AU2015304847B2 - Tricyclic nitrogen containing compounds for treating Neisseria gonorrhoea infection - Google Patents
Tricyclic nitrogen containing compounds for treating Neisseria gonorrhoea infection Download PDFInfo
- Publication number
- AU2015304847B2 AU2015304847B2 AU2015304847A AU2015304847A AU2015304847B2 AU 2015304847 B2 AU2015304847 B2 AU 2015304847B2 AU 2015304847 A AU2015304847 A AU 2015304847A AU 2015304847 A AU2015304847 A AU 2015304847A AU 2015304847 B2 AU2015304847 B2 AU 2015304847B2
- Authority
- AU
- Australia
- Prior art keywords
- dihydro
- methyl
- mmol
- acid
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- QSVHDWIAWJZROG-CQSZACIVSA-N CC1CCN(C[C@H](CN(C2=C(C=C3)C=C4)C3=O)N2C4=O)CC1 Chemical compound CC1CCN(C[C@H](CN(C2=C(C=C3)C=C4)C3=O)N2C4=O)CC1 QSVHDWIAWJZROG-CQSZACIVSA-N 0.000 description 2
- PZFAZQUREQIODZ-UHFFFAOYSA-N O=C(C=C1)N(CC(CN(CC2)CCC2NCc2ncc3OCCCc3c2)N23)C2=C1N=CC3=O Chemical compound O=C(C=C1)N(CC(CN(CC2)CCC2NCc2ncc3OCCCc3c2)N23)C2=C1N=CC3=O PZFAZQUREQIODZ-UHFFFAOYSA-N 0.000 description 1
- MMKKZZRTGQEWMB-GOSISDBHSA-N O=C(C=C1)N(C[C@@H](CN(CC2)CCC2NCc2ncc3OCSc3c2)N23)C2=C1C=CC3=O Chemical compound O=C(C=C1)N(C[C@@H](CN(CC2)CCC2NCc2ncc3OCSc3c2)N23)C2=C1C=CC3=O MMKKZZRTGQEWMB-GOSISDBHSA-N 0.000 description 1
- RRGLCNPHPFOBFS-CVEARBPZSA-N O=C(COc1c2)Nc1nc(CNC[C@@H]1OCCN(C[C@H](CN(C3=C(C=C4)C=C5)C4=O)N3C5=O)C1)c2Cl Chemical compound O=C(COc1c2)Nc1nc(CNC[C@@H]1OCCN(C[C@H](CN(C3=C(C=C4)C=C5)C4=O)N3C5=O)C1)c2Cl RRGLCNPHPFOBFS-CVEARBPZSA-N 0.000 description 1
- UTOPGSISJNOHQK-OAHLLOKOSA-N O=C1Nc2nc(CNC3CCN(C[C@H](CN(C4=C(C=C5)C=C6)C5=O)N4C6=O)CC3)nc(Cl)c2OC1 Chemical compound O=C1Nc2nc(CNC3CCN(C[C@H](CN(C4=C(C=C5)C=C6)C5=O)N4C6=O)CC3)nc(Cl)c2OC1 UTOPGSISJNOHQK-OAHLLOKOSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462040488P | 2014-08-22 | 2014-08-22 | |
| US62/040,488 | 2014-08-22 | ||
| PCT/IB2015/056325 WO2016027249A1 (en) | 2014-08-22 | 2015-08-20 | Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015304847A1 AU2015304847A1 (en) | 2017-02-23 |
| AU2015304847B2 true AU2015304847B2 (en) | 2018-10-25 |
Family
ID=54072911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015304847A Ceased AU2015304847B2 (en) | 2014-08-22 | 2015-08-20 | Tricyclic nitrogen containing compounds for treating Neisseria gonorrhoea infection |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10702521B2 (enExample) |
| EP (2) | EP3639824A1 (enExample) |
| JP (2) | JP6546654B2 (enExample) |
| KR (1) | KR20170043603A (enExample) |
| CN (2) | CN110403939A (enExample) |
| AR (1) | AR101674A1 (enExample) |
| AU (1) | AU2015304847B2 (enExample) |
| BR (1) | BR112017003705B1 (enExample) |
| CA (1) | CA2958800C (enExample) |
| CL (1) | CL2017000391A1 (enExample) |
| CO (1) | CO2017001658A2 (enExample) |
| CR (1) | CR20170069A (enExample) |
| DO (1) | DOP2017000049A (enExample) |
| EA (1) | EA031589B1 (enExample) |
| ES (1) | ES2759303T3 (enExample) |
| IL (1) | IL250251A0 (enExample) |
| MX (1) | MX2017002321A (enExample) |
| PE (1) | PE20170501A1 (enExample) |
| PH (1) | PH12017500315A1 (enExample) |
| SG (1) | SG11201700566SA (enExample) |
| TW (1) | TW201618779A (enExample) |
| WO (1) | WO2016027249A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015304847B2 (en) * | 2014-08-22 | 2018-10-25 | Glaxosmithkline Intellectual Property Development Limited | Tricyclic nitrogen containing compounds for treating Neisseria gonorrhoea infection |
| BR112018075297A2 (pt) | 2016-06-08 | 2019-03-19 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A | composto, composição farmacêutica, e, método para tratar uma infecção bacteriana |
| AU2017374992A1 (en) | 2016-12-16 | 2019-06-20 | Basf Se | Pesticidal compounds |
| US20220184071A1 (en) * | 2019-04-03 | 2022-06-16 | Glaxosmithkline Intellectual Property Development Limited | Gepotidacin for use in the treatment of bacterial urinary tract infections |
| JP2022528890A (ja) * | 2019-04-03 | 2022-06-16 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | 細菌性尿路感染症の治療に使用するためのゲポチダシン |
| GB201909191D0 (en) * | 2019-06-26 | 2019-08-07 | Ucb Biopharma Sprl | Therapeutic agents |
| ES2981617T3 (es) * | 2019-07-05 | 2024-10-09 | Glaxosmithkline Intellectual Property Dev | Combinación para el tratamiento de infecciones provocadas por Mycoplasma genitalium |
| AU2020394867A1 (en) | 2019-12-02 | 2022-05-26 | Storm Therapeutics Limited | Polyheterocyclic compounds as METTL3 inhibitors |
| JP2023528560A (ja) * | 2020-04-02 | 2023-07-05 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | ゲポチダシンを用いて淋菌感染症を治療するためのレジメン |
| EP4142731A1 (en) * | 2020-04-28 | 2023-03-08 | Noorik Biopharmaceuticals AG | Treatment of pulmonary complications of coronavirus infections |
| EP4143188A1 (en) | 2020-04-29 | 2023-03-08 | GlaxoSmithKline Intellectual Property Development Limited | Crystalline forms of gepotidacin |
| WO2022167515A1 (en) | 2021-02-05 | 2022-08-11 | Glaxosmithkline Intellectual Property Development Limited | Oral solid dose formulations |
| EP4316463A1 (en) | 2022-08-02 | 2024-02-07 | GlaxoSmithKline Intellectual Property Development Limited | Novel formulation |
| CA3259117A1 (en) | 2022-09-26 | 2024-04-04 | Glaxosmithkline Ip Dev Ltd | GEPOTIDACIN INTENDED FOR USE IN THE TREATMENT OF BACTERIAL PROSTATITIS |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010043714A1 (en) * | 2008-10-17 | 2010-04-22 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
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| ZA931343B (en) | 1992-03-06 | 1993-09-24 | Akzo Nv | 1,4-dioxino(2,3-b)pyridine derivatives. |
| ES2145072T3 (es) * | 1993-05-13 | 2000-07-01 | American Cyanamid Co | Preparacion y usos de proteinas de membranas externas carentes de los de cocos gramnegativos. |
| GB0207450D0 (en) | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| FR2798656B1 (fr) | 1999-09-17 | 2004-12-17 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
| DE60025048D1 (de) | 2000-07-21 | 2006-01-26 | Ljudmila Petrovna Maljuk | Teller für stehempfänge |
| DE60125373T2 (de) | 2000-07-26 | 2007-10-18 | Smithkline Beecham P.L.C., Brentford | Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung |
| NZ525055A (en) | 2000-09-29 | 2004-09-24 | Glaxo Group Ltd | Compounds useful in the treatment of inflammatory diseases |
| FR2816618B1 (fr) | 2000-11-15 | 2002-12-27 | Aventis Pharma Sa | Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent |
| GB0031088D0 (en) | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| AU2002219175A1 (en) | 2000-12-21 | 2002-07-01 | Ciba Speciality Chemicals Holding Inc. | Crystalline forms of cerivastatin sodium |
| GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0118238D0 (en) | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
| WO2003048081A2 (en) | 2001-12-04 | 2003-06-12 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
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| GB0217294D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicaments |
| FR2844268B1 (fr) | 2002-09-11 | 2004-10-22 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
| FR2844270B1 (fr) | 2002-09-11 | 2006-05-19 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent |
| WO2004035569A2 (de) | 2002-10-10 | 2004-04-29 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue verbindungen mit antibakterieller aktivität |
| JP4704755B2 (ja) | 2002-11-05 | 2011-06-22 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 抗菌剤 |
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| FR2867472B1 (fr) | 2004-03-12 | 2008-07-18 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
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| FR2872164B1 (fr) | 2004-06-29 | 2006-11-17 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
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| WO2010043714A1 (en) * | 2008-10-17 | 2010-04-22 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
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