AU2014363359B2 - Modified serpins for the treatment of bleeding disorders - Google Patents

Modified serpins for the treatment of bleeding disorders Download PDF

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Publication number
AU2014363359B2
AU2014363359B2 AU2014363359A AU2014363359A AU2014363359B2 AU 2014363359 B2 AU2014363359 B2 AU 2014363359B2 AU 2014363359 A AU2014363359 A AU 2014363359A AU 2014363359 A AU2014363359 A AU 2014363359A AU 2014363359 B2 AU2014363359 B2 AU 2014363359B2
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AU
Australia
Prior art keywords
residue
serpin
modified serpin
modified
rcl
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AU2014363359A
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AU2014363359A1 (en
Inventor
Trevor Baglin
James Andrew HUNTINGTON
Stephanie Polderdijk
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Cambridge Enterprise Ltd
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Cambridge Enterprise Ltd
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Priority to AU2018279054A priority Critical patent/AU2018279054A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2014363359A 2013-12-13 2014-12-15 Modified serpins for the treatment of bleeding disorders Active AU2014363359B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2018279054A AU2018279054A1 (en) 2013-12-13 2018-12-17 Modified serpins for the treatment of bleeding disorders

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1322091.8A GB201322091D0 (en) 2013-12-13 2013-12-13 Modified serpins for the treatment of bleeding disorders
GB1322091.8 2013-12-13
PCT/EP2014/077783 WO2015086854A1 (en) 2013-12-13 2014-12-15 Modified serpins for the treatment of bleeding disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018279054A Division AU2018279054A1 (en) 2013-12-13 2018-12-17 Modified serpins for the treatment of bleeding disorders

Publications (2)

Publication Number Publication Date
AU2014363359A1 AU2014363359A1 (en) 2016-07-21
AU2014363359B2 true AU2014363359B2 (en) 2019-01-03

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2014363359A Active AU2014363359B2 (en) 2013-12-13 2014-12-15 Modified serpins for the treatment of bleeding disorders
AU2018279054A Abandoned AU2018279054A1 (en) 2013-12-13 2018-12-17 Modified serpins for the treatment of bleeding disorders

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2018279054A Abandoned AU2018279054A1 (en) 2013-12-13 2018-12-17 Modified serpins for the treatment of bleeding disorders

Country Status (25)

Country Link
US (2) US9982035B2 (https=)
EP (2) EP3434689A1 (https=)
JP (2) JP6431541B2 (https=)
KR (2) KR101954945B1 (https=)
CN (2) CN105992771B (https=)
AU (2) AU2014363359B2 (https=)
CA (1) CA2933508C (https=)
CY (1) CY1121267T1 (https=)
DK (1) DK3080157T3 (https=)
EA (1) EA034050B1 (https=)
ES (1) ES2704058T3 (https=)
GB (1) GB201322091D0 (https=)
HR (1) HRP20182138T1 (https=)
HU (1) HUE042763T2 (https=)
IL (2) IL246180B (https=)
LT (1) LT3080157T (https=)
MX (1) MX357941B (https=)
NZ (1) NZ721918A (https=)
PL (1) PL3080157T3 (https=)
PT (1) PT3080157T (https=)
RS (1) RS58191B1 (https=)
SI (1) SI3080157T1 (https=)
SM (1) SMT201900016T1 (https=)
TR (1) TR201819781T4 (https=)
WO (1) WO2015086854A1 (https=)

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GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
JP6890831B2 (ja) 2015-07-08 2021-06-18 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド Ｈｉｖ予備免疫化および免疫療法
DK3402483T3 (da) 2016-01-15 2024-01-02 American Gene Tech Int Inc Fremgangsmåder og sammensætninger til aktivering af gamma-delta-T-celler
US10888613B2 (en) 2016-02-08 2021-01-12 American Gene Technologies International Inc. Method of producing cells resistant to HIV infection
DK3426777T3 (da) 2016-03-09 2022-04-25 American Gene Tech Int Inc Kombinationsvektorer og fremgangsmåder til behandling af cancer
US11976292B2 (en) 2016-06-08 2024-05-07 American Gene Technologies International Inc. Non-integrating viral delivery system and methods related thereto
IL284348B2 (en) 2016-07-08 2025-06-01 American Gene Tech Int Inc Hiv pre-immunization and immunotherapy
DK3585808T3 (da) * 2017-02-23 2022-01-31 Preclinics Ges Fuer Praeklinische Forschung Mbh Modificerede serpiner til behandlingen af bradykinin formidlet sygdom
CA3057142A1 (en) 2017-04-03 2018-10-11 American Gene Technologies International Inc. Compositions and methods for treating phenylketonuria
RU2663464C1 (ru) * 2018-02-26 2018-08-06 Общество с ограниченной ответственностью "Международный Биотехнологический Центр "Генериум" Комбинаторная терапия для лечения геморрагического шока
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EP4707391A1 (en) * 2024-09-10 2026-03-11 e-therapeutics PLC Nucleic acid compounds for zpi inhibition

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Also Published As

Publication number Publication date
SI3080157T1 (sl) 2018-12-31
US20160311887A1 (en) 2016-10-27
EP3080157A1 (en) 2016-10-19
CN105992771A (zh) 2016-10-05
NZ721918A (en) 2019-12-20
IL262879A (en) 2018-12-31
CN110330563A (zh) 2019-10-15
HUE042763T2 (hu) 2019-07-29
TR201819781T4 (tr) 2019-01-21
PL3080157T3 (pl) 2019-03-29
CY1121267T1 (el) 2020-05-29
KR20190022945A (ko) 2019-03-06
KR101954945B1 (ko) 2019-03-07
JP6431541B2 (ja) 2018-11-28
EA201691235A1 (ru) 2016-12-30
HRP20182138T1 (hr) 2019-02-08
LT3080157T (lt) 2018-12-10
US9982035B2 (en) 2018-05-29
CA2933508C (en) 2021-04-06
IL246180A0 (en) 2016-07-31
AU2014363359A1 (en) 2016-07-21
MX357941B (es) 2018-07-31
DK3080157T3 (en) 2018-12-17
AU2018279054A1 (en) 2019-01-17
CN110330563B (zh) 2024-03-29
ES2704058T3 (es) 2019-03-14
KR102186924B1 (ko) 2020-12-04
IL246180B (en) 2018-11-29
KR20160092025A (ko) 2016-08-03
JP2019037242A (ja) 2019-03-14
WO2015086854A1 (en) 2015-06-18
PT3080157T (pt) 2019-01-11
RS58191B1 (sr) 2019-03-29
US20180273610A1 (en) 2018-09-27
EP3434689A1 (en) 2019-01-30
CA2933508A1 (en) 2015-06-18
EP3080157B1 (en) 2018-10-03
EA034050B1 (ru) 2019-12-23
JP6723319B2 (ja) 2020-07-15
MX2016007711A (es) 2016-12-09
JP2017505114A (ja) 2017-02-16
CN105992771B (zh) 2019-08-23
SMT201900016T1 (it) 2019-02-28
BR112016013591A2 (pt) 2017-10-03
US10351619B2 (en) 2019-07-16
GB201322091D0 (en) 2014-01-29

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