO2016157091A1 (en) 2015-04-02 2016-03-30 7-(morpholin-4-yl)pyrazole[1,5-a]pyrimidine derivatives which are useful for the treatment of immune or inflammatory diseases or cancer

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CN107743489A CN107743489A (zh) 2018-02-27
CN107743489B true CN107743489B (zh) 2021-05-04

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US (1) US10138247B2 (enExample)
EP (1) EP3277687B1 (enExample)
JP (1) JP6665201B2 (enExample)
KR (1) KR102559190B1 (enExample)
CN (1) CN107743489B (enExample)
AU (1) AU2016241568B2 (enExample)
BR (1) BR112017020131B1 (enExample)
CA (1) CA2978828A1 (enExample)
DK (1) DK3277687T3 (enExample)
EA (1) EA032826B1 (enExample)
ES (1) ES2765642T3 (enExample)
HR (1) HRP20192195T1 (enExample)
HU (1) HUE047822T2 (enExample)
MX (1) MX2017011423A (enExample)
PL (2) PL236355B1 (enExample)
PT (1) PT3277687T (enExample)
SI (1) SI3277687T1 (enExample)
WO (1) WO2016157091A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12486274B2 (en) 2020-01-13 2025-12-02 Verge Analytics, Inc. Substituted pyrazolo-pyrimidines and uses thereof
WO2022064458A1 (en) * 2020-09-28 2022-03-31 1ST Biotherapeutics, Inc. Indazoles as hematopoietic progenitor kinase 1 (hpk1) inhibitors and methods of using same
EP4229063A4 (en) * 2020-10-19 2024-12-25 TME Therapeutics LLC NOVEL PIKFYVE INHIBITORS AND METHODS OF USE THEREOF
CN114957261B (zh) * 2022-05-17 2023-06-23 重庆文理学院 一种具有抗头颈癌作用的化合物及其制备方法和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1205009A (zh) * 1996-02-07 1999-01-13 詹森药业有限公司 吡唑并嘧啶类化合物
WO2006084634A1 (en) * 2005-02-11 2006-08-17 F.Hoffmann-La Roche Ag Pyrazolo-pyrimidine derivatives as mglur2 antagonists
CN101516887A (zh) * 2006-09-20 2009-08-26 伊莱利利公司 作为crf1受体拮抗剂的噻唑吡唑并嘧啶类
WO2010037765A2 (en) * 2008-10-03 2010-04-08 Merck Serono S.A. 4-morpholino-pyrido[3,2-d]pyrimidines
CN101835779A (zh) * 2007-10-26 2010-09-15 霍夫曼-拉罗奇有限公司 作为pi3激酶抑制剂的嘌呤衍生物
WO2010136491A1 (en) * 2009-05-27 2010-12-02 F. Hoffmann-La Roche Ag Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1918172B (zh) 2003-12-23 2011-09-14 活跃生物工艺学公司 利福霉素类似物及其用途
EA201001359A1 (ru) 2008-02-26 2011-04-29 Новартис Аг Гетероциклические соединения в качестве ингибиторов cxcr2
ES2533788T3 (es) * 2008-05-30 2015-04-14 Genentech, Inc. Compuestos inhibidores de PI3K de tipo purina y métodos de uso
WO2010074284A1 (ja) * 2008-12-26 2010-07-01 味の素株式会社 ピラゾロピリミジン化合物
NZ596185A (en) * 2009-04-16 2013-01-25 Ct Nac Investigaciones Oncologicas Cnio Imidazopyrazines for use as kinase inhibitors
MX2011012520A (es) * 2009-05-27 2011-12-12 Hoffmann La Roche Compuestos inhibidores de pi3k de pirimidina biciclicos selectivos para p110 delta y metodos de uso de los mismos.
GB0912745D0 (en) 2009-07-22 2009-08-26 Wolfson Microelectronics Plc Improvements relating to DC-DC converters
MX2012009059A (es) 2010-02-22 2012-09-07 Hoffmann La Roche Compuestos inhibidores de fosfoinositida 3-cinasa delta (pi3k) pirido [3,2-d]pirimidina y metodos de uso.
CA2789475C (en) 2010-03-04 2018-05-29 Merck Sharp & Dohme Corp. Inhibitors of catechol o-methyl transferase and their use in the treatment of psychotic disorders
WO2013028263A1 (en) * 2011-08-24 2013-02-28 Glaxosmithkline Llc Pyrazolopyrimidine derivatives as pi3 kinase inhibitors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1205009A (zh) * 1996-02-07 1999-01-13 詹森药业有限公司 吡唑并嘧啶类化合物
WO2006084634A1 (en) * 2005-02-11 2006-08-17 F.Hoffmann-La Roche Ag Pyrazolo-pyrimidine derivatives as mglur2 antagonists
CN101516887A (zh) * 2006-09-20 2009-08-26 伊莱利利公司 作为crf1受体拮抗剂的噻唑吡唑并嘧啶类
CN101835779A (zh) * 2007-10-26 2010-09-15 霍夫曼-拉罗奇有限公司 作为pi3激酶抑制剂的嘌呤衍生物
WO2010037765A2 (en) * 2008-10-03 2010-04-08 Merck Serono S.A. 4-morpholino-pyrido[3,2-d]pyrimidines
WO2010136491A1 (en) * 2009-05-27 2010-12-02 F. Hoffmann-La Roche Ag Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use

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Publication number Publication date
ES2765642T3 (es) 2020-06-10
BR112017020131B1 (pt) 2023-02-28
PL411864A1 (pl) 2016-10-10
CN107743489A (zh) 2018-02-27
HUE047822T2 (hu) 2020-05-28
KR102559190B1 (ko) 2023-07-25
HRP20192195T1 (hr) 2020-03-06
AU2016241568B2 (en) 2019-09-26
SI3277687T1 (sl) 2020-02-28
US20180111939A1 (en) 2018-04-26
PL3277687T3 (pl) 2020-09-21
US10138247B2 (en) 2018-11-27
EA032826B1 (ru) 2019-07-31
JP6665201B2 (ja) 2020-03-13
BR112017020131A2 (pt) 2018-05-29
PL236355B1 (pl) 2021-01-11
EP3277687A1 (en) 2018-02-07
DK3277687T3 (da) 2019-12-16
PT3277687T (pt) 2020-01-10
KR20170132275A (ko) 2017-12-01
AU2016241568A1 (en) 2017-10-19
JP2018510192A (ja) 2018-04-12
CA2978828A1 (en) 2016-10-06
MX2017011423A (es) 2018-05-17
EP3277687B1 (en) 2019-10-30
EA201792087A1 (ru) 2018-03-30
WO2016157091A1 (en) 2016-10-06

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