AU2015304847B2 - Tricyclic nitrogen containing compounds for treating Neisseria gonorrhoea infection - Google Patents
Tricyclic nitrogen containing compounds for treating Neisseria gonorrhoea infection Download PDFInfo
- Publication number
- AU2015304847B2 AU2015304847B2 AU2015304847A AU2015304847A AU2015304847B2 AU 2015304847 B2 AU2015304847 B2 AU 2015304847B2 AU 2015304847 A AU2015304847 A AU 2015304847A AU 2015304847 A AU2015304847 A AU 2015304847A AU 2015304847 B2 AU2015304847 B2 AU 2015304847B2
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- AU
- Australia
- Prior art keywords
- dihydro
- methyl
- mmol
- acid
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- QSVHDWIAWJZROG-CQSZACIVSA-N CC1CCN(C[C@H](CN(C2=C(C=C3)C=C4)C3=O)N2C4=O)CC1 Chemical compound CC1CCN(C[C@H](CN(C2=C(C=C3)C=C4)C3=O)N2C4=O)CC1 QSVHDWIAWJZROG-CQSZACIVSA-N 0.000 description 2
- PZFAZQUREQIODZ-UHFFFAOYSA-N O=C(C=C1)N(CC(CN(CC2)CCC2NCc2ncc3OCCCc3c2)N23)C2=C1N=CC3=O Chemical compound O=C(C=C1)N(CC(CN(CC2)CCC2NCc2ncc3OCCCc3c2)N23)C2=C1N=CC3=O PZFAZQUREQIODZ-UHFFFAOYSA-N 0.000 description 1
- MMKKZZRTGQEWMB-GOSISDBHSA-N O=C(C=C1)N(C[C@@H](CN(CC2)CCC2NCc2ncc3OCSc3c2)N23)C2=C1C=CC3=O Chemical compound O=C(C=C1)N(C[C@@H](CN(CC2)CCC2NCc2ncc3OCSc3c2)N23)C2=C1C=CC3=O MMKKZZRTGQEWMB-GOSISDBHSA-N 0.000 description 1
- RRGLCNPHPFOBFS-CVEARBPZSA-N O=C(COc1c2)Nc1nc(CNC[C@@H]1OCCN(C[C@H](CN(C3=C(C=C4)C=C5)C4=O)N3C5=O)C1)c2Cl Chemical compound O=C(COc1c2)Nc1nc(CNC[C@@H]1OCCN(C[C@H](CN(C3=C(C=C4)C=C5)C4=O)N3C5=O)C1)c2Cl RRGLCNPHPFOBFS-CVEARBPZSA-N 0.000 description 1
- UTOPGSISJNOHQK-OAHLLOKOSA-N O=C1Nc2nc(CNC3CCN(C[C@H](CN(C4=C(C=C5)C=C6)C5=O)N4C6=O)CC3)nc(Cl)c2OC1 Chemical compound O=C1Nc2nc(CNC3CCN(C[C@H](CN(C4=C(C=C5)C=C6)C5=O)N4C6=O)CC3)nc(Cl)c2OC1 UTOPGSISJNOHQK-OAHLLOKOSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462040488P | 2014-08-22 | 2014-08-22 | |
| US62/040,488 | 2014-08-22 | ||
| PCT/IB2015/056325 WO2016027249A1 (en) | 2014-08-22 | 2015-08-20 | Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015304847A1 AU2015304847A1 (en) | 2017-02-23 |
| AU2015304847B2 true AU2015304847B2 (en) | 2018-10-25 |
Family
ID=54072911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015304847A Ceased AU2015304847B2 (en) | 2014-08-22 | 2015-08-20 | Tricyclic nitrogen containing compounds for treating Neisseria gonorrhoea infection |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10702521B2 (enExample) |
| EP (2) | EP3182973B1 (enExample) |
| JP (2) | JP6546654B2 (enExample) |
| KR (1) | KR20170043603A (enExample) |
| CN (2) | CN106659717B (enExample) |
| AR (1) | AR101674A1 (enExample) |
| AU (1) | AU2015304847B2 (enExample) |
| BR (1) | BR112017003705B1 (enExample) |
| CA (1) | CA2958800C (enExample) |
| CL (1) | CL2017000391A1 (enExample) |
| CO (1) | CO2017001658A2 (enExample) |
| CR (1) | CR20170069A (enExample) |
| DO (1) | DOP2017000049A (enExample) |
| EA (1) | EA031589B1 (enExample) |
| ES (1) | ES2759303T3 (enExample) |
| IL (1) | IL250251A0 (enExample) |
| MX (1) | MX2017002321A (enExample) |
| PE (1) | PE20170501A1 (enExample) |
| PH (1) | PH12017500315A1 (enExample) |
| SG (1) | SG11201700566SA (enExample) |
| TW (1) | TW201618779A (enExample) |
| WO (1) | WO2016027249A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR101674A1 (es) * | 2014-08-22 | 2017-01-04 | Glaxosmithkline Ip Dev Ltd | Uso de un compuesto tricíclico que contiene nitrógeno |
| EP3468975B1 (en) | 2016-06-08 | 2020-04-01 | Aziende Chimiche Riunite Angelini Francesco A.C.R. | New antibacterial compounds |
| US20200077658A1 (en) | 2016-12-16 | 2020-03-12 | Basf Se | Pesticidal Compounds |
| US20220184071A1 (en) * | 2019-04-03 | 2022-06-16 | Glaxosmithkline Intellectual Property Development Limited | Gepotidacin for use in the treatment of bacterial urinary tract infections |
| BR112021018815A2 (pt) * | 2019-04-03 | 2022-03-03 | Glaxosmithkline Ip Dev Ltd | Gepotidacina para uso no tratamento de infecções bacterianas do trato urinário |
| GB201909191D0 (en) * | 2019-06-26 | 2019-08-07 | Ucb Biopharma Sprl | Therapeutic agents |
| CN114173789A (zh) * | 2019-07-05 | 2022-03-11 | 葛兰素史克知识产权发展有限公司 | 用于治疗由生殖支原体引起的感染的组合 |
| US12195458B2 (en) | 2019-12-02 | 2025-01-14 | Storm Therapeutics Limited | Polyheterocyclic compounds as METTL3 inhibitors |
| JP2023528560A (ja) * | 2020-04-02 | 2023-07-05 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | ゲポチダシンを用いて淋菌感染症を治療するためのレジメン |
| EP4142731A1 (en) * | 2020-04-28 | 2023-03-08 | Noorik Biopharmaceuticals AG | Treatment of pulmonary complications of coronavirus infections |
| CN115667261A (zh) * | 2020-04-29 | 2023-01-31 | 葛兰素史克知识产权发展有限公司 | 吉泊达星的结晶形式 |
| WO2022167515A1 (en) | 2021-02-05 | 2022-08-11 | Glaxosmithkline Intellectual Property Development Limited | Oral solid dose formulations |
| EP4316463A1 (en) | 2022-08-02 | 2024-02-07 | GlaxoSmithKline Intellectual Property Development Limited | Novel formulation |
| CN119546302A (zh) | 2022-09-26 | 2025-02-28 | 葛兰素史密斯克莱知识产权发展有限公司 | 用于治疗细菌性前列腺炎的吉泊达星 |
| CN121537412B (zh) * | 2026-01-16 | 2026-04-03 | 南京道尔医药研究院有限公司 | 一种吉泊达星甲磺酸盐的制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010043714A1 (en) * | 2008-10-17 | 2010-04-22 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
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| ZA931343B (en) | 1992-03-06 | 1993-09-24 | Akzo Nv | 1,4-dioxino(2,3-b)pyridine derivatives. |
| DK0624376T3 (da) * | 1993-05-13 | 2000-07-24 | American Cyanamid Co | Fremstilling og anvendelse af LOS-udtømte ydre membranproteiner af gram-negative cocci |
| GB0207450D0 (en) | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| FR2798656B1 (fr) | 1999-09-17 | 2004-12-17 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
| PL364808A1 (en) | 2000-07-21 | 2004-12-13 | Ljudmila Petrovna Maljuk | Plate for a stand-up meal |
| CN1452619A (zh) | 2000-07-26 | 2003-10-29 | 史密斯克莱·比奇曼公司 | 具有抗细菌活性的氨基哌啶喹啉和它们的氮杂等排的类似物 |
| IL155092A0 (en) | 2000-09-29 | 2003-10-31 | Glaxo Group Ltd | Compounds useful in the treatment of inflammatory diseases |
| FR2816618B1 (fr) | 2000-11-15 | 2002-12-27 | Aventis Pharma Sa | Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent |
| GB0031088D0 (en) | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
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| AR040336A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
| GB0217294D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicaments |
| FR2844268B1 (fr) | 2002-09-11 | 2004-10-22 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
| FR2844270B1 (fr) | 2002-09-11 | 2006-05-19 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent |
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| TW200507841A (en) | 2003-03-27 | 2005-03-01 | Glaxo Group Ltd | Antibacterial agents |
| FR2852954B1 (fr) | 2003-03-28 | 2006-07-14 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
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| FR2858619B1 (fr) | 2003-08-08 | 2006-12-22 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2867472B1 (fr) | 2004-03-12 | 2008-07-18 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
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| FR2872164B1 (fr) | 2004-06-29 | 2006-11-17 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
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| WO2010043714A1 (en) * | 2008-10-17 | 2010-04-22 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
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