AU2015348043B2 - Antifungal agents - Google Patents

Antifungal agents Download PDF

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Publication number
AU2015348043B2
AU2015348043B2 AU2015348043A AU2015348043A AU2015348043B2 AU 2015348043 B2 AU2015348043 B2 AU 2015348043B2 AU 2015348043 A AU2015348043 A AU 2015348043A AU 2015348043 A AU2015348043 A AU 2015348043A AU 2015348043 B2 AU2015348043 B2 AU 2015348043B2
Authority
AU
Australia
Prior art keywords
phenyl
compound
piperazin
dimethyl
pyrrol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2015348043A
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English (en)
Other versions
AU2015348043A1 (en
Inventor
Michael Birch
Derek Law
Jason David Oliver
Graham Edward Morris SIBLEY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F2G Ltd
Original Assignee
F2G Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420743.5A external-priority patent/GB201420743D0/en
Priority claimed from GBGB1505891.0A external-priority patent/GB201505891D0/en
Application filed by F2G Ltd filed Critical F2G Ltd
Publication of AU2015348043A1 publication Critical patent/AU2015348043A1/en
Application granted granted Critical
Publication of AU2015348043B2 publication Critical patent/AU2015348043B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
    • A01G7/00—Botany in general
    • A01G7/06—Treatment of growing trees or plants, e.g. for preventing decay of wood, for tingeing flowers or wood, for prolonging the life of plants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Ecology (AREA)
  • Forests & Forestry (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU2015348043A 2014-11-21 2015-11-20 Antifungal agents Active AU2015348043B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1420743.5 2014-11-21
GBGB1420743.5A GB201420743D0 (en) 2014-11-21 2014-11-21 Antifungal agents
GBGB1505891.0A GB201505891D0 (en) 2015-04-07 2015-04-07 Antifungal agents
GB1505891.0 2015-04-07
PCT/GB2015/053546 WO2016079536A1 (en) 2014-11-21 2015-11-20 Antifungal agents

Publications (2)

Publication Number Publication Date
AU2015348043A1 AU2015348043A1 (en) 2017-06-08
AU2015348043B2 true AU2015348043B2 (en) 2019-08-22

Family

ID=54704024

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015348043A Active AU2015348043B2 (en) 2014-11-21 2015-11-20 Antifungal agents

Country Status (20)

Country Link
US (3) US10201524B2 (enExample)
EP (2) EP3415511A1 (enExample)
JP (1) JP6681894B2 (enExample)
KR (1) KR102550341B1 (enExample)
CN (2) CN107207470B (enExample)
AU (1) AU2015348043B2 (enExample)
BR (1) BR112017010439B1 (enExample)
CA (1) CA2982660C (enExample)
CY (1) CY1120907T1 (enExample)
DK (1) DK3221308T3 (enExample)
ES (1) ES2694637T3 (enExample)
HR (1) HRP20182139T1 (enExample)
IL (1) IL252368B (enExample)
LT (1) LT3221308T (enExample)
MX (1) MX2017006447A (enExample)
PL (1) PL3221308T3 (enExample)
PT (1) PT3221308T (enExample)
RU (1) RU2727520C2 (enExample)
SI (1) SI3221308T1 (enExample)
WO (1) WO2016079536A1 (enExample)

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US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
US10201524B2 (en) 2014-11-21 2019-02-12 F2G Limited Antifungal agents
US9973887B2 (en) * 2016-01-21 2018-05-15 Google Llc Sharing navigation data among co-located computing devices
CA3015662A1 (en) 2016-03-07 2017-09-14 Agrofresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
GB201609222D0 (en) * 2016-05-25 2016-07-06 F2G Ltd Pharmaceutical formulation
MX2019012116A (es) 2017-04-10 2019-11-21 Scynexis Inc Agentes antifungicos utilizados en combinacion.
AU2018375795A1 (en) 2017-11-30 2020-07-02 Boragen, Inc. Benzoxaborole compounds and formulations thereof
US11236115B2 (en) 2018-08-18 2022-02-01 5Metis, Inc. Solid forms of substituted benzoxaborole and compositions thereof
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection
CN115811989A (zh) 2020-05-29 2023-03-17 法国国家科学研究中心 抗真菌前体药物
CN112358974B (zh) * 2020-12-09 2022-06-10 昆明理工大学 一株植物内生真菌黑附球菌fzt214及其应用
CN116675704A (zh) * 2020-12-21 2023-09-01 深圳市祥根生物医药有限公司 一种吡咯衍生物及其制备方法和用途
CN115109040A (zh) * 2021-03-23 2022-09-27 博瑞生物医药（苏州）股份有限公司 抗真菌化合物，包含其的药物组合物和制剂，及其应用
CN113429396A (zh) * 2021-06-08 2021-09-24 深圳市祥根生物医药有限公司 一种五元杂芳环衍生物及其制备方法和用途
TW202521521A (zh) * 2023-08-08 2025-06-01 大陸商上海森輝醫藥有限公司 一種４－苯基哌啶衍生物及其應用

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Also Published As

Publication number Publication date
EP3221308A1 (en) 2017-09-27
US10596150B2 (en) 2020-03-24
ES2694637T3 (es) 2018-12-26
CN107207470B (zh) 2019-12-03
KR102550341B1 (ko) 2023-06-30
PL3221308T3 (pl) 2019-03-29
IL252368B (en) 2020-04-30
US10201524B2 (en) 2019-02-12
DK3221308T3 (en) 2018-12-10
KR20170102241A (ko) 2017-09-08
BR112017010439B1 (pt) 2023-03-07
US20170340607A1 (en) 2017-11-30
CN111096967B (zh) 2023-03-10
RU2017121370A (ru) 2018-12-21
PT3221308T (pt) 2018-12-17
HRP20182139T1 (hr) 2019-05-03
CN107207470A (zh) 2017-09-26
WO2016079536A1 (en) 2016-05-26
JP6681894B2 (ja) 2020-04-15
US20190314333A1 (en) 2019-10-17
EP3415511A1 (en) 2018-12-19
SI3221308T1 (sl) 2018-12-31
IL252368A0 (en) 2017-07-31
LT3221308T (lt) 2018-12-27
CA2982660A1 (en) 2016-05-26
JP2017536371A (ja) 2017-12-07
US20200179340A1 (en) 2020-06-11
MX2017006447A (es) 2018-01-30
AU2015348043A1 (en) 2017-06-08
RU2017121370A3 (enExample) 2019-03-28
CA2982660C (en) 2023-01-24
EP3221308B1 (en) 2018-09-19
US11065228B2 (en) 2021-07-20
RU2727520C2 (ru) 2020-07-22
CN111096967A (zh) 2020-05-05
BR112017010439A2 (pt) 2017-12-26
CY1120907T1 (el) 2019-12-11

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