IL250391B - Crystalline forms of glutaminase inhibitors - Google Patents

Crystalline forms of glutaminase inhibitors

Info

Publication number
IL250391B
IL250391B IL250391A IL25039117A IL250391B IL 250391 B IL250391 B IL 250391B IL 250391 A IL250391 A IL 250391A IL 25039117 A IL25039117 A IL 25039117A IL 250391 B IL250391 B IL 250391B
Authority
IL
Israel
Prior art keywords
crystal forms
glutaminase inhibitors
glutaminase
inhibitors
crystal
Prior art date
Application number
IL250391A
Other languages
English (en)
Hebrew (he)
Other versions
IL250391A0 (en
Original Assignee
Calithera Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calithera Biosciences Inc filed Critical Calithera Biosciences Inc
Publication of IL250391A0 publication Critical patent/IL250391A0/en
Publication of IL250391B publication Critical patent/IL250391B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL250391A 2014-08-07 2017-02-01 Crystalline forms of glutaminase inhibitors IL250391B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462034547P 2014-08-07 2014-08-07
PCT/US2015/044301 WO2016022969A1 (en) 2014-08-07 2015-08-07 Crystal forms of glutaminase inhibitors

Publications (2)

Publication Number Publication Date
IL250391A0 IL250391A0 (en) 2017-03-30
IL250391B true IL250391B (en) 2021-10-31

Family

ID=55264662

Family Applications (1)

Application Number Title Priority Date Filing Date
IL250391A IL250391B (en) 2014-08-07 2017-02-01 Crystalline forms of glutaminase inhibitors

Country Status (13)

Country Link
US (2) US10316030B2 (enExample)
EP (1) EP3193876B1 (enExample)
JP (3) JP6889101B2 (enExample)
KR (1) KR20170082494A (enExample)
CN (1) CN106999490A (enExample)
AU (2) AU2015300825B2 (enExample)
BR (1) BR112017002403A2 (enExample)
CA (1) CA2957225A1 (enExample)
EA (1) EA037738B1 (enExample)
IL (1) IL250391B (enExample)
MX (1) MX2017001620A (enExample)
SG (1) SG11201700816YA (enExample)
WO (1) WO2016022969A1 (enExample)

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US9682952B2 (en) 2012-09-04 2017-06-20 Celgene Corporation Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl) piperidine-2-6-dione and methods of preparation thereof
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AU2015274361B2 (en) 2014-06-13 2020-11-05 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors
EA037738B1 (ru) 2014-08-07 2021-05-17 Калитера Байосайенсиз, Инк. Кристаллические формы ингибиторов глутаминазы
JP6768693B2 (ja) * 2015-03-30 2020-10-14 キャリセラ バイオサイエンシーズ， インコーポレイテッド グルタミナーゼ阻害剤を投与する方法
US10441587B2 (en) 2015-04-06 2019-10-15 Calithera Biosciences, Inc. Treatment of lung cancer with inhibitors of glutaminase
WO2017062354A1 (en) 2015-10-05 2017-04-13 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors and immuno-oncology agents
CN109982703A (zh) 2016-08-25 2019-07-05 卡利泰拉生物科技公司 用谷氨酰胺酶抑制剂的组合疗法
WO2018039544A1 (en) 2016-08-25 2018-03-01 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors
US20210177880A1 (en) * 2017-10-31 2021-06-17 President And Fellows Of Harvard College Methods and compositions for treating acute myeloid leukemia
CN113811358A (zh) * 2019-03-26 2021-12-17 通尼克斯制药控股有限公司 S-(n,n-二乙基氨基甲酰基)谷胱甘肽的盐形式
CN114295836B (zh) * 2021-12-22 2024-12-31 融智生物科技（青岛）有限公司 一种计算设备、存储介质和胶质瘤idh分型检测装置及系统

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WO2014089048A1 (en) * 2012-12-03 2014-06-12 Calithera Biosciences, Inc. Treatment of cancer with heterocyclic inhibitors of glutaminase

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Also Published As

Publication number Publication date
IL250391A0 (en) 2017-03-30
SG11201700816YA (en) 2017-02-27
CN106999490A (zh) 2017-08-01
US20190359607A1 (en) 2019-11-28
US10676472B2 (en) 2020-06-09
BR112017002403A2 (pt) 2017-12-05
MX2017001620A (es) 2017-05-10
JP6889101B2 (ja) 2021-06-18
JP2017523991A (ja) 2017-08-24
AU2015300825A1 (en) 2017-03-09
US10316030B2 (en) 2019-06-11
JP2020037588A (ja) 2020-03-12
EP3193876A1 (en) 2017-07-26
CA2957225A1 (en) 2016-02-11
EP3193876A4 (en) 2017-12-27
EA201790337A1 (ru) 2017-09-29
JP2021165286A (ja) 2021-10-14
AU2019284149A1 (en) 2020-01-30
EA037738B1 (ru) 2021-05-17
US20170226101A1 (en) 2017-08-10
KR20170082494A (ko) 2017-07-14
AU2015300825B2 (en) 2019-10-10
WO2016022969A1 (en) 2016-02-11
EP3193876B1 (en) 2022-01-12

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