AU2015295073B2 - A method of preparing amorphous solid dispersion in submicron range by co-precipitation - Google Patents

A method of preparing amorphous solid dispersion in submicron range by co-precipitation Download PDF

Info

Publication number
AU2015295073B2
AU2015295073B2 AU2015295073A AU2015295073A AU2015295073B2 AU 2015295073 B2 AU2015295073 B2 AU 2015295073B2 AU 2015295073 A AU2015295073 A AU 2015295073A AU 2015295073 A AU2015295073 A AU 2015295073A AU 2015295073 B2 AU2015295073 B2 AU 2015295073B2
Authority
AU
Australia
Prior art keywords
solvent
active compound
pharmaceutically active
range
stabilizing agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2015295073A
Other languages
English (en)
Other versions
AU2015295073A1 (en
Inventor
Iris DUARTE
Filipe GASPER
Ruben PEREIRA
Marcio Temtem
Joao Vicente
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hovione International Ltd
Original Assignee
Hovione Inter AG
Hovione International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Inter AG, Hovione International Ltd filed Critical Hovione Inter AG
Publication of AU2015295073A1 publication Critical patent/AU2015295073A1/en
Application granted granted Critical
Publication of AU2015295073B2 publication Critical patent/AU2015295073B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0008—Sols of inorganic materials in water
    • B01J13/0013—Sols of inorganic materials in water from a precipitate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2015295073A 2014-08-01 2015-07-31 A method of preparing amorphous solid dispersion in submicron range by co-precipitation Active AU2015295073B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT107846 2014-08-01
PT10784614A PT107846B (pt) 2014-08-01 2014-08-01 Produção de nano- partículas de dispersões sólidas amorfas por co-precipitação controlada
PCT/GB2015/052233 WO2016016665A1 (en) 2014-08-01 2015-07-31 A method of preparing amorphous solid dispersion in submicron range by co-precipitation

Publications (2)

Publication Number Publication Date
AU2015295073A1 AU2015295073A1 (en) 2017-02-23
AU2015295073B2 true AU2015295073B2 (en) 2019-12-19

Family

ID=54011738

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015295073A Active AU2015295073B2 (en) 2014-08-01 2015-07-31 A method of preparing amorphous solid dispersion in submicron range by co-precipitation

Country Status (9)

Country Link
US (1) US20170209372A1 (https=)
EP (1) EP3174528A1 (https=)
JP (4) JP2017523205A (https=)
CN (2) CN107205931A (https=)
AU (1) AU2015295073B2 (https=)
CA (1) CA2956732C (https=)
IL (1) IL250372A0 (https=)
PT (1) PT107846B (https=)
WO (1) WO2016016665A1 (https=)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2802314B1 (en) 2012-01-13 2020-11-25 XSpray Microparticles AB A method for producing stable, amorphous hybrid nanoparticles comprising at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix- forming component.
JO3754B1 (ar) 2012-06-04 2021-01-31 Pharmacyclics Llc أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون
SG11201700849XA (en) 2014-08-07 2017-03-30 Pharmacyclics Llc Novel formulations of a bruton's tyrosine kinase inhibitor
IL315294A (en) 2015-03-03 2024-10-01 Pharmacyclics Llc Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
PT108368B (pt) 2015-03-31 2018-11-05 Hovione Farm S A Produção contínua de partículas
CN105963257B (zh) * 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 一种缓释微粒的制备方法
CN105878190B (zh) * 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 缓释微粒的制备方法、制得的缓释微粒及其应用
CN105963258B (zh) * 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 一种缓释微粒的制备方法
CN105878191B (zh) * 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 缓释微粒的制备方法、制得的缓释微粒及其应用
US11491114B2 (en) * 2016-10-12 2022-11-08 Curioralrx, Llc Formulations for enteric delivery of therapeutic agents
ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
JP2020506905A (ja) * 2017-01-20 2020-03-05 コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． （ｒ）−ｎ−（（４−メトキシ−６−メチル−２−オキソ−１，２−ジヒドロピリジン−３−イル）メチル）−２−メチル−１−（１−（１−（２，２，２−トリフルオロエチル）ピペリジン−４−イル）エチル）−１ｈ−インドール−３−カルボキサミド固体分散液
CN110494422A (zh) * 2017-03-15 2019-11-22 太阳制药先进研究有限公司 4-甲基-3-喹啉-3-基乙炔基-苯甲酸n’-(2-氯-6-甲基-苯甲酰基)酰肼的新型无定形分散体
CN107157941B (zh) * 2017-05-16 2020-12-25 北京化工大学 一种达沙替尼纳米制剂及其制备方法
PT110585B (pt) * 2018-02-22 2021-04-22 Hovione Farmaciencia Sa Processo de produção contínua de partículas compreendendo secagem por atomização com preparação contínua da solução de atomização
EP3793527A1 (en) * 2018-05-14 2021-03-24 Capsugel Belgium NV Solid dosage forms with high active agent loading
CN113292537B (zh) 2018-06-15 2024-04-05 汉达癌症医药责任有限公司 激酶抑制剂的盐类及其组合物
BR112021006821A2 (pt) 2018-10-12 2021-07-13 Hovione Scientia Limited método de tratamento de inflamação e patologias oftálmicas, dispersão sólida, formulação farmacêutica, método de matar ácaros e kit
KR102941878B1 (ko) * 2019-02-05 2026-03-23 린디 바이오사이언시스, 아이엔씨. 단리된 세포 배양 성분 및 액체 세포 배양 배지로부터 이를 단리하는 방법
CN113573712A (zh) 2019-02-18 2021-10-29 斯莱班克制药有限责任公司 尼洛替尼的药物组合物
WO2021064123A1 (en) * 2019-10-03 2021-04-08 Synthon B.V. Pharmaceutical composition comprising enzalutamide
WO2021072635A1 (zh) * 2019-10-15 2021-04-22 诸暨易联众创企业管理服务有限公司 一种棒状氯化亚铁纳米材料的制备方法
JP7378279B2 (ja) * 2019-11-18 2023-11-13 日本化薬株式会社 ニロチニブを有効成分とする医薬錠剤及びその製造方法
CN110693839B (zh) * 2019-11-19 2022-03-08 乐普药业股份有限公司 一种甲磺酸仑伐替尼固体分散体及其制备方法和用途
CN112933049B (zh) * 2019-11-26 2024-02-06 深圳微芯生物科技股份有限公司 含无定型态芳杂环化合物的组合物、其制备方法及用途
WO2021134647A1 (zh) * 2019-12-31 2021-07-08 广州帝奇医药技术有限公司 一种持续释放组合物及其制备方法
EP4714503A2 (en) 2020-01-24 2026-03-25 Handa Therapeutics, LLC Amorphous solid dispersions of dasatinib and uses thereof
CA3168680A1 (en) 2020-01-31 2021-08-05 Nanocopoeia, Llc Amorphous nilotinib microparticles and uses thereof
EP3884930A1 (en) * 2020-03-23 2021-09-29 Bayer AG Nano-dry-melting
WO2021222739A1 (en) * 2020-04-30 2021-11-04 Nanocopoeia, Llc Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib
TW202521099A (zh) * 2020-06-05 2025-06-01 美商應用材料股份有限公司 經塗佈的藥物組成物及製備彼之方法
EP4164618A4 (en) * 2020-06-10 2024-06-19 Board of Regents, The University of Texas System 3D LASER SINTERING PROCESS FOR IMPROVED ACTIVE INGREDIENT RELEASE
CN112121014A (zh) * 2020-08-19 2020-12-25 汕尾市前瞻高等理工研究院 一种制备稳定无定型药物固体制剂的方法
US20230414510A1 (en) * 2020-09-08 2023-12-28 Crititech, Inc. Niclosamide particles and uses thereof
MX2023003556A (es) * 2020-09-29 2023-06-13 Shenzhen Pharmacin Co Ltd Composiciones farmaceuticas.
PT117030B (pt) * 2021-01-25 2024-03-08 Hovione Farm S A Método de secagem de pós farmacêuticos
CN113069415B (zh) * 2021-04-09 2022-09-09 湖北中医药大学 难溶性药物纳米混悬剂及其制备方法
WO2023283616A1 (en) * 2021-07-09 2023-01-12 Regents Of The University Of Minnesota Amorphous solid dispersion of sorafenib and solid formualtion comprising the same
US11980619B2 (en) 2021-07-28 2024-05-14 Nanocopoeia, Llc Pharmaceutical compositions and crushable tablets including amorphous solid dispersions of dasatinib and uses
TW202444365A (zh) 2023-01-31 2024-11-16 漢達生技醫藥股份有限公司 改良之卡博替尼組合物及其使用方法
CN116688139B (zh) * 2023-06-25 2024-03-29 深圳市新阳唯康科技有限公司 一种克唑替尼药物组合物及其制备方法和应用
US20260096994A1 (en) * 2024-10-07 2026-04-09 Boehringer Ingelheim International Gmbh Solid dispersions having stabilized emulsion particles
CN120919059B (zh) * 2025-10-15 2026-02-03 浙江奥翔药业股份有限公司 一种芦可替尼药物组合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
WO2000018374A1 (en) * 1998-10-01 2000-04-06 Elan Pharma International, Ltd. Controlled release nanoparticulate compositions
US6869617B2 (en) 2000-12-22 2005-03-22 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
AU2004206109A1 (en) * 2003-01-21 2004-08-05 Ranbaxy Laboratories Limited Co-precipitated amorphous losartan and dosage forms comprising the same
EP1898882B1 (en) * 2005-06-09 2009-10-28 Elan Pharma International Limited Nanoparticulate ebastine formulations
BRPI0613631A8 (pt) * 2005-07-18 2017-12-26 Univ Massachusetts Lowell nanoemulsão e método,
WO2009118356A2 (en) * 2008-03-25 2009-10-01 Formac Pharmaceuticals N.V. Preparation method for solid disupersions
US8187554B2 (en) * 2008-04-23 2012-05-29 Microfluidics International Corporation Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems
GB0909154D0 (en) * 2008-09-25 2009-07-08 Nanomaterials Tech Pte Ltd A process for making particles for delivery of drug nanoparticles
CN201337903Y (zh) 2008-12-30 2009-11-04 河北科技大学 一种用于制备超细无定型头孢呋辛酯的微反应器
CN101507908B (zh) * 2009-04-09 2010-12-01 北京化工大学 微通道套管式装置及其应用
HUP0900376A2 (en) * 2009-06-19 2011-01-28 Nangenex Nanotechnologiai Zartkoerueen Muekoedoe Reszvenytarsasag Nanoparticulate candesartan cilexetil composition
HUP1000327A2 (en) * 2010-06-18 2012-01-30 Druggability Technologies Ip Holdco Jersey Ltd Composition containing nanostructured ezetibime and process for it's preparation
HUP1000325A2 (en) * 2010-06-18 2012-01-30 Druggability Technologies Ip Holdco Jersey Ltd Nanostructured aprepitant compositions and process for their preparation
US20120167410A1 (en) * 2010-12-21 2012-07-05 Basf Se Spray drying techniques
EP2802314B1 (en) 2012-01-13 2020-11-25 XSpray Microparticles AB A method for producing stable, amorphous hybrid nanoparticles comprising at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix- forming component.
CN112353762A (zh) * 2013-01-22 2021-02-12 霍夫曼-拉罗奇有限公司 具有改善的生物利用度的药物组合物
PT108368B (pt) * 2015-03-31 2018-11-05 Hovione Farm S A Produção contínua de partículas

Also Published As

Publication number Publication date
JP2020183426A (ja) 2020-11-12
JP2025060664A (ja) 2025-04-10
IL250372A0 (en) 2017-03-30
WO2016016665A1 (en) 2016-02-04
JP2023012459A (ja) 2023-01-25
US20170209372A1 (en) 2017-07-27
JP2017523205A (ja) 2017-08-17
PT107846B (pt) 2019-03-22
CA2956732C (en) 2022-11-22
CA2956732A1 (en) 2016-02-04
CN107205931A (zh) 2017-09-26
EP3174528A1 (en) 2017-06-07
CN117159474A (zh) 2023-12-05
AU2015295073A1 (en) 2017-02-23
PT107846A (pt) 2016-02-01

Similar Documents

Publication Publication Date Title
AU2015295073B2 (en) A method of preparing amorphous solid dispersion in submicron range by co-precipitation
JP7203078B2 (ja) 粒子の連続製造方法
Dhumal et al. Preparation of amorphous cefuroxime axetil nanoparticles by sonoprecipitation for enhancement of bioavailability
RU2595841C2 (ru) Композиции наноструктурированного апрепитанта, способ их получения и содержащие их фармацевтические композиции
WO2016155655A1 (zh) Parp抑制剂固体药物剂型及其应用
EA028009B1 (ru) Фармацевтическая композиция с улучшенной биодоступностью
WO1999002665A1 (en) Nanocrystalline formulations of human immunodeficiency virus (hiv) protease inhibitors using cellulosic surface stabilizers and methods of making such formulations
Chary et al. Optimizing entrectinib nanosuspension: quality by design for enhanced oral bioavailability and minimized fast-fed variability
Kumar et al. Novel approaches for enhancement of drug bioavailability
CA2534471A1 (en) Method and apparatus for producing ultrafine drug particles
EP2170289A2 (en) Preparation method for solid disupersions
TW201014615A (en) A complex organic compound powder for medicine, the preparation method thereof and the suspension
Armstrong et al. Formulation and scale-up of fast-dissolving lumefantrine nanoparticles for oral malaria therapy
Duarte et al. Production of nano-solid dispersions using a novel solvent-controlled precipitation process—Benchmarking their in vivo performance with an amorphous micro-sized solid dispersion produced by spray drying
Markad et al. Review on: Solubility Enhancement of Poorly Water Soluble Drugs
WO2006073154A1 (ja) 医薬組成物及びその製造方法
Nekkanti et al. Developing nanoparticle formulations of poorly soluble drugs
ES2988334T3 (es) Producción continua de partículas
Pillai Development and Characterization of Solid Dosage form Incorporating Camptothecin Analog Nanoparticles
TW202128138A (zh) 製備奈米顆粒活性成分之方法

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)