EA037738B1 - Кристаллические формы ингибиторов глутаминазы - Google Patents
Кристаллические формы ингибиторов глутаминазы Download PDFInfo
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- EA037738B1 EA037738B1 EA201790337A EA201790337A EA037738B1 EA 037738 B1 EA037738 B1 EA 037738B1 EA 201790337 A EA201790337 A EA 201790337A EA 201790337 A EA201790337 A EA 201790337A EA 037738 B1 EA037738 B1 EA 037738B1
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- cancer
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US8604016B2 (en) | 2011-11-21 | 2013-12-10 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
| ES2814952T3 (es) | 2012-09-04 | 2021-03-29 | Celgene Corp | Isotopólogos de 3-(5-amino-2-metil-4-oxoquinazolin-3(4H)-il) piperidina-2-6-diona y métodos de preparación de los mismos |
| SMT202100589T1 (it) | 2012-11-16 | 2021-11-12 | Calithera Biosciences Inc | Inibitori di glutaminasi eterociclici |
| SG11201610333VA (en) | 2014-06-13 | 2017-01-27 | Calithera Biosciences Inc | Combination therapy with glutaminase inhibitors |
| EP3193876B1 (en) | 2014-08-07 | 2022-01-12 | Calithera Biosciences Inc. | Crystal forms of glutaminase inhibitors |
| US20160287564A1 (en) * | 2015-03-30 | 2016-10-06 | Calithera Biosciences, Inc. | Methods of administering glutaminase inhibitors |
| JP6944377B2 (ja) | 2015-04-06 | 2021-10-06 | キャリセラ バイオサイエンシーズ， インコーポレイテッド | グルタミナーゼの阻害剤を用いる肺がんの処置 |
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| JP2019524852A (ja) | 2016-08-25 | 2019-09-05 | キャリセラ バイオサイエンシーズ， インコーポレイテッド | グルタミナーゼ阻害剤を用いる併用療法 |
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| US20210177880A1 (en) * | 2017-10-31 | 2021-06-17 | President And Fellows Of Harvard College | Methods and compositions for treating acute myeloid leukemia |
| EP3946601A1 (en) * | 2019-03-26 | 2022-02-09 | Tonix Pharma Holdings Limited | Salt forms of s-(n, n-diethylcarbamoyl)glutathione |
| CN114295836B (zh) * | 2021-12-22 | 2024-12-31 | 融智生物科技（青岛）有限公司 | 一种计算设备、存储介质和胶质瘤idh分型检测装置及系统 |
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| WO2013078123A1 (en) * | 2011-11-21 | 2013-05-30 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
| US20130157998A1 (en) * | 2011-11-21 | 2013-06-20 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
| WO2014078645A1 (en) * | 2012-11-16 | 2014-05-22 | Calithera Biosciences, Inc. | Heterocyclic glutaminase inhibitors |
| WO2014089048A1 (en) * | 2012-12-03 | 2014-06-12 | Calithera Biosciences, Inc. | Treatment of cancer with heterocyclic inhibitors of glutaminase |
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| EP3193876A4 (en) | 2017-12-27 |
| WO2016022969A1 (en) | 2016-02-11 |
| US10676472B2 (en) | 2020-06-09 |
| CN106999490A (zh) | 2017-08-01 |
| US10316030B2 (en) | 2019-06-11 |
| IL250391A0 (en) | 2017-03-30 |
| JP2017523991A (ja) | 2017-08-24 |
| SG11201700816YA (en) | 2017-02-27 |
| JP6889101B2 (ja) | 2021-06-18 |
| AU2015300825B2 (en) | 2019-10-10 |
| IL250391B (en) | 2021-10-31 |
| EP3193876B1 (en) | 2022-01-12 |
| CA2957225A1 (en) | 2016-02-11 |
| AU2019284149A1 (en) | 2020-01-30 |
| BR112017002403A2 (pt) | 2017-12-05 |
| JP2021165286A (ja) | 2021-10-14 |
| MX2017001620A (es) | 2017-05-10 |
| EA201790337A1 (ru) | 2017-09-29 |
| US20170226101A1 (en) | 2017-08-10 |
| AU2015300825A1 (en) | 2017-03-09 |
| JP2020037588A (ja) | 2020-03-12 |
| US20190359607A1 (en) | 2019-11-28 |
| KR20170082494A (ko) | 2017-07-14 |
| EP3193876A1 (en) | 2017-07-26 |
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