AU2015238296B2 - Substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine derivatives and 5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine derivatives as ROS1 inhibitors - Google Patents
Substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine derivatives and 5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine derivatives as ROS1 inhibitors Download PDFInfo
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- AU2015238296B2 AU2015238296B2 AU2015238296A AU2015238296A AU2015238296B2 AU 2015238296 B2 AU2015238296 B2 AU 2015238296B2 AU 2015238296 A AU2015238296 A AU 2015238296A AU 2015238296 A AU2015238296 A AU 2015238296A AU 2015238296 B2 AU2015238296 B2 AU 2015238296B2
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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| TW202016113A (zh) * | 2018-06-08 | 2020-05-01 | 大陸商貝達藥業股份有限公司 | Erk抑制劑及其應用 |
| EP3909583A4 (en) * | 2019-01-11 | 2022-08-17 | Shionogi & Co., Ltd | DIHYDROPYRAZOLOPYRAZINONE DERIVATIVES WITH MGAT2 INHIBITORY ACTIVITY |
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| CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
| US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
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| KR101238585B1 (ko) | 2008-04-07 | 2013-02-28 | 노파르티스 아게 | 단백질 키나제 억제제로서의 화합물 및 조성물 |
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| WO2011153553A2 (en) * | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
| RU2014102935A (ru) | 2011-08-02 | 2015-09-10 | Пфайзер Инк. | Кризотиниб для применения в лечении рака |
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| EP3129376B1 (en) | 2018-12-26 |
| MX2016012668A (es) | 2016-12-14 |
| CA2940918C (en) | 2023-10-24 |
| IL247947B (en) | 2019-03-31 |
| EA201691930A1 (ru) | 2017-02-28 |
| MX367914B (es) | 2019-09-11 |
| ES2715676T3 (es) | 2019-06-05 |
| WO2015144799A1 (en) | 2015-10-01 |
| BR112016022105A2 (cg-RX-API-DMAC7.html) | 2017-08-15 |
| US20170174690A1 (en) | 2017-06-22 |
| JP6522646B2 (ja) | 2019-05-29 |
| JP2017508779A (ja) | 2017-03-30 |
| CN106164076B (zh) | 2019-03-26 |
| EA032255B1 (ru) | 2019-04-30 |
| KR20160137576A (ko) | 2016-11-30 |
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