IL252311B - 4-oxo-4,3-dihydro-3,2,1-benzotriazines as G protein-coupled receptor modulators 139 - Google Patents

4-oxo-4,3-dihydro-3,2,1-benzotriazines as G protein-coupled receptor modulators 139

Info

Publication number
IL252311B
IL252311B IL252311A IL25231117A IL252311B IL 252311 B IL252311 B IL 252311B IL 252311 A IL252311 A IL 252311A IL 25231117 A IL25231117 A IL 25231117A IL 252311 B IL252311 B IL 252311B
Authority
IL
Israel
Prior art keywords
gpr139
benzotriazines
modulators
dihydro
oxo
Prior art date
Application number
IL252311A
Other languages
English (en)
Hebrew (he)
Other versions
IL252311A0 (en
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of IL252311A0 publication Critical patent/IL252311A0/en
Publication of IL252311B publication Critical patent/IL252311B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL252311A 2014-11-20 2017-05-16 4-oxo-4,3-dihydro-3,2,1-benzotriazines as G protein-coupled receptor modulators 139 IL252311B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462082539P 2014-11-20 2014-11-20
US201562184729P 2015-06-25 2015-06-25
PCT/US2015/061607 WO2016081736A1 (en) 2014-11-20 2015-11-19 4-oxo-3,4-dihydro-1,2,3-benzotriazines as modulators of gpr139

Publications (2)

Publication Number Publication Date
IL252311A0 IL252311A0 (en) 2017-07-31
IL252311B true IL252311B (en) 2020-07-30

Family

ID=55022667

Family Applications (1)

Application Number Title Priority Date Filing Date
IL252311A IL252311B (en) 2014-11-20 2017-05-16 4-oxo-4,3-dihydro-3,2,1-benzotriazines as G protein-coupled receptor modulators 139

Country Status (40)

Country Link
US (5) US9556130B2 (OSRAM)
EP (2) EP3221298B1 (OSRAM)
JP (2) JP6637501B2 (OSRAM)
KR (1) KR102582021B1 (OSRAM)
CN (2) CN107108531B (OSRAM)
AU (1) AU2015349866B2 (OSRAM)
CA (1) CA2968242C (OSRAM)
CL (1) CL2017001292A1 (OSRAM)
CO (1) CO2017005959A2 (OSRAM)
CR (1) CR20170275A (OSRAM)
CY (2) CY1122613T1 (OSRAM)
DK (2) DK3536324T3 (OSRAM)
DO (1) DOP2017000120A (OSRAM)
EA (1) EA033728B1 (OSRAM)
EC (1) ECSP17038999A (OSRAM)
ES (2) ES2734735T3 (OSRAM)
GE (1) GEP20196961B (OSRAM)
HR (2) HRP20191003T1 (OSRAM)
HU (2) HUE044145T2 (OSRAM)
IL (1) IL252311B (OSRAM)
JO (1) JO3719B1 (OSRAM)
LT (2) LT3536324T (OSRAM)
MA (1) MA40993B1 (OSRAM)
MD (1) MD3221298T2 (OSRAM)
MX (1) MX378158B (OSRAM)
MY (1) MY187423A (OSRAM)
NZ (1) NZ732208A (OSRAM)
PE (1) PE20170899A1 (OSRAM)
PH (1) PH12017500920A1 (OSRAM)
PL (2) PL3221298T3 (OSRAM)
PT (2) PT3221298T (OSRAM)
RS (2) RS62563B1 (OSRAM)
SG (1) SG11201704002UA (OSRAM)
SI (2) SI3221298T1 (OSRAM)
SM (2) SMT201900355T1 (OSRAM)
TN (1) TN2017000196A1 (OSRAM)
TW (1) TWI684590B (OSRAM)
UA (1) UA120375C2 (OSRAM)
UY (1) UY36406A (OSRAM)
WO (1) WO2016081736A1 (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3719B1 (ar) * 2014-11-20 2021-01-31 Takeda Pharmaceuticals Co 4- أوكسو-4،3- داي هيدرو-3،2،1- بنزوترايازينات كمواد ضابطة لأجل gpr139
US12042496B2 (en) 2018-10-16 2024-07-23 The University Of Florida Research Foundation, Incorporated Methods related to opioid therapeutics
WO2020097609A1 (en) * 2018-11-09 2020-05-14 Blackthorn Therapeutics, Inc. Gpr139 receptor modulators
CR20220160A (es) * 2019-09-16 2022-06-16 Takeda Pharmaceuticals Co Derivados de piridazin-3(2h)-ona fusionados con azol
WO2021127459A1 (en) * 2019-12-20 2021-06-24 Blackthorn Therapeutics, Inc. Gpr139 receptor modulators
JP7697974B2 (ja) * 2020-05-08 2025-06-24 武田薬品工業株式会社 Ｇｐｒ１３９アゴニストの置換ベンゾトリアジノン代謝物
JP2023541485A (ja) * 2020-09-21 2023-10-02 武田薬品工業株式会社 統合失調症のための処置
US11760788B2 (en) 2021-03-02 2023-09-19 Pathways Neuro Pharma, Inc. Neuroreceptor compositions and methods of use
CN116693545A (zh) * 2022-03-01 2023-09-05 上海科技大学 噻吩并含氮杂环类化合物、含其的药物组合物、其制备方法及其应用
WO2023165263A1 (zh) * 2022-03-01 2023-09-07 上海科技大学 吡咯并三嗪酮类化合物、含其的药物组合物、其制备方法及其应用
CN117986183A (zh) * 2022-10-28 2024-05-07 浙江友宁生物医药科技有限公司 一种gpr139受体激动剂、其制备方法及其应用
WO2024102802A1 (en) * 2022-11-11 2024-05-16 Takeda Pharmaceutical Company Limited Zelatriazin for the treatment of depression
WO2025119351A1 (zh) * 2023-12-08 2025-06-12 深圳湾实验室 Gpr139激动剂
WO2025162441A1 (zh) * 2024-02-02 2025-08-07 上海科技大学 稠杂环类化合物与其制备方法、药物组合物及应用

Family Cites Families (13)

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US3794726A (en) * 1972-08-21 1974-02-26 Uniroyal Inc Inhibiting aggressive behavior with 1,2,3-benzotriazin-(3h)-one
WO1987004928A1 (fr) 1986-02-24 1987-08-27 Mitsui Petrochemical Industries, Ltd. Agents therapeutiques de la neuropathie
ATE108791T1 (de) 1987-11-04 1994-08-15 Beecham Group Plc Neue 4-oxobenzotriazine und 4-oxochinazoline.
PE20050630A1 (es) 2003-06-09 2005-09-22 Boehringer Ingelheim Int Compuestos heterociclicos como inhibidores del papiloma virus
CA2533824A1 (en) 2003-07-31 2005-02-10 Irm, Llc Bicyclic compounds and compositions as pdf inhibitors
FR2875805B1 (fr) 2004-09-27 2006-12-29 Genfit S A Composes derives de n-(benzyl) phenylacetamide substitues, preparation et utilisations
UY30048A1 (es) 2005-12-23 2007-07-31 Astrazeneca Ab Derivados sustituidos de la n,2-(1h-benzimidazol-1-il) acetamida, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones
TWI433839B (zh) 2006-08-11 2014-04-11 Neomed Inst 新穎的苯并咪唑衍生物290
MX2009010218A (es) * 2007-03-23 2009-10-19 Hoffmann La Roche Derivados de aza-piridopirimidinona.
CA2709784A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2011138265A2 (en) 2010-05-03 2011-11-10 Evotec Ag Indole and indazole derivatives as orexin receptor antagonists
JP2016515138A (ja) * 2013-03-14 2016-05-26 ヤンセン ファーマシューティカ エヌ．ベー． Ｇｐｒ１３９の生理的リガンド
JO3719B1 (ar) * 2014-11-20 2021-01-31 Takeda Pharmaceuticals Co 4- أوكسو-4،3- داي هيدرو-3،2،1- بنزوترايازينات كمواد ضابطة لأجل gpr139

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Publication number Publication date
CA2968242C (en) 2022-11-08
JO3719B1 (ar) 2021-01-31
PH12017500920B1 (en) 2017-11-20
HRP20191003T1 (hr) 2019-08-23
JP6918088B2 (ja) 2021-08-11
TW201625566A (zh) 2016-07-16
JP2020063285A (ja) 2020-04-23
ES2734735T3 (es) 2019-12-11
CN112062730B (zh) 2023-09-29
BR112017010311A2 (pt) 2017-12-26
TN2017000196A1 (en) 2018-10-19
EP3221298A1 (en) 2017-09-27
US10561662B2 (en) 2020-02-18
LT3536324T (lt) 2021-12-10
AU2015349866A1 (en) 2017-06-15
PT3221298T (pt) 2019-06-28
SI3221298T1 (sl) 2019-10-30
SG11201704002UA (en) 2017-06-29
CN112062730A (zh) 2020-12-11
US20190070187A1 (en) 2019-03-07
CA2968242A1 (en) 2016-05-26
US11173161B2 (en) 2021-11-16
KR20170084324A (ko) 2017-07-19
US20170095480A1 (en) 2017-04-06
TWI684590B (zh) 2020-02-11
HUE057451T2 (hu) 2022-05-28
JP2017535559A (ja) 2017-11-30
CR20170275A (es) 2017-10-30
PH12017500920A1 (en) 2017-11-20
PE20170899A1 (es) 2017-07-12
PL3536324T3 (pl) 2022-02-07
HUE044145T2 (hu) 2019-09-30
CO2017005959A2 (es) 2017-10-20
RS62563B1 (sr) 2021-12-31
ECSP17038999A (es) 2017-10-31
MX378158B (es) 2025-03-10
DK3221298T3 (da) 2019-06-24
GEP20196961B (en) 2019-03-25
PT3536324T (pt) 2021-11-10
EA033728B1 (ru) 2019-11-20
SMT202200142T1 (it) 2022-05-12
NZ732208A (en) 2023-02-24
US20160145218A1 (en) 2016-05-26
CN107108531A (zh) 2017-08-29
US20200129518A1 (en) 2020-04-30
AU2015349866B2 (en) 2020-12-03
EP3221298B1 (en) 2019-04-03
CN107108531B (zh) 2020-10-20
ES2897545T3 (es) 2022-03-01
UA120375C2 (uk) 2019-11-25
EP3536324B1 (en) 2021-10-06
JP6637501B2 (ja) 2020-01-29
CY1124929T1 (el) 2023-01-05
KR102582021B1 (ko) 2023-09-22
US9556130B2 (en) 2017-01-31
EA201791096A1 (ru) 2017-11-30
US9770450B2 (en) 2017-09-26
DK3536324T3 (da) 2021-10-25
SI3536324T1 (sl) 2021-12-31
PL3221298T3 (pl) 2019-10-31
CL2017001292A1 (es) 2018-02-16
IL252311A0 (en) 2017-07-31
MA40993A (fr) 2017-09-27
MA40993B1 (fr) 2019-07-31
HRP20212009T1 (hr) 2022-04-01
MX2017006448A (es) 2017-09-12
DOP2017000120A (es) 2017-06-15
MY187423A (en) 2021-09-22
CY1122613T1 (el) 2021-05-05
MD3221298T2 (ro) 2019-10-31
LT3221298T (lt) 2019-08-12
WO2016081736A1 (en) 2016-05-26
RS59078B1 (sr) 2019-09-30
US10159677B2 (en) 2018-12-25
EP3536324A1 (en) 2019-09-11
UY36406A (es) 2016-06-30
US20170348319A1 (en) 2017-12-07
SMT201900355T1 (it) 2019-07-11

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