AU2015269198B2 - Sulfur(VI) fluoride compounds and methods for the preparation thereof - Google Patents

Sulfur(VI) fluoride compounds and methods for the preparation thereof Download PDF

Info

Publication number
AU2015269198B2
AU2015269198B2 AU2015269198A AU2015269198A AU2015269198B2 AU 2015269198 B2 AU2015269198 B2 AU 2015269198B2 AU 2015269198 A AU2015269198 A AU 2015269198A AU 2015269198 A AU2015269198 A AU 2015269198A AU 2015269198 B2 AU2015269198 B2 AU 2015269198B2
Authority
AU
Australia
Prior art keywords
nmr
group
mhz
compound
nonaromatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2015269198A
Other languages
English (en)
Other versions
AU2015269198A1 (en
Inventor
Aleksandra Baranczak
Wentao Chen
Jiajia Dong
Jeffery W. Kelly
K. Barry Sharpless
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of AU2015269198A1 publication Critical patent/AU2015269198A1/en
Application granted granted Critical
Publication of AU2015269198B2 publication Critical patent/AU2015269198B2/en
Priority to AU2021201062A priority Critical patent/AU2021201062B2/en
Priority to AU2023200095A priority patent/AU2023200095B2/en
Priority to AU2024219511A priority patent/AU2024219511A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/14Quaternary ammonium compounds, e.g. edrophonium, choline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41681,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/473Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/655Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/31Somatostatins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0404Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0491Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0497Organic compounds conjugates with a carrier being an organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00Esters of sulfuric acids
    • C07C305/26Halogenosulfates, i.e. monoesters of halogenosulfuric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/041,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/081,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/187-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2/00Peptides of undefined number of amino acids; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/16Oxytocins; Vasopressins; Related peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18Fluorenes; Hydrogenated fluorenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Rheumatology (AREA)
AU2015269198A 2014-06-06 2015-06-05 Sulfur(VI) fluoride compounds and methods for the preparation thereof Active AU2015269198B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2021201062A AU2021201062B2 (en) 2014-06-06 2021-02-18 Sulfur(VI) fluoride compounds and methods for the preparation thereof
AU2023200095A AU2023200095B2 (en) 2014-06-06 2023-01-09 Sulfur(VI) fluoride compounds and methods for the preparation thereof
AU2024219511A AU2024219511A1 (en) 2014-06-06 2024-09-09 Sulfur(VI) fluoride compounds and methods for the preparation thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462008925P 2014-06-06 2014-06-06
US62/008,925 2014-06-06
PCT/US2015/034516 WO2015188120A1 (en) 2014-06-06 2015-06-05 Sulfur(vi) fluoride compounds and methods for the preparation thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021201062A Division AU2021201062B2 (en) 2014-06-06 2021-02-18 Sulfur(VI) fluoride compounds and methods for the preparation thereof

Publications (2)

Publication Number Publication Date
AU2015269198A1 AU2015269198A1 (en) 2016-12-22
AU2015269198B2 true AU2015269198B2 (en) 2020-12-10

Family

ID=54767460

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2015269198A Active AU2015269198B2 (en) 2014-06-06 2015-06-05 Sulfur(VI) fluoride compounds and methods for the preparation thereof
AU2021201062A Active AU2021201062B2 (en) 2014-06-06 2021-02-18 Sulfur(VI) fluoride compounds and methods for the preparation thereof
AU2023200095A Active AU2023200095B2 (en) 2014-06-06 2023-01-09 Sulfur(VI) fluoride compounds and methods for the preparation thereof
AU2024219511A Pending AU2024219511A1 (en) 2014-06-06 2024-09-09 Sulfur(VI) fluoride compounds and methods for the preparation thereof

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2021201062A Active AU2021201062B2 (en) 2014-06-06 2021-02-18 Sulfur(VI) fluoride compounds and methods for the preparation thereof
AU2023200095A Active AU2023200095B2 (en) 2014-06-06 2023-01-09 Sulfur(VI) fluoride compounds and methods for the preparation thereof
AU2024219511A Pending AU2024219511A1 (en) 2014-06-06 2024-09-09 Sulfur(VI) fluoride compounds and methods for the preparation thereof

Country Status (8)

Country Link
US (5) US10117840B2 (OSRAM)
EP (3) EP3151817B1 (OSRAM)
JP (3) JP6738326B2 (OSRAM)
CN (2) CN106659700B (OSRAM)
AU (4) AU2015269198B2 (OSRAM)
CA (1) CA2953237C (OSRAM)
ES (2) ES2956953T3 (OSRAM)
WO (1) WO2015188120A1 (OSRAM)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11406742B2 (en) 2014-07-18 2022-08-09 M.A. Med Alliance SA Coating for intraluminal expandable catheter providing contact transfer of drug micro-reservoirs
CA2990625C (en) 2015-06-22 2023-12-05 The Scripps Research Institute Polymerization of silyl- and fluoro-containing monomers
US11884612B2 (en) 2016-03-16 2024-01-30 The Regents Of The University Of California Covalent peptide binders
MX2019005823A (es) * 2016-11-19 2019-07-10 Trinapco Inc Metodo de elaboracion de n-(fluorosulfonil) dimetilamina.
US11254702B2 (en) * 2016-11-29 2022-02-22 The Scripps Research Institute Thionyl tetrafluoride modified compounds and uses
KR102747905B1 (ko) 2017-01-31 2024-12-31 아비나스 오퍼레이션스, 인코포레이티드 세레블론 리간드 및 이를 포함하는 이작용성 화합물
CN107353287B (zh) * 2017-05-26 2019-11-05 重庆文理学院 一种喹喔啉并杂氮环丁酮类化合物及其在抗肿瘤中的应用
WO2019036517A1 (en) 2017-08-14 2019-02-21 Bioduro, Llc REAGENTS FOR THE FLUOROSULFATION OF ALCOHOLS OR AMINES
EP3715342B1 (en) 2017-11-22 2024-08-07 Zhonghongxin Investment Holdings (Shenzhen) Co., Ltd Fluorosulfonyl-containing compound, intermediate thereof, preparation method therefor and use thereof
CN109867648A (zh) * 2017-12-02 2019-06-11 浙江医药股份有限公司新昌制药厂 一种依帕列净有关物质impd的合成方法
WO2019139979A2 (en) * 2018-01-09 2019-07-18 The Scripps Research Institute Arylfluorosulfate compounds and methods
CN110217764B (zh) * 2018-03-02 2022-08-09 中国科学院上海有机化学研究所 一种双氟磺酰亚胺的有机碱盐的制备方法
KR102062848B1 (ko) * 2018-03-06 2020-01-06 서울대학교산학협력단 선택적으로 기능화된 타이로신을 가지는 생체 물질의 제조방법, 선택적으로 기능화된 타이로신을 가지는 생체 물질 및 이를 유효성분으로 함유하는 약학적 조성물
CA3093377A1 (en) * 2018-03-08 2019-09-12 The Regents Of The University Of California Bioreactive compositions and methods of use thereof
CN108530372A (zh) * 2018-05-08 2018-09-14 武汉理工大学 一种5-磺酰氟取代异恶唑类化合物的制备方法
WO2020119595A1 (zh) * 2018-12-13 2020-06-18 中国科学院上海有机化学研究所 一种酚盐及其应用
WO2020167951A1 (en) 2019-02-14 2020-08-20 Knepper Paul A Composition and method for inhibiting platelet aggregation
EP3931330A4 (en) 2019-02-25 2023-03-15 Ginkgo Bioworks, Inc. BIOSYNTHESIS OF CANNABINOIDS AND CANNABINOID PRECURSORS
CN110429336B (zh) * 2019-07-24 2022-07-12 江苏国泰超威新材料有限公司 一种非水电解液及锂离子电池
CN110668978B (zh) * 2019-09-23 2025-08-26 广州天赐高新材料股份有限公司 双磺酸酯化合物及其制备方法以及电解液和储能装置
US12466819B2 (en) 2019-12-13 2025-11-11 712 North Inc. Tricyclic compounds with OMA1/OPA1 modulatory properties
PH12022551486A1 (en) 2019-12-19 2023-11-13 Arvinas Operations Inc Compounds and methods for the targeted degradation of androgen receptor
CN111040165A (zh) * 2019-12-26 2020-04-21 白银图微新材料科技有限公司 聚磺酸酯类聚合物及其聚合方法
CN113121401B (zh) * 2020-01-16 2022-10-04 中国科学院上海有机化学研究所 一种n-取代羰基氟磺酰胺化合物、制备方法及其应用
US20230111856A1 (en) * 2020-03-02 2023-04-13 University Of Southern California Opioid receptor antagonists
CN112028987B (zh) * 2020-06-01 2021-07-30 广东圣赛生物科技有限公司 一种结合免疫抑制分子pd-l1的蛋白药物
CN111793010B (zh) * 2020-06-28 2022-03-15 浙江工业大学 一种2,5二氯-4氨基苯磺酰氟的制备方法
KR20230054416A (ko) 2020-08-21 2023-04-24 에스이에스 홀딩스 피티이. 엘티디. 비스무트 트리플루오라이드를 이용한 n,n-분지형 설파모일 플루오라이드 화합물의 합성
KR102888292B1 (ko) 2020-10-30 2025-11-19 주식회사 엘지화학 술포닐플루오라이드기 함유 화합물 및 이의 제조방법
CN112675298B (zh) * 2020-12-28 2024-05-03 中国医学科学院医学生物学研究所 一种免疫佐剂、含有所述免疫佐剂的疫苗及制备方法和应用
WO2022160357A1 (zh) * 2021-02-01 2022-08-04 苏州大学 高分子凝胶用单体及高分子凝胶与制备方法
CN114907241B (zh) * 2021-02-09 2024-05-17 中宏鑫投资控股(深圳)有限公司 一种含氟磺酰基的胍类化合物及其制备方法和应用
JP2024512297A (ja) * 2021-03-01 2024-03-19 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア 生体反応性化合物及びその使用方法
CN113097644B (zh) * 2021-04-01 2023-03-31 河南锂动电源有限公司 一种SOFs-P5G/PVDF锂离子电池隔膜的制备方法
EP4330214A4 (en) * 2021-04-28 2025-11-26 Univ California BIOREACTIVE PROTEINS CONTAINING NON-NATURAL AMINO ACIDS
CN113248444B (zh) * 2021-05-31 2022-07-19 福州大学 一种氟磺酰基自由基试剂及其制备方法和应用
EP4347543A4 (en) * 2021-06-02 2025-10-15 Univ California PROTEINS WITH UNNATURAL AMINO ACIDS AND METHODS OF USE
CN113548986B (zh) * 2021-07-14 2023-05-23 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) 一种磺酰氟基化合物及其应用
CN113387845B (zh) * 2021-07-16 2022-12-20 国药集团化学试剂有限公司 一种苯甲基磺酰氟的制备方法
EP4212151B1 (en) 2022-01-13 2025-03-12 Paul A. Knepper Stilbene, flavonol or curcumin compounds for use in the treatment of age-related macular degeneration (amd; armd)
US20250179012A1 (en) * 2022-03-04 2025-06-05 H. Lee Moffitt Cancer Center And Research Institute, Inc. Synthesis of sulfur(vi) compounds and reagents for same
CA3266847A1 (en) * 2022-09-16 2024-03-21 Dogwood Therapeutics, Inc. VALACYCLOVIR AND CELECOXIB FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND COVID-19
EP4612127A1 (en) * 2022-11-02 2025-09-10 The Regents Of The University Of California Bioreactive proteins containing unnatural amino acids
CN118546080A (zh) * 2024-05-15 2024-08-27 济南大学 一种芳基氟磺酸盐化合物的制备方法
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion
CN119751372B (zh) * 2024-12-20 2025-11-25 江南大学 一种2-氧代-4-苯基恶嗪磺酰氟的制备方法
CN120040411B (zh) * 2025-01-07 2025-11-07 浙江大学衢州研究院 一种一锅法制备芳基冠醚化合物的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD299029A5 (de) * 1989-10-25 1992-03-26 Zentralinstitut Fuer Anorganische Chemie,De Insektizide und fungizide mittel auf basis neuer c-fluorierter aminosulfonsaeurederivate
WO1997022589A1 (en) * 1995-12-15 1997-06-26 Glaxo Group Limited Benzamide derivatives as thrombin inhibitors
WO2004103070A2 (en) * 2003-05-12 2004-12-02 Divergence, Inc. Nematicidal compositions and methods
WO2014031791A1 (en) * 2012-08-21 2014-02-27 Abbvie Inc. Process for preparing antiviral compounds
EP2727905A1 (en) * 2011-06-29 2014-05-07 Central Glass Company, Limited Process for producing fluorosulfuric acid aromatic-ring esters

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE532394C (de) * 1930-08-08 1931-08-27 Willy Lange Dr Verfahren zur Darstellung von Arylfluorsulfonaten und ihren Derivaten
US3733304A (en) * 1971-04-01 1973-05-15 American Cyanamid Co Aryl sulfate polymers and methods for their production
FR2297211A1 (fr) * 1975-01-13 1976-08-06 Eastman Kodak Co Nouveaux composes aromatiques fluorosulfones
US5112866A (en) * 1988-09-06 1992-05-12 Ortho Pharmaceutical Corporation Ethanesulfonamide derivatives
US4874771A (en) * 1988-09-06 1989-10-17 Ortho Pharmaceutical Corporation Ethanesulfonamide derivatives
ES2052954T3 (es) 1988-12-15 1994-07-16 Rhone Poulenc Sante Derivados de imino-2-polifluoroalcoxi-6-benzotiazol, sus procedimientos de preparacion y los medicamentos que les contienen.
US5245027A (en) * 1989-11-21 1993-09-14 Bristol-Myers Squibb Company 3-fluorosulfonyloxyceph-3-em compounds
IL104303A0 (en) * 1992-01-06 1993-05-13 Smithkline Beecham Corp Process
US5457194A (en) * 1993-03-17 1995-10-10 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
DE4337321A1 (de) * 1993-11-02 1995-05-04 Basf Ag Cyclische Acetale, Verfahren zu deren Herstellung und deren Umsetzung zu Pflanzenschutzmitteln
WO1995014023A1 (en) 1993-11-19 1995-05-26 Abbott Laboratories Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5688825A (en) * 1996-05-31 1997-11-18 University Of Connecticut Anandamide amidase inhibitors as analgesic agents
US6015815A (en) * 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
AU764123B2 (en) * 1998-09-02 2003-08-07 Pharmagenesis, Inc. Triptolide prodrugs having high aqueous solubility
WO2006060654A2 (en) 2004-12-01 2006-06-08 Divergence, Inc. Pesticidal compositions and methods
US7919629B2 (en) * 2005-12-12 2011-04-05 Phostech Lithium Inc. Sulphonyl-1,2,4-triazole salts
EP1976495A2 (en) * 2006-01-06 2008-10-08 Aarhus Universitet Compounds acting on the serotonin transporter
JP5607930B2 (ja) 2006-10-12 2014-10-15 ビーエイチアイ リミテッド パートナーシップ 3−アミノ−1−プロパンスルホン酸を送達するための方法、化合物、組成物および媒体
KR100873270B1 (ko) * 2006-10-25 2008-12-11 주식회사 엘지화학 비수 전해액 및 이를 포함하는 전기화학소자
JP5412742B2 (ja) * 2008-03-31 2014-02-12 セントラル硝子株式会社 4−パーフルオロイソプロピルアニリン類の製造方法
JP5338138B2 (ja) * 2008-05-29 2013-11-13 セントラル硝子株式会社 ハロゲン化α−フルオロエーテル類の製造方法
CN102341390A (zh) * 2009-01-09 2012-02-01 哈佛学院董事会 含氟化合物及其使用方法
WO2010113151A1 (en) 2009-03-31 2010-10-07 Technion Research & Development Foundation Ltd. Conjugated antimicrobial agents
EP2485727A4 (en) * 2009-10-06 2013-05-01 Afraxis Inc PYRROLOPYRAZOLE FOR THE TREATMENT OF CNS DISEASES
JP5850848B2 (ja) * 2009-11-25 2016-02-03 ノヴォ ノルディスク アー/エス ポリペプチドの製造方法
CN104025364B (zh) * 2011-12-22 2017-03-08 吉坤日矿日石能源株式会社 有机电解质和有机电解质蓄电池
AR091651A1 (es) * 2012-07-03 2015-02-18 Ardea Biosciences Inc Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico
WO2014078725A1 (en) * 2012-11-16 2014-05-22 Trinapco, Inc. Synthesis of tetrabutylammonium bis(fluorosulfonyl)imide and related salts

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD299029A5 (de) * 1989-10-25 1992-03-26 Zentralinstitut Fuer Anorganische Chemie,De Insektizide und fungizide mittel auf basis neuer c-fluorierter aminosulfonsaeurederivate
WO1997022589A1 (en) * 1995-12-15 1997-06-26 Glaxo Group Limited Benzamide derivatives as thrombin inhibitors
WO2004103070A2 (en) * 2003-05-12 2004-12-02 Divergence, Inc. Nematicidal compositions and methods
EP2727905A1 (en) * 2011-06-29 2014-05-07 Central Glass Company, Limited Process for producing fluorosulfuric acid aromatic-ring esters
WO2014031791A1 (en) * 2012-08-21 2014-02-27 Abbvie Inc. Process for preparing antiviral compounds

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
Brouwer, A. J., et.al., "Synthesis and biological evaluation of novel irreversible serine protease inhibitors using amino acid based sulfonyl fluorides as an electrophilic trap", Bioorganic & medicinal chemistry, 19(7), 2011, 2397-2406. *
Cramer, R. and Coffman, C. "New synthesis of aryl fluorides and aryl fluorosulfonates from oxyfluorides of sulfur", The Journal of Organic Chemistry, 26(10), 1961, 4164-4165. *
CRAMER, R. and Coffman, D. D., "Iminosulfur Oxydifluorides", The Journal of Organic Chemistry, 26(10), 1961, 4010-4014. *
Dong, J., Krasnova, L., Finn, M. G., and Sharpless, K. B., "Sulfur (VI) fluoride exchange (SuFEx): another good reaction for click chemistry", Angewandte Chemie International Edition, 53(36), 2014, 9430-9448. *
Firth Jr, W. C., " Preparation of aromatic polysulfates and copoly (sulfate carbonates)", Journal of Polymer Science Part B: Polymer Letters, 10(8), 1972, 637-641. *
Krutak, J. J., Burpitt, R. D., Moore, W. H. and Hyatt, J. A., "Chemistry of ethenesulfonyl fluoride. Fluorosulfonylethylation of organic compounds", The Journal of Organic Chemistry, 44(22), 1979, 3847-3858. *
Mannhold, R., et. al., "6-Substituted benzopyrans as potassium channel activators: synthesis, vasodilator properties, and multivariate analysis", Journal of medicinal chemistry, 42(6), 1999, 981-991. *
Matesic, L., et. al., "Ascertaining the suitability of aryl sulfonyl fluorides for [18F] radiochemistry applications: a systematic investigation using microfluidics" The Journal of Organic Chemistry, 78(22), 2013, 11262-11270. *
McGuire, M. A., et al., The Journal of Organic Chemistry, 59(22), 1994, 6683-6686. *
Mews, R., and Henle, H., "Amino-sulphur-fluorine derivatives as fluoride ion donors: preparation of three-and four-coordinated cations of sulphur (IV) and (VI)" Journal of Fluorine Chemistry, 14(6), 1979, 495-510. *
Pridgen, L. N., and Huang, G. K., "An optimized palladium catalyzed cross-coupling of nonracemic trifluoromethylsulfonyl and fluorosulfonyl enol ethers to arylboronic acids", Tetrahedron letters, 39(46), 1998, 8421-8424. *
Roth, G. P. and Fuller, C. E., "Palladium cross-coupling reactions of aryl fluorosulfonates: an alternative to triflate chemistry", The Journal of Organic Chemistry, 56(11), 1991, 3493-3496. *
Soltani, S., Babaei, H., Zeynali, K. A., and Jouyban, A., "Modelling vasorelaxant activity of some drugs/drug candidates using artificial neural networks", Journal of Pharmacology and Toxicology, 2, 2007, 411-426. *
Stevens, T. E., "Reaction of azoxy compounds with fluorosulfonic acid and fluorosulfonic acid-difluoramine", The Journal of Organic Chemistry, 33(7), 1968, 2667-2671. *
von Halasz, S. P. and Glemser, O., "Darstellung von Piperidino‐schwefel (VI)‐oxidtrifluorid sowie neuen Aminoschwefel (VI)‐oxidmonofluoridimiden", Chemische Berichte, 104(4), 1971, 1256-1263. *

Also Published As

Publication number Publication date
US12390424B2 (en) 2025-08-19
US20190029972A1 (en) 2019-01-31
CN111689929A (zh) 2020-09-22
AU2023200095A1 (en) 2023-02-09
EP4295841A3 (en) 2024-03-13
EP3151817A1 (en) 2017-04-12
US10117840B2 (en) 2018-11-06
CN106659700B (zh) 2020-07-10
JP6738326B2 (ja) 2020-08-12
US11141385B2 (en) 2021-10-12
ES2956953T3 (es) 2024-01-05
US20170196985A1 (en) 2017-07-13
US10765645B2 (en) 2020-09-08
US20220000799A1 (en) 2022-01-06
ES2873962T3 (es) 2021-11-04
CA2953237C (en) 2024-06-11
CA2953237A1 (en) 2015-12-10
JP2023075089A (ja) 2023-05-30
CN106659700A (zh) 2017-05-10
AU2021201062A1 (en) 2021-03-11
AU2024219511A1 (en) 2024-10-03
AU2021201062B2 (en) 2022-11-24
US20200397719A1 (en) 2020-12-24
AU2015269198A1 (en) 2016-12-22
JP2017524731A (ja) 2017-08-31
EP3892610B1 (en) 2023-08-16
EP4295841A2 (en) 2023-12-27
US20220313624A1 (en) 2022-10-06
CN111689929B (zh) 2024-05-31
EP3151817A4 (en) 2018-01-17
JP2020186242A (ja) 2020-11-19
EP3892610A1 (en) 2021-10-13
EP3151817B1 (en) 2021-03-03
JP7227946B2 (ja) 2023-02-22
AU2023200095B2 (en) 2024-06-13
WO2015188120A1 (en) 2015-12-10

Similar Documents

Publication Publication Date Title
AU2023200095B2 (en) Sulfur(VI) fluoride compounds and methods for the preparation thereof
AU745845B2 (en) Potassium channel inhibitors
BR112020000863A2 (pt) Inibidores de magl
US11555013B2 (en) Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
HK40104062A (en) Sulfur (vi) fluoride compounds and their use in click-reaction
US20100286182A1 (en) Hydrazide compounds as thyroid hormone receptor modulators and uses thereof
US7932264B2 (en) Sinomenine derivatives and preparation and uses thereof
HK40036897B (zh) 氟化硫(vi)化合物及其制备方法
HK40036897A (en) Sulfur(vi) fluoride compounds and methods for the preparation thereof
EP4448491A2 (en) N-((adamantan-1-yl)carbamoyl)-benzenesulfonamide derivatives as soluble epoxide hydrolase inhibitors for the treatment of hypertension
TW201840530A (zh) 用於預防及/或治療自體免疫、發炎或感染相關疾病的磺醯胺或醯胺化合物、組合物與方法
HK40086425A (zh) 秋水仙碱衍生物的制备方法及其用途
KR19990058666A (ko) Nmda 수용체 길항제로 작용하는 4-(말단치환-알콕시)-퀴놀린-2-카복실산 유도체

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)