AU2015300825B2 - Crystal forms of glutaminase inhibitors - Google Patents

Crystal forms of glutaminase inhibitors Download PDF

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Publication number
AU2015300825B2
AU2015300825B2 AU2015300825A AU2015300825A AU2015300825B2 AU 2015300825 B2 AU2015300825 B2 AU 2015300825B2 AU 2015300825 A AU2015300825 A AU 2015300825A AU 2015300825 A AU2015300825 A AU 2015300825A AU 2015300825 B2 AU2015300825 B2 AU 2015300825B2
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AU
Australia
Prior art keywords
cancer
salt
compound
crystalline
cell
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2015300825A
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English (en)
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AU2015300825A1 (en
Inventor
James J. Springer
Timothy F. Stanton
Jacqueline N. Williams
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Calithera Biosciences Inc
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Calithera Biosciences Inc
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Publication of AU2015300825A1 publication Critical patent/AU2015300825A1/en
Application granted granted Critical
Publication of AU2015300825B2 publication Critical patent/AU2015300825B2/en
Priority to AU2019284149A priority Critical patent/AU2019284149A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2015300825A 2014-08-07 2015-08-07 Crystal forms of glutaminase inhibitors Ceased AU2015300825B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2019284149A AU2019284149A1 (en) 2014-08-07 2019-12-31 Crystal forms of glutaminase inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462034547P 2014-08-07 2014-08-07
US62/034,547 2014-08-07
PCT/US2015/044301 WO2016022969A1 (en) 2014-08-07 2015-08-07 Crystal forms of glutaminase inhibitors

Related Child Applications (1)

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AU2019284149A Division AU2019284149A1 (en) 2014-08-07 2019-12-31 Crystal forms of glutaminase inhibitors

Publications (2)

Publication Number Publication Date
AU2015300825A1 AU2015300825A1 (en) 2017-03-09
AU2015300825B2 true AU2015300825B2 (en) 2019-10-10

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AU2015300825A Ceased AU2015300825B2 (en) 2014-08-07 2015-08-07 Crystal forms of glutaminase inhibitors
AU2019284149A Abandoned AU2019284149A1 (en) 2014-08-07 2019-12-31 Crystal forms of glutaminase inhibitors

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AU2019284149A Abandoned AU2019284149A1 (en) 2014-08-07 2019-12-31 Crystal forms of glutaminase inhibitors

Country Status (13)

Country Link
US (2) US10316030B2 (enExample)
EP (1) EP3193876B1 (enExample)
JP (3) JP6889101B2 (enExample)
KR (1) KR20170082494A (enExample)
CN (1) CN106999490A (enExample)
AU (2) AU2015300825B2 (enExample)
BR (1) BR112017002403A2 (enExample)
CA (1) CA2957225A1 (enExample)
EA (1) EA037738B1 (enExample)
IL (1) IL250391B (enExample)
MX (1) MX2017001620A (enExample)
SG (1) SG11201700816YA (enExample)
WO (1) WO2016022969A1 (enExample)

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EA026100B1 (ru) 2011-03-11 2017-03-31 Селджин Корпорейшн Твердые формы 3-(5-амино-2-метил-4-оксо-4н-хиназолин-3-ил)пиперидин-2,6-диона и их фармацевтические композиции и применение
US8604016B2 (en) 2011-11-21 2013-12-10 Calithera Biosciences Inc. Heterocyclic inhibitors of glutaminase
US9682952B2 (en) 2012-09-04 2017-06-20 Celgene Corporation Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl) piperidine-2-6-dione and methods of preparation thereof
JP6275153B2 (ja) 2012-11-16 2018-02-07 キャリセラ バイオサイエンシーズ， インコーポレイテッド ヘテロ環式グルタミナーゼ阻害剤
AU2015274361B2 (en) 2014-06-13 2020-11-05 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors
EA037738B1 (ru) 2014-08-07 2021-05-17 Калитера Байосайенсиз, Инк. Кристаллические формы ингибиторов глутаминазы
JP6768693B2 (ja) * 2015-03-30 2020-10-14 キャリセラ バイオサイエンシーズ， インコーポレイテッド グルタミナーゼ阻害剤を投与する方法
US10441587B2 (en) 2015-04-06 2019-10-15 Calithera Biosciences, Inc. Treatment of lung cancer with inhibitors of glutaminase
WO2017062354A1 (en) 2015-10-05 2017-04-13 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors and immuno-oncology agents
CN109982703A (zh) 2016-08-25 2019-07-05 卡利泰拉生物科技公司 用谷氨酰胺酶抑制剂的组合疗法
WO2018039544A1 (en) 2016-08-25 2018-03-01 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors
US20210177880A1 (en) * 2017-10-31 2021-06-17 President And Fellows Of Harvard College Methods and compositions for treating acute myeloid leukemia
CN113811358A (zh) * 2019-03-26 2021-12-17 通尼克斯制药控股有限公司 S-(n,n-二乙基氨基甲酰基)谷胱甘肽的盐形式
CN114295836B (zh) * 2021-12-22 2024-12-31 融智生物科技（青岛）有限公司 一种计算设备、存储介质和胶质瘤idh分型检测装置及系统

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Also Published As

Publication number Publication date
IL250391A0 (en) 2017-03-30
SG11201700816YA (en) 2017-02-27
CN106999490A (zh) 2017-08-01
US20190359607A1 (en) 2019-11-28
US10676472B2 (en) 2020-06-09
BR112017002403A2 (pt) 2017-12-05
MX2017001620A (es) 2017-05-10
JP6889101B2 (ja) 2021-06-18
JP2017523991A (ja) 2017-08-24
AU2015300825A1 (en) 2017-03-09
US10316030B2 (en) 2019-06-11
JP2020037588A (ja) 2020-03-12
EP3193876A1 (en) 2017-07-26
CA2957225A1 (en) 2016-02-11
EP3193876A4 (en) 2017-12-27
EA201790337A1 (ru) 2017-09-29
JP2021165286A (ja) 2021-10-14
AU2019284149A1 (en) 2020-01-30
EA037738B1 (ru) 2021-05-17
US20170226101A1 (en) 2017-08-10
KR20170082494A (ko) 2017-07-14
IL250391B (en) 2021-10-31
WO2016022969A1 (en) 2016-02-11
EP3193876B1 (en) 2022-01-12

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