AU2013340831B2 - Fc gamma receptor IIB variants - Google Patents

Fc gamma receptor IIB variants Download PDF

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Publication number
AU2013340831B2
AU2013340831B2 AU2013340831A AU2013340831A AU2013340831B2 AU 2013340831 B2 AU2013340831 B2 AU 2013340831B2 AU 2013340831 A AU2013340831 A AU 2013340831A AU 2013340831 A AU2013340831 A AU 2013340831A AU 2013340831 B2 AU2013340831 B2 AU 2013340831B2
Authority
AU
Australia
Prior art keywords
protein
seq
nucleic acid
acid sequence
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013340831A
Other languages
English (en)
Other versions
AU2013340831A1 (en
Inventor
Uwe Jacob
Thomas Pohl
Peter Sondermann
Dominik TER MEER
Reno WINTER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suppremol GmbH
Original Assignee
Suppremol GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suppremol GmbH filed Critical Suppremol GmbH
Publication of AU2013340831A1 publication Critical patent/AU2013340831A1/en
Application granted granted Critical
Publication of AU2013340831B2 publication Critical patent/AU2013340831B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
AU2013340831A 2012-10-30 2013-10-30 Fc gamma receptor IIB variants Ceased AU2013340831B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/663,527 2012-10-30
US13/663,527 US10028998B2 (en) 2012-10-30 2012-10-30 Method for treating an inflammatory disease and/or an autoimmune disease with a soluble FcγRIIb
PCT/EP2013/072741 WO2014068012A1 (en) 2012-10-30 2013-10-30 Fc gamma receptor iib variants

Publications (2)

Publication Number Publication Date
AU2013340831A1 AU2013340831A1 (en) 2015-04-30
AU2013340831B2 true AU2013340831B2 (en) 2017-11-23

Family

ID=49679480

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013340831A Ceased AU2013340831B2 (en) 2012-10-30 2013-10-30 Fc gamma receptor IIB variants

Country Status (27)

Country Link
US (1) US10028998B2 (enExample)
EP (1) EP2914624B1 (enExample)
JP (2) JP6423351B2 (enExample)
KR (1) KR102170674B1 (enExample)
CN (1) CN104918955B (enExample)
AU (1) AU2013340831B2 (enExample)
BR (1) BR112015008815A2 (enExample)
CA (1) CA2887164C (enExample)
CL (1) CL2015001127A1 (enExample)
DK (1) DK2914624T3 (enExample)
EA (1) EA033437B9 (enExample)
ES (1) ES2628049T3 (enExample)
HR (1) HRP20170894T1 (enExample)
HU (1) HUE032786T2 (enExample)
IL (1) IL238528A (enExample)
IN (1) IN2015DN03206A (enExample)
LT (1) LT2914624T (enExample)
MX (1) MX359802B (enExample)
MY (1) MY173686A (enExample)
NZ (1) NZ706884A (enExample)
PH (1) PH12015500771B1 (enExample)
PL (1) PL2914624T3 (enExample)
PT (1) PT2914624T (enExample)
RS (1) RS56075B1 (enExample)
SG (1) SG11201502749VA (enExample)
SI (1) SI2914624T1 (enExample)
WO (1) WO2014068012A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10669324B2 (en) 2012-10-30 2020-06-02 Suppremol Gmbh Vector encoding an Fc gamma receptor IIB protein and composition of the encoded protein
US10028998B2 (en) 2012-10-30 2018-07-24 Suppremol Gmbh Method for treating an inflammatory disease and/or an autoimmune disease with a soluble FcγRIIb
EP2796144A1 (en) * 2013-04-26 2014-10-29 SuppreMol GmbH Highly concentrated Formulations of soluble Fc receptors
EP2837637A1 (en) 2013-08-16 2015-02-18 SuppreMol GmbH Novel anti-FcyRIIB IgG-type antibody
CN105873600B (zh) 2013-10-16 2019-11-05 苏伯利莫尔公司 用于自身免疫性大疱病治疗的可溶性Fcγ受体
JP6710451B2 (ja) * 2016-03-31 2020-06-17 東ソー株式会社 改変型組換えＦｃγＲＩＩｂ
US20210260611A1 (en) * 2018-06-25 2021-08-26 Basf Coatings Gmbh Method for producing an optimized coating, and coating which can be obtained using said method
CN111454914A (zh) * 2019-01-18 2020-07-28 嘉兴安宇生物科技有限公司 一种腺病毒快速纯化方法
US12030945B2 (en) 2022-10-25 2024-07-09 Seismic Therapeutic, Inc. Variant IgG Fc polypeptides and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032767A1 (en) * 1998-12-03 2000-06-08 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. RECOMBINANT SOLUBLE Fc RECEPTORS

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3626187B2 (ja) 1993-06-07 2005-03-02 バイカル インコーポレイテッド 遺伝子治療に適するプラスミド
CA2225460A1 (en) 1995-06-23 1997-01-09 Winston Campbell Patterson Transcriptional regulation of genes encoding vascular endothelial growth factor receptors
US6849719B2 (en) 1997-09-17 2005-02-01 Human Genome Sciences, Inc. Antibody to an IL-17 receptor like protein
DE10157290A1 (de) * 2001-11-22 2003-06-05 Max Planck Gesellschaft Pharmazeutische Zusammensetzung enthaltend sFcRgamma IIb oder sFcRgamma III
US20040132101A1 (en) * 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
ES2371468T3 (es) 2003-11-26 2012-01-03 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. SUSTANCIA QUE SE UNE AL RECEPTOR HUMANO llb MEDIANTE Fc DE IgG (Fc? Rllb).
ES2359218T3 (es) 2005-12-13 2011-05-19 Suppremol Gmbh POLIPÉPTIDOS Y POLIMÉRICOS PARA LOS RECEPTORES Fc.
EP1870442A1 (en) * 2006-06-19 2007-12-26 DSMIP Assets B.V. Air drying resin and composition
EP1870422A1 (en) 2006-06-20 2007-12-26 SuppreMol GmbH Means for the treatment of diseases characterized by an excessive immune reaction
WO2009158696A1 (en) 2008-06-27 2009-12-30 Zymogenetics, Inc. SOLUBLE HYBRID Fcγ RECEPTORS AND RELATED METHODS
US10028998B2 (en) 2012-10-30 2018-07-24 Suppremol Gmbh Method for treating an inflammatory disease and/or an autoimmune disease with a soluble FcγRIIb
US10669324B2 (en) 2012-10-30 2020-06-02 Suppremol Gmbh Vector encoding an Fc gamma receptor IIB protein and composition of the encoded protein

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032767A1 (en) * 1998-12-03 2000-06-08 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. RECOMBINANT SOLUBLE Fc RECEPTORS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Press release by SuppreMol GmbH dated 12th April 2010, SuppreMol Initiates Phase Ib/Iia Clinical Trial With Its Lead Candidate SM101. *
Press release by SuppreMol GmbH dated 24th January 2011, SuppreMol Completes Successful Pre-IND Meeting with FDA. *

Also Published As

Publication number Publication date
CN104918955B (zh) 2018-10-09
AU2013340831A1 (en) 2015-04-30
SI2914624T1 (sl) 2017-07-31
CA2887164A1 (en) 2014-05-08
PL2914624T3 (pl) 2017-09-29
MY173686A (en) 2020-02-15
EA033437B1 (ru) 2019-10-31
IL238528A0 (en) 2015-06-30
US20140120080A1 (en) 2014-05-01
MX359802B (es) 2018-10-10
EA201590845A1 (ru) 2015-08-31
KR20150122621A (ko) 2015-11-02
JP6423351B2 (ja) 2018-11-14
EP2914624A1 (en) 2015-09-09
PT2914624T (pt) 2017-06-07
PH12015500771A1 (en) 2015-06-08
LT2914624T (lt) 2017-06-26
JP2016503289A (ja) 2016-02-04
CA2887164C (en) 2020-12-29
PH12015500771B1 (en) 2018-12-14
HRP20170894T1 (hr) 2017-09-08
JP2018186833A (ja) 2018-11-29
EP2914624B1 (en) 2017-03-15
US10028998B2 (en) 2018-07-24
EA033437B9 (ru) 2020-03-19
NZ706884A (en) 2019-05-31
BR112015008815A2 (pt) 2017-11-21
CL2015001127A1 (es) 2015-12-18
WO2014068012A1 (en) 2014-05-08
RS56075B1 (sr) 2017-10-31
KR102170674B1 (ko) 2020-10-28
ES2628049T3 (es) 2017-08-01
CN104918955A (zh) 2015-09-16
HK1209765A1 (en) 2016-04-08
DK2914624T3 (en) 2017-06-26
SG11201502749VA (en) 2015-05-28
IN2015DN03206A (enExample) 2015-10-02
MX2015005266A (es) 2015-10-26
HUE032786T2 (en) 2017-10-30
IL238528A (en) 2017-07-31

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired