EA037738B1 - Кристаллические формы ингибиторов глутаминазы - Google Patents
Кристаллические формы ингибиторов глутаминазы Download PDFInfo
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- EA037738B1 EA037738B1 EA201790337A EA201790337A EA037738B1 EA 037738 B1 EA037738 B1 EA 037738B1 EA 201790337 A EA201790337 A EA 201790337A EA 201790337 A EA201790337 A EA 201790337A EA 037738 B1 EA037738 B1 EA 037738B1
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- cancer
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
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| LT2420498T (lt) | 2006-09-26 | 2017-10-25 | Celgene Corporation | 5-pakeistieji chinazolinono dariniai, kaip priešvėžiniai agentai |
| RS56770B1 (sr) | 2011-03-11 | 2018-04-30 | Celgene Corp | Čvrste forme 3-(5-amino-2-metil-4-okso-4h-hinazolin-3-il)-piperidin-2,6-diona i njihove farmaceutske smeše i upotrebe |
| US8604016B2 (en) | 2011-11-21 | 2013-12-10 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
| CN104755472A (zh) | 2012-09-04 | 2015-07-01 | 细胞基因公司 | 3-(5-氨基-2-甲基-4-氧代喹唑啉-3(4h)-基)哌啶-2,6-二酮的同位素体及其制备方法 |
| LT2920168T (lt) | 2012-11-16 | 2021-10-25 | Calithera Biosciences, Inc. | Heterociklinis gliutaminazės inhibitorius |
| EP3154590B1 (en) | 2014-06-13 | 2021-04-14 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
| EA037738B1 (ru) | 2014-08-07 | 2021-05-17 | Калитера Байосайенсиз, Инк. | Кристаллические формы ингибиторов глутаминазы |
| EA037152B1 (ru) * | 2015-03-30 | 2021-02-11 | Калитера Байосайенсиз, Инк. | Способ лечения рака |
| EP3280415A4 (en) | 2015-04-06 | 2018-12-26 | Calithera Biosciences Inc. | Treatment of lung cancer with inhibitors of glutaminase |
| CA3000996A1 (en) | 2015-10-05 | 2017-04-13 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors and immuno-oncology agents |
| MX2019002108A (es) | 2016-08-25 | 2019-07-08 | Calithera Biosciences Inc | Terapia de combinacion con inhibidores de glutaminasa. |
| WO2018039441A1 (en) | 2016-08-25 | 2018-03-01 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
| US20210177880A1 (en) * | 2017-10-31 | 2021-06-17 | President And Fellows Of Harvard College | Methods and compositions for treating acute myeloid leukemia |
| AU2020249868A1 (en) * | 2019-03-26 | 2021-10-21 | Tonix Pharma Holdings Limited | Salt forms of S-(N, N-diethylcarbamoyl)glutathione |
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| WO2013078123A1 (en) * | 2011-11-21 | 2013-05-30 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
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| IL250391B (en) | 2021-10-31 |
| EA201790337A1 (ru) | 2017-09-29 |
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| EP3193876A4 (en) | 2017-12-27 |
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| EP3193876B1 (en) | 2022-01-12 |
| BR112017002403A2 (pt) | 2017-12-05 |
| US10316030B2 (en) | 2019-06-11 |
| JP2017523991A (ja) | 2017-08-24 |
| AU2015300825A1 (en) | 2017-03-09 |
| SG11201700816YA (en) | 2017-02-27 |
| US20190359607A1 (en) | 2019-11-28 |
| US20170226101A1 (en) | 2017-08-10 |
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