AU2015328173B2 - Engineered renal tissues, arrays thereof, and methods of making the same - Google Patents

Engineered renal tissues, arrays thereof, and methods of making the same Download PDF

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Publication number
AU2015328173B2
AU2015328173B2 AU2015328173A AU2015328173A AU2015328173B2 AU 2015328173 B2 AU2015328173 B2 AU 2015328173B2 AU 2015328173 A AU2015328173 A AU 2015328173A AU 2015328173 A AU2015328173 A AU 2015328173A AU 2015328173 B2 AU2015328173 B2 AU 2015328173B2
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renal
cells
layer
epithelial
interstitial
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AU2015328173A1 (en
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Shelby Marie King
Deborah Lynn Greene Nguyen
Sharon C. Presnell
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Organovo Inc
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Organovo Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/25—Urinary tract cells, renal cells
    • C12N2502/256—Renal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2015328173A 2014-10-06 2015-10-06 Engineered renal tissues, arrays thereof, and methods of making the same Active AU2015328173B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462060416P 2014-10-06 2014-10-06
US62/060,416 2014-10-06
US201562140285P 2015-03-30 2015-03-30
US62/140,285 2015-03-30
PCT/US2015/054315 WO2016057571A1 (en) 2014-10-06 2015-10-06 Engineered renal tissues, arrays thereof, and methods of making the same

Publications (2)

Publication Number Publication Date
AU2015328173A1 AU2015328173A1 (en) 2017-04-13
AU2015328173B2 true AU2015328173B2 (en) 2022-01-27

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AU2015328173A Active AU2015328173B2 (en) 2014-10-06 2015-10-06 Engineered renal tissues, arrays thereof, and methods of making the same

Country Status (11)

Country Link
US (4) US9481868B2 (cg-RX-API-DMAC7.html)
EP (1) EP3204488B1 (cg-RX-API-DMAC7.html)
JP (2) JP2017529877A (cg-RX-API-DMAC7.html)
KR (1) KR20170064547A (cg-RX-API-DMAC7.html)
CN (1) CN107002033B (cg-RX-API-DMAC7.html)
AU (1) AU2015328173B2 (cg-RX-API-DMAC7.html)
CA (1) CA2962778C (cg-RX-API-DMAC7.html)
MA (1) MA40495A (cg-RX-API-DMAC7.html)
RU (1) RU2017110275A (cg-RX-API-DMAC7.html)
SG (1) SG11201702795QA (cg-RX-API-DMAC7.html)
WO (1) WO2016057571A1 (cg-RX-API-DMAC7.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
AU2012308715A1 (en) * 2011-09-12 2014-04-24 Organovo, Inc. Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same
CN106661548B (zh) 2014-05-28 2020-12-11 儿童医院医疗中心 用于经由定向分化将前体细胞转化为胃组织的方法和系统
RU2017110275A (ru) 2014-10-06 2018-11-15 Органово, Инк. Сконструированные ткани почки, матрицы на их основе и способы их получения
WO2016061464A1 (en) 2014-10-17 2016-04-21 Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intetine using pluripotent stem cells and methods of making and using same
AU2016352873B2 (en) 2015-11-09 2023-01-05 Organovo, Inc. Improved methods for tissue fabrication
WO2017123722A1 (en) 2016-01-12 2017-07-20 Cleveland State University 3d-printed miniature biological constructs
EP3447143A4 (en) * 2016-04-19 2019-11-20 Toppan Printing Co., Ltd. METHOD OF EVALUATING ANTICROBIAL AGENT
WO2017192997A1 (en) 2016-05-05 2017-11-09 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
DK3519558T3 (da) 2016-09-28 2023-11-13 Organovo Inc Anvendelse af modificeret nyrevæv i assays
NZ753051A (en) 2016-11-04 2023-03-31 Children’S Hospital Medical Center Liver organoid compositions and methods of making and using same
WO2018089743A1 (en) * 2016-11-10 2018-05-17 Organovo, Inc. Engineered intestinal tissue and uses thereof
CN110087772B (zh) 2016-11-17 2022-07-19 克利夫兰州立大学 用于微阵列3d生物打印的芯片平台
KR102807995B1 (ko) 2016-12-05 2025-05-16 칠드런즈 호스피탈 메디칼 센터 결장 유사장기 및 이를 제조 및 사용하는 방법
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
JP6915692B2 (ja) * 2017-08-21 2021-08-04 凸版印刷株式会社 抗がん効果の評価方法、及びがん免疫療法の奏効性予測方法
EP3694603A4 (en) 2017-10-10 2021-07-14 Children's Hospital Medical Center ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF
US11262349B2 (en) 2017-10-11 2022-03-01 Cleveland State University Multiplexed immune cell assays on a micropillar/microwell chip platform
JP2021500356A (ja) 2017-10-20 2021-01-07 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション ブタ細胞の足場なし３ｄバイオ印刷
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
CN108130313B (zh) * 2017-12-28 2021-04-30 杭州枫霖科技有限公司 一种基于生物3d打印构建三维胶质瘤组织的方法
DE102018111751A1 (de) * 2018-05-16 2019-11-21 Cellbricks Gmbh Verfahren zur Herstellung eines Zellkultureinsatzes mit mindestens einer Membran
SG11202100533VA (en) 2018-07-26 2021-02-25 Childrens Hospital Med Ct Hepato-biliary-pancreatic tissues and methods of making same
SG11202102431YA (en) 2018-09-12 2021-04-29 Childrens Hospital Med Ct Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
EP3927378A1 (en) * 2019-02-21 2021-12-29 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Method for reduction drug-induced nephrotoxicity
CA3141807A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
AU2020338051A1 (en) * 2019-08-23 2022-03-10 Murdoch Children's Research Institute Bio-printed kidney tissue
US12019040B2 (en) 2019-09-30 2024-06-25 Cornell University System and devices for monitoring cell-containing materials and methods of their use
KR102438496B1 (ko) * 2020-09-07 2022-09-02 포항공과대학교 산학협력단 생체외 인공장기 모델 및 세포 치료제로의 적용이 가능한 관류형 이중 근위세뇨관 관상 세포 구조체 및 그 생성 방법
WO2025153590A1 (en) * 2024-01-16 2025-07-24 Universite Libre De Bruxelles An in vitro method and kit for determining, predicting, and/or monitoring fibrotoxicity of an agent and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130190210A1 (en) * 2011-09-12 2013-07-25 Organovo, Inc. Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4759764A (en) 1985-05-24 1988-07-26 Clayton Foundation For Research Peripheral nerve regeneration
US4808435A (en) 1987-04-06 1989-02-28 International Business Machines Corporation Screen printing method for producing lines of uniform width and height
US5099090A (en) 1988-05-11 1992-03-24 Ariel Electronics, Inc. Circuit writer
EP0929271B1 (en) * 1996-09-05 2004-02-25 Children's Medical Center Corporation Prosthetic kidney
US6537567B1 (en) 1997-07-03 2003-03-25 Massachusetts Institute Of Technology Tissue-engineered tubular construct having circumferentially oriented smooth muscle cells
US6401795B1 (en) 1997-10-28 2002-06-11 Sandia Corporation Method for freeforming objects with low-binder slurry
JP4564655B2 (ja) 1998-04-21 2010-10-20 ユニバーシティ オブ コネチカット 多光子励起を用いたフリーフォームナノ製作
US6697694B2 (en) 1998-08-26 2004-02-24 Electronic Materials, L.L.C. Apparatus and method for creating flexible circuits
US7338798B2 (en) 1998-09-15 2008-03-04 The Regents Of The University Of Michigan System and method for forming a cardiac muscle construct
DE69907397T2 (de) 1999-02-17 2004-01-22 Hewlett-Packard Co. (N.D.Ges.D.Staates Delaware), Palo Alto Druckvorrichtung
US6979670B1 (en) 1999-03-10 2005-12-27 Biora Bioex Ab Matrix protein compositions for grafting
US6642243B1 (en) 1999-07-22 2003-11-04 Ashkan Imanzahrai Migraine medicine and method for treating same
JP2001145956A (ja) 1999-11-19 2001-05-29 Meiko:Kk 光硬化性樹脂三次元造形物の積層造形装置及びその積層造形方法
US6503273B1 (en) 1999-11-22 2003-01-07 Cyograft Tissue Engineering, Inc. Tissue engineered blood vessels and methods and apparatus for their manufacture
US6454972B1 (en) 1999-11-24 2002-09-24 Sandia Corporation Solid freeform fabrication using chemically reactive suspensions
US6520997B1 (en) 1999-12-08 2003-02-18 Baxter International Inc. Porous three dimensional structure
US6315469B1 (en) 2000-01-19 2001-11-13 Hewlett-Packard Company Tool and method for adjustment of printhead to platen spacing in a printer
DE10013223C2 (de) 2000-03-13 2002-07-18 Co Don Ag Verfahren zur in vitro-Herstellung von dreidimensionalem, vitalem Knorpel- oder Knochengewebe und dessen Verwendung als Transplantationsmaterial
US20050091576A1 (en) 2003-10-24 2005-04-28 Microsoft Corporation Programming interface for a computer platform
DE10018987A1 (de) 2000-04-17 2001-10-31 Envision Technologies Gmbh Vorrichtung und Verfahren zum Herstellen von dreidimensionalen Objekten
AU2001283492A1 (en) 2000-07-11 2002-01-21 The Johns Hopkins University School Of Medicine Methods of patterning protein and cell adhesivity
US7998735B2 (en) 2000-08-21 2011-08-16 Victorian Tissue Engineering Centre Pty. Ltd. Vascularized tissue graft
US6561607B1 (en) 2000-10-05 2003-05-13 Eastman Kodak Company Apparatus and method for maintaining a substantially constant closely spaced working distance between an inkjet printhead and a printing receiver
US6939489B2 (en) 2001-03-23 2005-09-06 Ivoclar Vivadent Ag Desktop process for producing dental products by means of 3-dimensional plotting
WO2002085246A2 (en) 2001-04-19 2002-10-31 Case Western Reserve University Fabrication of a polymeric prosthetic implant
DE10127225A1 (de) 2001-05-22 2002-11-28 Zeiss Carl Ultraviolettlicht-Abschwächungsfilter
US20030049839A1 (en) 2001-08-01 2003-03-13 The University Of Texas System Transparent multi-channel cell scaffold that creates a cellular and/or molecular gradient
WO2003017745A2 (en) 2001-08-23 2003-03-06 Sciperio, Inc. Architecture tool and methods of use
JP4023597B2 (ja) * 2001-09-25 2007-12-19 独立行政法人科学技術振興機構 基底膜標品等を用いた再構築人工組織及びその製造方法
US6934600B2 (en) 2002-03-14 2005-08-23 Auburn University Nanotube fiber reinforced composite materials and method of producing fiber reinforced composites
US20030175410A1 (en) 2002-03-18 2003-09-18 Campbell Phil G. Method and apparatus for preparing biomimetic scaffold
US20100254900A1 (en) 2002-03-18 2010-10-07 Campbell Phil G Biocompatible polymers and Methods of use
US6907307B2 (en) 2002-07-02 2005-06-14 3D Systems, Inc. Support volume calculation for a CAD model
WO2004006840A2 (en) 2002-07-12 2004-01-22 The Regents Of The University Of California Three dimensional cell patterned bioploymer scaffolds and method of making the same
US7641898B2 (en) 2003-03-21 2010-01-05 Materials Evolution And Development Usa, Inc. Keratinocyte-fibrocyte concomitant grafting for wound healing
US20040197375A1 (en) 2003-04-02 2004-10-07 Alireza Rezania Composite scaffolds seeded with mammalian cells
AU2004229465B2 (en) * 2003-04-09 2010-04-29 The United States Of America Department Of Veterans Affairs Compositions and methods related to production of erythropoietin
US7051654B2 (en) 2003-05-30 2006-05-30 Clemson University Ink-jet printing of viable cells
US7338517B2 (en) 2003-06-04 2008-03-04 University Of South Carolina Tissue scaffold having aligned fibrils and artificial tissue comprising the same
JP4474858B2 (ja) 2003-07-07 2010-06-09 セイコーエプソン株式会社 ギャップ調整装置、これに使用されるキャリブレーション用治具、およびギャップ調整装置を備えた液滴吐出装置、並びに電気光学装置の製造方法
US20050074877A1 (en) 2003-07-28 2005-04-07 Mao Jeremy Jian Biological engineering of articular structures containing both cartilage and bone
FR2859128B1 (fr) 2003-08-29 2006-03-10 Centre Nat Rech Scient Procede et dispositif de fabrication d'un composant multimateriaux tridimensionnel par impression du type jet d'encre
US8043614B2 (en) 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
DE10353281A1 (de) 2003-11-14 2005-06-16 Bayer Cropscience Ag Wirkstoffkombination mit insektiziden und akariziden Eigenschaften
US20050276791A1 (en) 2004-02-20 2005-12-15 The Ohio State University Multi-layer polymer scaffolds
WO2005081970A2 (en) 2004-02-24 2005-09-09 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
US20090142307A1 (en) 2004-07-09 2009-06-04 Athanasiou Kyriacos A Shape-Based Approach for Scaffoldless Tissue Engineering
WO2007115337A2 (en) 2006-04-05 2007-10-11 William Marsh Rice University Chondrocyte differentiation from human embryonic stem cells and their use in tissue engineering
US7939003B2 (en) 2004-08-11 2011-05-10 Cornell Research Foundation, Inc. Modular fabrication systems and methods
US7651665B2 (en) 2004-09-07 2010-01-26 Hewlett-Packard Development Company, L.P. Microtray for handling biosubstances
US7767446B2 (en) 2004-09-16 2010-08-03 Becton, Dickinson And Company Perfusion bioreactors for culturing cells
KR100606457B1 (ko) 2004-11-11 2006-11-23 한국기계연구원 3차원 프린팅 조형시스템
JP4539316B2 (ja) 2004-12-08 2010-09-08 セイコーエプソン株式会社 ヘッド位置補正方法およびヘッド位置補正装置、並びに液滴吐出装置、電気光学装置の製造方法
US7568904B2 (en) 2005-03-03 2009-08-04 Laser Solutions Co., Ltd. Stereolithography apparatus
JP4729948B2 (ja) 2005-03-09 2011-07-20 ブラザー工業株式会社 液体供給装置、この液体供給装置を備えたインクジェット記録装置
US7780897B2 (en) 2005-04-22 2010-08-24 Board Of Regents, The University Of Texas System Hydrogel constructs using stereolithography
EP2495310A3 (en) 2005-05-24 2013-03-27 The Regents Of the University of California Microscale micropatterned engineered in vitro tissue
WO2007126411A2 (en) 2005-07-28 2007-11-08 Carnegie Mellon University Biocompatible polymers and methods of use
US8690957B2 (en) 2005-12-21 2014-04-08 Warsaw Orthopedic, Inc. Bone graft composition, method and implant
US20070200276A1 (en) 2006-02-24 2007-08-30 Micron Technology, Inc. Method for rapid printing of near-field and imprint lithographic features
US7680555B2 (en) 2006-04-03 2010-03-16 Stratasys, Inc. Auto tip calibration in an extrusion apparatus
US20070231787A1 (en) 2006-04-04 2007-10-04 Voelker Mark A Methods and devices for imaging and manipulating biological samples
WO2007124023A2 (en) 2006-04-21 2007-11-01 Wake Forest University Health Sciences Ink-jet printing of tissues
JP4051077B2 (ja) 2006-04-28 2008-02-20 シャープ株式会社 液滴塗布装置、液滴吐出部のギャップ測定方法、および、液滴吐出部のギャップ調整方法
FR2901143B1 (fr) 2006-05-16 2008-10-03 Centre Nat Rech Scient "methode de construction de materiaux vivants fonctionnels, materiaux obtenus et applications"
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
DE102006053121B3 (de) 2006-11-10 2007-12-27 Eos Gmbh Electro Optical Systems Vorrichtung und Verfahren zum Herstellen eines dreidimensionalen Objektes mittels eines Beschichters für pulverförmiges Aufbaumaterial
WO2009038594A2 (en) * 2007-01-10 2009-03-26 Brett Blackman Use of an in vitro hemodynamic endothelial/smooth muscle cell co-culture model to identify new therapeutic targets for vascular disease
US8764828B2 (en) 2007-02-02 2014-07-01 The Regents Of The University Of Michigan System and method for forming bone, ligament, and bone-ligament constructs
US8343740B2 (en) 2007-03-29 2013-01-01 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Micro-organ device
CN101796186B (zh) 2007-06-07 2013-05-22 韦克福里斯特大学健康科学院 喷墨基因打印
EP2664444B1 (en) 2007-07-25 2018-03-28 Stratasys Ltd. Solid freeform fabrication using a plurality of modeling materials
EP2195131B1 (en) 2007-08-29 2011-10-26 Vito NV Method for producing a three-dimensional macroporous filament construct based on phase inversion and construct thereby obtained
US20090076531A1 (en) 2007-09-18 2009-03-19 Richardson Charles L Method and apparatus for bypass graft
EP2203129A4 (en) 2007-10-15 2011-11-23 Univ Wake Forest Health Sciences METHOD AND COMPOSITIONS FOR PRINTING BIOCOMPATIBLE NANOROUS COMPOSITES FROM AUTOLOGOUS TISSUE
US7923846B2 (en) 2007-11-16 2011-04-12 Stats Chippac Ltd. Integrated circuit package-in-package system with wire-in-film encapsulant
EP2090584A1 (en) 2008-02-13 2009-08-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Identification of a novel cysteine-rich cell penetrating peptide
KR100922232B1 (ko) 2008-02-13 2009-10-16 연세대학교 산학협력단 전기수력학 프린팅 기법을 이용한 살아있는 세포의 직접패터닝 방법 및 장치
WO2009102484A2 (en) 2008-02-14 2009-08-20 Wake Forest University Health Sciences Inkjet printing of tissues and cells
US20090248145A1 (en) 2008-03-28 2009-10-01 Nanyang Technological University Method of forming a three-dimensional structure of unidirectionally aligned cells
US8876513B2 (en) 2008-04-25 2014-11-04 3D Systems, Inc. Selective deposition modeling using CW UV LED curing
US9303245B2 (en) 2008-06-20 2016-04-05 Universiteit Maastricht Self-assembling tissue modules
KR101611936B1 (ko) 2008-06-24 2016-04-12 더 큐레이터스 오브 더 유니버시티 오브 미주리 자가-조립가능 다세포체 및 이들을 이용하여 3차원 생물학적 구조체를 생산하는 방법
US9097702B2 (en) 2008-07-29 2015-08-04 Cornell University Pathologically relevant tumor microenvironments for high-throughput drug screening
US20110212501A1 (en) 2008-09-12 2011-09-01 The Brigham And Women's Hospital, Inc. 3-dimensional multi-layered hydrogels and methods of making the same
US20110250688A1 (en) 2008-11-24 2011-10-13 Immunotrex Corporation Three Dimensional Tissue Generation
EP2450707B1 (en) 2010-11-04 2016-04-27 University of Pécs Lung tissue model
WO2011038373A2 (en) 2009-09-28 2011-03-31 Virginia Tech Intellectual Properties, Inc. Three-dimensional bioprinting of biosynthetic cellulose (bc) implants and scaffolds for tissue engineering
US8409603B2 (en) 2009-10-01 2013-04-02 University Of South Carolina Compositions and methods for tissue engineering, tissue regeneration and wound healing
KR101812820B1 (ko) 2010-01-08 2017-12-27 웨이크 포리스트 유니버시티 헬스 사이언시즈 전달 시스템
EP2523656A4 (en) 2010-01-15 2013-12-11 Univ Utah Res Found RETICULATED HYDROGELS AND METHODS OF MAKING AND USING THE SAME
JP2013518591A (ja) 2010-02-02 2013-05-23 ザ キュレーターズ オブ ザ ユニバーシティ オブ ミズーリ 改変された生物学的神経移植片の製造およびその用途
US9039998B2 (en) 2010-03-04 2015-05-26 Institut National De La Sante Et De La Recherche Medical (Inserm) Bioprinting station, assembly comprising such bioprinting station and bioprinting method
GB2489081B (en) 2010-03-16 2013-03-27 Organovo Inc Multilayered vascular tubes
US9012415B2 (en) 2010-03-26 2015-04-21 Stemmatters, Biotecnologia E Medicina Regenerativa S.A. Photo-crosslinked gellan gum-based hydrogels: preparation methods and uses thereof
US9592255B2 (en) 2010-07-01 2017-03-14 The Regents Of The University Of Michigan Scaffold-free three dimensional nerve fibroblast constructs
US20120089238A1 (en) 2010-10-06 2012-04-12 Hyun-Wook Kang Integrated organ and tissue printing methods, system and apparatus
CA2812766C (en) 2010-10-21 2021-06-29 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue
DE202011003443U1 (de) 2011-03-02 2011-12-23 Bego Medical Gmbh Vorrichtung zur generativen Herstellung dreidimensionaler Bauteile
EP2683328B1 (en) 2011-03-07 2017-11-08 Wake Forest University Health Sciences Delivery system
GB201105226D0 (en) 2011-03-29 2011-05-11 Univ Leiden Methods
JP5599356B2 (ja) 2011-03-31 2014-10-01 富士フイルム株式会社 シミュレーション方法、プログラムおよびそれを記録した記録媒体、並びに、それらを利用した液滴配置パターンの作成方法、ナノインプリント方法、パターン化基板の製造方法およびインクジェット装置。
CN103930066A (zh) 2011-09-12 2014-07-16 奥加诺沃公司 用于工程化的可植入组织和器官的平台及其制备方法
PT2773955T (pt) * 2011-11-04 2018-10-26 Inregen Triagem de fármaco e ensaios de potência
WO2013116443A1 (en) 2012-02-01 2013-08-08 Nscrypt, Inc. Micro-dispensing multi-layered 3d objects with curing steps
US10072257B2 (en) 2012-02-29 2018-09-11 Massachusetts Institute Of Technology Inverse patterning process for three-dimensional multi-compartmental micro-organization of multiple cell types
KR20140142278A (ko) 2012-03-06 2014-12-11 더 유에이비 리서치 파운데이션 삼차원, 예비맥관화, 조작 조직 구조체, 조직 구조체의 제조 방법 및 사용 방법
US9499779B2 (en) 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
US20140099709A1 (en) 2012-06-19 2014-04-10 Organovo, Inc. Engineered three-dimensional connective tissue constructs and methods of making the same
WO2014025953A2 (en) 2012-08-08 2014-02-13 Makerbot Industries, Llc Printed circuit board with integrated temperature sensing
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
WO2014144482A1 (en) 2013-03-15 2014-09-18 Matterfab Corp. Apparatus and methods for manufacturing
US9802360B2 (en) 2013-06-04 2017-10-31 Stratsys, Inc. Platen planarizing process for additive manufacturing system
BR112016002149A2 (pt) 2013-07-31 2017-08-01 Organovo Inc métodos, sistemas e dispositivos automatizados para a fabricação de tecido
EP3065875A4 (en) 2013-11-04 2018-02-07 University of Iowa Research Foundation Bioprinter and methods of using same
RU2017110275A (ru) 2014-10-06 2018-11-15 Органово, Инк. Сконструированные ткани почки, матрицы на их основе и способы их получения
DK3519558T3 (da) 2016-09-28 2023-11-13 Organovo Inc Anvendelse af modificeret nyrevæv i assays

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130190210A1 (en) * 2011-09-12 2013-07-25 Organovo, Inc. Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same

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