AU2014358677A1 - Reduction of inflammatory disease symptoms by short peptides that inhibit signaling through CD28 - Google Patents

Reduction of inflammatory disease symptoms by short peptides that inhibit signaling through CD28 Download PDF

Info

Publication number
AU2014358677A1
AU2014358677A1 AU2014358677A AU2014358677A AU2014358677A1 AU 2014358677 A1 AU2014358677 A1 AU 2014358677A1 AU 2014358677 A AU2014358677 A AU 2014358677A AU 2014358677 A AU2014358677 A AU 2014358677A AU 2014358677 A1 AU2014358677 A1 AU 2014358677A1
Authority
AU
Australia
Prior art keywords
isolated peptide
pharmaceutical composition
seq
peptide
denoted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2014358677A
Other languages
English (en)
Inventor
Gila Arad
Raymond Kaempfer
Anat Shirvan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ATOX BIO Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
ATOX BIO Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ATOX BIO Ltd, Yissum Research Development Co of Hebrew University of Jerusalem filed Critical ATOX BIO Ltd
Publication of AU2014358677A1 publication Critical patent/AU2014358677A1/en
Priority to AU2017261479A priority Critical patent/AU2017261479B2/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70521CD28, CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
AU2014358677A 2013-12-06 2014-12-07 Reduction of inflammatory disease symptoms by short peptides that inhibit signaling through CD28 Abandoned AU2014358677A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017261479A AU2017261479B2 (en) 2013-12-06 2017-11-14 Reduction of inflammatory disease symptoms by short peptides that inhibit signaling through CD28

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361912631P 2013-12-06 2013-12-06
US61/912,631 2013-12-06
US201461924869P 2014-01-08 2014-01-08
US61/924,869 2014-01-08
PCT/IL2014/051067 WO2015083173A1 (en) 2013-12-06 2014-12-07 Reduction of inflammatory disease symptoms by short peptides that inhibit signaling through cd28

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017261479A Division AU2017261479B2 (en) 2013-12-06 2017-11-14 Reduction of inflammatory disease symptoms by short peptides that inhibit signaling through CD28

Publications (1)

Publication Number Publication Date
AU2014358677A1 true AU2014358677A1 (en) 2016-06-02

Family

ID=52396781

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2014358677A Abandoned AU2014358677A1 (en) 2013-12-06 2014-12-07 Reduction of inflammatory disease symptoms by short peptides that inhibit signaling through CD28
AU2017261479A Ceased AU2017261479B2 (en) 2013-12-06 2017-11-14 Reduction of inflammatory disease symptoms by short peptides that inhibit signaling through CD28

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017261479A Ceased AU2017261479B2 (en) 2013-12-06 2017-11-14 Reduction of inflammatory disease symptoms by short peptides that inhibit signaling through CD28

Country Status (7)

Country Link
US (2) US9963497B2 (enExample)
EP (1) EP3077415B1 (enExample)
JP (1) JP6757667B2 (enExample)
AU (2) AU2014358677A1 (enExample)
CA (1) CA2932150A1 (enExample)
SG (2) SG10201804750XA (enExample)
WO (1) WO2015083173A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201804750XA (en) * 2013-12-06 2018-07-30 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Reduction of inflammatory disease symptoms by short peptides that inhibit signaling through cd28
CN110753555A (zh) 2017-04-19 2020-02-04 得克萨斯州大学系统董事会 表达工程化抗原受体的免疫细胞
US11304989B2 (en) 2017-10-06 2022-04-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Peptides for use in the treatment of viral infections
EP3755349A4 (en) 2018-02-21 2021-11-17 Board of Regents, The University of Texas System PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES
CN111253469B (zh) * 2020-03-06 2021-09-07 暨南大学 一种自组装短肽及其在治疗痤疮方面的应用
CA3233983A1 (en) * 2021-11-02 2023-05-11 Ole-Jan Iversen (Deceased) Tri-, tetra and pentapeptides, compositions thereof and their use in the therapy of psoriasis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8535672B2 (en) * 2002-04-04 2013-09-17 Yissum Research Development Of The Hebrew University Of Jerusalem Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between CD28 and the superantigen and uses thereof
AU2003272065A1 (en) 2003-04-03 2004-10-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between cd28 and the superantigen and uses thereof
US20110097339A1 (en) * 2008-07-18 2011-04-28 Domantis Limited Compositions monovalent for CD28 binding and methods of use
WO2011101791A1 (en) * 2010-02-18 2011-08-25 Tcl Pharma Anti-cd28 humanized antibodies
DE102012008730A1 (de) 2011-12-02 2013-06-06 Dr. Budz GmbH Orale Zusammensetzungen mit ungesättigten C18-Fettsäuren und ihre Verwendung
AU2013210739B2 (en) 2012-01-16 2017-07-20 Atox Bio Ltd. Synthetic peptides for treatment of bacterial infections
SG10201804750XA (en) * 2013-12-06 2018-07-30 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Reduction of inflammatory disease symptoms by short peptides that inhibit signaling through cd28

Also Published As

Publication number Publication date
US20180215804A1 (en) 2018-08-02
EP3077415A1 (en) 2016-10-12
US9963497B2 (en) 2018-05-08
SG10201804750XA (en) 2018-07-30
US10280209B2 (en) 2019-05-07
SG11201604512XA (en) 2016-07-28
AU2017261479A1 (en) 2017-11-30
AU2017261479B2 (en) 2019-05-02
US20160289295A1 (en) 2016-10-06
EP3077415B1 (en) 2020-02-12
WO2015083173A1 (en) 2015-06-11
JP6757667B2 (ja) 2020-09-23
CA2932150A1 (en) 2015-06-11
JP2017501999A (ja) 2017-01-19

Similar Documents

Publication Publication Date Title
US10280209B2 (en) Reduction of inflammatory disease symptoms by short peptides that inhibit signaling through CD28
KR20220048988A (ko) 대식세포 특이적 인게이저 조성물 및 이의 사용 방법
EP2680872B1 (en) Use of pif peptides for treating infections, atherosclerosis and peritonitis
KR20160020405A (ko) 약학적 조성물
CN113508129A (zh) 突变的白介素-34(il-34)多肽及其在治疗中的用途
CN114786701A (zh) 用于治疗癌症的包括包含il-2蛋白和cd80蛋白的融合蛋白和免疫检查点抑制剂的药物组合物
JP2023036860A (ja) 腫瘍浸潤t細胞集団を生成する方法
KR102456666B1 (ko) HLA-B57 개방 이형태체(open conformer)
WO2021053681A1 (en) Il-2 chimeric proteins for immunosuppression
JP7778070B2 (ja) 免疫調節のための化合物
KR101913333B1 (ko) 신규 ctl 에피토프 4 연결 펩타이드
US20230190865A1 (en) VIP Antagonists and Uses in Treating Cancer
EP3836951A1 (en) Peptides and compositions for targeted treatment and imaging
EP3126377B1 (en) An isolated donor mhc-derived peptide and uses thereof
IL254335B2 (en) Isolated peptides derived from the dimerization regions of b7
CA3218327A1 (en) Trem-2/dap-12 inhibitors for treating lung disease and injury and combinations thereof
JP6758022B2 (ja) 血管内皮細胞増殖因子受容体阻害ペプチド
KR20180132766A (ko) 신규한 tslp 저해인자
RU2851193C2 (ru) Мутантный полипептид интерлейкина-34 (IL-34) и его применение в терапии
JP7245844B2 (ja) 抗悪性腫瘍剤による末梢神経障害の症状軽減及び/又は発症抑制のための医薬
JP2020505324A (ja) シェーグレン症候群の治療用ペプチド
EP4082562A2 (en) Polypeptides comprising mutated forms of human vegf-a with rearrangements of disulfide bonds and compositions containing same
WO2025217056A2 (en) Vasoactive intestinal polypeptide (vip) receptor antagonists fc fusions and methods of use
HK40012892B (en) Antibodies and polypeptides directed against cd127
HK40012892A (en) Antibodies and polypeptides directed against cd127

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted