AU2015349866B2 - 4-oxo-3,4-dihydro-1,2,3-benzotriazines as modulators of GPR139 - Google Patents

4-oxo-3,4-dihydro-1,2,3-benzotriazines as modulators of GPR139 Download PDF

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Publication number
AU2015349866B2
AU2015349866B2 AU2015349866A AU2015349866A AU2015349866B2 AU 2015349866 B2 AU2015349866 B2 AU 2015349866B2 AU 2015349866 A AU2015349866 A AU 2015349866A AU 2015349866 A AU2015349866 A AU 2015349866A AU 2015349866 B2 AU2015349866 B2 AU 2015349866B2
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triazin
oxobenzo
acetamide
ethyl
methoxy
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AU2015349866A1 (en
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Stephen Hitchcock
Betty Lam
Holger Monenschein
Holly REICHARD
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Takeda Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2015349866A 2014-11-20 2015-11-19 4-oxo-3,4-dihydro-1,2,3-benzotriazines as modulators of GPR139 Active AU2015349866B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462082539P 2014-11-20 2014-11-20
US62/082,539 2014-11-20
US201562184729P 2015-06-25 2015-06-25
US62/184,729 2015-06-25
PCT/US2015/061607 WO2016081736A1 (en) 2014-11-20 2015-11-19 4-oxo-3,4-dihydro-1,2,3-benzotriazines as modulators of gpr139

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AU2015349866A1 AU2015349866A1 (en) 2017-06-15
AU2015349866B2 true AU2015349866B2 (en) 2020-12-03

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EP (2) EP3536324B1 (OSRAM)
JP (2) JP6637501B2 (OSRAM)
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CN (2) CN107108531B (OSRAM)
AU (1) AU2015349866B2 (OSRAM)
CA (1) CA2968242C (OSRAM)
CL (1) CL2017001292A1 (OSRAM)
CO (1) CO2017005959A2 (OSRAM)
CR (1) CR20170275A (OSRAM)
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DO (1) DOP2017000120A (OSRAM)
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UA (1) UA120375C2 (OSRAM)
UY (1) UY36406A (OSRAM)
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JO3719B1 (ar) 2014-11-20 2021-01-31 Takeda Pharmaceuticals Co 4- أوكسو-4،3- داي هيدرو-3،2،1- بنزوترايازينات كمواد ضابطة لأجل gpr139
US12042496B2 (en) 2018-10-16 2024-07-23 The University Of Florida Research Foundation, Incorporated Methods related to opioid therapeutics
WO2020097609A1 (en) * 2018-11-09 2020-05-14 Blackthorn Therapeutics, Inc. Gpr139 receptor modulators
PH12022550597A1 (en) * 2019-09-16 2024-03-04 Takeda Pharmaceuticals Co Azole-fused pyridazin-3(2h)-one derivatives
WO2021127459A1 (en) * 2019-12-20 2021-06-24 Blackthorn Therapeutics, Inc. Gpr139 receptor modulators
WO2021224680A1 (en) * 2020-05-08 2021-11-11 Takeda Pharmaceutical Company Limited Substituted benzotriazinone metabolites of a gpr139 agonist
TW202227087A (zh) * 2020-09-21 2022-07-16 日商武田藥品工業股份有限公司 精神分裂症之治療
US11760788B2 (en) 2021-03-02 2023-09-19 Pathways Neuro Pharma, Inc. Neuroreceptor compositions and methods of use
WO2023165262A1 (zh) * 2022-03-01 2023-09-07 上海科技大学 噻吩并含氮杂环类化合物、含其的药物组合物、其制备方法及其应用
WO2023165263A1 (zh) * 2022-03-01 2023-09-07 上海科技大学 吡咯并三嗪酮类化合物、含其的药物组合物、其制备方法及其应用
CN117986183A (zh) * 2022-10-28 2024-05-07 浙江友宁生物医药科技有限公司 一种gpr139受体激动剂、其制备方法及其应用
WO2024102802A1 (en) * 2022-11-11 2024-05-16 Takeda Pharmaceutical Company Limited Zelatriazin for the treatment of depression
WO2025119351A1 (zh) * 2023-12-08 2025-06-12 深圳湾实验室 Gpr139激动剂
CN120424068A (zh) * 2024-02-02 2025-08-05 上海科技大学 稠杂环类化合物与其制备方法、药物组合物及应用

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JP6637501B2 (ja) 2020-01-29
US20160145218A1 (en) 2016-05-26
HUE057451T2 (hu) 2022-05-28
PH12017500920A1 (en) 2017-11-20
US20170095480A1 (en) 2017-04-06
DOP2017000120A (es) 2017-06-15
GEP20196961B (en) 2019-03-25
LT3536324T (lt) 2021-12-10
PH12017500920B1 (en) 2017-11-20
MY187423A (en) 2021-09-22
US11173161B2 (en) 2021-11-16
CY1124929T1 (el) 2023-01-05
KR20170084324A (ko) 2017-07-19
CY1122613T1 (el) 2021-05-05
CN112062730A (zh) 2020-12-11
MA40993A (fr) 2017-09-27
US20190070187A1 (en) 2019-03-07
MD3221298T2 (ro) 2019-10-31
AU2015349866A1 (en) 2017-06-15
IL252311A0 (en) 2017-07-31
EP3221298B1 (en) 2019-04-03
KR102582021B1 (ko) 2023-09-22
EP3536324B1 (en) 2021-10-06
CL2017001292A1 (es) 2018-02-16
SG11201704002UA (en) 2017-06-29
BR112017010311A2 (pt) 2017-12-26
CO2017005959A2 (es) 2017-10-20
US9556130B2 (en) 2017-01-31
CN112062730B (zh) 2023-09-29
NZ732208A (en) 2023-02-24
PT3221298T (pt) 2019-06-28
HRP20212009T1 (hr) 2022-04-01
ES2897545T3 (es) 2022-03-01
RS62563B1 (sr) 2021-12-31
EA201791096A1 (ru) 2017-11-30
IL252311B (en) 2020-07-30
ECSP17038999A (es) 2017-10-31
SI3536324T1 (sl) 2021-12-31
MX378158B (es) 2025-03-10
SMT201900355T1 (it) 2019-07-11
WO2016081736A1 (en) 2016-05-26
ES2734735T3 (es) 2019-12-11
US20170348319A1 (en) 2017-12-07
UY36406A (es) 2016-06-30
DK3536324T3 (da) 2021-10-25
PT3536324T (pt) 2021-11-10
DK3221298T3 (da) 2019-06-24
SI3221298T1 (sl) 2019-10-30
JO3719B1 (ar) 2021-01-31
CN107108531B (zh) 2020-10-20
CR20170275A (es) 2017-10-30
JP2020063285A (ja) 2020-04-23
PL3221298T3 (pl) 2019-10-31
CA2968242A1 (en) 2016-05-26
LT3221298T (lt) 2019-08-12
TW201625566A (zh) 2016-07-16
US9770450B2 (en) 2017-09-26
CN107108531A (zh) 2017-08-29
SMT202200142T1 (it) 2022-05-12
MA40993B1 (fr) 2019-07-31
PE20170899A1 (es) 2017-07-12
US10561662B2 (en) 2020-02-18
UA120375C2 (uk) 2019-11-25
TN2017000196A1 (en) 2018-10-19
HRP20191003T1 (hr) 2019-08-23
EP3536324A1 (en) 2019-09-11
MX2017006448A (es) 2017-09-12
JP6918088B2 (ja) 2021-08-11
JP2017535559A (ja) 2017-11-30
TWI684590B (zh) 2020-02-11
US10159677B2 (en) 2018-12-25
RS59078B1 (sr) 2019-09-30
EP3221298A1 (en) 2017-09-27
EA033728B1 (ru) 2019-11-20
CA2968242C (en) 2022-11-08
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US20200129518A1 (en) 2020-04-30

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