AU2014274457B2 - Capsid-modified, rAAV3 vector compositions and uses in gene therapy of human liver cancer - Google Patents

Capsid-modified, rAAV3 vector compositions and uses in gene therapy of human liver cancer Download PDF

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Publication number
AU2014274457B2
AU2014274457B2 AU2014274457A AU2014274457A AU2014274457B2 AU 2014274457 B2 AU2014274457 B2 AU 2014274457B2 AU 2014274457 A AU2014274457 A AU 2014274457A AU 2014274457 A AU2014274457 A AU 2014274457A AU 2014274457 B2 AU2014274457 B2 AU 2014274457B2
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vectors
cell
cells
accordance
vector
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AU2014274457A1 (en
Inventor
Mavis Agbandje-Mckenna
George V. Aslanidi
Chen LING
Arun Srivastava
Kim M. VAN VLIET
Li Zhong
Sergei Zolotukhin
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University of Florida Research Foundation Inc
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University of Florida
University of Florida Research Foundation Inc
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Priority to AU2020200041A priority Critical patent/AU2020200041B2/en
Priority to AU2022204246A priority patent/AU2022204246A1/en
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/34—Antigenic peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4244—Enzymes
    • A61K40/4246—Telomerase or [telomerase reverse transcriptase [TERT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0091—Purification or manufacturing processes for gene therapy compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/864—Parvoviral vectors, e.g. parvovirus, densovirus
    • C12N15/8645—Adeno-associated virus
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6027—Vectors comprising as targeting moiety peptide derived from defined protein from viruses ssDNA viruses

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AU2014274457A 2013-05-21 2014-05-21 Capsid-modified, rAAV3 vector compositions and uses in gene therapy of human liver cancer Active AU2014274457B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2020200041A AU2020200041B2 (en) 2013-05-21 2020-01-03 Capsid-modified, rAAV3 vector compositions and uses in gene therapy of human liver cancer
AU2022204246A AU2022204246A1 (en) 2013-05-21 2022-06-17 Capsid-modified, raav3 vector compositions and uses in gene therapy of human liver cancer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/899,481 2013-05-21
US13/899,481 US9920097B2 (en) 2007-04-09 2013-05-21 Capsid-modified rAAV vector compositions having improved transduction efficiencies, and methods of use
PCT/US2014/039015 WO2014193716A2 (en) 2013-05-21 2014-05-21 Capsid-modified, raav3 vector compositions and methods of use in gene therapy of human liver cancer

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AU2020200041A Division AU2020200041B2 (en) 2013-05-21 2020-01-03 Capsid-modified, rAAV3 vector compositions and uses in gene therapy of human liver cancer

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AU2014274457A1 AU2014274457A1 (en) 2016-01-21
AU2014274457B2 true AU2014274457B2 (en) 2019-10-24

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AU2014274457A Active AU2014274457B2 (en) 2013-05-21 2014-05-21 Capsid-modified, rAAV3 vector compositions and uses in gene therapy of human liver cancer
AU2020200041A Active AU2020200041B2 (en) 2013-05-21 2020-01-03 Capsid-modified, rAAV3 vector compositions and uses in gene therapy of human liver cancer
AU2022204246A Abandoned AU2022204246A1 (en) 2013-05-21 2022-06-17 Capsid-modified, raav3 vector compositions and uses in gene therapy of human liver cancer

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AU2020200041A Active AU2020200041B2 (en) 2013-05-21 2020-01-03 Capsid-modified, rAAV3 vector compositions and uses in gene therapy of human liver cancer
AU2022204246A Abandoned AU2022204246A1 (en) 2013-05-21 2022-06-17 Capsid-modified, raav3 vector compositions and uses in gene therapy of human liver cancer

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EP (2) EP2999791B1 (enExample)
JP (3) JP6628286B2 (enExample)
KR (4) KR102298579B1 (enExample)
CN (3) CN111763690A (enExample)
AU (3) AU2014274457B2 (enExample)
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DK (1) DK2999791T3 (enExample)
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