AU2013407264B2 - Small molecule inhibitors of influenza a RNA-dependent RNA polymerase - Google Patents

Small molecule inhibitors of influenza a RNA-dependent RNA polymerase Download PDF

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Publication number
AU2013407264B2
AU2013407264B2 AU2013407264A AU2013407264A AU2013407264B2 AU 2013407264 B2 AU2013407264 B2 AU 2013407264B2 AU 2013407264 A AU2013407264 A AU 2013407264A AU 2013407264 A AU2013407264 A AU 2013407264A AU 2013407264 B2 AU2013407264 B2 AU 2013407264B2
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Australia
Prior art keywords
pharmaceutical composition
independently
virus
ethyl
influenza
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AU2013407264A
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AU2013407264A1 (en
Inventor
Oleksandr Buzko
Justin Golovato
Anne-Laure Le Ny
Kayvan Niazi
Shahrooz Rabizadeh
Patrick Soon-Shiong
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Nant Holdings IP LLC
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Nant Holdings IP LLC
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Priority to AU2016273938A priority Critical patent/AU2016273938B2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2013407264A 2013-12-11 2013-12-11 Small molecule inhibitors of influenza a RNA-dependent RNA polymerase Active AU2013407264B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2016273938A AU2016273938B2 (en) 2013-12-11 2016-12-15 Small molecule inhibitors of influenza a RNA-dependent RNA polymerase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2013/074415 WO2015088516A1 (en) 2013-12-11 2013-12-11 Small molecule inhibitors of influenza a rna-dependent rna polymerase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016273938A Division AU2016273938B2 (en) 2013-12-11 2016-12-15 Small molecule inhibitors of influenza a RNA-dependent RNA polymerase

Publications (2)

Publication Number Publication Date
AU2013407264A1 AU2013407264A1 (en) 2016-07-28
AU2013407264B2 true AU2013407264B2 (en) 2016-09-29

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2013407264A Active AU2013407264B2 (en) 2013-12-11 2013-12-11 Small molecule inhibitors of influenza a RNA-dependent RNA polymerase
AU2016273938A Active AU2016273938B2 (en) 2013-12-11 2016-12-15 Small molecule inhibitors of influenza a RNA-dependent RNA polymerase

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2016273938A Active AU2016273938B2 (en) 2013-12-11 2016-12-15 Small molecule inhibitors of influenza a RNA-dependent RNA polymerase

Country Status (7)

Country Link
EP (1) EP3079693B1 (ko)
JP (1) JP6415568B2 (ko)
KR (1) KR101868128B1 (ko)
CN (1) CN106232119B (ko)
AU (2) AU2013407264B2 (ko)
CA (1) CA2939036C (ko)
WO (1) WO2015088516A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108603218A (zh) * 2016-02-05 2018-09-28 豪夫迈·罗氏有限公司 用于具有抗流感活性的化合物的测定
JP7305658B2 (ja) * 2018-01-31 2023-07-10 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー 抗ｒｓｖ活性を有するシクロアルキル置換ピラゾロピリミジン
WO2021032611A1 (en) * 2019-08-20 2021-02-25 Curovir Ab Heteroaromatic compounds useful in therapy
KR102405727B1 (ko) 2020-01-22 2022-06-07 한국한의학연구원 코로나바이러스 감염증 치료제 스크리닝 시스템
CN111388477B (zh) * 2020-04-24 2021-06-25 山东师范大学 2-苯基吡唑[1,5-a]嘧啶类化合物作为肿瘤耐药逆转剂的应用
TW202348228A (zh) 2022-02-24 2023-12-16 德商艾斯巴赫生物有限公司 病毒組合療法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050203106A1 (en) * 2002-05-10 2005-09-15 Gudmundsson Kristjan S. Therapeutic compounds
US20130231331A1 (en) * 2012-03-05 2013-09-05 Bristol-Myers Squibb Company Inhibitors of Human Immunodeficiency Virus Replication
US20130243725A1 (en) * 2012-03-13 2013-09-19 Gilead Sciences, Inc. 2'-substituted carba-nucleoside analogs for antiviral treatment

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE174917T1 (de) * 1991-04-22 1999-01-15 Otsuka Pharma Co Ltd Pyrazolo(1,5-a>pyrimidinderivate und sie enthaltende antiinflammatorische mittel
JP2008531656A (ja) * 2005-03-02 2008-08-14 ビーエーエスエフ ソシエタス・ヨーロピア ２−置換７−アミノアゾロピリミジン、それの製造方法および病原性菌類防除におけるそれの使用、ならびにその化合物を含む薬剤
CN101133058A (zh) * 2005-03-02 2008-02-27 巴斯福股份公司 2-取代的7-氨基唑并嘧啶、其制备方法及其在防治有害真菌中的用途以及包含这些化合物的组合物
WO2007076055A2 (en) * 2005-12-22 2007-07-05 Entremed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
JP2011507910A (ja) * 2007-12-21 2011-03-10 ユニバーシティー オブ ロチェスター 真核生物の寿命を変更するための方法
WO2010001967A1 (ja) * 2008-07-02 2010-01-07 国立大学法人筑波大学 インフルエンザウイルス由来のrnaポリメラーゼ発現系構築と結晶化及び抗インフルエンザ薬のスクリーニング方法
WO2012087769A2 (en) * 2010-12-22 2012-06-28 Indiana Research And Technology Corporation A novel cell-based assay to identify polymerase inhibitors for viral infectious disease
US8633198B1 (en) * 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
WO2013123974A1 (en) * 2012-02-21 2013-08-29 Universita' Degli Studi Di Padova New inhibitors of influenza a and b viruses acting by disrupting pa and pb1 subunit interactions of heterotrimeric viral rna polymerase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050203106A1 (en) * 2002-05-10 2005-09-15 Gudmundsson Kristjan S. Therapeutic compounds
US20130231331A1 (en) * 2012-03-05 2013-09-05 Bristol-Myers Squibb Company Inhibitors of Human Immunodeficiency Virus Replication
US20130243725A1 (en) * 2012-03-13 2013-09-19 Gilead Sciences, Inc. 2'-substituted carba-nucleoside analogs for antiviral treatment

Also Published As

Publication number Publication date
CA2939036A1 (en) 2015-06-18
AU2016273938B2 (en) 2018-08-23
CN106232119A (zh) 2016-12-14
AU2016273938A1 (en) 2017-01-05
JP6415568B2 (ja) 2018-10-31
EP3079693B1 (en) 2019-09-04
EP3079693A4 (en) 2017-05-31
CN106232119B (zh) 2021-02-19
CA2939036C (en) 2020-09-22
JP2017500314A (ja) 2017-01-05
KR20160138943A (ko) 2016-12-06
AU2013407264A1 (en) 2016-07-28
KR101868128B1 (ko) 2018-06-18
WO2015088516A1 (en) 2015-06-18
EP3079693A1 (en) 2016-10-19

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